Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL42 Gene

Aliases for MRPL42 Gene

  • Mitochondrial Ribosomal Protein L42 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML42 3 4
  • 39S Ribosomal Protein L31, Mitochondrial 3 4
  • MRP-L31 3 4
  • MRP-L42 3 4
  • MRPL31 3 4
  • MRPS32 3 4
  • RPML31 3 4
  • L31MT 3 4
  • L42MT 3 4
  • 28S Ribosomal Protein S32, Mitochondrial 3
  • 39S Ribosomal Protein L42, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S32 2
  • HSPC204 3
  • MRP-S32 3
  • PTD007 3
  • S32MT 3

External Ids for MRPL42 Gene

Previous GeneCards Identifiers for MRPL42 Gene

  • GC12M093060
  • GC12P094382
  • GC12P093794
  • GC12P092363
  • GC12P093861
  • GC12P090927

Summaries for MRPL42 Gene

Entrez Gene Summary for MRPL42 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]

GeneCards Summary for MRPL42 Gene

MRPL42 (Mitochondrial Ribosomal Protein L42) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL42 Gene

Additional gene information for MRPL42 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL42 Gene

Genomics for MRPL42 Gene

GeneHancer (GH) Regulatory Elements for MRPL42 Gene

Promoters and enhancers for MRPL42 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I093466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 570.2 +0.5 466 2.1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B MRPL42 UBE2N RN7SL737P
GH12I093440 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15 -25.7 -25748 3.4 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF766 UBE2N MRPL42 GC12M093281
GH12I093183 Enhancer 1.1 Ensembl ENCODE 10.6 -282.7 -282732 2.1 HDGF PKNOX1 IRF4 ZNF766 ZNF143 ATF7 RUNX3 MCM3 ZNF592 MEF2D EEA1 MRPL42 ENSG00000257322 LINC02412 GC12P093160 GC12P093215 GC12M093152 LOC643339
GH12I093435 Enhancer 0.9 Ensembl ENCODE 12.8 -30.5 -30520 3 HDAC1 BCOR HDGF PKNOX1 BMI1 BATF IRF4 ZNF366 SCRT2 ATF7 MRPL42 ENSG00000257252 UBE2N GC12M093281
GH12I093375 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.4 -88.6 -88624 6.7 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 FOS ENSG00000257252 NUDT4 LOC643339 ENSG00000257512 UBE2N MRPL42 PIR61938 GC12P093405 GC12P093403 GC12M093281
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL42 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL42 gene promoter:

Genomic Locations for MRPL42 Gene

Genomic Locations for MRPL42 Gene
chr12:93,467,488-93,516,213
(GRCh38/hg38)
Size:
48,726 bases
Orientation:
Plus strand
chr12:93,861,264-93,897,548
(GRCh37/hg19)

Genomic View for MRPL42 Gene

Genes around MRPL42 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL42 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL42 Gene

Proteins for MRPL42 Gene

  • Protein details for MRPL42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6G3-RM42_HUMAN
    Recommended name:
    39S ribosomal protein L42, mitochondrial
    Protein Accession:
    Q9Y6G3
    Secondary Accessions:
    • Q6FID1
    • Q96Q48
    • Q9P0S1

    Protein attributes for MRPL42 Gene

    Size:
    142 amino acids
    Molecular mass:
    16661 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAF36124.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL42 Gene

neXtProt entry for MRPL42 Gene

Post-translational modifications for MRPL42 Gene

  • Ubiquitination at Lys73, isoforms=114, and Lys120

No data available for DME Specific Peptides for MRPL42 Gene

Domains & Families for MRPL42 Gene

Gene Families for MRPL42 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL42 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6G3

UniProtKB/Swiss-Prot:

RM42_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL42 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL42 family.
genes like me logo Genes that share domains with MRPL42: view

Function for MRPL42 Gene

Gene Ontology (GO) - Molecular Function for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPL42: view
genes like me logo Genes that share phenotypes with MRPL42: view

