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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL36 Gene

protein-coding   GIFtS: 45
GCID: GC05M001851

mitochondrial ribosomal protein L36

 Explore 2 diseases affiliated with
MRPL36 via our new
 Human Malady Compendium 
Biological research products
for MRPL36
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L361 2     RPMJ1 2
BRIP11 2 3     BRCA1-Interacting Protein 12 3
L36mt1 2 3     39S Ribosomal Protein L36, Mitochondrial2
MRP-L361 2 3     Putative BRCA1-Interacting Protein2
PRPL361 2     

External Ids:    HGNC: 144901   Entrez Gene: 649792   Ensembl: ENSG000001714217   OMIM: 6118425   UniProtKB: Q9P0J63   

Export aliases for MRPL36 gene to outside databases

Previous GC identifers: GC05M001939 GC05M001831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL36:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
A pseudogene corresponding to this gene is found on chromosome 2p. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6
Function: Component of the large subunit of the mitochondrial ribosome (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL36 gene promoter:
         ER-alpha   RFX1   Pax-2   MIF-1   Pax-2a   PPAR-gamma1   c-Myb   Msx-1   ZIC2/Zic2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL36 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.3

MRPL36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL36 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001851:  view genomic region     (about GC identifiers)

Start:
1,798,499 bp from pter      End:
1,801,480 bp from pter
Size:
2,982 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6 (See protein sequence)
Recommended Name: 39S ribosomal protein L36, mitochondrial precursor  
Size: 103 amino acids; 11784 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAF04788.1; Type=Erroneous initiation;
Secondary accessions: A4UCS0 B2R4Z2 Q3SWV6 Q9UKL7

Explore the universe of human proteins at neXtProt for MRPL36: NX_Q9P0J6

MRPL36 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_115868.1  
ENSEMBL proteins: 
 ENSP00000427152   ENSP00000372093   ENSP00000423152   ENSP00000423399   ENSP00000424366  

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Uscn Proteins for MRPL36

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005762mitochondrial large ribosomal subunit NAS11279069
GO:0005840ribosome ----


MRPL36 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRPL36 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR000473 Ribosomal_L36

Graphical View of Domain Structure for InterPro Entry Q9P0J6

ProtoNet protein and cluster: Q9P0J6

1 Blocks protein family: IPB000473 Ribosomal protein L36

UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6
Similarity: Belongs to the ribosomal protein L36P family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: RM36_HUMAN, Q9P0J6
Function: Component of the large subunit of the mitochondrial ribosome (Potential)

miRNA
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Inhib. RNA
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003735structural constituent of ribosome IEA--


MRPL36 for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL36

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/27 Interacting proteins for MRPL36 (Q9P0J63 ENSP000003720934) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
InteractantInteraction Details
GeneCardExternal ID(s)
BRCA1P383983, ENSP000003502834I2D: score=1 STRING: ENSP00000350283
RRASP103013, ENSP000002467924I2D: score=2 STRING: ENSP00000246792
MRPL3ENSP000002649954STRING: ENSP00000264995
RPS16ENSP000002514534STRING: ENSP00000251453
UPF1ENSP000002628034STRING: ENSP00000262803
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006412translation NAS11279069


MRPL36 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRPL36
Search CenterWatch for drugs/clinical trials and news about MRPL36 / RM36 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRPL36 gene: 
NM_032479.3  

Unigene Cluster for MRPL36:

Mitochondrial ribosomal protein L36
Hs.719465  [show with all ESTs]
Unigene Representative Sequence: BG250351
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000505818 ENST00000382647 ENST00000505059(uc003jcx.4) ENST00000508987
ENST00000510999

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidMRPL36 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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OriGene shRNA RFP: MRPL36
Browse OriGene siRNA
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Clone
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GenScript: all cDNA clones in your preferred vector: MRPL36 (NM_032479)
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL36

Additional cDNA sequence: 

AB049654.1 AF151109.1 AF155653.1 AK312001.1 BC020642.1 BC104652.1 EF036487.1 

6 DOTS entries:

DT.75192658  DT.95369944  DT.91752418  DT.91752435  DT.95186808  DT.99971246 

24/166 AceView cDNA sequences (see all 166):

