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Aliases for MRPL45 Gene

Aliases for MRPL45 Gene

  • Mitochondrial Ribosomal Protein L45 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML45 3 4
  • MRP-L45 3 4
  • L45mt 3 4
  • 39S Ribosomal Protein L45, Mitochondrial 3

External Ids for MRPL45 Gene

Previous GeneCards Identifiers for MRPL45 Gene

  • GC17M035907
  • GC17P038369
  • GC17P036363
  • GC17P036827
  • GC17P033706
  • GC17P032251

Summaries for MRPL45 Gene

Entrez Gene Summary for MRPL45 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]

GeneCards Summary for MRPL45 Gene

MRPL45 (Mitochondrial Ribosomal Protein L45) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL45 Gene

Genomics for MRPL45 Gene

Regulatory Elements for MRPL45 Gene

Enhancers for MRPL45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G037707 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -586.1 -586101 7.3 HDGF FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS ZNF263 HNF1B MRPL45 HMGB1P24 ACACA LOC105371754
GH17G038284 1.2 Ensembl ENCODE dbSUPER 7.6 -11.3 -11320 3.3 PKNOX1 NR2F1 MAFG ZNF316 ZNF366 GATA2 IKZF1 ZNF600 PRDM10 EMSY MRPL45 LOC105371760 GC17M038268
GH17G038255 1.6 FANTOM5 ENCODE dbSUPER 5 -40.3 -40316 2.5 PKNOX1 ZFP64 SIN3A ZNF766 GLIS2 ZNF143 KLF7 ZNF263 SP3 ZNF623 ENSG00000277501 LOC100287808 TBC1D3 MRPL45 LOC440434 ENSG00000274284 GC17M038232
GH17G037486 1.7 Ensembl ENCODE dbSUPER 4.6 -806.3 -806263 8.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TADA2A DUSP14 ACACA DDX52 SYNRG MRPL45 GC17M037483 PIR41271
GH17G038323 0.8 FANTOM5 ENCODE 9.4 +27.8 27817 2.0 SOX13 SSRP1 RFX1 CEBPG ZEB2 PRDM1 SOCS7 MRPL45 TBC1D3 GPR179 GC17P038300 PIR49079
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL45 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000093740 177 1201 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MRPL45 Gene

38,297,023 bp from pter
38,323,218 bp from pter
26,196 bases
Plus strand

Genomic View for MRPL45 Gene

Genes around MRPL45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL45 Gene

Proteins for MRPL45 Gene

  • Protein details for MRPL45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L45, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A1L436
    • Q6ZMJ5

    Protein attributes for MRPL45 Gene

    306 amino acids
    Molecular mass:
    35351 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    • Sequence=BC006235; Type=Frameshift; Positions=40; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL45 Gene

neXtProt entry for MRPL45 Gene

Post-translational modifications for MRPL45 Gene

  • Ubiquitination at posLast=4949, posLast=5454, Lys62, Lys71, posLast=102102, posLast=177177, Lys240, and Lys273
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL45 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL45 Gene

Domains & Families for MRPL45 Gene

Gene Families for MRPL45 Gene

Protein Domains for MRPL45 Gene

Suggested Antigen Peptide Sequences for MRPL45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the mitochondrion-specific ribosomal protein mL45 family.
  • Belongs to the mitochondrion-specific ribosomal protein mL45 family.
genes like me logo Genes that share domains with MRPL45: view

Function for MRPL45 Gene

Gene Ontology (GO) - Molecular Function for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL45: view
genes like me logo Genes that share phenotypes with MRPL45: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL45 Gene

Localization for MRPL45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL45 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL45 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
genes like me logo Genes that share ontologies with MRPL45: view

Pathways & Interactions for MRPL45 Gene

genes like me logo Genes that share pathways with MRPL45: view

Interacting Proteins for MRPL45 Gene

Gene Ontology (GO) - Biological Process for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL45: view

No data available for SIGNOR curated interactions for MRPL45 Gene

Drugs & Compounds for MRPL45 Gene

No Compound Related Data Available

Transcripts for MRPL45 Gene

mRNA/cDNA for MRPL45 Gene

Unigene Clusters for MRPL45 Gene

Mitochondrial ribosomal protein L45:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL45 Gene

No ASD Table

Relevant External Links for MRPL45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL45 Gene

Protein differential expression in normal tissues from HIPED for MRPL45 Gene

This gene is overexpressed in Breast (45.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRPL45 Gene

Protein tissue co-expression partners for MRPL45 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL45 Gene:


SOURCE GeneReport for Unigene cluster for MRPL45 Gene:


Evidence on tissue expression from TISSUES for MRPL45 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MRPL45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL45 Gene

Orthologs for MRPL45 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL45 34
  • 98.04 (n)
(Bos Taurus)
Mammalia MRPL45 34
  • 86.38 (n)
(Canis familiaris)
Mammalia MRPL45 34
  • 86.31 (n)
(Rattus norvegicus)
Mammalia Mrpl45 34
  • 82.79 (n)
(Mus musculus)
Mammalia Mrpl45 34 16
  • 82.24 (n)
(Gallus gallus)
Aves MRPL45 34
  • 60.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl45 34
  • 61.48 (n)
Str.2539 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53772 34
(Danio rerio)
Actinopterygii mrpl45 34
  • 64.44 (n)
zgc56480 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9478 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL45 36 34
  • 54.22 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002412 34
  • 52.26 (n)
Species where no ortholog for MRPL45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL45 Gene

Gene Tree for MRPL45 (if available)
Gene Tree for MRPL45 (if available)

Paralogs for MRPL45 Gene

No data available for Paralogs for MRPL45 Gene

Variants for MRPL45 Gene

Sequence variations from dbSNP and Humsavar for MRPL45 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000020856 -- 38,299,846(+) ATCCT(C/T)CTGCC intron-variant
rs1000033474 -- 38,318,037(+) ACCCC(A/T)TCTCT intron-variant
rs1000392358 -- 38,322,346(+) CGTGG(G/T)CTCCT intron-variant
rs1000401130 -- 38,296,460(+) CTGCC(A/C)CCAAG upstream-variant-2KB
rs1000433911 -- 38,295,350(+) TCTCA(A/G)AGTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL45 Gene

Variant ID Type Subtype PubMed ID
esv2758688 CNV gain+loss 17122850
esv33106 CNV gain 17666407
nsv1146669 OTHER inversion 26484159
nsv428341 CNV gain+loss 18775914
nsv471507 CNV gain 19718026
nsv960482 CNV duplication 23825009

Variation tolerance for MRPL45 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL45 Gene

Disorders for MRPL45 Gene

Relevant External Links for MRPL45

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL45 Gene

Publications for MRPL45 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPL45 Gene

Sources for MRPL45 Gene

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