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MRPL37 Gene

protein-coding   GIFtS: 52
GCID: GC01P054649

Mitochondrial Ribosomal Protein L37

  Search for MRPL37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L371 2     MRP-L372 3
39S Ribosomal Protein L2, Mitochondrial2 3     MRPL22 3
L2mt2 3     RPML22 3
L37mt2 3     39S Ribosomal Protein L37, Mitochondrial2
MRP-L22 3     Ribosomal Protein, Mitochondrial, L22

External Ids:    HGNC: 140341   Entrez Gene: 512532   Ensembl: ENSG000001162217   OMIM: 6118435   UniProtKB: Q9BZE13   

Export aliases for MRPL37 gene to outside databases

Previous GC identifers: GC01P054495 GC01P053554 GC01P054023 GC01P054035 GC01P054378 GC01P052781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL37 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL37 Gene:
MRPL37 (mitochondrial ribosomal protein L37) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL37 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL37 gene promoter:
         RP58   Pax-5   AML1a   RORalpha2   POU2F1   POU2F1a   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL37 promoter sequence
   Search Chromatin IP Primers for MRPL37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.1   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32.1

MRPL37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL37 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P054649:  view genomic region     (about GC identifiers)

Start:
54,649,714 bp from pter      End:
54,691,137 bp from pter
Size:
41,424 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RM37_HUMAN, Q9BZE1 (See protein sequence)
Recommended Name: 39S ribosomal protein L37, mitochondrial precursor  
Size: 423 amino acids; 48117 Da
Sequence caution: Sequence=AAF36155.1; Type=Frameshift; Positions=9, 13, 25, 30, 326;
Secondary accessions: Q96Q67 Q9BWR1 Q9P0P3

Explore the universe of human proteins at neXtProt for MRPL37: NX_Q9BZE1

Explore proteomics data for MRPL37 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172
  • Modification sites at PhosphoSitePlus

  • See MRPL37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057575.2  
    ENSEMBL proteins: 
     ENSP00000354086   ENSP00000473980   ENSP00000392216   ENSP00000338526  

    MRPL37 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MRPL37

     
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    Cloud-Clone Corp. ELISAs for MRPL37
    Cloud-Clone Corp. CLIAs for MRPL37
    Search eBioscience for ELISAs for MRPL37 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR010793 Ribosomal_L37/S30

    Graphical View of Domain Structure for InterPro Entry Q9BZE1

    ProtoNet protein and cluster: Q9BZE1

    UniProtKB/Swiss-Prot: RM37_HUMAN, Q9BZE1
    Similarity: Belongs to the ribosomal protein S30/L37 family


    Find genes that share domains with MRPL37           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MRPL37           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL37
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    miRNA
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    miRTarBase miRNAs that target MRPL37:
    hsa-let-7b-5p (MIRT052195), hsa-mir-454-3p (MIRT039232), hsa-mir-378a-3p (MIRT043932)

    Block miRNA regulation of human, mouse, rat MRPL37 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat MRPL37

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RM37_HUMAN, Q9BZE1: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005761mitochondrial ribosome NAS11543634
    GO:0005840ribosome ----

    Find genes that share ontologies with MRPL37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL37
    Interactions:

        Search GeneGlobe Interaction Network for MRPL37

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for MRPL37 (Q9BZE12, 3 ENSP000003540864) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271322 I2D: score=2 
    SMN2Q166372, 3MINT-8271322 I2D: score=2 
    TK1P041832, 3MINT-8273763 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634

    Find genes that share ontologies with MRPL37           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL37 (RM37)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPL37 gene: 
    NM_016491.3  

    Unigene Cluster for MRPL37:

    Mitochondrial ribosomal protein L37
    Hs.584908  [show with all ESTs]
    Unigene Representative Sequence: BM926908
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487096 ENST00000360840(uc001cxa.4 uc009vzp.3) ENST00000605337
    ENST00000490670 ENST00000398219 ENST00000336230
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MRPL37
      QuantiFast Probe-based Assays in human, mouse, rat MRPL37

    Additional mRNA sequence: 

    AF325707.1 AK024572.1 AK026171.1 AY421759.1 BC000041.2 

    21 DOTS entries:

    DT.99994497  DT.100882618  DT.91766919  DT.75124194  DT.100882621  DT.100882611  DT.121355005  DT.91766903 
    DT.95375927  DT.95375912  DT.95375931  DT.100033328  DT.100673001  DT.100882610  DT.121354950  DT.121355011 
    DT.75172057  DT.91766920  DT.92010062  DT.40210377  DT.86857741 