Animal Model Products

miRNA for MRPL42 Gene

miRTarBase miRNAs that target MRPL42

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL42 Gene

Localization for MRPL42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL42 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL42 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
extracellular 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL42: view

Pathways & Interactions for MRPL42 Gene

genes like me logo Genes that share pathways with MRPL42: view

Gene Ontology (GO) - Biological Process for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL42: view

No data available for SIGNOR curated interactions for MRPL42 Gene

Drugs & Compounds for MRPL42 Gene

No Compound Related Data Available

Transcripts for MRPL42 Gene

Unigene Clusters for MRPL42 Gene

Mitochondrial ribosomal protein L42:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL42 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - -
SP9:

Relevant External Links for MRPL42 Gene

GeneLoc Exon Structure for
MRPL42
ECgene alternative splicing isoforms for
MRPL42

Expression for MRPL42 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL42 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL42 Gene

This gene is overexpressed in Pancreas (22.8), Lung (22.7), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL42 Gene



Protein tissue co-expression partners for MRPL42 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL42 Gene:

MRPL42

SOURCE GeneReport for Unigene cluster for MRPL42 Gene:

Hs.199579

Evidence on tissue expression from TISSUES for MRPL42 Gene

  • Nervous system(4.6)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with MRPL42: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL42 Gene

Orthologs for MRPL42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL42 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL42 33 34
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia MRPL42 33 34
  • 91.08 (n)
cow
(Bos Taurus)
Mammalia MRPL42 33 34
  • 89.91 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl42 33
  • 80.24 (n)
mouse
(Mus musculus)
Mammalia Mrpl42 33 16 34
  • 79.29 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL42 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL42 33 34
  • 72.63 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL42 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl42 33
  • 65.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8079 33
zebrafish
(Danio rerio)
Actinopterygii LOC568235 33
  • 60.53 (n)
MRPL42 34
  • 48 (a)
OneToOne
Dr.15742 33
Species where no ortholog for MRPL42 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL42 Gene

ENSEMBL:
Gene Tree for MRPL42 (if available)
TreeFam:
Gene Tree for MRPL42 (if available)

Paralogs for MRPL42 Gene

(1) SIMAP similar genes for MRPL42 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MRPL42: view

No data available for Paralogs for MRPL42 Gene

Variants for MRPL42 Gene

Sequence variations from dbSNP and Humsavar for MRPL42 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000150608 -- 93,497,163(+) T/C intron_variant
rs1000161991 -- 93,497,363(+) A/T intron_variant
rs1000194108 -- 93,489,077(+) AATGAAT/AAT intron_variant
rs1000322548 -- 93,495,932(+) AAA/ intron_variant
rs1000428127 -- 93,489,473(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL42 Gene

Variant ID Type Subtype PubMed ID
dgv305e199 CNV deletion 23128226
esv2658394 CNV deletion 23128226
esv2746217 CNV deletion 23290073
esv275262 CNV gain+loss 21479260
esv2865014 CNV insertion 24192839
esv3549592 CNV deletion 23714750
esv3630400 CNV loss 21293372
esv3630401 CNV loss 21293372
esv9445 CNV loss 19470904
nsv1044791 CNV gain 25217958
nsv1054852 CNV gain 25217958
nsv1070121 CNV deletion 25765185
nsv1111077 CNV tandem duplication 24896259
nsv1127284 CNV deletion 24896259
nsv1134249 CNV deletion 24896259
nsv438227 CNV loss 16468122
nsv7234 OTHER inversion 18451855
nsv957426 CNV deletion 24416366
nsv983354 CNV duplication 23825009

Variation tolerance for MRPL42 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL42 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL42

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL42 Gene

Disorders for MRPL42 Gene

Additional Disease Information for MRPL42

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL42 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL42 Gene

Publications for MRPL42 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 2 3 4 58
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for MRPL42 Gene

Sources for MRPL42 Gene

Content
Loading form....