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MRPL38 Gene(Protein Coding)

Mitochondrial Ribosomal Protein L38

GCID:
GC17M075900
GIFtS:
48
Genes Participants
UDN Logo

Aliases for MRPL38 Gene

Aliases for MRPL38 Gene

  • Mitochondrial Ribosomal Protein L38 2 3 5
  • MRP-L38 3 4
  • L38MT 3 4
  • 39S Ribosomal Protein L38, Mitochondrial 3
  • HSPC262 3
  • MRP-L3 3
  • RPML3 3

External Ids for MRPL38 Gene

Previous GeneCards Identifiers for MRPL38 Gene

  • GC17U990214
  • GC17M076921
  • GC17M074358
  • GC17M074491
  • GC17M071406
  • GC17M073894
  • GC17M069320

Summaries for MRPL38 Gene

Entrez Gene Summary for MRPL38 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL38 Gene

MRPL38 (Mitochondrial Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL38 Gene

Genomics for MRPL38 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MRPL38 Gene

Enhancers for MRPL38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075776 2.2 ENCODE 13.1 +126.9 126887 4.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ENSG00000266980 MFSD11 UNK NT5C METTL23 ENSG00000264829 HMGN2P43 ENSG00000267342 MRPL38 H3F3B
GH17F075863 1.4 FANTOM5 Ensembl ENCODE 10.9 +40.6 40613 2.0 KLF1 PKNOX1 ZMYM3 EBF1 ZIC2 ZBTB40 RELA HIC1 GLIS2 PATZ1 TRIM65 UNK H3F3B MIR4738 MRPL38 TRIM47 WBP2 ENSG00000267801
GH17F074986 1.4 FANTOM5 ENCODE 9.8 +917.2 917225 2.9 ATF1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 YY1 GLIS2 FOS ZNF263 HID1 KCTD2 MRPL38 ATP5H CDR2L RAB37 GC17M074998
GH17F075861 1.2 Ensembl ENCODE 11.4 +44.0 44012 0.8 MLX ARID4B ZNF48 ZNF302 ZNF143 ZMIZ1 SP5 REST PPARG MIER3 TRIM65 UBE2O UNK MRPL38 H3F3B MIR4738 TRIM47 WBP2 ENSG00000267801
GH17F075868 1.3 Ensembl ENCODE 10.1 +35.5 35486 2.5 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 SLC30A9 ZNF207 SP5 NFYC MIER2 UNK TRIM65 ENSG00000267342 ENSG00000264829 HMGN2P43 NUP85 LINC02080 MFSD11 CDK3 TRIM47
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL38 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL38 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353507 513 1801 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1

Transcription factor binding sites by QIAGEN in the MRPL38 gene promoter:

Genomic Location for MRPL38 Gene

Chromosome:
17
Start:
75,898,643 bp from pter
End:
75,905,413 bp from pter
Size:
6,771 bases
Orientation:
Minus strand

Genomic View for MRPL38 Gene

Genes around MRPL38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL38 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MRPL38 Gene

Proteins for MRPL38 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MRPL38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DV4-RM38_HUMAN
    Recommended name:
    39S ribosomal protein L38, mitochondrial
    Protein Accession:
    Q96DV4
    Secondary Accessions:
    • B3KN96
    • Q96Q66
    • Q9P0B9

    Protein attributes for MRPL38 Gene

    Size:
    380 amino acids
    Molecular mass:
    44597 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    SequenceCaution:
    • Sequence=AAH13311.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL38 Gene

    Alternative splice isoforms for MRPL38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL38 Gene

Protein Expression for MRPL38 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MRPL38 Gene

  • Ubiquitination at Lys 96 and Lys 107
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL38 Gene

Domains & Families for MRPL38 Gene

No data available for UniProtKB/Swiss-Prot for MRPL38 Gene

Function for MRPL38 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry
genes like me logo Genes that share phenotypes with MRPL38: view

