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Aliases for MRPL35 Gene

Aliases for MRPL35 Gene

  • Mitochondrial Ribosomal Protein L35 2 3 5
  • MRP-L35 3 4
  • L35mt 3 4

External Ids for MRPL35 Gene

Previous GeneCards Identifiers for MRPL35 Gene

  • GC02P086321
  • GC02P086720
  • GC02P086401
  • GC02P086338
  • GC02P086426

Summaries for MRPL35 Gene

Entrez Gene Summary for MRPL35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL35 Gene

MRPL35 (Mitochondrial Ribosomal Protein L35) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL35 Gene

Genomics for MRPL35 Gene

Regulatory Elements for MRPL35 Gene

Promoters for MRPL35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL35 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL35 Gene

Chromosome:
2
Start:
86,199,355 bp from pter
End:
86,213,794 bp from pter
Size:
14,440 bases
Orientation:
Plus strand

Genomic View for MRPL35 Gene

Genes around MRPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL35 Gene

Proteins for MRPL35 Gene

  • Protein details for MRPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZE8-RM35_HUMAN
    Recommended name:
    39S ribosomal protein L35, mitochondrial
    Protein Accession:
    Q9NZE8
    Secondary Accessions:
    • A6NKV6
    • B2RB93
    • Q658U7
    • Q8WWA2

    Protein attributes for MRPL35 Gene

    Size:
    188 amino acids
    Molecular mass:
    21514 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64263.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL35 Gene

    Alternative splice isoforms for MRPL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL35 Gene

Proteomics data for MRPL35 Gene at MOPED

Post-translational modifications for MRPL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL35 Gene

No data available for DME Specific Peptides for MRPL35 Gene

Domains & Families for MRPL35 Gene

Gene Families for MRPL35 Gene

Protein Domains for MRPL35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZE8

UniProtKB/Swiss-Prot:

RM35_HUMAN :
  • Belongs to the ribosomal protein L35P family.
Family:
  • Belongs to the ribosomal protein L35P family.
genes like me logo Genes that share domains with MRPL35: view

Function for MRPL35 Gene

genes like me logo Genes that share phenotypes with MRPL35: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL35 Gene

Localization for MRPL35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL35 Gene COMPARTMENTS Subcellular localization image for MRPL35 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL35: view

Pathways & Interactions for MRPL35 Gene

genes like me logo Genes that share pathways with MRPL35: view

Interacting Proteins for MRPL35 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338389%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000338389 for MRPL35 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL35: view

No data available for SIGNOR curated interactions for MRPL35 Gene

Drugs & Compounds for MRPL35 Gene

No Compound Related Data Available

Transcripts for MRPL35 Gene

Unigene Clusters for MRPL35 Gene

Mitochondrial ribosomal protein L35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for MRPL35 Gene

GeneLoc Exon Structure for
MRPL35
ECgene alternative splicing isoforms for
MRPL35

Expression for MRPL35 Gene

mRNA expression in normal human tissues for MRPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL35 Gene

This gene is overexpressed in Breast (34.3), Lung (10.2), Pancreatic juice (8.8), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MRPL35 Gene



SOURCE GeneReport for Unigene cluster for MRPL35 Gene Hs.433439

genes like me logo Genes that share expression patterns with MRPL35: view

Protein tissue co-expression partners for MRPL35 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL35 Gene

Orthologs for MRPL35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL35 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL35 35
  • 84.57 (n)
  • 83.51 (a)
MRPL35 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL35 35
  • 85.59 (n)
  • 79.46 (a)
MRPL35 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl35 35
  • 81.56 (n)
  • 76.6 (a)
Mrpl35 16
Mrpl35 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL35 35
  • 99.29 (n)
  • 98.94 (a)
MRPL35 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl35 35
  • 79.61 (n)
  • 77.13 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL35 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL35 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL35 35
  • 65.56 (n)
  • 64.9 (a)
MRPL35 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL35 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl35 35
  • 63.95 (n)
  • 70.07 (a)
Str.19278 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15585 35
mrpl35 35
  • 58.87 (n)
  • 60.82 (a)
mrpl35 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.888 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL35 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for MRPL35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL35 Gene

ENSEMBL:
Gene Tree for MRPL35 (if available)
TreeFam:
Gene Tree for MRPL35 (if available)

Paralogs for MRPL35 Gene

Pseudogenes.org Pseudogenes for MRPL35 Gene

genes like me logo Genes that share paralogs with MRPL35: view

No data available for Paralogs for MRPL35 Gene

Variants for MRPL35 Gene

Sequence variations from dbSNP and Humsavar for MRPL35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_030010 -
rs34044771 - 86,207,187(+) GGGGG(A/C/G)CATTC reference, missense
rs3192352 - 86,207,191(+) GGCCC(C/T)CGTGC reference, missense
rs17851803 - 86,206,132(+) TTTTG(A/G)CATCT reference, missense
rs1051949 - 86,206,148(+) CTACC(A/G)CAACT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRPL35 Gene

Variant ID Type Subtype PubMed ID
esv2751903 CNV Gain 17911159
nsv458563 CNV Gain 19166990
nsv458574 CNV Gain 19166990

Variation tolerance for MRPL35 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL35 Gene

HapMap Linkage Disequilibrium report
MRPL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL35 Gene

Disorders for MRPL35 Gene

Relevant External Links for MRPL35

Genetic Association Database (GAD)
MRPL35
Human Genome Epidemiology (HuGE) Navigator
MRPL35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL35

No disorders were found for MRPL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL35 Gene

Publications for MRPL35 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for MRPL35 Gene

Sources for MRPL35 Gene

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