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Aliases for MRPL4 Gene

Aliases for MRPL4 Gene

  • Mitochondrial Ribosomal Protein L4 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL4m 3 4
  • MRP-L4 3 4
  • L4mt 3 4
  • 39S Ribosomal Protein L4, Mitochondrial 3
  • CGI-28 3

External Ids for MRPL4 Gene

Previous GeneCards Identifiers for MRPL4 Gene

  • GC19P010484
  • GC19P010585
  • GC19P010207
  • GC19P010223
  • GC19P010362
  • GC19P009942

Summaries for MRPL4 Gene

Entrez Gene Summary for MRPL4 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL4 Gene

MRPL4 (Mitochondrial Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL4 Gene

Additional gene information for MRPL4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL4 Gene

Genomics for MRPL4 Gene

Regulatory Elements for MRPL4 Gene

Enhancers for MRPL4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010235 2 FANTOM5 Ensembl ENCODE dbSUPER 9.4 -14.6 -14553 4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 YY1 ZNF766 S1PR5 COL5A3 RDH8 MRPL4 S1PR2 ATG4D C19orf66 TYK2 DNM2 FBXL12
GH19H010400 1.5 FANTOM5 ENCODE 12.5 +152.3 152317 6 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 ICAM1 KANK2 MRPL4 ICAM5 ICAM4 RAVER1 PDE4A TYK2 C19orf38 P2RY11
GH19H010338 1 Ensembl ENCODE 12.1 +87.4 87443 2 BCOR HDGF TBL1XR1 MAX BACH1 SIN3A ZNF384 EBF1 RELA YY1 ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM5 ICAM4 ICAM1 MRPL4 PIR48013
GH19H010258 0.8 ENCODE 14.5 +7.9 7872 2 HDGF PKNOX1 ARID4B RAD21 TCF12 EGR1 SCRT2 ZNF143 FOS RUNX3 MRPL4 C19orf66 ENSG00000267105 GC19P010259 GC19P010260
GH19H010388 0.9 ENCODE 12.8 +137.2 137159 0 PKNOX1 ARID4B RAD21 ZNF143 ZNF207 IKZF2 DEK PAF1 SMARCA5 ZNF654 ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G GC19P010382 MIR1181
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL4 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106979 199 1401 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766

Genomic Location for MRPL4 Gene

Chromosome:
19
Start:
10,251,901 bp from pter
End:
10,260,060 bp from pter
Size:
8,160 bases
Orientation:
Plus strand

Genomic View for MRPL4 Gene

Genes around MRPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL4 Gene

Proteins for MRPL4 Gene

  • Protein details for MRPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYD3-RM04_HUMAN
    Recommended name:
    39S ribosomal protein L4, mitochondrial
    Protein Accession:
    Q9BYD3
    Secondary Accessions:
    • A6NNV7
    • Q9BW07
    • Q9H4N2
    • Q9Y317

    Protein attributes for MRPL4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAD27737.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305}; Sequence=AAG02005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL4 Gene

    Alternative splice isoforms for MRPL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL4 Gene

Post-translational modifications for MRPL4 Gene

  • Ubiquitination at posLast=131131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPL4 Gene

Domains & Families for MRPL4 Gene

Gene Families for MRPL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL4 Gene

Suggested Antigen Peptide Sequences for MRPL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYD3

UniProtKB/Swiss-Prot:

RM04_HUMAN :
  • Belongs to the universal ribosomal protein uL4 family.
Family:
  • Belongs to the universal ribosomal protein uL4 family.
genes like me logo Genes that share domains with MRPL4: view

Function for MRPL4 Gene

Phenotypes From GWAS Catalog for MRPL4 Gene

Gene Ontology (GO) - Molecular Function for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL4: view
genes like me logo Genes that share phenotypes with MRPL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL4 Gene

Localization for MRPL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL4 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL4 gene
Compartment Confidence
mitochondrion 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0022626 cytosolic ribosome IBA --
genes like me logo Genes that share ontologies with MRPL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL4 Gene

Pathways & Interactions for MRPL4 Gene

genes like me logo Genes that share pathways with MRPL4: view

Gene Ontology (GO) - Biological Process for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL4: view

No data available for SIGNOR curated interactions for MRPL4 Gene

Drugs & Compounds for MRPL4 Gene

No Compound Related Data Available

Transcripts for MRPL4 Gene

Unigene Clusters for MRPL4 Gene

Mitochondrial ribosomal protein L4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for MRPL4 Gene

GeneLoc Exon Structure for
MRPL4
ECgene alternative splicing isoforms for
MRPL4

Expression for MRPL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL4 Gene

Protein differential expression in normal tissues from HIPED for MRPL4 Gene

This gene is overexpressed in Breast (27.0) and Lung (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL4 Gene



Protein tissue co-expression partners for MRPL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL4 Gene:

MRPL4

SOURCE GeneReport for Unigene cluster for MRPL4 Gene:

Hs.279652

Evidence on tissue expression from TISSUES for MRPL4 Gene

  • Lung(4.4)
  • Nervous system(2.5)
  • Skin(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MRPL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL4 Gene

Orthologs for MRPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL4 33 34
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia MRPL4 33 34
  • 84.58 (n)
dog
(Canis familiaris)
Mammalia MRPL4 33 34
  • 83.22 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl4 33
  • 80.61 (n)
mouse
(Mus musculus)
Mammalia Mrpl4 33 16 34
  • 79.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL4 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL4 34
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL4 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl4 33
  • 63.38 (n)
zebrafish
(Danio rerio)
Actinopterygii zgmrpl4 33 34
  • 64.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL4 35 33 34
  • 57.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007937 33
  • 56.29 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-4 34 33
  • 49.39 (n)
OneToOne
T23B12.2 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML6 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20060 33
  • 44.27 (n)
rice
(Oryza sativa)
Liliopsida Os11g0585700 33
  • 45.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2665 34
  • 34 (a)
OneToOne
Species where no ortholog for MRPL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL4 Gene

ENSEMBL:
Gene Tree for MRPL4 (if available)
TreeFam:
Gene Tree for MRPL4 (if available)

Paralogs for MRPL4 Gene

No data available for Paralogs for MRPL4 Gene

Variants for MRPL4 Gene

Sequence variations from dbSNP and Humsavar for MRPL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000048519 -- 10,257,153(+) CTAAA(C/T)CGTGG intron-variant
rs1000172059 -- 10,253,590(+) GTTGC(A/C)GACCA intron-variant
rs1000172980 -- 10,250,456(+) TCTAC(-/A)AAAAA upstream-variant-2KB
rs1000224272 -- 10,253,773(+) GGCGA(C/T)AGAGA intron-variant
rs1000229903 -- 10,251,590(+) AACCC(A/G/T)GGAGG upstream-variant-2KB

Variation tolerance for MRPL4 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.28; 81.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL4 Gene

Disorders for MRPL4 Gene

Relevant External Links for MRPL4

Genetic Association Database (GAD)
MRPL4
Human Genome Epidemiology (HuGE) Navigator
MRPL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL4

No disorders were found for MRPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL4 Gene

Publications for MRPL4 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 60

Products for MRPL4 Gene

Sources for MRPL4 Gene

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