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Aliases for MRPL41 Gene

Aliases for MRPL41 Gene

  • Mitochondrial Ribosomal Protein L41 2 3 5
  • Bcl-2-Interacting Mitochondrial Ribosomal Protein L41 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML41 3 4
  • Cell Proliferation-Inducing Gene 3 Protein 3 4
  • 39S Ribosomal Protein L27 Homolog 3 4
  • MRP-L27 Homolog 3 4
  • MRP-L41 3 4
  • MRPL27 3 4
  • RPML27 3 4
  • L41mt 3 4
  • BMRP 3 4
  • 39S Ribosomal Protein L41, Mitochondrial 3
  • Proliferation-Inducing Gene 3 3
  • MRP-L27 3
  • PIG3 3

External Ids for MRPL41 Gene

Previous GeneCards Identifiers for MRPL41 Gene

  • GC09P131796
  • GC09M132098
  • GC09P133748
  • GC09P135664
  • GC09P137722
  • GC09P139565
  • GC09P140445
  • GC09P109910

Summaries for MRPL41 Gene

Entrez Gene Summary for MRPL41 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL41 Gene

MRPL41 (Mitochondrial Ribosomal Protein L41) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL41 Gene

  • Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).

Gene Wiki entry for MRPL41 Gene

Additional gene information for MRPL41 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL41 Gene

Genomics for MRPL41 Gene

Regulatory Elements for MRPL41 Gene

Enhancers for MRPL41 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H137221 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -324.1 -324104 11 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 EHMT1 LOC651337 SDCCAG3 ANAPC2 RNF208 CYSRT1 NDOR1 RNF224 SLC34A3 MRPL41
GH09H137549 1.1 ENCODE 9.2 +0.0 29 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B ZNF143 ZNF207 PNPLA7 EHMT1 ANAPC2 DPH7 MAN1B1 EXD3 MRPL41 ZMYND19
GH09H137233 1.8 FANTOM5 ENCODE dbSUPER 5.2 -312.9 -312894 9 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A ZFP41 EHMT1 SDCCAG3 NDOR1 ANAPC2 LOC651337 INPP5E DPH7 MAN1B1 SEC16A IL9RP1
GH09H137756 1.7 FANTOM5 Ensembl ENCODE dbSUPER 4.3 +209.3 209255 8 HDGF PKNOX1 TBL1XR1 RB1 NSD2 BMI1 BATF YY1 SCRT2 ZNF143 EHMT1 LOC651337 PNPLA7 ARRDC1 MRPL41 GC09P137764 SETP5
GH09H137604 1.3 ENCODE dbSUPER 5.3 +55.8 55756 4 ARID4B SIN3A DMAP1 YY1 ZNF121 GLIS2 ELK1 ZNF143 ZNF207 ATF7 EHMT1 ZMYND19 MRPL41 ENSG00000283411 ARRDC1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL41 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243226 201 2001 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZBTB7B ZNF143 ZNF207 FOS

Genomic Location for MRPL41 Gene

Chromosome:
9
Start:
137,551,199 bp from pter
End:
137,552,555 bp from pter
Size:
1,357 bases
Orientation:
Plus strand

Genomic View for MRPL41 Gene

Genes around MRPL41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL41 Gene

Proteins for MRPL41 Gene

  • Protein details for MRPL41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXM3-RM41_HUMAN
    Recommended name:
    39S ribosomal protein L41, mitochondrial
    Protein Accession:
    Q8IXM3
    Secondary Accessions:
    • Q96Q49

    Protein attributes for MRPL41 Gene

    Size:
    137 amino acids
    Molecular mass:
    15383 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503, PubMed:25838379). Interacts with BCL2 (PubMed:15547950).

    Three dimensional structures from OCA and Proteopedia for MRPL41 Gene

neXtProt entry for MRPL41 Gene

Post-translational modifications for MRPL41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL41 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL41 Gene

Domains & Families for MRPL41 Gene

Gene Families for MRPL41 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXM3

UniProtKB/Swiss-Prot:

RM41_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL41 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL41 family.
genes like me logo Genes that share domains with MRPL41: view

Function for MRPL41 Gene

Molecular function for MRPL41 Gene

UniProtKB/Swiss-Prot Function:
Component of the mitochondrial ribosome large subunit (PubMed:25278503, PubMed:25838379). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796).

