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Aliases for MRPL39 Gene

Aliases for MRPL39 Gene

  • Mitochondrial Ribosomal Protein L39 2 3
  • MRPL5 3 4 6
  • 39S Ribosomal Protein L5, Mitochondrial 3 4
  • C21orf92 3 4
  • MRP-L39 3 4
  • MRP-L5 3 4
  • L39mt 3 4
  • RPML5 3 4
  • L5mt 3 4
  • 39S Ribosomal Protein L39, Mitochondrial 3
  • MSTP003 3
  • PRED22 3
  • PRED66 3

External Ids for MRPL39 Gene

Previous GeneCards Identifiers for MRPL39 Gene

  • GC21M023536
  • GC21M025879
  • GC21M026957
  • GC21M012361

Summaries for MRPL39 Gene

Entrez Gene Summary for MRPL39 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL39 Gene

MRPL39 (Mitochondrial Ribosomal Protein L39) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is TARS.

Gene Wiki entry for MRPL39 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL39 Gene

Genomics for MRPL39 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL39 Gene

25,585,656 bp from pter
25,607,517 bp from pter
21,862 bases
Minus strand

Genomic View for MRPL39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL39 Gene

No data available for Regulatory Elements for MRPL39 Gene

Proteins for MRPL39 Gene

  • Protein details for MRPL39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L39, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • C9JYA5
    • Q32Q74
    • Q5QTR3
    • Q96Q65
    • Q9BSQ7
    • Q9BZV6
    • Q9NX44

    Protein attributes for MRPL39 Gene

    338 amino acids
    Molecular mass:
    38712 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF44696.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ13505.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91177.1; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL39 Gene

    Alternative splice isoforms for MRPL39 Gene


neXtProt entry for MRPL39 Gene

Proteomics data for MRPL39 Gene at MOPED

Post-translational modifications for MRPL39 Gene

  • Ubiquitination at Lys315
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL39 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL39 Gene

Domains for MRPL39 Gene

Gene Families for MRPL39 Gene

Protein Domains for MRPL39 Gene

Suggested Antigen Peptide Sequences for MRPL39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L39 family.
  • Belongs to the ribosomal protein L39 family.
genes like me logo Genes that share domains with MRPL39: view

Function for MRPL39 Gene

Gene Ontology (GO) - Molecular Function for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL39: view

Phenotypes for MRPL39 Gene

GenomeRNAi human phenotypes for MRPL39:
genes like me logo Genes that share phenotypes with MRPL39: view

Animal Model Products

miRNA for MRPL39 Gene

miRTarBase miRNAs that target MRPL39

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL39

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL39 Gene

Localization for MRPL39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL39 Gene


Subcellular locations from

Jensen Localization Image for MRPL39 Gene COMPARTMENTS Subcellular localization image for MRPL39 gene
Compartment Confidence
mitochondrion 5
cytosol 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11167009
genes like me logo Genes that share ontologies with MRPL39: view

Pathways for MRPL39 Gene

SuperPathways for MRPL39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL39: view

No data available for Pathways by source for MRPL39 Gene

Transcripts for MRPL39 Gene

Unigene Clusters for MRPL39 Gene

Mitochondrial ribosomal protein L39:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL39

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL39 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP2: -
SP3: -

Relevant External Links for MRPL39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL39 Gene

mRNA expression in normal human tissues for MRPL39 Gene

Protein differential expression in normal tissues for MRPL39 Gene

This gene is overexpressed in Breast (37.0) and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL39 Gene

SOURCE GeneReport for Unigene cluster for MRPL39 Gene Hs.420696

mRNA Expression by UniProt/SwissProt for MRPL39 Gene

Tissue specificity: Isoform 1 is ubiquitously expressed. Isoform 2 is heart-specific
genes like me logo Genes that share expressions with MRPL39: view

Expression partners for MRPL39 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MRPL39 Gene

Orthologs for MRPL39 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL39 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL39 35
  • 88.23 (n)
  • 88.44 (a)
MRPL39 36
  • 85 (a)
(Canis familiaris)
Mammalia MRPL39 35
  • 89.41 (n)
  • 89.31 (a)
MRPL39 36
  • 84 (a)
(Mus musculus)
Mammalia Mrpl39 35
  • 84.7 (n)
  • 88.05 (a)
Mrpl39 16
Mrpl39 36
  • 84 (a)
(Pan troglodytes)
Mammalia MRPL39 35
  • 98.87 (n)
  • 98.02 (a)
MRPL39 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mrpl39 35
  • 81.25 (n)
  • 82.64 (a)
(Monodelphis domestica)
Mammalia MRPL39 36
  • 74 (a)
(Gallus gallus)
Aves MRPL39 35
  • 71.82 (n)
  • 71.05 (a)
MRPL39 36
  • 64 (a)
(Anolis carolinensis)
Reptilia MRPL39 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl39 35
  • 66.44 (n)
  • 68.56 (a)
Str.11934 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16628 35
(Danio rerio)
Actinopterygii mrpl39 35
  • 54.15 (n)
  • 49.84 (a)
mrpl39 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL5 37
  • 39 (a)
mRpL39 35
  • 48.8 (n)
  • 42.45 (a)
mRpL39 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010644 35
  • 46.19 (n)
  • 38.93 (a)
(Caenorhabditis elegans)
Secernentea tars-1 36
  • 9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THS1 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for MRPL39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL39 Gene

Gene Tree for MRPL39 (if available)
Gene Tree for MRPL39 (if available)

Paralogs for MRPL39 Gene

Paralogs for MRPL39 Gene Pseudogenes for MRPL39 Gene

genes like me logo Genes that share paralogs with MRPL39: view

Variants for MRPL39 Gene

Sequence variations from dbSNP and Humsavar for MRPL39 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs71317420 -- 25,592,933(+) TAAGA(A/G)GGCCC reference, missense
rs71183503 -- 25,596,546(+) ATAAC(-/TAAC)CCAAT intron-variant
rs68178145 -- 25,605,455(+) ATACA(-/AC)ACAGA intron-variant
rs67668070 -- 25,587,675(+) CTTAT(-/ATGA)ATAAT intron-variant, utr-variant-3-prime
rs66689950 -- 25,595,699(+) TACAC(-/TGAG)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL39 Gene

Variant ID Type Subtype PubMed ID
nsv510501 CNV Loss 20534489

Relevant External Links for MRPL39 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL39 Gene

Disorders for MRPL39 Gene

Relevant External Links for MRPL39

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL39 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL39 Gene

Publications for MRPL39 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. (PMID: 10593885) O'Brien T.W. … Graack H.R. (J. Biol. Chem. 1999) 3 4
  3. Heart-specific splice-variant of a human mitochondrial ribosomal protein (mRNA processing; tissue specific splicing). (PMID: 11167009) Spirina O. … Fischel-Ghodsian N. (Gene 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPL39 Gene

Sources for MRPL39 Gene

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