MRPL45 Gene
protein-coding GIFtS: 48
GCID: GC17P036363
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|
mitochondrial ribosomal protein L45
| |
Aliases for MRPL45 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L451 2 | | L45mt2 3 | | MRP-L452 3 | | MGC113211 | | 39S Ribosomal Protein L45, Mitochondrial2 |
Export aliases for MRPL45 gene to outside databasesPrevious GC identifers: GC17M035907 GC17P038369 GC17P036827 GC17P033706 GC17P032251 |
Summaries for MRPL45 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MRPL45: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. (provided by RefSeq, Jul 2008)
|
Genomic Views for MRPL45 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPL45 gene promoter: AhR Nkx3-1 v4 STAT1 Bach2 STAT1beta FOXD1 Lmo2 STAT1alpha Arnt STAT3 Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL45
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL45 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q21.2MRPL45 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P036363: view genomic region
(about GC identifiers)
Start:
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36,452,989 bp from pter |
End:
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36,479,101 bp from pter |
Size:
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26,113 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17+,PATCHES 36,452,997-36,479,100 |
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Proteins for MRPL45 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RM45_HUMAN, Q9BRJ2 (See
protein sequence)Recommended Name: 39S ribosomal protein L45, mitochondrial precursor Size: 306 amino acids; 35351 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=BC006235; Type=Frameshift; Positions=40;
Secondary accessions: A1L436 Q6ZMJ5Explore the universe of human proteins at neXtProt for MRPL45: NX_Q9BRJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BRJ2 MRPL45 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115727.4 ENSEMBL proteins: ENSP00000308901 ENSP00000464686 ENSP00000462622 ENSP00000462875 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
NAS | -- | | GO:0005744 | mitochondrial inner membrane presequence translocase complex |
IEA | -- | | GO:0005840 | ribosome |
IEA | -- |
MRPL45 for ontologies About GeneDecksing
MRPL45 Antibody Products: Assay Products for MRPL45: |
Protein
Domains / Families for MRPL45 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL45 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BRJ2ProtoNet protein and cluster: Q9BRJ2 UniProtKB/Swiss-Prot: RM45_HUMAN, Q9BRJ2Similarity: Belongs to the ribosomal protein L45 family |
Function for MRPL45 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL45 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL45 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL45 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | -- | | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
IEA | -- |
MRPL45 for ontologies About GeneDecksing
|
Pathways & Interactions for MRPL45 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL45
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
 5/14 Interacting proteins for MRPL45 (Q9BRJ23 ENSP000003089014) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
NAS | -- | | GO:0006886 | intracellular protein transport |
IEA | -- |
MRPL45 for ontologies About GeneDecksing
|
Drugs & Compounds for MRPL45 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MRPL45 Search CenterWatch for drugs/clinical trials and news about MRPL45 / RM45 
|
Transcripts for MRPL45 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MRPL45 gene: NM_032351.4 Unigene Cluster for MRPL45: Mitochondrial ribosomal protein L45 Hs.744110 [show with all ESTs]Unigene Representative Sequence: NM_0323515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312513(uc002hpy.3) ENST00000582535 ENST00000580762 ENST00000581817 ENST00000579911
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL45 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL45 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPL45 (NM_032351) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL45 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL45  |
Additional cDNA sequence: AK172741.1 AK225031.1 AK293605.1 BC006235.2 BC105297.1 BC130382.1 BC130384.1 8 DOTS entries: DT.454776 DT.100876933 DT.95193057 DT.91767844 DT.95193056 DT.91767848 DT.100029810 DT.92024037 24 AceView cDNA sequences: BC067758 BI459352 CB132789 BF033913 BG719833 BQ889294 BX642763 BU597225 AW391997 BI909541 AW118467 CD389339 BI458516 CB117780 BE080771 BQ307162 BI044775 H69151 BQ345978 BM830008 BF210921 BF816808 BE077412 BU589152 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL45 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MRPL45
|
Expression for MRPL45 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL45 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GACCAGCCTT
About this image See MRPL45 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPL45
SOURCE GeneReport for Unigene cluster: Hs.744110 SABiosciences Custom PCR Arrays for MRPL45
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL45 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL45 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL45 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL45 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL45 |
Orthologs for MRPL45 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL45 gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Mrpl451 , 5 |
mitochondrial ribosomal protein L451, 5 |
82.24(n)1 79.41(a)1 |
  |
11 (60.95 cM)5 670361 NM_025927.41 NP_080203.11 973157165 |
chicken (Gallus gallus) |
Aves |
MRPL451 |
mitochondrial ribosomal protein L45 |
60.94(n) 59.79(a) |
  |
426233 NM_001193585.1 NP_001180514.1 |
lizard (Anolis carolinensis) |
Reptilia |
MRPL456 |
-- |
59(a) |
1 ↔ 1 |
6(74047232-74055299) |
African clawed frog (Xenopus laevis) |
Amphibia |
MGC537722 |
similar to mitochondrial ribosomal protein L45 |
71.11(n) |
  |
BC043883.1 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc564802 |
similar to mitochondrial ribosomal protein L45 |
72.49(n) |
  |
393277 BC050166.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
mRpL451 , 3 |
structural constituent of ribosome3 mitochondrial ribosomal protein L451 |
43(a)3 52.59(n)1 42.63(a)1 |
  |
94B63 426711 NM_142815.31 NP_651072.11 |
worm (Caenorhabditis elegans) |
Secernentea |
mrpl-451 |
Protein MRPL-45 |
48.13(n) 40.36(a) |
  |
191044 NM_064946.4 NP_497347.3 |
ENSEMBL Gene Tree for MRPL45 (if available) TreeFam Gene Tree for MRPL45 (if available)  |
Paralogs for MRPL45 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MRPL45 gene
18/53 SIMAP similar genes for MRPL45 using alignment to 4 protein entries: RM45_HUMAN (see all proteins)
(see all similar genes):RHBG NLN SNRPF C12orf76 NDC80 SMYD4 KIAA1651 PFKFB3 RRM2B TUBA1C ACTR10 KIAA0101 DOCK8 FLJ00047 SLC24A1 UBXN4 COQ5 FANCA
MRPL45 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRPL45 PGOHUM00000262958 PGOHUM00000240139
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Genomic Variants for MRPL45 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL45 (36452989 - 36479101 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MRPL45 2 CNVs: 4034 7157  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL45 |
|
Disorders
/ Diseases for MRPL45 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL45 for disorders About GeneDecksing
OMIM gene information: 611850
OMIM disorders: --
1 disease for MRPL45: About MalaCardscarcinoma Human Genome Epidemiology (HuGE) Navigator: MRPL45 (1 document) Export disorders for MRPL45 gene to outside databases
|
Publications for MRPL45 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL45 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with MRPL45) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C....Spremulli L.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1, 3 Zhang Z. and Gerstein M. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
|
External Searches for MRPL45 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MRPL45 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL45 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL45 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MRPL45 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL45 gene: Search GeneIP for patents involving MRPL45
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MRPL45 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | MRPL45 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL45 |
|  |  |  | | | Search ThermoFisher Antibodies for MRPL45 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL45 |
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