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MRPL41 Gene

protein-coding   GIFtS: 49
GCID: GC09P140445

Mitochondrial Ribosomal Protein L41

  Search for MRPL41
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L411 2     MRP-L412 3
MRPL272 3 5     RPML272 3
Bcl-2-Interacting Mitochondrial Ribosomal Protein L412 3     MRP-L27 Homolog2 3
Cell Proliferation-Inducing Gene 3 Protein2 3     39S Ribosomal Protein L41, Mitochondrial2
39S Ribosomal Protein L27 Homolog2 3     MRP-L272
BMRP2 3     Proliferation-Inducing Gene 32
L41mt2 3     

External Ids:    HGNC: 144921   Entrez Gene: 649752   Ensembl: ENSG000001821547   OMIM: 6118465   UniProtKB: Q8IXM33   

Export aliases for MRPL41 gene to outside databases

Previous GC identifers: GC09P131796 GC09M132098 GC09P133748 GC09P135664 GC09P137722 GC09P139565 GC09P109910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL41 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the YmL27 ribosomal protein family. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL41 Gene:
MRPL41 (mitochondrial ribosomal protein L41) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle.
Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory
condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the
G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins

Gene Wiki entry for MRPL41 (Mitochondrial ribosomal protein L41) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL41 gene promoter:
         E2F-3a   E2F-4   E2F-5   Tal-1   Nkx2-5   E2F-2   E47   NRF-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL41 promoter sequence
   Search Chromatin IP Primers for MRPL41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

MRPL41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL41 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140445:  view genomic region     (about GC identifiers)

Start:
140,445,651 bp from pter      End:
140,447,007 bp from pter
Size:
1,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3 (See protein sequence)
Recommended Name: 39S ribosomal protein L41, mitochondrial precursor  
Size: 137 amino acids; 15383 Da
Subunit: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50
distinct proteins. Interacts with BCL2
Secondary accessions: Q96Q49

Explore the universe of human proteins at neXtProt for MRPL41: NX_Q8IXM3

Explore proteomics data for MRPL41 at MOPED


See MRPL41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_115866.1  
ENSEMBL proteins: 
 ENSP00000360498  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MRPL: Mitochondrial ribosomal proteins / large subunits

1 InterPro protein domain:
 IPR019189 Ribosomal_L27/L41_mit

Graphical View of Domain Structure for InterPro Entry Q8IXM3

ProtoNet protein and cluster: Q8IXM3

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Similarity: Belongs to the ribosomal protein L41 family


Find genes that share domains with MRPL41           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RM41_HUMAN, Q8IXM3
Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle.
Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory
condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the
G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003735structural constituent of ribosome IDA16024796
GO:0005515protein binding IPI18157088
GO:0044822poly(A) RNA binding IDA--
     
Find genes that share ontologies with MRPL41           About GenesLikeMe


Animal Models:
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miRNA
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miRTarBase miRNAs that target MRPL41:
hsa-mir-24-3p (MIRT030593)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RM41_HUMAN, Q8IXM3: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
extracellular2
cytosol1
endoplasmic reticulum1
nucleus1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--
GO:0005762mitochondrial large ribosomal subunit IDA16024796
GO:0030529ribonucleoprotein complex IDA16024796

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL41
Interactions:

    Search GeneGlobe Interaction Network for MRPL41

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

Selected Interacting proteins for MRPL41 (Q8IXM31, 2, 3 ENSP000003604984) via UniProtKB, MINT, STRING, and/or I2D (see all 256)
InteractantInteraction Details
GeneCardExternal ID(s)
TRIM63Q969Q11, 2, 3, ENSP000003633904EBI-912501,EBI-5661333 MINT-6492226 MINT-6503690 I2D: score=1 STRING: ENSP00000363390
SMURF2Q9HAU42, 3, ENSP000002624354MINT-6504060 I2D: score=1 STRING: ENSP00000262435
ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
MRPL47Q9HD332, ENSP000004176024MINT-8079030 STRING: ENSP00000417602
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation IDA16024796
GO:0006915apoptotic process IEA--
GO:0007049cell cycle IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MRPL41 (RM41)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MRPL41 gene: 
NM_032477.2  

Unigene Cluster for MRPL41:

Mitochondrial ribosomal protein L41
Hs.44017  [show with all ESTs]
Unigene Representative Sequence: BQ955623
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000371443(uc004cnh.4)
miRNA
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL41
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL41
Primer
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  QuantiFast Probe-based Assays in human, mouse, rat MRPL41

Additional mRNA sequence: 

AY232291.1 BC040035.1 

10 DOTS entries:

DT.87001237  DT.450215  DT.87077214  DT.91779100  DT.98131734  DT.121187687  DT.100883254  DT.100883250 
DT.100883257  DT.447660 

Selected AceView cDNA sequences (see all 443):

