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Aliases for MRPL42 Gene

Aliases for MRPL42 Gene

  • Mitochondrial Ribosomal Protein L42 2 3
  • MRPL31 3 4 6
  • MRPS32 3 4 6
  • 28S Ribosomal Protein S32, Mitochondrial 3 4
  • 39S Ribosomal Protein L31, Mitochondrial 3 4
  • MRP-L31 3 4
  • MRP-L42 3 4
  • MRP-S32 3 4
  • RPML31 3 4
  • L31MT 3 4
  • L42MT 3 4
  • S32MT 3 4
  • 39S Ribosomal Protein L42, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S32 2
  • HSPC204 3
  • PTD007 3

External Ids for MRPL42 Gene

Previous GeneCards Identifiers for MRPL42 Gene

  • GC12M093060
  • GC12P094382
  • GC12P093794
  • GC12P092363
  • GC12P093861
  • GC12P090927

Summaries for MRPL42 Gene

Entrez Gene Summary for MRPL42 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]

GeneCards Summary for MRPL42 Gene

MRPL42 (Mitochondrial Ribosomal Protein L42) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL42 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL42 Gene

Genomics for MRPL42 Gene

Regulatory Elements for MRPL42 Gene

Genomic Location for MRPL42 Gene

93,467,488 bp from pter
93,516,213 bp from pter
48,726 bases
Plus strand

Genomic View for MRPL42 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL42 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL42 Gene

Proteins for MRPL42 Gene

  • Protein details for MRPL42 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L42, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6FID1
    • Q96Q48
    • Q9P0S1

    Protein attributes for MRPL42 Gene

    142 amino acids
    Molecular mass:
    16661 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=AAF36124.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL42 Gene

neXtProt entry for MRPL42 Gene

Proteomics data for MRPL42 Gene at MOPED

Post-translational modifications for MRPL42 Gene

  • Ubiquitination at Lys73, Lys114, and Lys120
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for MRPL42 Gene

Domains for MRPL42 Gene

Gene Families for MRPL42 Gene

Protein Domains for MRPL42 Gene


Suggested Antigen Peptide Sequences for MRPL42 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL42: view

No data available for UniProtKB/Swiss-Prot for MRPL42 Gene

Function for MRPL42 Gene

Gene Ontology (GO) - Molecular Function for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL42: view

Phenotypes for MRPL42 Gene

GenomeRNAi human phenotypes for MRPL42:
genes like me logo Genes that share phenotypes with MRPL42: view

Animal Model Products

CRISPR Products

miRNA for MRPL42 Gene

miRTarBase miRNAs that target MRPL42

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL42

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL42 Gene

Localization for MRPL42 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL42 Gene


Subcellular locations from

Jensen Localization Image for MRPL42 Gene COMPARTMENTS Subcellular localization image for MRPL42 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with MRPL42: view

Pathways for MRPL42 Gene

SuperPathways for MRPL42 Gene

No Data Available

Interacting Proteins for MRPL42 Gene

Gene Ontology (GO) - Biological Process for MRPL42 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL42: view

No data available for Pathways by source for MRPL42 Gene

Transcripts for MRPL42 Gene

Unigene Clusters for MRPL42 Gene

Mitochondrial ribosomal protein L42:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL42

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL42 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - - - -
SP8: - -

Relevant External Links for MRPL42 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL42 Gene

mRNA expression in normal human tissues for MRPL42 Gene

Protein differential expression in normal tissues for MRPL42 Gene

This gene is overexpressed in Pancreas (22.8), Lung (22.7), and Blymphocyte (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL42 Gene

SOURCE GeneReport for Unigene cluster for MRPL42 Gene Hs.199579

genes like me logo Genes that share expressions with MRPL42: view

Expression partners for MRPL42 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL42 Gene

Orthologs for MRPL42 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL42 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL42 35
  • 89.91 (n)
  • 87.32 (a)
MRPL42 36
  • 87 (a)
(Canis familiaris)
Mammalia MRPL42 35
  • 91.08 (n)
  • 85.92 (a)
MRPL42 36
  • 20 (a)
(Mus musculus)
Mammalia Mrpl42 35
  • 79.29 (n)
  • 76.43 (a)
Mrpl42 16
Mrpl42 36
  • 75 (a)
(Pan troglodytes)
Mammalia MRPL42 35
  • 99.06 (n)
  • 98.59 (a)
MRPL42 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl42 35
  • 80.24 (n)
  • 77.14 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL42 36
  • 58 (a)
(Gallus gallus)
Aves MRPL42 35
  • 72.63 (n)
  • 69.92 (a)
MRPL42 36
  • 56 (a)
(Anolis carolinensis)
Reptilia MRPL42 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl42 35
  • 65.56 (n)
  • 61.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8079 35
(Danio rerio)
Actinopterygii Dr.15742 35
LOC568235 35
  • 60.53 (n)
  • 54.4 (a)
MRPL42 36
  • 48 (a)
Species with no ortholog for MRPL42:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL42 Gene

Gene Tree for MRPL42 (if available)
Gene Tree for MRPL42 (if available)

Paralogs for MRPL42 Gene

(1) SIMAP similar genes for MRPL42 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MRPL42: view

No data available for Paralogs for MRPL42 Gene

Variants for MRPL42 Gene

Sequence variations from dbSNP and Humsavar for MRPL42 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs56225938 -- 93,472,212(+) TTCCA(C/T)TATCA intron-variant
rs55824565 -- 93,467,546(+) GAGAA(A/G)CCGTC utr-variant-5-prime, nc-transcript-variant
rs35972769 -- 93,467,356(+) CCTTA(-/G)TAACA upstream-variant-2KB
rs35963955 -- 93,504,003(+) TTTTT(-/T)CTTAT downstream-variant-500B
rs35896803 -- 93,494,612(+) ACATG(-/T)TCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL42 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv438227 CNV Loss 16468122
esv275262 CNV Gain+Loss 21479260
dgv305e199 CNV Deletion 23128226
esv2746217 CNV Deletion 23290073
esv9445 CNV Loss 19470904
esv2658394 CNV Deletion 23128226

Relevant External Links for MRPL42 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL42 Gene

Disorders for MRPL42 Gene

Relevant External Links for MRPL42

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL42 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL42 Gene

Publications for MRPL42 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for MRPL42 Gene

Sources for MRPL42 Gene

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