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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL41 Gene

protein-coding   GIFtS: 48
GCID: GC09P140445

Mitochondrial Ribosomal Protein L41

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L411 2     MRP-L412 3
MRPL272 3 5     RPML272 3
Bcl-2-Interacting Mitochondrial Ribosomal Protein L412 3     MRP-L27 Homolog2 3
Cell Proliferation-Inducing Gene 3 Protein2 3     39S Ribosomal Protein L41, Mitochondrial2
39S Ribosomal Protein L27 Homolog2 3     MRP-L272
BMRP2 3     Proliferation-Inducing Gene 32
L41mt2 3     

External Ids:    HGNC: 144921   Entrez Gene: 649752   Ensembl: ENSG000001821547   OMIM: 6118465   UniProtKB: Q8IXM33   

Export aliases for MRPL41 gene to outside databases

Previous GC identifers: GC09P131796 GC09M132098 GC09P133748 GC09P135664 GC09P137722 GC09P139565 GC09P109910


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL41 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the YmL27 ribosomal protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL41 Gene: 
MRPL41 (mitochondrial ribosomal protein L41) is a protein-coding gene. Diseases associated with MRPL41 include duodenogastric reflux, and breast cancer. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle.
Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory
condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the
G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins

Gene Wiki entry for MRPL41 (Mitochondrial ribosomal protein L41) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL41 gene promoter:
         E2F-3a   E2F-4   E2F-5   Tal-1   Nkx2-5   E2F-2   E47   NRF-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL41 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL41

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

MRPL41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL41 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140445:  view genomic region     (about GC identifiers)

Start:
140,445,651 bp from pter      End:
140,447,007 bp from pter
Size:
1,357 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3 (See protein sequence)
Recommended Name: 39S ribosomal protein L41, mitochondrial precursor  
Size: 137 amino acids; 15383 Da
Subunit: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50
distinct proteins. Interacts with BCL2
Subcellular location: Mitochondrion
Secondary accessions: Q96Q49

Explore the universe of human proteins at neXtProt for MRPL41: NX_Q8IXM3

Explore proteomics data for MRPL41 at MOPED 

MRPL41 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MRPL41 Protein Expression

REFSEQ proteins: NP_115866.1  
ENSEMBL proteins: 
 ENSP00000360498  

Human Recombinant Protein Products for MRPL41: 
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Cloud-Clone Corp. Proteins for MRPL41 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--
GO:0005762mitochondrial large ribosomal subunit IDA16024796
GO:0030529ribonucleoprotein complex IDA16024796

MRPL41 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for MRPL41


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
MRPL: Mitochondrial ribosomal proteins / large subunits

1 InterPro protein domain:
 IPR019189 Ribosomal_L27/L41_mit

Graphical View of Domain Structure for InterPro Entry Q8IXM3

ProtoNet protein and cluster: Q8IXM3

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Similarity: Belongs to the ribosomal protein L41 family


MRPL41 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RM41_HUMAN, Q8IXM3
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle.
Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory
condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the
G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003735structural constituent of ribosome IDA16024796
GO:0005515protein binding IPI18157088
     
MRPL41 for ontologies           About GeneDecksing


Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL41

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/250 Interacting proteins for MRPL41 (Q8IXM32, 3 ENSP000003604984) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
InteractantInteraction Details
GeneCardExternal ID(s)
TRIM63Q969Q12, 3, ENSP000003633904MINT-6492226 MINT-6503690 I2D: score=1 STRING: ENSP00000363390
SMURF2Q9HAU42, 3, ENSP000002624354MINT-6504060 I2D: score=1 STRING: ENSP00000262435
ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation IDA16024796
GO:0006915apoptotic process IEA--
GO:0007049cell cycle IEA--

MRPL41 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRPL41 (RM41)

Search CenterWatch for drugs/clinical trials and news about MRPL41 / RM41

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRPL41 gene: 
NM_032477.2  

Unigene Cluster for MRPL41:

Mitochondrial ribosomal protein L41
Hs.44017  [show with all ESTs]
Unigene Representative Sequence: BQ955623
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000371443(uc004cnh.4)
miRNA
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Additional mRNA sequence: 

AY232291.1 BC040035.1 

10 DOTS entries:

DT.87001237  DT.450215  DT.87077214  DT.91779100  DT.98131734  DT.121187687  DT.100883254  DT.100883250 
DT.100883257  DT.447660 

24/443 AceView cDNA sequences (see all 443):

BM747202 BE327270 AI436612 AW964075 AI718881 AI524305 AA806712 BE220356 
AI083816 AI700754 AI761746 BM757596 AW000775 AI215919 BF590583 BE550774 
BQ883789 AI362811 AI298799 AI459014 BU737881 BQ644139 AY232291 AI367117 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRPL41 expression in normal human tissues (normalized intensities)      MRPL41 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCGTCCTGG
MRPL41 Expression
About this image


