Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL36 Gene

Aliases for MRPL36 Gene

  • Mitochondrial Ribosomal Protein L36 2 3 5
  • 39S Ribosomal Protein L36, Mitochondrial 2 3
  • Putative BRCA1-Interacting Protein 2 3
  • BRCA1-Interacting Protein 1 3 4
  • MRP-L36 3 4
  • BRIP1 3 4
  • L36mt 3 4
  • PRPL36 3
  • RPMJ 3

External Ids for MRPL36 Gene

Previous GeneCards Identifiers for MRPL36 Gene

  • GC05M001939
  • GC05M001831

Summaries for MRPL36 Gene

Entrez Gene Summary for MRPL36 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL36 Gene

MRPL36 (Mitochondrial Ribosomal Protein L36) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL36 Gene

Genomics for MRPL36 Gene

Regulatory Elements for MRPL36 Gene

Enhancers for MRPL36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F001798 1.2 ENCODE 28.5 +0.7 681 4.1 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 MRPL36 LOC100132773 LOC728613 ENSG00000271119 GC05P001799 NDUFS6
GH05F001788 1.3 Ensembl ENCODE 18.6 +9.2 9222 6.6 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF2 ZNF143 ZNF207 ZNF548 FOS MRPL36 LOC100132773 LOC101929003 PIR36348
GH05F001948 1.3 Ensembl ENCODE 10.5 -148.1 -148050 2.7 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 ZNF548 FOS SP3 YY2 LOC100132773 CTD-2194D22.4 LINC02116 MTCO2P32 LOC105374620 LOC728613 MRPL36 NDUFS6 ENSG00000249731 ENSG00000248994
GH05F001640 1.2 Ensembl ENCODE 10.8 +160.0 159975 1.1 ATF1 ARNT ARID4B ZNF2 ZNF143 DEK SP5 MIER2 REST ZNF592 SDHAP3 LOC728613 MRPL36 NDUFS6 ENSG00000250173 GC05M001591
GH05F001644 1.2 Ensembl ENCODE 10.8 +156.4 156355 1.4 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF143 DEK ZNF263 REST SMARCB1 LOC728613 ENSG00000271119 SDHAP3 MRPL36 NDUFS6 ENSG00000250173 GC05M001591 PIR51678
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL36 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL36 Gene

1,798,385 bp from pter
1,801,423 bp from pter
3,039 bases
Minus strand

Genomic View for MRPL36 Gene

Genes around MRPL36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL36 Gene

Proteins for MRPL36 Gene

  • Protein details for MRPL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L36, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A4UCS0
    • B2R4Z2
    • Q3SWV6
    • Q9UKL7

    Protein attributes for MRPL36 Gene

    103 amino acids
    Molecular mass:
    11784 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    • Sequence=AAF04788.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL36 Gene

neXtProt entry for MRPL36 Gene

Post-translational modifications for MRPL36 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MRPL36 Gene

Domains & Families for MRPL36 Gene

Gene Families for MRPL36 Gene

Protein Domains for MRPL36 Gene


Suggested Antigen Peptide Sequences for MRPL36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L36P family.
  • Belongs to the ribosomal protein L36P family.
genes like me logo Genes that share domains with MRPL36: view

Function for MRPL36 Gene

Gene Ontology (GO) - Molecular Function for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL36: view
genes like me logo Genes that share phenotypes with MRPL36: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL36 Gene

Localization for MRPL36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL36 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL36 gene
Compartment Confidence
mitochondrion 5
nucleus 5
plasma membrane 1
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit NAS 11279069
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL36: view

Pathways & Interactions for MRPL36 Gene

genes like me logo Genes that share pathways with MRPL36: view

Gene Ontology (GO) - Biological Process for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279069
GO:0042254 ribosome biogenesis IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL36: view

No data available for SIGNOR curated interactions for MRPL36 Gene

Transcripts for MRPL36 Gene

Unigene Clusters for MRPL36 Gene

Mitochondrial ribosomal protein L36:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP2: -

Relevant External Links for MRPL36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MRPL36 Gene:


SOURCE GeneReport for Unigene cluster for MRPL36 Gene:

genes like me logo Genes that share expression patterns with MRPL36: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MRPL36 Gene

Orthologs for MRPL36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL36 34 35
  • 99.03 (n)
(Monodelphis domestica)
Mammalia MRPL36 35
  • 72 (a)
(Mus musculus)
Mammalia Mrpl36 34 16 35
  • 69.73 (n)
(Rattus norvegicus)
Mammalia LOC100910528 34
  • 68.73 (n)
(Bos Taurus)
Mammalia MRPL36 35
  • 54 (a)
(Canis familiaris)
Mammalia MRPL36 35
  • 52 (a)
(Anolis carolinensis)
Reptilia MRPL36 35
  • 75 (a)
(Danio rerio)
Actinopterygii mrpl36 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTC6 37
Species where no ortholog for MRPL36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL36 Gene

Gene Tree for MRPL36 (if available)
Gene Tree for MRPL36 (if available)

Paralogs for MRPL36 Gene

No data available for Paralogs for MRPL36 Gene

Variants for MRPL36 Gene

Sequence variations from dbSNP and Humsavar for MRPL36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs754131778 Likely benign 1,801,434(+) GATGA(C/T)CTTCT upstream-variant-2KB, reference, missense
rs376509886 Uncertain significance 1,801,442(+) TCTGC(A/C/G/T)GGCTG upstream-variant-2KB, reference, synonymous-codon, missense
rs754448417 Uncertain significance 1,802,317(+) TTTTT(C/T)CAGGT intron-variant, upstream-variant-2KB
rs797045734 Uncertain significance 1,801,421(+) AAATG(A/G)CGGCG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs145747389 Benign 1,801,406(+) AAGGC(C/T)AGCGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL36 Gene

Variant ID Type Subtype PubMed ID
nsv1033147 CNV gain 25217958
esv3603817 CNV gain 21293372

Variation tolerance for MRPL36 Gene

Residual Variation Intolerance Score: 66.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL36 Gene

Disorders for MRPL36 Gene

Relevant External Links for MRPL36

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL36 Gene

Publications for MRPL36 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 64
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 64

Products for MRPL36 Gene

Sources for MRPL36 Gene

Loading form....