MRPL38 Gene
protein-coding GIFtS: 47
GCID: GC17M073894
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|
Mitochondrial Ribosomal Protein L38
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Aliases
for MRPL38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L381 2 | | MRP-L32 | | MRP-L382 3 | | RPML32 | | 39S Ribosomal Protein L38, Mitochondrial2 | | L38mt3 | | L38MT2 | | |
Export aliases for MRPL38 gene to outside databasesPrevious GC identifers: GC17U990214 GC17M076921 GC17M074358 GC17M074491 GC17M071406 GC17M069320 |
Summaries
for MRPL38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL38 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.(provided by RefSeq, Jul 2008)
GeneCards Summary for MRPL38 Gene: 
MRPL38 (mitochondrial ribosomal protein L38) is a protein-coding gene.
|
Genomic Views
for MRPL38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NT_010783.15 NC_018928.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL38 gene promoter:
ER-alpha AML1a HTF Tal-1beta Egr-4 GATA-2 PPAR-alpha Egr-2 CP2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q23-q25MRPL38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M073894: view genomic region
(about GC identifiers)
Start:
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73,894,724 bp from pter |
End:
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73,905,899 bp from pter |
Size:
|
11,176 bases |
Orientation:
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minus strand |
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Proteins
for MRPL38 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: RM38_HUMAN, Q96DV4 (See
protein sequence)Recommended Name: 39S ribosomal protein L38, mitochondrial precursor Size: 380 amino acids; 44597 Da
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAH13311.1; Type=Erroneous initiation;
Secondary accessions: Q96Q66 Q9P0B9Explore the universe of human proteins at neXtProt for MRPL38: NX_Q96DV4
Explore proteomics data for MRPL38 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q96DV4
MRPL38 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_115867.2
ENSEMBL proteins: ENSP00000308275 ENSP00000387085
Human Recombinant Protein Products for MRPL38:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MRPL38 for ontologies About GeneDecksing
MRPL38 Antibody Products:
Assay Products for MRPL38: |
Protein
Domains /
Families
for MRPL38 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| HGNC Gene Families:
MRPL: Mitochondrial ribosomal proteins / large subunits
1 InterPro protein domain:Graphical View of Domain Structure for InterPro Entry Q96DV4ProtoNet protein and cluster: Q96DV4 1 Blocks protein domain: IPB001858 Phosphatidylethanolamine-binding protein
MRPL38 for domains About GeneDecksing
|
Function
for MRPL38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Mrpl38):
MRPL38 for phenotypes About GeneDecksing
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL38 |
|
Pathways & Interactions
for MRPL38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL38
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/12 Interacting proteins for MRPL38 (Q96DV42, 3 ENSP000003082754) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
|
Drugs & Compounds
for MRPL38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
IUPHAR,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL38 (RM38)
Search CenterWatch for drugs/clinical trials and news about MRPL38 / RM38
|
Transcripts
for MRPL38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL38 gene: NM_032478.3 Unigene Cluster for MRPL38: Mitochondrial ribosomal protein L38 Hs.442609 [show with all ESTs]Unigene Representative Sequence: BM92655818 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309352(uc010wso.1) ENST00000486101 ENST00000480203 ENST00000588620
ENST00000483393 ENST00000477371 ENST00000477023 ENST00000471434 ENST00000477736
ENST00000493104 ENST00000494179 ENST00000585475 ENST00000493383 ENST00000474548
ENST00000461602 ENST00000464758 ENST00000410030 ENST00000409963(uc002jpz.1)
Primer
Products: |  | OriGene qPCR primer pairs and template standards for MRPL38
OriGene qSTAR qPCR primer pairs in human, mouse for MRPL38
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL38 |
Additional mRNA sequence: AF161380.1 AK313283.1 BC013311.2 BC034460.1 18 DOTS entries: DT.101984203 DT.449856 DT.95166381 DT.100791418 DT.92440931 DT.101959303 DT.95166368 DT.95217875 DT.121007965 DT.121007935 DT.121007836 DT.121007860 DT.121007983 DT.91724161 DT.95213831 DT.95166377 DT.95166380 DT.97816590 24/450 AceView cDNA sequences (see all 450): AI912558 CB069388 AA937341 AI827499 BU543028 AI566678 BI761920 AA973892 AA029064 AW303296 BM850106 CB164221 AI719051 BG655930 BM920362 CA952906 AI972555 BU952078 AK057261 BP363558 BQ883558 BM353577 CA942082 BU526978
GeneLoc Exon Structure
|
Expression
for MRPL38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL38 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATTTCTTGCC
About this image
See MRPL38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL38
SOURCE GeneReport for Unigene cluster: Hs.442609
SABiosciences Custom PCR Arrays for MRPL38
Primer
Products: | | OriGene qPCR primer pairs and template standards for MRPL38
OriGene qSTAR qPCR primer pairs in human, mouse for MRPL38
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL38 |
Orthologs
for MRPL38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL38 gene from 7/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl381 , 5 |
mitochondrial ribosomal protein L381, 5 |
86.32(n)1
86.58(a)1 |
|
11 (80.91 cM)5
604411 NM_024177.31 NP_077139.21
1161318175 |
chicken
(Gallus gallus) |
Aves |
MRPL381 |
mitochondrial ribosomal protein L38 |
65.34(n)
64.55(a) |
|
770172 NM_001114629.1 NP_001108101.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MRPL386 |
mitochondrial ribosomal protein L38 |
62(a) |
1 ↔ 1 |
2(113415193-113432042) |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX844742.12 |
-- |
73.15(n) |
|
BX844742.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.119892 |
Transcribed sequence with weak similarity to protein more |
70.45(n) |
|
AL909100.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mRpL381 |
mitochondrial ribosomal protein L38 |
53.78(n)
42(a) |
|
32375 NM_078597.2 NP_511152.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
mrpl-386 |
Protein MRPL-38 |
17(a) |
1 ↔ 1 |
I(1019825-1029952) |
ENSEMBL Gene Tree for MRPL38 (if available)
TreeFam Gene Tree for MRPL38 (if available) |
Paralogs
for MRPL38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL38 gene
1 SIMAP similar gene for MRPL38 using alignment to 3 protein entries: RM38_HUMAN (see all proteins):PEBP1
MRPL38 for paralogs About GeneDecksing
|
Genomic Variants
for MRPL38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL38 (73894724 - 73905899 bp)
Structural Variations
Database of Genomic Variants (DGV) 7 variations for MRPL38: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL38 |
|
Disorders
/ Diseases
for MRPL38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL38 for disorders About MalaCards
MRPL38 for disorders About GeneDecksing
OMIM gene information: 611844
OMIM disorders: --
Export disorders for MRPL38 gene to outside databases
|
Publications
for MRPL38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL38 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with MRPL38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
- A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
- p32/gC1qR is indispensable for fetal development and m itochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A bead-based approach for large-scale identification o f in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for MRPL38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL38 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL38 gene:
Search GeneIP for patents involving MRPL38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL38 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL38 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL38 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL38 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL38 |
|  |  |  |  | | | | ThermoFisher Antibodies for MRPL38 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL38 |
| |  |  | | | | LSBio Antibodies in human, mouse, rat for MRPL38 |
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