Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL43 Gene

Aliases for MRPL43 Gene

  • Mitochondrial Ribosomal Protein L43 2 3 5
  • Mitochondrial Ribosomal Protein BMRP36a 3 4
  • MRP-L43 3 4
  • L43mt 3 4
  • BMRP36a 3

External Ids for MRPL43 Gene

Previous GeneCards Identifiers for MRPL43 Gene

  • GC10M101639
  • GC10M101971
  • GC10M102860
  • GC10M102402
  • GC10M102727
  • GC10M102737
  • GC10M096366

Summaries for MRPL43 Gene

Entrez Gene Summary for MRPL43 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL43 Gene

MRPL43 (Mitochondrial Ribosomal Protein L43) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL43 Gene

Genomics for MRPL43 Gene

Regulatory Elements for MRPL43 Gene

Genomic Location for MRPL43 Gene

Chromosome:
10
Start:
100,969,458 bp from pter
End:
100,987,515 bp from pter
Size:
18,058 bases
Orientation:
Minus strand

Genomic View for MRPL43 Gene

Genes around MRPL43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL43 Gene

Proteins for MRPL43 Gene

  • Protein details for MRPL43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N983-RM43_HUMAN
    Recommended name:
    39S ribosomal protein L43, mitochondrial
    Protein Accession:
    Q8N983
    Secondary Accessions:
    • B1AL06
    • B1AL07
    • B1AL09
    • B1AL10
    • C9J5Q3
    • D3DR71
    • Q5JW06
    • Q7Z719
    • Q7Z7H6
    • Q86XN1
    • Q9BYC7

    Protein attributes for MRPL43 Gene

    Size:
    215 amino acids
    Molecular mass:
    23431 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB40861.1; Type=Frameshift; Positions=131; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL43 Gene

    Alternative splice isoforms for MRPL43 Gene

neXtProt entry for MRPL43 Gene

Proteomics data for MRPL43 Gene at MOPED

Post-translational modifications for MRPL43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRPL43 Gene

Domains & Families for MRPL43 Gene

Gene Families for MRPL43 Gene

Protein Domains for MRPL43 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N983

UniProtKB/Swiss-Prot:

RM43_HUMAN :
  • Belongs to the ribosomal protein S25/L51 family.
Family:
  • Belongs to the ribosomal protein S25/L51 family.
genes like me logo Genes that share domains with MRPL43: view

Function for MRPL43 Gene

Phenotypes for MRPL43 Gene

genes like me logo Genes that share phenotypes with MRPL43: view

Animal Model Products

miRNA for MRPL43 Gene

miRTarBase miRNAs that target MRPL43

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL43 Gene

Localization for MRPL43 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL43 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL43 Gene COMPARTMENTS Subcellular localization image for MRPL43 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MRPL43 Gene

Pathways & Interactions for MRPL43 Gene

genes like me logo Genes that share pathways with MRPL43: view

Gene Ontology (GO) - Biological Process for MRPL43 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0032543 mitochondrial translation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL43: view

No data available for SIGNOR curated interactions for MRPL43 Gene

Drugs & Compounds for MRPL43 Gene

No Compound Related Data Available

Transcripts for MRPL43 Gene

Unigene Clusters for MRPL43 Gene

Mitochondrial ribosomal protein L43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL43 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for MRPL43 Gene

GeneLoc Exon Structure for
MRPL43
ECgene alternative splicing isoforms for
MRPL43

Expression for MRPL43 Gene

mRNA expression in normal human tissues for MRPL43 Gene

Protein differential expression in normal tissues from HIPED for MRPL43 Gene

This gene is overexpressed in Bone (19.0) and Pancreas (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL43 Gene



SOURCE GeneReport for Unigene cluster for MRPL43 Gene Hs.421848

mRNA Expression by UniProt/SwissProt for MRPL43 Gene

Q8N983-RM43_HUMAN
Tissue specificity: High relative levels in skeletal muscle and testis. Lower levels of expression in the heart, brain, placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and leukocytes. Expression is coregulated with PEO1.
genes like me logo Genes that share expression patterns with MRPL43: view

Protein tissue co-expression partners for MRPL43 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MRPL43 Gene

Orthologs for MRPL43 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL43 35
  • 99.57 (n)
  • 100 (a)
MRPL43 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL43 36
  • 75 (a)
OneToOne
MRPL43 35
  • 88.17 (n)
  • 89.68 (a)
dog
(Canis familiaris)
Mammalia MRPL43 35
  • 88.17 (n)
  • 90.97 (a)
MRPL43 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl43 36
  • 81 (a)
OneToOne
Mrpl43 16
Mrpl43 35
  • 83.98 (n)
  • 83.12 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL43 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL43 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL43 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC54002 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl43 35
  • 63.79 (n)
  • 69.78 (a)
Str.1656 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11068 35
zebrafish
(Danio rerio)
Actinopterygii mrpl43 36
  • 55 (a)
OneToOne
Dr.18076 35
mrpl43 35
  • 62.75 (n)
  • 61.03 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012837 35
  • 55 (n)
  • 49.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL43 36
  • 34 (a)
OneToOne
mRpL43 35
  • 51.85 (n)
  • 46.83 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-34 35
  • 39.19 (n)
  • 35.88 (a)
mrpl-34 36
  • 28 (a)
OneToOne
Species with no ortholog for MRPL43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL43 Gene

ENSEMBL:
Gene Tree for MRPL43 (if available)
TreeFam:
Gene Tree for MRPL43 (if available)

Paralogs for MRPL43 Gene

No data available for Paralogs for MRPL43 Gene

Variants for MRPL43 Gene

Structural Variations from Database of Genomic Variants (DGV) for MRPL43 Gene

Variant ID Type Subtype PubMed ID
nsv831965 CNV Loss 17160897
nsv467443 CNV Loss 19166990
nsv517698 CNV Loss 19592680
nsv895961 CNV Loss 21882294

Variation tolerance for MRPL43 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL43 Gene

HapMap Linkage Disequilibrium report
MRPL43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MRPL43 Gene

Disorders for MRPL43 Gene

Relevant External Links for MRPL43

Genetic Association Database (GAD)
MRPL43
Human Genome Epidemiology (HuGE) Navigator
MRPL43
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL43

No disorders were found for MRPL43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL43 Gene

Publications for MRPL43 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3

Products for MRPL43 Gene

Sources for MRPL43 Gene

Back to Top

Content