Gene Ontology (GO) - Molecular Function for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IDA 16024796
GO:0005515 protein binding IPI 18157088
genes like me logo Genes that share ontologies with MRPL41: view

Phenotypes for MRPL41 Gene

MGI mutant phenotypes for MRPL41:
inferred from 1 alleles
GenomeRNAi human phenotypes for MRPL41:
genes like me logo Genes that share phenotypes with MRPL41: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL41 Gene

Localization for MRPL41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL41 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL41 gene
Compartment Confidence
mitochondrion 5
extracellular 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 16024796
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA,IDA 16024796
genes like me logo Genes that share ontologies with MRPL41: view

Pathways & Interactions for MRPL41 Gene

genes like me logo Genes that share pathways with MRPL41: view

Gene Ontology (GO) - Biological Process for MRPL41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IDA 16024796
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL41: view

No data available for SIGNOR curated interactions for MRPL41 Gene

Drugs & Compounds for MRPL41 Gene

No Compound Related Data Available

Transcripts for MRPL41 Gene

mRNA/cDNA for MRPL41 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(443) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL41 Gene

Mitochondrial ribosomal protein L41:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL41
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL41 Gene

No ASD Table

Relevant External Links for MRPL41 Gene

GeneLoc Exon Structure for
MRPL41
ECgene alternative splicing isoforms for
MRPL41

Expression for MRPL41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL41 Gene

Protein differential expression in normal tissues from HIPED for MRPL41 Gene

This gene is overexpressed in Lung (26.9) and Bone (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL41 Gene



Protein tissue co-expression partners for MRPL41 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPL41 Gene:

MRPL41

SOURCE GeneReport for Unigene cluster for MRPL41 Gene:

Hs.44017

mRNA Expression by UniProt/SwissProt for MRPL41 Gene:

Q8IXM3-RM41_HUMAN
Tissue specificity: Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).

Evidence on tissue expression from TISSUES for MRPL41 Gene

  • Lung(4.3)
  • Muscle(3.1)
  • Nervous system(3)
  • Heart(2.6)
  • Intestine(2.5)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPL41: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL41 Gene

Orthologs for MRPL41 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL41 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL41 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia MRPL41 33 34
  • 81.92 (n)
cow
(Bos Taurus)
Mammalia MRPL41 33 34
  • 79.51 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL41 34
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6434 34
  • 77 (a)
OneToMany
Mrpl41 33 16 34
  • 73.83 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl41 33
  • 73.63 (n)
chicken
(Gallus gallus)
Aves MRPL41 34 33
  • 76.54 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl41 33
  • 66.91 (n)
Str.1501 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6809 33
zebrafish
(Danio rerio)
Actinopterygii mrpl41 33 34
  • 63.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL41 34
  • 27 (a)
OneToOne
Species where no ortholog for MRPL41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL41 Gene

ENSEMBL:
Gene Tree for MRPL41 (if available)
TreeFam:
Gene Tree for MRPL41 (if available)

Paralogs for MRPL41 Gene

No data available for Paralogs for MRPL41 Gene

Variants for MRPL41 Gene

Sequence variations from dbSNP and Humsavar for MRPL41 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001177799 -- 137,552,474(+) CTCTA(C/T)CCCAG upstream-variant-2KB, reference, synonymous-codon
rs1001462123 -- 137,552,775(+) GCACT(G/T)GTCAG downstream-variant-500B
rs1001966535 -- 137,552,735(+) CAGGA(A/G)AAAGA downstream-variant-500B
rs1002828601 -- 137,550,686(+) TGGGG(A/G)GGGGG upstream-variant-2KB
rs1002896465 -- 137,552,895(+) CCCAA(A/G)ATGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL41 Gene

Variant ID Type Subtype PubMed ID
dgv13012n54 CNV loss 21841781
nsv616023 CNV loss 21841781
nsv831762 CNV loss 17160897
nsv831763 CNV loss 17160897

Variation tolerance for MRPL41 Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL41 Gene

Disorders for MRPL41 Gene

Relevant External Links for MRPL41

Genetic Association Database (GAD)
MRPL41
Human Genome Epidemiology (HuGE) Navigator
MRPL41
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL41

No disorders were found for MRPL41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL41 Gene

Publications for MRPL41 Gene

  1. BMRP is a Bcl-2 binding protein that induces apoptosis. (PMID: 15547950) Chintharlapalli SR … González-García M (Journal of cellular biochemistry 2005) 3 4 22 60
  2. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). (PMID: 16256947) Kim MJ … Yoo YD (Biochemical and biophysical research communications 2005) 3 4 22 60
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 60
  4. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60

Products for MRPL41 Gene

Sources for MRPL41 Gene

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