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Aliases for MRPL37 Gene

Aliases for MRPL37 Gene

  • Mitochondrial Ribosomal Protein L37 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML37 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3 4
  • MRP-L37 3 4
  • MRP-L2 3 4
  • L37mt 3 4
  • MRPL2 3 4
  • RPML2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L37, Mitochondrial 3
  • Ribosomal Protein, Mitochondrial, L2 3

External Ids for MRPL37 Gene

Previous GeneCards Identifiers for MRPL37 Gene

  • GC01P054495
  • GC01P053554
  • GC01P054023
  • GC01P054035
  • GC01P054378
  • GC01P054649
  • GC01P052781

Summaries for MRPL37 Gene

Entrez Gene Summary for MRPL37 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL37 Gene

MRPL37 (Mitochondrial Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL37 Gene

Genomics for MRPL37 Gene

Regulatory Elements for MRPL37 Gene

Enhancers for MRPL37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G054228 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +45.4 45408 1.6 FOXA2 AGO1 ZMYM3 ZFHX2 POLR2A GATA2 NR2F6 FOS ZNF600 EGR2 MRPL37 GC01P054226 SSBP3-AS1
GH01G054218 1.4 Ensembl ENCODE dbSUPER 11.1 +36.1 36095 3.1 ZFP64 RAD21 EGR1 ZNF354C SCRT2 EGR2 ZNF680 ZNF654 SP3 ZBTB11 SSBP3-AS1 MAGOH CYB5RL PARS2 HSPB11 C1orf123 MRPL37 CDCP2 USP24 PIR40840
GH01G054227 1.3 Ensembl ENCODE dbSUPER 10.8 +43.6 43606 1.3 CTCF KLF1 INSM2 KLF17 ZIC2 HIC1 GLIS2 POLR2A ZBTB48 PATZ1 MRPL37 GC01P054226 SSBP3-AS1
GH01G054248 2 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +65.8 65787 2.9 CREB3L1 ZFP64 DMAP1 ZNF143 ZNF263 SP3 NFYC ZNF610 NBN NR2C1 SSBP3-AS1 HSPB11 SSBP3 MRPL37 GC01P054263
GH01G054229 0.8 ENCODE dbSUPER 10 +44.6 44554 0.1 SREBF1 POLR2A AGO1 ZMYM3 MRPL37 SSBP3-AS1 GC01P054226
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL37 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL37 Gene

Chromosome:
1
Start:
54,184,041 bp from pter
End:
54,226,682 bp from pter
Size:
42,642 bases
Orientation:
Plus strand

Genomic View for MRPL37 Gene

Genes around MRPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL37 Gene

Proteins for MRPL37 Gene

  • Protein details for MRPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE1-RM37_HUMAN
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Protein Accession:
    Q9BZE1
    Secondary Accessions:
    • Q96Q67
    • Q9BWR1
    • Q9P0P3

    Protein attributes for MRPL37 Gene

    Size:
    423 amino acids
    Molecular mass:
    48117 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.
    SequenceCaution:
    • Sequence=AAF36155.1; Type=Frameshift; Positions=9, 13, 25, 30, 326; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL37 Gene

neXtProt entry for MRPL37 Gene

Post-translational modifications for MRPL37 Gene

  • Ubiquitination at Lys172
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL37 Gene

No data available for DME Specific Peptides for MRPL37 Gene

Domains & Families for MRPL37 Gene

Gene Families for MRPL37 Gene

Protein Domains for MRPL37 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZE1

UniProtKB/Swiss-Prot:

RM37_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL37 family.
genes like me logo Genes that share domains with MRPL37: view

Function for MRPL37 Gene

Gene Ontology (GO) - Molecular Function for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS,IEA 11543634
genes like me logo Genes that share ontologies with MRPL37: view
genes like me logo Genes that share phenotypes with MRPL37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL37 Gene

Localization for MRPL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL37 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL37 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL37: view

Pathways & Interactions for MRPL37 Gene

genes like me logo Genes that share pathways with MRPL37: view

Gene Ontology (GO) - Biological Process for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IEA 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL37: view

No data available for SIGNOR curated interactions for MRPL37 Gene

Drugs & Compounds for MRPL37 Gene

No Compound Related Data Available

Transcripts for MRPL37 Gene

Unigene Clusters for MRPL37 Gene

Mitochondrial ribosomal protein L37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for MRPL37 Gene

GeneLoc Exon Structure for
MRPL37
ECgene alternative splicing isoforms for
MRPL37

Expression for MRPL37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9), Breast (6.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL37 Gene



Protein tissue co-expression partners for MRPL37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL37 Gene:

MRPL37

SOURCE GeneReport for Unigene cluster for MRPL37 Gene:

Hs.584908

Evidence on tissue expression from TISSUES for MRPL37 Gene

  • Muscle(4.5)
  • Blood(4.3)
  • Nervous system(4.1)
  • Lung(2.8)
  • Skin(2.4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MRPL37: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL37 Gene

Orthologs for MRPL37 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL37 34 35
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia MRPL37 34 35
  • 85.42 (n)
cow
(Bos Taurus)
Mammalia MRPL37 34 35
  • 85.26 (n)
-- 35
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrpl37 34
  • 82.35 (n)
mouse
(Mus musculus)
Mammalia Mrpl37 34 16 35
  • 82.27 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL37 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL37 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL37 34 35
  • 64.14 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL37 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl37 34
  • 59.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25339 34
zebrafish
(Danio rerio)
Actinopterygii mrpl37 34 35
  • 59.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL37 34 35
  • 45.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002400 34
  • 41.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8616 35
  • 25 (a)
OneToOne
Species where no ortholog for MRPL37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL37 Gene

ENSEMBL:
Gene Tree for MRPL37 (if available)
TreeFam:
Gene Tree for MRPL37 (if available)

Paralogs for MRPL37 Gene

Pseudogenes.org Pseudogenes for MRPL37 Gene

genes like me logo Genes that share paralogs with MRPL37: view

No data available for Paralogs for MRPL37 Gene

Variants for MRPL37 Gene

Sequence variations from dbSNP and Humsavar for MRPL37 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000084632 -- 54,202,070(+) TGATC(A/G)TGCCT intron-variant, upstream-variant-2KB
rs1000229995 -- 54,221,365(+) ATGCA(C/G)GTGAC intron-variant
rs1000242823 -- 54,215,870(+) GAAAT(C/T)GCCTC intron-variant
rs1000452424 -- 54,220,106(+) AGGAG(C/T)TGGTG intron-variant
rs1000464287 -- 54,223,751(+) AGTGA(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL37 Gene

Variant ID Type Subtype PubMed ID
nsv477486 CNV novel sequence insertion 20440878

Variation tolerance for MRPL37 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.69; 95.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL37 Gene

Disorders for MRPL37 Gene

Relevant External Links for MRPL37

Genetic Association Database (GAD)
MRPL37
Human Genome Epidemiology (HuGE) Navigator
MRPL37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL37

No disorders were found for MRPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL37 Gene

Publications for MRPL37 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. [The structure and specific features of the cDNA expression of the human gene MRPL37]. (PMID: 15562971) Levshenkova E.V. … Frolova E.I. (Bioorg. Khim. 2004) 3 22 64

Products for MRPL37 Gene

Sources for MRPL37 Gene

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