MRPL39 Gene
protein-coding GIFtS: 48
GCID: GC21M026957
|
|
mitochondrial ribosomal protein L39
| |
Aliases
for MRPL39 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L391 2 | | 39S Ribosomal Protein L5, Mitochondrial2 3 | | C21orf921 2 3 | | L5mt2 3 | | L39mt1 2 3 | | MRP-L392 3 | | MRP-L51 2 3 | | FLJ204511 | | RPML51 2 3 | | MGC1041741 | | MRPL52 3 5 | | MGC34001 | | PRED221 2 | | MSTP0031 | | PRED661 2 | | 39S Ribosomal Protein L39, Mitochondrial2 |
Export aliases for MRPL39 gene to outside databasesPrevious GC identifers: GC21M023536 GC21M025879 GC21M012361 |
Summaries
for MRPL39 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL39:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene isfound on chromosome 5q. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPL39
|
Genomic Views
for MRPL39 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MRPL39
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL39
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL39 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q21.3 Ensembl cytogenetic band: 21q21.3 HGNC cytogenetic band: 21q11.2-q21MRPL39 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M026957: view genomic region
(about GC identifiers)
Start:
|
26,957,968 bp from pter |
End:
|
26,979,829 bp from pter |
Size:
|
21,862 bases |
Orientation:
|
minus strand |
|
Proteins
for MRPL39 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM39_HUMAN, Q9NYK5 (See
protein sequence)Recommended Name: 39S ribosomal protein L39, mitochondrial Size: 338 amino acids; 38712 Da
Subcellular location: Mitochondrion
Caution: Ref.1 indicates C21orf8 as a synonym for this orf, this is incorrect, C21orf8 is already assigned to anotherchromosome 21 region
Caution: It is uncertain whether Met-1 or Met-6 is the initiator
Sequence caution: Sequence=AAF44696.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAQ13505.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91177.1;Type=Frameshift; Positions=72;
Secondary accessions: C9JYA5 Q32Q74 Q5QTR3 Q96Q65 Q9BSQ7 Q9BZV6 Q9NX44Alternative splicing: 2 isoforms: Q9NYK5-1 Q9NYK5-2 Explore the universe of human proteins at neXtProt for MRPL39: NX_Q9NYK5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NYK5
MRPL39 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_059142.2 NP_542984.2
ENSEMBL proteins: ENSP00000284967 ENSP00000305682 ENSP00000404426
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL39 for ontologies About GeneDecksing
MRPL39 Antibody Products:
Assay Products for MRPL39: |
Protein
Domains /
Families
for MRPL39 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL39 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NYK5ProtoNet protein and cluster: Q9NYK5 UniProtKB/Swiss-Prot: RM39_HUMAN, Q9NYK5Similarity: To the N-terminal of threonyl-tRNA synthetases |
Function
for MRPL39 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL39 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MRPL39 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL39 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL39 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003674 | molecular_function |
ND | -- |
MRPL39 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRPL39:
|
Pathways & Interactions
for MRPL39 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL39
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/238 Interacting proteins for MRPL39 (Q9NYK52, 3 ENSP000003056824) via UniProtKB, MINT, STRING, and/or I2D (see all 238)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MRPL39 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL39 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL39
Search CenterWatch for drugs/clinical trials and news about MRPL39 / RM39
|
Transcripts
for MRPL39 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL39 gene (2 alternative transcripts): NM_017446.3 NM_080794.3 Unigene Cluster for MRPL39: Mitochondrial ribosomal protein L39 Hs.420696 [show with all ESTs]Unigene Representative Sequence: BX6483353 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000352957(uc002ylo.3) ENST00000307301(uc002yln.3) ENST00000419219
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL39 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL39 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL39 (NM_080794) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL39 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL39 |
Additional cDNA sequence: AF109357.1 AF239727.1 AF270511.1 AK000458.1 AK225878.1 BC004896.2 BC107719.1 BX648335.1 9 DOTS entries: DT.416474 DT.121138158 DT.101968028 DT.70103684 DT.95376051 DT.100786544 DT.100025654 DT.120831587 DT.92432375 24/171 AceView cDNA sequences (see all 171): CD365644 AV706014 W93466 AW661737 BE278484 BF111473 AI470380 AA426183 CR598909 AI306121 AI263419 AA424729 CR614734 AL554345 AA780368 BF984441 AI361801 W93467 CB529237 AA844710 BP871228 BE294550 BV206506 BU932494
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL39 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL39
|
Expression
for MRPL39 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL39 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTAATTTA
About this image
See MRPL39 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL39
SOURCE GeneReport for Unigene cluster: Hs.420696
UniProtKB/Swiss-Prot: RM39_HUMAN, Q9NYK5Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific
SABiosciences Custom PCR Arrays for MRPL39
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL39
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL39 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL39 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL39 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL39 |
Orthologs
for MRPL39 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL39 gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl391 , 5 |
mitochondrial ribosomal protein L391, 5 |
83.63(n)1
86.23(a)1 |
|
16 (46.92 cM)5
273931 NM_017404.41 NP_059100.31
847175765 |
chicken
(Gallus gallus) |
Aves |
MRPL391 |
mitochondrial ribosomal protein L39 |
71.94(n)
70.97(a) |
|
418475 XM_416683.3 XP_416683.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MRPL396 |
-- |
67(a) |
1 ↔ 1 |
3(148336200-148352233) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.166282 |
Xenopus laevis transcribed sequence with moderate similarity more |
73.33(n) |
|
BX855294.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
mrpl391 |
mitochondrial ribosomal protein L39 |
54.54(n)
51.15(a) |
|
334588 NM_199915.2 NP_956209.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mRpL53
mRpL391 |
protein biosynthesis threonine-tRNA ligase3
mitochondrial ribosomal protein L391 |
39(a)3
49.21(n)1
42.91(a)1 |
|
71B13
396271 NM_079351.31 NP_524075.21 |
ENSEMBL Gene Tree for MRPL39 (if available)
TreeFam Gene Tree for MRPL39 (if available) |
Paralogs
for MRPL39 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL39 gene
- TARS22 TARSL22 TARS2
MRPL39 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL39
PGOHUM00000235246
|
Genomic Variants
for MRPL39 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL39 (26957968 - 26979829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL39: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL39 |
|
Disorders
/ Diseases
for MRPL39 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL39 for disorders About GeneDecksing
OMIM gene information: 611845
OMIM disorders: --
4  diseases for MRPL39: About MalaCardsgenetic disease pneumonia tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRPL39 (1 document)
Export disorders for MRPL39 gene to outside databases
|
Publications
for MRPL39 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL39 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MRPL39) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing). (PubMed id 11167009)1, 2 Spirina O....Fischel-Ghodsian N. (2000)
- Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. (PubMed id 10593885)1, 2 O'Brien T.W.... Graack H.R. (1999)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Biochemical and phosphoproteomic analysis of the helix -loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for MRPL39 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL39 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL39 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL39 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL39 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL39 gene:
Search GeneIP for patents involving MRPL39
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL39 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL39 |
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