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Aliases for MRPL37 Gene

Aliases for MRPL37 Gene

  • Mitochondrial Ribosomal Protein L37 2 3 5
  • 39S Ribosomal Protein L2, Mitochondrial 3 4
  • MRP-L37 3 4
  • MRP-L2 3 4
  • L37mt 3 4
  • MRPL2 3 4
  • RPML2 3 4
  • L2mt 3 4
  • Ribosomal Protein, Mitochondrial, L2 3

External Ids for MRPL37 Gene

Previous GeneCards Identifiers for MRPL37 Gene

  • GC01P054495
  • GC01P053554
  • GC01P054023
  • GC01P054035
  • GC01P054378
  • GC01P054649
  • GC01P052781

Summaries for MRPL37 Gene

Entrez Gene Summary for MRPL37 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL37 Gene

MRPL37 (Mitochondrial Ribosomal Protein L37) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL37 Gene

Genomics for MRPL37 Gene

Regulatory Elements for MRPL37 Gene

Enhancers for MRPL37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL37 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL37 Gene

Chromosome:
1
Start:
54,184,041 bp from pter
End:
54,226,682 bp from pter
Size:
42,642 bases
Orientation:
Plus strand

Genomic View for MRPL37 Gene

Genes around MRPL37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL37 Gene

Proteins for MRPL37 Gene

  • Protein details for MRPL37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZE1-RM37_HUMAN
    Recommended name:
    39S ribosomal protein L37, mitochondrial
    Protein Accession:
    Q9BZE1
    Secondary Accessions:
    • Q96Q67
    • Q9BWR1
    • Q9P0P3

    Protein attributes for MRPL37 Gene

    Size:
    423 amino acids
    Molecular mass:
    48117 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36155.1; Type=Frameshift; Positions=9, 13, 25, 30, 326; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL37 Gene

neXtProt entry for MRPL37 Gene

Proteomics data for MRPL37 Gene at MOPED

Post-translational modifications for MRPL37 Gene

  • Ubiquitination at Lys 172
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL37 Gene

No data available for DME Specific Peptides for MRPL37 Gene

Domains & Families for MRPL37 Gene

Gene Families for MRPL37 Gene

Protein Domains for MRPL37 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BZE1

UniProtKB/Swiss-Prot:

RM37_HUMAN :
  • Belongs to the ribosomal protein S30/L37 family.
Family:
  • Belongs to the ribosomal protein S30/L37 family.
genes like me logo Genes that share domains with MRPL37: view

Function for MRPL37 Gene

genes like me logo Genes that share phenotypes with MRPL37: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL37 Gene

Localization for MRPL37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL37 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL37 Gene COMPARTMENTS Subcellular localization image for MRPL37 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL37: view

Pathways & Interactions for MRPL37 Gene

genes like me logo Genes that share pathways with MRPL37: view

Gene Ontology (GO) - Biological Process for MRPL37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL37: view

No data available for SIGNOR curated interactions for MRPL37 Gene

Drugs & Compounds for MRPL37 Gene

No Compound Related Data Available

Transcripts for MRPL37 Gene

Unigene Clusters for MRPL37 Gene

Mitochondrial ribosomal protein L37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4: - - -

Relevant External Links for MRPL37 Gene

GeneLoc Exon Structure for
MRPL37
ECgene alternative splicing isoforms for
MRPL37

Expression for MRPL37 Gene

mRNA expression in normal human tissues for MRPL37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9), Breast (6.3), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL37 Gene



SOURCE GeneReport for Unigene cluster for MRPL37 Gene Hs.584908

genes like me logo Genes that share expression patterns with MRPL37: view

Protein tissue co-expression partners for MRPL37 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL37 Gene

Orthologs for MRPL37 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL37 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL37 35
  • 85.26 (n)
  • 82.98 (a)
-- 36
  • 68 (a)
OneToMany
MRPL37 36
  • 81 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRPL37 35
  • 85.42 (n)
  • 79.91 (a)
MRPL37 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl37 35
  • 82.27 (n)
  • 79.91 (a)
Mrpl37 16
Mrpl37 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL37 35
  • 99.21 (n)
  • 99.05 (a)
MRPL37 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl37 35
  • 82.35 (n)
  • 79.2 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL37 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL37 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL37 35
  • 64.14 (n)
  • 57.11 (a)
MRPL37 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL37 36
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl37 35
  • 59.45 (n)
  • 53.56 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25339 35
zebrafish
(Danio rerio)
Actinopterygii mrpl37 35
  • 59.25 (n)
  • 52.55 (a)
mrpl37 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002400 35
  • 41.41 (n)
  • 31.06 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL37 35
  • 45.14 (n)
  • 29.15 (a)
mRpL37 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8616 36
  • 25 (a)
OneToOne
Species with no ortholog for MRPL37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL37 Gene

ENSEMBL:
Gene Tree for MRPL37 (if available)
TreeFam:
Gene Tree for MRPL37 (if available)

Paralogs for MRPL37 Gene

Pseudogenes.org Pseudogenes for MRPL37 Gene

genes like me logo Genes that share paralogs with MRPL37: view

No data available for Paralogs for MRPL37 Gene

Variants for MRPL37 Gene

Sequence variations from dbSNP and Humsavar for MRPL37 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2275408 - 54,212,632(+) GTGCC(C/G)TGGCT reference, missense
rs13571 - 54,216,247(-) CGTTA(A/C/G)AGTCC reference, missense
rs6621 -- 54,218,252(+) TGAGC(A/C/G)GAGGA intron-variant, utr-variant-3-prime
rs15921 -- 54,218,183(+) GTTGG(C/G)CCAGT intron-variant, reference, synonymous-codon
rs642990 -- 54,222,843(+) GCAGC(C/T)TGCCT intron-variant

Variation tolerance for MRPL37 Gene

Residual Variation Intolerance Score: 18.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.69; 95.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPL37 Gene

Disorders for MRPL37 Gene

Relevant External Links for MRPL37

Genetic Association Database (GAD)
MRPL37
Human Genome Epidemiology (HuGE) Navigator
MRPL37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL37

No disorders were found for MRPL37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL37 Gene

Publications for MRPL37 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. [The structure and specific features of the cDNA expression of the human gene MRPL37]. (PMID: 15562971) Levshenkova E.V. … Frolova E.I. (Bioorg. Khim. 2004) 3 23
  3. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. (PMID: 10600119) Graack H.R. … O'Brien T.W. (Biochemistry 1999) 2 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for MRPL37 Gene

Sources for MRPL37 Gene

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