MRPL41 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/32 selected tissues (see all 32) fully expand
 
 Testis (Reproductive System)    fully expand to see all 4 entries
         Leydig Cells Testis Interstitium
         seminal vesicle ; glandular cells   
 
 Epithelium (Reproductive System)    fully expand to see all 4 entries
         cervix, uterine ; squamous epithelial cells   
 
 Uterus
         uterus, post-menopause ; glandular cells   
 
 Breast
         breast ; glandular cells   
         MAMMARY GLAND   
 
 Tonsil (Hematopoietic System)    fully expand to see all 3 entries
         tonsil ; squamous epithelial cells   

See MRPL41 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL41

SOURCE GeneReport for Unigene cluster: Hs.44017

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at
protein level)

    SABiosciences Custom PCR Arrays for MRPL41
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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL41

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MRPL41 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrpl411 , 5 mitochondrial ribosomal protein L411, 5 73.83(n)1
77.04(a)1
  2 (16.88 cM)5
1077331  NM_001031808.21  NP_001026978.21 
 249741175 
chicken
(Gallus gallus)
Aves MRPL411 mitochondrial ribosomal protein L41 76.54(n)
73.33(a)
  417261  XM_415536.2  XP_415536.1 
African clawed frog
(Xenopus laevis)
Amphibia Xl.68092 Xenopus laevis transcribed sequences 74.28(n)    48030705 
zebrafish
(Danio rerio)
Actinopterygii mrpl411 mitochondrial ribosomal protein L41 63.21(n)
60(a)
  553805  NM_001020767.1  NP_001018603.1 
fruit fly
(Drosophila melanogaster)
Insecta mRpL416
mitochondrial ribosomal protein L41
28(a)
1 ↔ 1
2R(11104529-11105118)


ENSEMBL Gene Tree for MRPL41 (if available)
TreeFam Gene Tree for MRPL41 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/11 SNPs in MRPL41 are shown (see all 11)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs126846051,2
C,F,H--109908456(+) ctgcaC/Atccag 1 -- us2k11Minor allele frequency- A:0.00NA 2
rs1902413211,2
--109908468(+) TTGGGC/TGACAG 1 -- us2k10--------
rs107465631,2
C,F,A,H--109908547(+) CCCGTC/TTCTAC 1 -- us2k17Minor allele frequency- T:0.13NA WA CSA 15
rs350571791,2
C,F--140444016(+) GACTCC/TGTCTC 2 -- int13Minor allele frequency- T:0.50NA 6
rs577324541,2
C--140444022(+) AAAAAA/-GTTCA 2 -- int11Minor allele frequency- -:0.00NA 2
rs1889798591,2
--140447490(+) TAATCA/CCAGCA 1 -- ds50010--------
rs598868791,2
----140444022(+) AAAAA-/AGTTCA 2 -- int10--------
rs625902201,2
----109908706(+) GTCTTA/GGGAAA 1 -- us2k11Minor allele frequency- G:0.00NA 2
rs173521821,2
----140447007(+) CAGCTA/CAGAAA 1 -- ut310--------
rs173521751,2
----140447006(+) CCAGCC/GAAAAA 2 -- ut310--------

HapMap Linkage Disequilibrium report for MRPL41 (140445651 - 140447007 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MRPL41:    About this table     
Variant IDTypeSubtypePubMed ID
nsv894502CNV Loss21882294
dgv8416n71CNV Loss21882294
nsv831763CNV Loss17160897
nsv894663CNV Loss21882294
nsv894664CNV Loss21882294
nsv831762CNV Loss17160897
dgv8423n71CNV Loss21882294
dgv8412n71CNV Loss21882294
nsv894387CNV Gain21882294

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SeqTarget long-range PCR primers for resequencing MRPL41
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611846    OMIM disorders: --

2 diseases for MRPL41:    About MalaCards
duodenogastric reflux    breast cancer


MRPL41 for disorders           About GeneDecksing

Genetic Association Database (GAD): MRPL41
Human Genome Epidemiology (HuGE) Navigator: MRPL41 (1 document)

Export disorders for MRPL41 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MRPL41 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with MRPL41)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
  2. BMRP is a Bcl-2 binding protein that induces apoptosis. (PubMed id 15547950)1, 2, 9 Chintharlapalli S.R.... Gonzalez-Garcia M. (2005)
  3. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). (PubMed id 16256947)1, 2, 9 Kim M.J.... Yoo Y.D. (2005)
  4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
  5. Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. (PubMed id 16024796)1, 2 Yoo Y.A.... Yoo Y.D. (2005)
  6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2 Koc E.C....Spremulli L.L. (2001)
  9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
  10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64975 HGNC: 14492 AceView: MRPL41 Ensembl:ENSG00000182154 euGenes: HUgn64975
ECgene: MRPL41 H-InvDB: MRPL41

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRPL41 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRPL41 gene:
Search GeneIP for patents involving MRPL41

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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