AI290984 AI281964 AI568381 BM747202 BE327270 AI436612 AW964075 AI091177 
AI673185 AI435280 BU736883 BM757578 BM966868 AA557326 AA973444 BF437724 
BM758605 AI741170 AW025026 AI056473 AI799958 AW302701 AI784074 AA923129 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRPL41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCGTCCTGG
MRPL41 Expression
About this image


MRPL41 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)
         Oviduct
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Testis (Reproductive System)
         Leydig Cells Testis Interstitium
MRPL41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRPL41 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.44017

UniProtKB/Swiss-Prot: RM41_HUMAN, Q8IXM3
Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at
protein level)

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QuantiFast Probe-based Assays in human, mouse, rat MRPL41
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for MRPL41 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrpl411 , 5 mitochondrial ribosomal protein L411, 5 73.83(n)1
77.04(a)1
  2 (16.88 cM)5
1077331  NM_001031808.21  NP_001026978.21 
 249741175 
chicken
(Gallus gallus)
Aves MRPL411 mitochondrial ribosomal protein L41 76.54(n)
73.33(a)
  417261  NM_001277866.1  NP_001264795.1 
African clawed frog
(Xenopus laevis)
Amphibia Xl.68092 Xenopus laevis transcribed sequences 74.28(n)    48030705 
zebrafish
(Danio rerio)
Actinopterygii mrpl411 mitochondrial ribosomal protein L41 63.21(n)
60(a)
  553805  NM_001020767.1  NP_001018603.1 
fruit fly
(Drosophila melanogaster)
Insecta mRpL416
mitochondrial ribosomal protein L41
27(a)
1 ↔ 1
2R(11104529-11105118)


ENSEMBL Gene Tree for MRPL41 (if available)
TreeFam Gene Tree for MRPL41 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MRPL41 (see all 11)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs126846051,2
C,F,H--109908456(+) ctgcaC/Atccag 1 -- us2k11Minor allele frequency- A:0.00NA 2
rs1902413211,2
--109908468(+) TTGGGC/TGACAG 1 -- us2k10--------
rs107465631,2
C,F,A,H--109908547(+) CCCGTC/TTCTAC 1 -- us2k17Minor allele frequency- T:0.13NA WA CSA 15
rs350571791,2
C,F--140444016(+) GACTCC/TGTCTC 2 -- int13Minor allele frequency- T:0.50NA 6
rs577324541,2
C--140444022(+) AAAAAA/-GTTCA 2 -- int11Minor allele frequency- -:0.00NA 2
rs1889798591,2
--140447490(+) TAATCA/CCAGCA 1 -- ds50010--------
rs598868791,2
----140444022(+) AAAAA-/AGTTCA 2 -- int10--------
rs625902201,2
----109908706(+) GTCTTA/GGGAAA 1 -- us2k11Minor allele frequency- G:0.00NA 2
rs173521821,2
----140447007(+) CAGCTA/CAGAAA 1 -- ut310--------
rs173521751,2
----140447006(+) CCAGCC/GAAAAA 2 -- ut310--------

HapMap Linkage Disequilibrium report for MRPL41 (140445651 - 140447007 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MRPL41:    About this table    
Variant IDTypeSubtypePubMed ID
nsv894502CNV Loss21882294
dgv8416n71CNV Loss21882294
nsv831763CNV Loss17160897
nsv894663CNV Loss21882294
nsv894664CNV Loss21882294
nsv831762CNV Loss17160897
dgv8423n71CNV Loss21882294
dgv8412n71CNV Loss21882294
nsv894387CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing MRPL41
DNA2.0 Custom Variant and Variant Library Synthesis for MRPL41

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611846    OMIM disorders: --


Find genes that share disorders with MRPL41           About GenesLikeMe

Genetic Association Database (GAD): MRPL41
Human Genome Epidemiology (HuGE) Navigator: MRPL41 (1 document)

Export disorders for MRPL41 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRPL41 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with MRPL41)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N.... Tanaka T. (Genomics 2001)
  2. BMRP is a Bcl-2 binding protein that induces apoptosis. (PubMed id 15547950)1, 2, 9 Chintharlapalli S.R.... Gonzalez-Garcia M. (J. Cell. Biochem. 2005)
  3. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). (PubMed id 16256947)1, 2, 9 Kim M.J.... Yoo Y.D. (Biochem. Biophys. Res. Commun. 2005)
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  5. Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. (PubMed id 16024796)1, 2 Yoo Y.A.... Yoo Y.D. (Mol. Cell. Biol. 2005)
  6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
  9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
  10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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OMIM
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 64975 HGNC: 14492 AceView: MRPL41 Ensembl:ENSG00000182154 euGenes: HUgn64975
ECgene: MRPL41 H-InvDB: MRPL41

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRPL41 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRPL41 gene:
Search GeneIP for patents involving MRPL41

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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