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Aliases for MRPL39 Gene

Aliases for MRPL39 Gene

  • Mitochondrial Ribosomal Protein L39 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML39 3 4
  • 39S Ribosomal Protein L5, Mitochondrial 3 4
  • C21orf92 3 4
  • MRP-L39 3 4
  • MRP-L5 3 4
  • L39mt 3 4
  • MRPL5 3 4
  • RPML5 3 4
  • L5mt 3 4
  • 39S Ribosomal Protein L39, Mitochondrial 3
  • MSTP003 3
  • PRED22 3
  • PRED66 3

External Ids for MRPL39 Gene

Previous GeneCards Identifiers for MRPL39 Gene

  • GC21M023536
  • GC21M025879
  • GC21M026957
  • GC21M012361

Summaries for MRPL39 Gene

Entrez Gene Summary for MRPL39 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL39 Gene

MRPL39 (Mitochondrial Ribosomal Protein L39) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and nucleotide binding. An important paralog of this gene is TARSL2.

Gene Wiki entry for MRPL39 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL39 Gene

Genomics for MRPL39 Gene

Regulatory Elements for MRPL39 Gene

Enhancers for MRPL39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G025570 1.4 Ensembl ENCODE dbSUPER 27.5 +34.6 34617 4.8 HDAC1 HDGF TBP PKNOX1 ATF1 SIN3A RAD21 GATA2 EGR1 FOS MRPL39 GC21P025574 MIR155HG
GH21G025606 1.2 ENCODE 28 +0.1 127 2.4 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ZFP41 MRPL39 RPL13AP7 LINC00515
GH21G025567 1.2 Ensembl ENCODE dbSUPER 27.6 +39.8 39838 1.7 HDGF TBP CTCF WRNIP1 RAD21 POLR2A EED CREM SMAD5 ZBED1 MRPL39 GC21P025574 MIR155HG
GH21G025638 0.9 ENCODE 25.3 -31.7 -31696 2.4 ZNF76 RAD21 GLIS2 EGR1 ZNF366 ZNF143 RELB CREM EGR2 SP3 MRPL39 ATP5J GABPA JAM2 RNGTTP1
GH21G025561 1.1 ENCODE dbSUPER 20.5 +45.2 45165 3.0 TBP TBL1XR1 WRNIP1 RAD21 EGR1 ZNF143 ZNF207 FOS RELB ETV6 MRPL39 MIR155HG GC21P025574
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL39 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000140751 146 2201 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ZFP41

Genomic Location for MRPL39 Gene

Chromosome:
21
Start:
25,585,656 bp from pter
End:
25,607,846 bp from pter
Size:
22,191 bases
Orientation:
Minus strand

Genomic View for MRPL39 Gene

Genes around MRPL39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL39 Gene

Proteins for MRPL39 Gene

  • Protein details for MRPL39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYK5-RM39_HUMAN
    Recommended name:
    39S ribosomal protein L39, mitochondrial
    Protein Accession:
    Q9NYK5
    Secondary Accessions:
    • C9JYA5
    • Q32Q74
    • Q5QTR3
    • Q96Q65
    • Q9BSQ7
    • Q9BZV6
    • Q9NX44

    Protein attributes for MRPL39 Gene

    Size:
    338 amino acids
    Molecular mass:
    38712 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAF44696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91177.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL39 Gene

    Alternative splice isoforms for MRPL39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL39 Gene

Post-translational modifications for MRPL39 Gene

  • Ubiquitination at posLast=315315
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL39 Gene

No data available for DME Specific Peptides for MRPL39 Gene

Domains & Families for MRPL39 Gene

Gene Families for MRPL39 Gene

Protein Domains for MRPL39 Gene

Suggested Antigen Peptide Sequences for MRPL39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYK5

UniProtKB/Swiss-Prot:

RM39_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL39 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL39 family.
genes like me logo Genes that share domains with MRPL39: view