    Selected AceView cDNA sequences (see all 594):

    BG249980 CR625978 BF340029 BM020985 CD514360 BM477533 BI255963 BE386034 
    BM561876 BI768642 BM770985 BQ943417 BM846840 CR597035 BM700438 BX401225 
    BU957500 BQ424308 BX397130 CB160683 BE264044 BE748207 BE891490 CA405428 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL37    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                            -                                       
    SP2:                          -                 -                                       
    SP3:                          -                                                         
    SP4:                                -     -     -                                       


    ECgene alternative splicing isoforms for MRPL37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPL37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCTGCGTG
    MRPL37 Expression
    About this image


    MRPL37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    MRPL37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584908
        Custom PCR Arrays for MRPL37
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPL37 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl371 , 5 mitochondrial ribosomal protein L371, 5 82.27(n)1
    79.91(a)1
      4 (49.99 cM)5
    562801  NM_025500.21  NP_079776.11 
     1070558745 
    chicken
    (Gallus gallus)
    Aves MRPL371 mitochondrial ribosomal protein L37 64.14(n)
    57.11(a)
      772313  NM_001081505.1  NP_001074974.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL376
    mitochondrial ribosomal protein L37
    39(a)
    1 ↔ 1
    4(104987691-104998595)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253392 Xenopus laevis transcribed sequence with weak similarity more 74.5(n)    48062063 
    zebrafish
    (Danio rerio)
    Actinopterygii 570714162   -- 75.1(n)    57071416 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL371 mitochondrial ribosomal protein L37 45.14(n)
    29.15(a)
      41293  NM_079582.4  NP_524306.3 


    ENSEMBL Gene Tree for MRPL37 (if available)
    TreeFam Gene Tree for MRPL37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPL37 gene

    Find genes that share paralogs with MRPL37           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for MRPL37
    PGOHUM00000235073


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPL37 (see all 387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1898902891,2
    --54667926(+) TGCCTC/TGGCCT 1 -- int10--------
    rs1450463351,2
    --54668109(+) CCCCCA/GAAGTA 1 -- int10--------
    rs18905661,2
    C,F,A,H--54668278(+) AATCTA/GTCCTT 1 -- int131Minor allele frequency- G:0.28NS EA NA CSA WA 2962
    rs781117531,2
    C--54668288(+) TCCACC/GTAAGC 1 -- int10--------
    rs1929243561,2
    --54668381(+) CACATG/TGGCCA 1 -- int10--------
    rs1420379631,2
    --54668403(+) AAGCAA/GTCTAC 1 -- int10--------
    rs9464451,2
    C,F,H--54668427(+) CCAGAG/TTGCTG 1 -- int115Minor allele frequency- T:0.14NS EA NA WA 966
    rs171100871,2
    C,F,H--54668562(+) CTTCTG/ATTAAT 1 -- int132Minor allele frequency- A:0.06NA NS EA WA 3330
    rs1149294911,2
    C,F--54668612(+) TTCATT/CTGAAA 1 -- int11Minor allele frequency- C:0.02NA 120
    rs1845889851,2
    --54668716(+) GCTAGA/GGAGGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRPL37 (54649714 - 54691137 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MRPL37: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL37
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL37

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611843    OMIM disorders: --


    Find genes that share disorders with MRPL37           About GenesLikeMe

    Genetic Association Database (GAD): MRPL37
    Human Genome Epidemiology (HuGE) Navigator: MRPL37 (1 document)

    Export disorders for MRPL37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPL37 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MRPL37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N.... Tanaka T. (Genomics 2001)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. (PubMed id 10600119)1, 3 Graack H.R.... O'Brien T.W. (Biochemistry 1999)
    7. [The structure and specific features of the cDNA expression of the human gene MRPL37]. (PubMed id 15562971)1, 9 Levshenkova E.V....Frolova E.I. (Bioorg. Khim. 2004)
    8. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    9. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    10. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51253 HGNC: 14034 AceView: MRPL37 Ensembl:ENSG00000116221 euGenes: HUgn51253
    ECgene: MRPL37 H-InvDB: MRPL37

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPL37 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mrpl37/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPL37 gene:
    Search GeneIP for patents involving MRPL37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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