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Aliases for MRPL45 Gene

Aliases for MRPL45 Gene

  • Mitochondrial Ribosomal Protein L45 2 3
  • MRP-L45 3 4
  • L45mt 3 4

External Ids for MRPL45 Gene

Previous GeneCards Identifiers for MRPL45 Gene

  • GC17M035907
  • GC17P038369
  • GC17P036363
  • GC17P036827
  • GC17P033706
  • GC17P032251

Summaries for MRPL45 Gene

Entrez Gene Summary for MRPL45 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]

GeneCards Summary for MRPL45 Gene

MRPL45 (Mitochondrial Ribosomal Protein L45) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL45 Gene

Genomics for MRPL45 Gene

Regulatory Elements for MRPL45 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL45 Gene

Chromosome:
17
Start:
38,297,023 bp from pter
End:
38,323,218 bp from pter
Size:
26,196 bases
Orientation:
Plus strand

Genomic View for MRPL45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL45 Gene

Proteins for MRPL45 Gene

  • Protein details for MRPL45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRJ2-RM45_HUMAN
    Recommended name:
    39S ribosomal protein L45, mitochondrial
    Protein Accession:
    Q9BRJ2
    Secondary Accessions:
    • A1L436
    • Q6ZMJ5

    Protein attributes for MRPL45 Gene

    Size:
    306 amino acids
    Molecular mass:
    35351 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC006235; Type=Frameshift; Positions=40; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL45 Gene

neXtProt entry for MRPL45 Gene

Proteomics data for MRPL45 Gene at MOPED

Post-translational modifications for MRPL45 Gene

  • Ubiquitination at Lys 49, Lys 54, Lys 62, Lys 71, Lys 102, Lys 177, Lys 240, and Lys 273
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL45 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPL45 Gene

Domains & Families for MRPL45 Gene

Gene Families for MRPL45 Gene

Protein Domains for MRPL45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRJ2

UniProtKB/Swiss-Prot:

RM45_HUMAN :
  • Belongs to the ribosomal protein L45 family.
Family:
  • Belongs to the ribosomal protein L45 family.
genes like me logo Genes that share domains with MRPL45: view

Function for MRPL45 Gene

Gene Ontology (GO) - Molecular Function for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL45: view
genes like me logo Genes that share phenotypes with MRPL45: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL45

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL45 Gene

Localization for MRPL45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL45 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL45 Gene COMPARTMENTS Subcellular localization image for MRPL45 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL45: view

Pathways & Interactions for MRPL45 Gene

genes like me logo Genes that share pathways with MRPL45: view

Interacting Proteins for MRPL45 Gene

Selected Interacting proteins: Q9BRJ2-RM45_HUMAN for MRPL45 Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for MRPL45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL45: view

No data available for SIGNOR curated interactions for MRPL45 Gene

Drugs & Compounds for MRPL45 Gene

No Compound Related Data Available

Transcripts for MRPL45 Gene

mRNA/cDNA for MRPL45 Gene

Unigene Clusters for MRPL45 Gene

Mitochondrial ribosomal protein L45:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL45

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL45 Gene

No ASD Table

Relevant External Links for MRPL45 Gene

GeneLoc Exon Structure for
MRPL45
ECgene alternative splicing isoforms for
MRPL45

Expression for MRPL45 Gene

mRNA expression in normal human tissues for MRPL45 Gene

Protein differential expression in normal tissues from HIPED for MRPL45 Gene

This gene is overexpressed in Breast (45.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MRPL45 Gene



SOURCE GeneReport for Unigene cluster for MRPL45 Gene Hs.744110

genes like me logo Genes that share expression patterns with MRPL45: view

Protein tissue co-expression partners for MRPL45 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL45 Gene

Orthologs for MRPL45 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL45 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL45 35
  • 86.38 (n)
  • 82.68 (a)
dog
(Canis familiaris)
Mammalia MRPL45 35
  • 86.31 (n)
  • 81.79 (a)
mouse
(Mus musculus)
Mammalia Mrpl45 35
  • 82.24 (n)
  • 79.41 (a)
Mrpl45 16
chimpanzee
(Pan troglodytes)
Mammalia MRPL45 35
  • 98.04 (n)
  • 97.05 (a)
rat
(Rattus norvegicus)
Mammalia Mrpl45 35
  • 82.79 (n)
  • 79.41 (a)
chicken
(Gallus gallus)
Aves MRPL45 35
  • 60.82 (n)
  • 59.65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl45 35
  • 61.48 (n)
  • 56.54 (a)
Str.2539 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53772 35
zebrafish
(Danio rerio)
Actinopterygii mrpl45 35
  • 64.44 (n)
  • 60.56 (a)
zgc56480 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9478 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL45 37
  • 43 (a)
mRpL45 35
  • 54.22 (n)
  • 45.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002412 35
  • 52.26 (n)
  • 44.07 (a)
Species with no ortholog for MRPL45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL45 Gene

ENSEMBL:
Gene Tree for MRPL45 (if available)
TreeFam:
Gene Tree for MRPL45 (if available)

Paralogs for MRPL45 Gene

genes like me logo Genes that share paralogs with MRPL45: view

No data available for Paralogs for MRPL45 Gene

Variants for MRPL45 Gene

Sequence variations from dbSNP and Humsavar for MRPL45 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs10568 -- 38,322,800(-) AAAAA(A/G)AAGAG utr-variant-3-prime
rs12094 -- 38,322,797(-) AAGAA(A/G)AGTGT utr-variant-3-prime
rs14911 -- 38,323,049(-) CATCT(C/T)CCACT utr-variant-3-prime
rs2610354 -- 38,297,983(-) agtcg(C/T)tggga intron-variant
rs2611850 -- 38,299,225(+) TCTCT(A/T)CATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL45 Gene

Variant ID Type Subtype PubMed ID
dgv957e1 CNV Complex 17122850
esv33106 CNV Gain 17666407

Variation tolerance for MRPL45 Gene

Residual Variation Intolerance Score: 85.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.55; 86.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL45 Gene

HapMap Linkage Disequilibrium report
MRPL45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL45 Gene

Disorders for MRPL45 Gene

Relevant External Links for MRPL45

Genetic Association Database (GAD)
MRPL45
Human Genome Epidemiology (HuGE) Navigator
MRPL45
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL45
genes like me logo Genes that share disorders with MRPL45: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL45 Gene

Publications for MRPL45 Gene

  1. A pilot study of proteomic profiles of human hepatocellular carcinoma in the United States. (PMID: 19535095) Matos J.M. … Schmidt C.M. (J. Surg. Res. 2009) 23 67
  2. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PMID: 12706105) Zhang Z. … Gerstein M. (Genomics 2003) 2 67
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67

Products for MRPL45 Gene

Sources for MRPL45 Gene

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