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Aliases for MRPL4 Gene

Aliases for MRPL4 Gene

  • Mitochondrial Ribosomal Protein L4 2 3
  • MRP-L4 3 4
  • L4mt 3 4
  • 39S Ribosomal Protein L4, Mitochondrial 3
  • CGI-28 3

External Ids for MRPL4 Gene

Previous GeneCards Identifiers for MRPL4 Gene

  • GC19P010484
  • GC19P010585
  • GC19P010207
  • GC19P010223
  • GC19P010362
  • GC19P009942

Summaries for MRPL4 Gene

Entrez Gene Summary for MRPL4 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL4 Gene

MRPL4 (Mitochondrial Ribosomal Protein L4) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL4 Gene

Genomics for MRPL4 Gene

Genomic Location for MRPL4 Gene

Start:
10,251,901 bp from pter
End:
10,260,060 bp from pter
Size:
8,160 bases
Orientation:
Plus strand

Genomic View for MRPL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL4 Gene

Proteins for MRPL4 Gene

  • Protein details for MRPL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYD3-RM04_HUMAN
    Recommended name:
    39S ribosomal protein L4, mitochondrial
    Protein Accession:
    Q9BYD3
    Secondary Accessions:
    • A6NNV7
    • Q9BW07
    • Q9H4N2
    • Q9Y317

    Protein attributes for MRPL4 Gene

    Size:
    311 amino acids
    Molecular mass:
    34919 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27737.1; Type=Frameshift; Positions=128; Evidence={ECO:0000305}; Sequence=AAG02005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL4 Gene

    Alternative splice isoforms for MRPL4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL4 Gene

Proteomics data for MRPL4 Gene at MOPED

Post-translational modifications for MRPL4 Gene

  • Ubiquitination at Lys131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPL4 Gene

Domains for MRPL4 Gene

Gene Families for MRPL4 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL4 Gene

Suggested Antigen Peptide Sequences for MRPL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYD3

UniProtKB/Swiss-Prot:

RM04_HUMAN :
  • Q9BYD3
Family:
  • Belongs to the ribosomal protein L4P family.
genes like me logo Genes that share domains with MRPL4: view

Function for MRPL4 Gene

Gene Ontology (GO) - Molecular Function for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL4: view

miRNA for MRPL4 Gene

miRTarBase miRNAs that target MRPL4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL4 Gene

Localization for MRPL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL4 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL4 Gene COMPARTMENTS Subcellular localization image for MRPL4 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome --
GO:0022626 cytosolic ribosome IBA --
genes like me logo Genes that share ontologies with MRPL4: view

Pathways for MRPL4 Gene

SuperPathways for MRPL4 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL4: view

Pathways by source for MRPL4 Gene

1 KEGG pathway for MRPL4 Gene

Gene Ontology (GO) - Biological Process for MRPL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL4: view

Transcripts for MRPL4 Gene

Unigene Clusters for MRPL4 Gene

Mitochondrial ribosomal protein L4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for MRPL4 Gene

GeneLoc Exon Structure for
MRPL4
ECgene alternative splicing isoforms for
MRPL4

Expression for MRPL4 Gene

mRNA expression in normal human tissues for MRPL4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL4 Gene

SOURCE GeneReport for Unigene cluster for MRPL4 Gene Hs.279652

genes like me logo Genes that share expressions with MRPL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL4 Gene

Orthologs for MRPL4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL4 35
  • 99.57 (n)
  • 99.04 (a)
MRPL4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL4 35
  • 84.58 (n)
  • 83.33 (a)
MRPL4 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL4 35
  • 83.22 (n)
  • 80.95 (a)
MRPL4 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl4 35
  • 79.37 (n)
  • 80.95 (a)
Mrpl4 16
Mrpl4 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL4 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl4 35
  • 80.61 (n)
  • 82.31 (a)
lizard
(Anolis carolinensis)
Reptilia MRPL4 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl4 35
  • 63.38 (n)
  • 61.27 (a)
zebrafish
(Danio rerio)
Actinopterygii zgmrpl4 35
  • 64.73 (n)
  • 67.27 (a)
zgmrpl4 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007937 35
  • 56.29 (n)
  • 58.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL4 35
  • 57.87 (n)
  • 57.41 (a)
mRpL4 36
  • 46 (a)
OneToOne
mRpL4 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-4 35
  • 49.39 (n)
  • 49.09 (a)
mrpl-4 36
  • 40 (a)
OneToOne
T23B12.2 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YML6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20060 35
  • 44.27 (n)
  • 37.15 (a)
rice
(Oryza sativa)
Liliopsida Os11g0585700 35
  • 45.99 (n)
  • 39.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2665 36
  • 34 (a)
OneToOne
Species with no ortholog for MRPL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL4 Gene

ENSEMBL:
Gene Tree for MRPL4 (if available)
TreeFam:
Gene Tree for MRPL4 (if available)

Paralogs for MRPL4 Gene

No data available for Paralogs for MRPL4 Gene

Variants for MRPL4 Gene

Sequence variations from dbSNP and Humsavar for MRPL4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs11115 -- 10,259,866(+) AGCCT(C/T)AGGCC utr-variant-3-prime
rs1059840 -- 10,259,814(+) GTTGA(A/T)GTGAA utr-variant-3-prime
rs1059843 -- 10,259,829(+) CTCTT(C/T)TGAGC utr-variant-3-prime
rs1059849 -- 10,259,978(+) ACGGA(A/G)AGCCC utr-variant-3-prime
rs1059855 -- 10,259,994(+) GGCTT(C/T)TGCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL4 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294

Relevant External Links for MRPL4 Gene

HapMap Linkage Disequilibrium report
MRPL4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL4 Gene

Disorders for MRPL4 Gene

(1) University of Copenhagen DISEASES for MRPL4 Gene

Relevant External Links for MRPL4

Genetic Association Database (GAD)
MRPL4
Human Genome Epidemiology (HuGE) Navigator
MRPL4
genes like me logo Genes that share disorders with MRPL4: view

No data available for UniProtKB/Swiss-Prot for MRPL4 Gene

Publications for MRPL4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48

Products for MRPL4 Gene

Sources for MRPL4 Gene

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