H79084 BM703966 AA478610 BC020642 AB049654 AW572997 BQ671162 AA913056 
AA349759 H77420 BQ007463 H77596 AA443024 AI571297 BX111462 CF529678 
AI089399 AA454963 AA977298 AA503830 AW187987 CF529649 AI052480 AA830635 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL36    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1:                              
SP2:              -               


ECgene alternative splicing isoforms for MRPL36

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRPL36 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAATCTTT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See MRPL36 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL36

SOURCE GeneReport for Unigene cluster: Hs.719465
    SABiosciences Custom PCR Arrays for MRPL36
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL36
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL36
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL36
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL36

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MRPL36 gene from 5/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrpl361 , 5 mitochondrial ribosomal protein L361, 5 68.37(n)1
62.24(a)1
  13 (39.71 cM)5
940661  NM_053163.11  NP_444393.11 
 733310095 
chicken
(Gallus gallus)
Aves F1NQQ6_CHICK6
Ribosomal protein
30(a)
1 ↔ 1
2(88288566-88290305)
lizard
(Anolis carolinensis)
Reptilia MRPL366
--
73(a)
1 ↔ 1
4(68480488-68589301)
zebrafish
(Danio rerio)
Actinopterygii mrpl366
mitochondrial ribosomal protein L36
34(a)
1 ↔ 1
19(28769785-28775878)
fruit fly
(Drosophila melanogaster)
Insecta mRpL366
mitochondrial ribosomal protein L36
27(a)
1 ↔ 1
3L(8117684-8118232)


ENSEMBL Gene Tree for MRPL36 (if available)
TreeFam Gene Tree for MRPL36 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/54 NCBI SNPs in MRPL36 are shown (see all 54    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs42779511,2
C,F,A,H,--1798022(+) CTAGGG/TACTGA 1 -- ds50019Minor allele frequency- T:0.20NS EA NA WA 780
rs1146779121,2
F,--1798036(+) AGTGCG/AGTAGA 1 -- ds50011Minor allele frequency- A:0.03WA 118
rs1458208041,2
--1798049(+) TGACAC/TGCTGG 1 -- ds50010--------
rs1384586921,2
--1798106(+) TCTCTC/TGGGAC 1 -- ds50010--------
rs1165767871,2
F,--1798111(+) CGGGAC/GACTCT 1 -- ds50011Minor allele frequency- G:0.03WA 118
rs1881247381,2
--1798117(+) ACTCTC/TGGGAA 1 -- ds50010--------
rs45886291,2
C,F,H,--1798138(+) GGGCAG/ATGCAA 1 -- ds500122Minor allele frequency- A:0.21NS EA NA WA CSA 2755
rs42750101,2
C,F,H,--1798203(+) AGACCC/TCAGAC 1 -- ds50018Minor allele frequency- T:0.17NS EA WA CSA NA 649
rs100850111,2
C,F,A,H,--1798243(+) TCCTGC/Tagtta 1 -- ds500123Minor allele frequency- T:0.13NS EA NA WA 2532
rs593881491,2
F,--1798262(+) CAGATC/AAGACA 1 -- ds50011Minor allele frequency- A:0.08WA 118

HapMap Linkage Disequilibrium report for MRPL36 (1798499 - 1801480 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MRPL36: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MRPL36 for disorders           About GeneDecksing

OMIM gene information: 611842    OMIM disorders: --

2 diseases for MRPL36:    About MalaCards
wolf-hirschhorn syndrome    genital herpes

Human Genome Epidemiology (HuGE) Navigator: MRPL36 (1 document)

Export disorders for MRPL36 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MRPL36 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MRPL36)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N....Tanaka T. (2001)
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
  5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
  6. Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. (PubMed id 19318571)1 Piao L....Park J. (2009)
  7. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PubMed id 18624398)1 Wang J....He F. (2008)
  8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  9. BACH1 is a DNA repair protein supporting BRCA1 damage response. (PubMed id 16462773)1 Peng M....Cantor S.B. (2006)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 64979 HGNC: 14490 AceView: MRPL36 Ensembl:ENSG00000171421 euGenes: HUgn64979
ECgene: MRPL36 H-InvDB: MRPL36

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MRPL36 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MRPL36 gene:
Search GeneIP for patents involving MRPL36

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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