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Aliases for MRPL41 Gene

Aliases for MRPL41 Gene

  • Mitochondrial Ribosomal Protein L41 2 3
  • MRPL27 3 4 6
  • Bcl-2-Interacting Mitochondrial Ribosomal Protein L41 3 4
  • Cell Proliferation-Inducing Gene 3 Protein 3 4
  • 39S Ribosomal Protein L27 Homolog 3 4
  • MRP-L27 Homolog 3 4
  • MRP-L41 3 4
  • RPML27 3 4
  • L41mt 3 4
  • BMRP 3 4
  • 39S Ribosomal Protein L41, Mitochondrial 3
  • Proliferation-Inducing Gene 3 3
  • MRP-L27 3
  • PIG3 3

External Ids for MRPL41 Gene

Previous GeneCards Identifiers for MRPL41 Gene

  • GC09P131796
  • GC09M132098
  • GC09P133748
  • GC09P135664
  • GC09P137722
  • GC09P139565
  • GC09P140445
  • GC09P109910

Summaries for MRPL41 Gene

Entrez Gene Summary for MRPL41 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL41 Gene

MRPL41 (Mitochondrial Ribosomal Protein L41) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL41 Gene

  • Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.

Gene Wiki entry for MRPL41 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL41 Gene

Genomics for MRPL41 Gene

Regulatory Elements for MRPL41 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL41 Gene

Start:
137,551,199 bp from pter
End:
137,552,555 bp from pter
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for MRPL41 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL41 Gene

Proteins for MRPL41 Gene

  • Protein details for MRPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM3-RM41_HUMAN
    Recommended name:
    39S ribosomal protein L41, mitochondrial
    Protein Accession:
    Q8IXM3
    Secondary Accessions:
    • Q96Q49

    Protein attributes for MRPL41 Gene

    Size:
    137 amino acids
    Molecular mass:
    15383 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.

    Three dimensional structures from OCA and Proteopedia for MRPL41 Gene

neXtProt entry for MRPL41 Gene

Proteomics data for MRPL41 Gene at MOPED

Post-translational modifications for MRPL41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPL41 Gene

Domains for MRPL41 Gene

Gene Families for MRPL41 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXM3

UniProtKB/Swiss-Prot:

RM41_HUMAN :
  • Q8IXM3
Family:
  • Belongs to the ribosomal protein L41 family.
genes like me logo Genes that share domains with MRPL41: view

Function for MRPL41 Gene

Molecular function for MRPL41 Gene

UniProtKB/Swiss-Prot Function: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.

Gene Ontology (GO) - Molecular Function for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IDA 16024796
GO:0005515 protein binding IPI 18157088
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL41: view

Animal Model Products

CRISPR Products

miRNA for MRPL41 Gene

miRTarBase miRNAs that target MRPL41

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL41

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL41 Gene

Localization for MRPL41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL41 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL41 Gene COMPARTMENTS Subcellular localization image for MRPL41 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 16024796
GO:0030529 ribonucleoprotein complex IDA 16024796
genes like me logo Genes that share ontologies with MRPL41: view

Pathways for MRPL41 Gene

SuperPathways for MRPL41 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL41: view

Pathways by source for MRPL41 Gene

1 KEGG pathway for MRPL41 Gene

Gene Ontology (GO) - Biological Process for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IDA 16024796
GO:0006915 apoptotic process IEA --
GO:0006996 organelle organization TAS --
GO:0007049 cell cycle IEA --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL41: view

Transcripts for MRPL41 Gene

mRNA/cDNA for MRPL41 Gene

(443) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL41 Gene

Mitochondrial ribosomal protein L41:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL41

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL41 Gene

No ASD Table

Relevant External Links for MRPL41 Gene

GeneLoc Exon Structure for
MRPL41
ECgene alternative splicing isoforms for
MRPL41

Expression for MRPL41 Gene

mRNA expression in normal human tissues for MRPL41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL41 Gene

SOURCE GeneReport for Unigene cluster for MRPL41 Gene Hs.44017

mRNA Expression by UniProt/SwissProt for MRPL41 Gene

Q8IXM3-RM41_HUMAN
Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
genes like me logo Genes that share expressions with MRPL41: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MRPL41 Gene

Orthologs for MRPL41 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL41 35
  • 99.51 (n)
  • 100 (a)
MRPL41 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL41 35
  • 79.51 (n)
  • 75.56 (a)
MRPL41 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL41 35
  • 81.92 (n)
  • 72.88 (a)
MRPL41 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6434 36
  • 77 (a)
OneToMany
Mrpl41 35
  • 73.83 (n)
  • 77.04 (a)
Mrpl41 16
Mrpl41 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MRPL41 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl41 35
  • 73.63 (n)
  • 77.61 (a)
chicken
(Gallus gallus)
Aves MRPL41 35
  • 76.54 (n)
  • 73.33 (a)
MRPL41 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6809 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl41 35
  • 66.91 (n)
  • 63.7 (a)
Str.1501 35
zebrafish
(Danio rerio)
Actinopterygii mrpl41 35
  • 63.21 (n)
  • 60 (a)
mrpl41 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL41 36
  • 27 (a)
OneToOne
Species with no ortholog for MRPL41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL41 Gene

ENSEMBL:
Gene Tree for MRPL41 (if available)
TreeFam:
Gene Tree for MRPL41 (if available)

Paralogs for MRPL41 Gene

No data available for Paralogs for MRPL41 Gene

Variants for MRPL41 Gene

Sequence variations from dbSNP and Humsavar for MRPL41 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs62590222 -- 137,552,800(+) TATTC(A/G)CCCAG downstream-variant-500B
rs72765169 -- 137,552,820(+) ATACA(C/G)AGATG downstream-variant-500B
rs73569753 -- 137,552,640(+) TCTCA(C/T)GCAGA downstream-variant-500B
rs150942890 -- 137,552,871(+) GAAAT(A/G)ATCCG downstream-variant-500B
rs182672716 -- 137,552,788(+) CATCC(C/G)CCAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL41 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv831762 CNV Loss 17160897
nsv894663 CNV Loss 21882294
nsv831763 CNV Loss 17160897
nsv894664 CNV Loss 21882294

Relevant External Links for MRPL41 Gene

HapMap Linkage Disequilibrium report
MRPL41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL41 Gene

Disorders for MRPL41 Gene

Relevant External Links for MRPL41

Genetic Association Database (GAD)
MRPL41
Human Genome Epidemiology (HuGE) Navigator
MRPL41
genes like me logo Genes that share disorders with MRPL41: view

No data available for UniProtKB/Swiss-Prot for MRPL41 Gene

Publications for MRPL41 Gene

  1. BMRP is a Bcl-2 binding protein that induces apoptosis. (PMID: 15547950) Chintharlapalli S.R. … Gonzalez-Garcia M. (J. Cell. Biochem. 2005) 3 4 23
  2. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). (PMID: 16256947) Kim M.J. … Yoo Y.D. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  4. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL41 Gene

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