Function for MRPL39 Gene

Gene Ontology (GO) - Molecular Function for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL39: view
genes like me logo Genes that share phenotypes with MRPL39: view

Animal Model Products

CRISPR Products

miRNA for MRPL39 Gene

miRTarBase miRNAs that target MRPL39

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL39 Gene

Localization for MRPL39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL39 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL39 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11167009
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL39: view

Pathways & Interactions for MRPL39 Gene

genes like me logo Genes that share pathways with MRPL39: view

Gene Ontology (GO) - Biological Process for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL39: view

No data available for SIGNOR curated interactions for MRPL39 Gene

Drugs & Compounds for MRPL39 Gene

No Compound Related Data Available

Transcripts for MRPL39 Gene

Unigene Clusters for MRPL39 Gene

Mitochondrial ribosomal protein L39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL39 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -
SP3: -

Relevant External Links for MRPL39 Gene

GeneLoc Exon Structure for
MRPL39
ECgene alternative splicing isoforms for
MRPL39

Expression for MRPL39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL39 Gene

Protein differential expression in normal tissues from HIPED for MRPL39 Gene

This gene is overexpressed in Breast (37.0) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL39 Gene



Protein tissue co-expression partners for MRPL39 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL39 Gene:

MRPL39

SOURCE GeneReport for Unigene cluster for MRPL39 Gene:

Hs.420696

mRNA Expression by UniProt/SwissProt for MRPL39 Gene:

Q9NYK5-RM39_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific.

Evidence on tissue expression from TISSUES for MRPL39 Gene

  • Heart(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with MRPL39: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL39 Gene

Orthologs for MRPL39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL39 34 35
  • 98.87 (n)
dog
(Canis familiaris)
Mammalia MRPL39 34 35
  • 89.41 (n)
cow
(Bos Taurus)
Mammalia MRPL39 34 35
  • 88.23 (n)
mouse
(Mus musculus)
Mammalia Mrpl39 34 16 35
  • 84.7 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl39 34
  • 81.25 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL39 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL39 34 35
  • 71.82 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL39 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl39 34
  • 66.44 (n)
Str.11934 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16628 34
zebrafish
(Danio rerio)
Actinopterygii mrpl39 34 35
  • 54.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL39 34 35
  • 48.8 (n)
mRpL5 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010644 34
  • 46.19 (n)
worm
(Caenorhabditis elegans)
Secernentea tars-1 35
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 35
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToOne
Species where no ortholog for MRPL39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL39 Gene

ENSEMBL:
Gene Tree for MRPL39 (if available)
TreeFam:
Gene Tree for MRPL39 (if available)

Paralogs for MRPL39 Gene

Paralogs for MRPL39 Gene

Pseudogenes.org Pseudogenes for MRPL39 Gene

genes like me logo Genes that share paralogs with MRPL39: view

Variants for MRPL39 Gene

Sequence variations from dbSNP and Humsavar for MRPL39 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000113119 -- 25,594,777(+) CCAAG(A/T)CCCAT intron-variant
rs1000418789 -- 25,594,498(+) TGCCT(C/T)AGTCT intron-variant
rs1000453628 -- 25,596,442(+) TAACA(A/C)AGTAC intron-variant
rs1000618450 -- 25,590,003(+) AAAGT(C/T)TGGGG intron-variant
rs1000668971 -- 25,588,050(+) CTCAC(A/G)CCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL39 Gene

Variant ID Type Subtype PubMed ID
nsv510501 OTHER sequence alteration 20534489

Variation tolerance for MRPL39 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL39 Gene

Disorders for MRPL39 Gene

Relevant External Links for MRPL39

Genetic Association Database (GAD)
MRPL39
Human Genome Epidemiology (HuGE) Navigator
MRPL39
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL39

No disorders were found for MRPL39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL39 Gene

Publications for MRPL39 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 64
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPL39 Gene

Sources for MRPL39 Gene

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