Aliases for MRPL38 Gene
Aliases for MRPL38 Gene
External Ids for MRPL38 Gene
- HGNC: 14033
- Entrez Gene: 64978
- Ensembl: ENSG00000204316
- OMIM: 611844
- UniProtKB: Q96DV4
Previous GeneCards Identifiers for MRPL38 Gene
- GC17U990214
- GC17M076921
- GC17M074358
- GC17M074491
- GC17M071406
- GC17M073894
- GC17M069320
Summaries for MRPL38 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for MRPL38 Gene
MRPL38 (Mitochondrial Ribosomal Protein L38) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.
Additional gene information for MRPL38 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL38 Gene
Genomics for MRPL38 Gene
GeneHancer (GH) Regulatory Elements for MRPL38 Gene
Promoters and enhancers for MRPL38 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MRPL38 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MRPL38 Gene
Genomic Locations for MRPL38 Gene
- chr17:75,898,643-75,905,413
- (GRCh38/hg38)
- Size:
- 6,771 bases
- Orientation:
- Minus strand
- chr17:73,894,724-73,905,899
- (GRCh37/hg19)
Genomic View for MRPL38 Gene
Genes around MRPL38 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Ensembl
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
MRPL38 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MRPL38 Gene
Proteins for MRPL38 Gene
-
Protein details for MRPL38 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96DV4-RM38_HUMAN
- Recommended name:
- 39S ribosomal protein L38, mitochondrial
- Protein Accession:
- Q96DV4
- B3KN96
- Q96Q66
- Q9P0B9
Protein attributes for MRPL38 Gene
- Size:
- 380 amino acids
- Molecular mass:
- 44597 Da
- Quaternary structure:
-
- Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance.
- SequenceCaution:
-
- Sequence=AAH13311.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for MRPL38 Gene
Protein Expression for MRPL38 Gene
Post-translational modifications for MRPL38 Gene
- Ubiquitination at Lys96 and isoforms=107
Other Protein References for MRPL38 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MRPL38
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- GeneTex MRPL38 antibody for MRPL38
Protein Products
-
OriGene Purified Proteins for MRPL38
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- antibodies-online: Search results for 5 available MRPL38 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for MRPL38
Assay Products
No data available for DME Specific Peptides for MRPL38 Gene
Domains & Families for MRPL38 Gene
Gene Families for MRPL38 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPL38 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPL38 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93795, Homo sapiens mitochondrial ribosomal protein L38 (MRPL38), nucleargene encoding mitochondrial protein, mRNA (B2R894_HUMAN)
- cDNA FLJ13996 fis, clone Y79AA1002211, highly similar to Homo sapiens mitochondrial ribosomal protein L38 (MRPL38), nuclear gene encoding mitochondrial protein, mRNA (B3KN96_HUMAN)
- 39S ribosomal protein L38, mitochondrial (RM38_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96DV4UniProtKB/Swiss-Prot:
RM38_HUMAN :- Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
- Family:
-
- Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
Function for MRPL38 Gene
Phenotypes From GWAS Catalog for MRPL38 Gene
Phenotypes for MRPL38 Gene
- MGI mutant phenotypes for MRPL38:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRPL38:
-
- Increased vaccinia virus (VACV) infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL38 gene
-
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- Search ViGene Biosciences for MRPL38
CRISPR Products
-
OriGene CRISPR knockouts for MRPL38
- genomics-online: gRNA clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
- Applied Biological Materials CRISPR for MRPL38
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL38
- GenScript: Design CRISPR guide RNA sequences for MRPL38
miRNA for MRPL38 Gene
- miRTarBase miRNAs that target MRPL38
miRNA Products
- Search ViGene Biosciences for MRPL38
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRPL38
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- genomics-online: shRNA clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL38 gene
Clone Products
- Sino Biological Human cDNA Clone for MRPL38
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- VectorBuilder custom plasmid, inducible vectors for MRPL38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPL38
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MRPL38
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPL38 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPL38 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL38 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL38 Gene
Localization for MRPL38 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPL38 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 1 |
| cytosol | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005762 | mitochondrial large ribosomal subunit | IDA | 25278503 |
| GO:0005840 | ribosome | IEA | -- |
| GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for MRPL38 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial translation | ||
| 2 | Organelle biogenesis and maintenance | ||
Pathways by source for MRPL38 Gene
Interacting Proteins for MRPL38 Gene
Selected Interacting proteins:
Q96DV4-RM38_HUMAN
ENSP00000308275
for MRPL38 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070125 | mitochondrial translational elongation | TAS | -- |
| GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPL38 Gene
Transcripts for MRPL38 Gene
mRNA/cDNA for MRPL38 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPL38 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPL38
- genomics-online: gRNA clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
- Applied Biological Materials CRISPR for MRPL38
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPL38
- GenScript: Design CRISPR guide RNA sequences for MRPL38
miRNA Products
- Search ViGene Biosciences for MRPL38
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for MRPL38
- Browse OriGene Inhibitory RNA Products For MRPL38
- genomics-online: shRNA clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPL38 gene
Clone Products
- Sino Biological Human cDNA Clone for MRPL38
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for MRPL38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPL38
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MRPL38
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MRPL38 Gene
This gene is overexpressed in Lung (22.3), Liver (14.8), and Pancreas (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL38 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MRPL38 Gene:
MRPL38SOURCE GeneReport for Unigene cluster for MRPL38 Gene:
Hs.442609Evidence on tissue expression from TISSUES for MRPL38 Gene
- Intestine(4.3)
- Blood(4.1)
- Nervous system(4.1)
- Pancreas(3.1)
- Lung(2.7)
Primer Products
-
OriGene qPCR primer pairs for MRPL38
-
OriGene qPCR primer pairs and template standards for MRPL38
- genomics-online: primer clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL38 Gene
Orthologs for MRPL38 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MRPL38 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | MRPL38 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | MRPL38 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Mrpl38 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mrpl38 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MRPL38 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | MRPL38 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | MRPL38 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | MRPL38 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mrpl38 33 |
|
||
| Str.11091 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | mrpl38 33 34 |
|
||
| Dr.11989 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13875 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mRpL38 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000652 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | mrpl-38 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for MRPL38 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MRPL38 Gene
(2) SIMAP similar genes for MRPL38 Gene using alignment to 3 proteins:
No data available for Paralogs for MRPL38 Gene
Variants for MRPL38 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000162227 | -- | 75,898,241(-) | C/T | downstream_transcript_variant | |
| rs1000754049 | -- | 75,902,352(-) | C/G | intron_variant | |
| rs1000821356 | -- | 75,903,667(-) | G/A | intron_variant | |
| rs1000938712 | -- | 75,906,646(-) | C/A | upstream_transcript_variant | |
| rs1000949590 | -- | 75,900,506(-) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1127598 | CNV | deletion | 24896259 |
| nsv833545 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
93.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.53;
64.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MRPL38 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPL38
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL38 Gene
Disorders for MRPL38 Gene
Additional Disease Information for MRPL38
No disorders were found for MRPL38 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL38 Gene
Publications for MRPL38 Gene
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
- Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
Products for MRPL38 Gene
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for MRPL38
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for MRPL38
- VectorBuilder custom plasmid, inducible vectors for MRPL38
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPL38
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 16 available MRPL38 Antibodies ranked by validation data
- Compare Top MRPL38 Antibodies
- antibodies-online: Search results for available MRPL38 related products ranked by validation data
- antibodies-online: Search results for 5 available MRPL38 Proteins ranked by validation data
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- Quality Products:
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- Search ViGene Biosciences for MRPL38
- genomics-online: cdna clones - Search results for 123 available MRPL38 gene related products
- Overview of 123 available MRPL38 gene related products
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- genomics-online: gRNA clones - Search results for 123 available MRPL38 gene related products
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- Overview of 123 available MRPL38 gene related products
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- Overview of 123 available MRPL38 gene related products
Sources for MRPL38 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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