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Aliases for MRPL36 Gene

Aliases for MRPL36 Gene

  • Mitochondrial Ribosomal Protein L36 2 3
  • Putative BRCA1-Interacting Protein 2 3
  • BRCA1-Interacting Protein 1 3 4
  • MRP-L36 3 4
  • BRIP1 3 4
  • L36mt 3 4
  • 39S Ribosomal Protein L36, Mitochondrial 3
  • 39S Ribosomal Protein L36 2
  • Mitochondrial 2
  • PRPL36 3
  • RPMJ 3

External Ids for MRPL36 Gene

Previous GeneCards Identifiers for MRPL36 Gene

  • GC05M001939
  • GC05M001831

Summaries for MRPL36 Gene

Entrez Gene Summary for MRPL36 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 2p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL36 Gene

MRPL36 (Mitochondrial Ribosomal Protein L36) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Metabolism. GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL36 Gene

  • Component of the large subunit of the mitochondrial ribosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL36 Gene

Genomics for MRPL36 Gene

Regulatory Elements for MRPL36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL36 Gene

1,798,385 bp from pter
1,801,366 bp from pter
2,982 bases
Minus strand

Genomic View for MRPL36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL36 Gene

Proteins for MRPL36 Gene

  • Protein details for MRPL36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L36, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A4UCS0
    • B2R4Z2
    • Q3SWV6
    • Q9UKL7

    Protein attributes for MRPL36 Gene

    103 amino acids
    Molecular mass:
    11784 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF04788.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL36 Gene

neXtProt entry for MRPL36 Gene

Proteomics data for MRPL36 Gene at MOPED

Post-translational modifications for MRPL36 Gene

No Post-translational modifications

Other Protein References for MRPL36 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL36 Gene

Domains for MRPL36 Gene

Gene Families for MRPL36 Gene

Protein Domains for MRPL36 Gene


Suggested Antigen Peptide Sequences for MRPL36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L36P family.
  • Belongs to the ribosomal protein L36P family.
genes like me logo Genes that share domains with MRPL36: view

Function for MRPL36 Gene

Molecular function for MRPL36 Gene

UniProtKB/Swiss-Prot Function:
Component of the large subunit of the mitochondrial ribosome.

Gene Ontology (GO) - Molecular Function for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL36: view

Animal Model Products

miRNA for MRPL36 Gene

miRTarBase miRNAs that target MRPL36

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL36

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL36 Gene

Localization for MRPL36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL36 Gene


Subcellular locations from

Jensen Localization Image for MRPL36 Gene COMPARTMENTS Subcellular localization image for MRPL36 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit NAS 11279069
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL36: view

Pathways for MRPL36 Gene

genes like me logo Genes that share pathways with MRPL36: view

Pathways by source for MRPL36 Gene

Gene Ontology (GO) - Biological Process for MRPL36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279069
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042254 ribosome biogenesis IBA --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL36: view

Transcripts for MRPL36 Gene

Unigene Clusters for MRPL36 Gene

Mitochondrial ribosomal protein L36:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL36 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP2: -

Relevant External Links for MRPL36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL36 Gene

mRNA expression in normal human tissues for MRPL36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for MRPL36 Gene Hs.719465

genes like me logo Genes that share expressions with MRPL36: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MRPL36 Gene

Orthologs for MRPL36 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL36 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Mrpl36 35
  • 69.73 (n)
  • 62.24 (a)
Mrpl36 16
Mrpl36 36
  • 60 (a)
(Pan troglodytes)
Mammalia MRPL36 35
  • 99.03 (n)
  • 100 (a)
MRPL36 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100910528 35
  • 68.73 (n)
  • 61.86 (a)
(Bos Taurus)
Mammalia MRPL36 36
  • 54 (a)
(Canis familiaris)
Mammalia MRPL36 36
  • 52 (a)
(Monodelphis domestica)
Mammalia MRPL36 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MRPL36 36
  • 75 (a)
(Danio rerio)
Actinopterygii mrpl36 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTC6 38
Species with no ortholog for MRPL36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL36 Gene

Gene Tree for MRPL36 (if available)
Gene Tree for MRPL36 (if available)

Paralogs for MRPL36 Gene

No data available for Paralogs for MRPL36 Gene

Variants for MRPL36 Gene

Sequence variations from dbSNP and Humsavar for MRPL36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2291944 -- 1,799,207(+) AGCCC(C/T)GCGAT intron-variant
rs4275010 -- 1,798,089(+) AGACC(C/T)CAGAC downstream-variant-500B
rs4277951 -- 1,797,908(+) CTAGG(G/T)ACTGA downstream-variant-500B
rs4296838 -- 1,798,296(+) CTCAC(A/G)GAGAC downstream-variant-500B
rs4296839 -- 1,798,299(+) ACGGA(A/G)ACATA downstream-variant-500B

Relevant External Links for MRPL36 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL36 Gene

Disorders for MRPL36 Gene

Relevant External Links for MRPL36

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL36 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL36 Gene

Publications for MRPL36 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL36 Gene

Sources for MRPL36 Gene

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