Animal Model Products

miRNA for MRPL38 Gene

miRTarBase miRNAs that target MRPL38

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL38 Gene

Localization for MRPL38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL38 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL38 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPL38: view

Pathways & Interactions for MRPL38 Gene

genes like me logo Genes that share pathways with MRPL38: view

Gene Ontology (GO) - Biological Process for MRPL38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL38: view

No data available for SIGNOR curated interactions for MRPL38 Gene

Drugs & Compounds for MRPL38 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MRPL38 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MRPL38 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(450) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL38 Gene

Mitochondrial ribosomal protein L38:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL38 Gene

No ASD Table

Relevant External Links for MRPL38 Gene

GeneLoc Exon Structure for
MRPL38
ECgene alternative splicing isoforms for
MRPL38

Expression for MRPL38 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL38 Gene

mRNA expression in normal human tissues for MRPL38 Gene
mRNA expression by BioGPS for MRPL38 GenemRNA expression by GTEx for MRPL38 Gene

Protein differential expression in normal tissues from HIPED for MRPL38 Gene

This gene is overexpressed in Lung (22.3), Liver (14.8), and Pancreas (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL38 Gene



Protein tissue co-expression partners for MRPL38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL38 Gene:

MRPL38

SOURCE GeneReport for Unigene cluster for MRPL38 Gene:

Hs.442609
genes like me logo Genes that share expression patterns with MRPL38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL38 Gene

Orthologs for MRPL38 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MRPL38 34 35
  • 99.21 (n)
dog
(Canis familiaris)
 Mammalia MRPL38 34 35
  • 87.46 (n)
cow
(Bos Taurus)
 Mammalia MRPL38 34 35
  • 86.58 (n)
mouse
(Mus musculus)
 Mammalia Mrpl38 34 16 35
  • 86.32 (n)
rat
(Rattus norvegicus)
 Mammalia Mrpl38 34
  • 85.53 (n)
oppossum
(Monodelphis domestica)
 Mammalia MRPL38 35
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MRPL38 35
  • 73 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MRPL38 34 35
  • 65.34 (n)
lizard
(Anolis carolinensis)
 Reptilia MRPL38 35
  • 62 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mrpl38 34
  • 62.6 (n)
Str.11091 34
zebrafish
(Danio rerio)
 Actinopterygii mrpl38 34 35
  • 58.72 (n)
Dr.11989 34
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.13875 34
fruit fly
(Drosophila melanogaster)
 Insecta mRpL38 34 35
  • 54.17 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000652 34
  • 53.38 (n)
worm
(Caenorhabditis elegans)
 Secernentea mrpl-38 35
  • 18 (a)
 OneToOne
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 34 (a)
 OneToOne
Species where no ortholog for MRPL38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL38 Gene

ENSEMBL:
Gene Tree for MRPL38 (if available)
TreeFam:
Gene Tree for MRPL38 (if available)

Paralogs for MRPL38 Gene

(2) SIMAP similar genes for MRPL38 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MRPL38: view

No data available for Paralogs for MRPL38 Gene

Variants for MRPL38 Gene

Sequence variations from dbSNP and Humsavar for MRPL38 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1046446 -- 75,900,218(-) GGCCA(A/G)GGGGC intron-variant
rs111272450 -- 75,900,101(+) AGAGG(G/T)TCCTG intron-variant
rs111405920 -- 75,900,952(+) CAGCA(-/C)CCCCC intron-variant
rs111456080 -- 75,900,980(+) TACTC(A/T)CAGCA splice-donor-variant
rs111818280 -- 75,899,306(+) AAGAT(-/A)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL38 Gene

Variant ID Type Subtype PubMed ID
nsv1127598 CNV deletion 24896259
nsv833545 CNV gain 17160897

Variation tolerance for MRPL38 Gene

Residual Variation Intolerance Score: 93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL38 Gene

Disorders for MRPL38 Gene

Relevant External Links for MRPL38

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL38

No disorders were found for MRPL38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL38 Gene

Publications for MRPL38 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 64
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for MRPL38 Gene

Sources for MRPL38 Gene

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