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Aliases for MRPL4 Gene

Aliases for MRPL4 Gene

  • Mitochondrial Ribosomal Protein L4 2 3 5
  • MRP-L4 3 4
  • L4mt 3 4
  • CGI-28 3

External Ids for MRPL4 Gene

Previous GeneCards Identifiers for MRPL4 Gene

  • GC19P010484
  • GC19P010585
  • GC19P010207
  • GC19P010223
  • GC19P010362
  • GC19P009942

Summaries for MRPL4 Gene

Entrez Gene Summary for MRPL4 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL4 Gene

MRPL4 (Mitochondrial Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL4 Gene

Genomics for MRPL4 Gene

Regulatory Elements for MRPL4 Gene

Enhancers for MRPL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL4 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL4 Gene

Chromosome:
19
Start:
10,251,901 bp from pter
End:
10,260,060 bp from pter
Size:
8,160 bases
Orientation:
Plus strand

Genomic View for MRPL4 Gene

Genes around MRPL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL4 Gene

Proteins for MRPL4 Gene

  • Protein details for MRPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYD3-RM04_HUMAN
    Recommended name:
    39S ribosomal protein L4, mitochondrial
    Protein Accession:
    Q9BYD3
    Secondary Accessions:
    • A6NNV7
    • Q9BW07
    • Q9H4N2
    • Q9Y317

    Protein attributes for MRPL4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27737.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305}; Sequence=AAG02005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL4 Gene

    Alternative splice isoforms for MRPL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL4 Gene

Proteomics data for MRPL4 Gene at MOPED

Post-translational modifications for MRPL4 Gene

  • Ubiquitination at Lys 131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPL4 Gene

Domains & Families for MRPL4 Gene

Gene Families for MRPL4 Gene

Protein Domains for MRPL4 Gene

Suggested Antigen Peptide Sequences for MRPL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYD3

UniProtKB/Swiss-Prot:

RM04_HUMAN :
  • Belongs to the ribosomal protein L4P family.
Family:
  • Belongs to the ribosomal protein L4P family.
genes like me logo Genes that share domains with MRPL4: view

Function for MRPL4 Gene

Gene Ontology (GO) - Molecular Function for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL4: view
genes like me logo Genes that share phenotypes with MRPL4: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL4 Gene

Localization for MRPL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL4 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL4 Gene COMPARTMENTS Subcellular localization image for MRPL4 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0022626 cytosolic ribosome IBA --
genes like me logo Genes that share ontologies with MRPL4: view

Pathways & Interactions for MRPL4 Gene

genes like me logo Genes that share pathways with MRPL4: view

Gene Ontology (GO) - Biological Process for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL4: view

No data available for SIGNOR curated interactions for MRPL4 Gene

Drugs & Compounds for MRPL4 Gene

No Compound Related Data Available

Transcripts for MRPL4 Gene

Unigene Clusters for MRPL4 Gene

Mitochondrial ribosomal protein L4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for MRPL4 Gene

GeneLoc Exon Structure for
MRPL4
ECgene alternative splicing isoforms for
MRPL4

Expression for MRPL4 Gene

mRNA expression in normal human tissues for MRPL4 Gene

Protein differential expression in normal tissues from HIPED for MRPL4 Gene

This gene is overexpressed in Breast (27.0) and Lung (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL4 Gene



SOURCE GeneReport for Unigene cluster for MRPL4 Gene Hs.279652

genes like me logo Genes that share expression patterns with MRPL4: view

Protein tissue co-expression partners for MRPL4 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL4 Gene

Orthologs for MRPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL4 35
  • 84.58 (n)
  • 83.33 (a)
MRPL4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL4 35
  • 83.22 (n)
  • 80.95 (a)
MRPL4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl4 35
  • 79.37 (n)
  • 80.95 (a)
Mrpl4 16
Mrpl4 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL4 35
  • 99.57 (n)
  • 99.04 (a)
MRPL4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl4 35
  • 80.61 (n)
  • 82.31 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL4 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL4 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL4 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl4 35
  • 63.38 (n)
  • 61.27 (a)
zebrafish
(Danio rerio)
Actinopterygii zgmrpl4 35
  • 64.73 (n)
  • 67.27 (a)
zgmrpl4 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL4 37
  • 43 (a)
mRpL4 35
  • 57.87 (n)
  • 57.41 (a)
mRpL4 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007937 35
  • 56.29 (n)
  • 58.16 (a)
worm
(Caenorhabditis elegans)
Secernentea T23B12.2 37
  • 40 (a)
mrpl-4 35
  • 49.39 (n)
  • 49.09 (a)
mrpl-4 36
  • 40 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20060 35
  • 44.27 (n)
  • 37.15 (a)
rice
(Oryza sativa)
Liliopsida Os11g0585700 35
  • 45.99 (n)
  • 39.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2665 36
  • 34 (a)
OneToOne
Species with no ortholog for MRPL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL4 Gene

ENSEMBL:
Gene Tree for MRPL4 (if available)
TreeFam:
Gene Tree for MRPL4 (if available)

Paralogs for MRPL4 Gene

No data available for Paralogs for MRPL4 Gene

Variants for MRPL4 Gene

Sequence variations from dbSNP and Humsavar for MRPL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12981881 -- 10,251,697(+) aaaaa(A/C)aaaaa upstream-variant-2KB
rs8104608 -- 10,259,457(+) CAAGC(A/G)GCCAG intron-variant, reference, missense, utr-variant-3-prime
rs17000211 -- 10,258,410(+) TCCAC(C/T)AGGAC intron-variant
rs71162056 -- 10,252,781(-) GGTAC(-/A)AAGCC intron-variant
rs8108218 -- 10,250,389(+) gagaa(C/T)tgctt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL4 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294

Variation tolerance for MRPL4 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.28; 81.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL4 Gene

Disorders for MRPL4 Gene

Relevant External Links for MRPL4

Genetic Association Database (GAD)
MRPL4
Human Genome Epidemiology (HuGE) Navigator
MRPL4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL4

No disorders were found for MRPL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL4 Gene

Publications for MRPL4 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MRPL4 Gene

Sources for MRPL4 Gene

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