MRPL35 Gene
protein-coding GIFtS: 44
GCID: GC02P086426
|
|
mitochondrial ribosomal protein L35
| |
Aliases
for MRPL35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L351 2 | | L35mt2 3 | | MRP-L352 3 | | 39S Ribosomal Protein L35, Mitochondrial2 |
Export aliases for MRPL35 gene to outside databasesPrevious GC identifers: GC02P086321 GC02P086720 GC02P086401 GC02P086338 |
Summaries
for MRPL35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL35:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found onchromosomes 6p, 10q, and Xp. (provided by RefSeq, Jul 2008)
|
Genomic Views
for MRPL35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL35 gene promoter:
Pax-5 Pax-2 Pax-2a IRF-1 NF-AT Max POU2F1 POU2F1a c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2MRPL35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P086426: view genomic region
(about GC identifiers)
Start:
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86,426,556 bp from pter |
End:
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86,440,917 bp from pter |
Size:
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14,362 bases |
Orientation:
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plus strand |
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Proteins
for MRPL35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM35_HUMAN, Q9NZE8 (See
protein sequence)Recommended Name: 39S ribosomal protein L35, mitochondrial precursor Size: 188 amino acids; 21514 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAF64263.1; Type=Frameshift; Positions=122;
Secondary accessions: A6NKV6 B2RB93 Q658U7 Q8WWA2Alternative splicing: 2 isoforms: Q9NZE8-1 Q9NZE8-2 Explore the universe of human proteins at neXtProt for MRPL35: NX_Q9NZE8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZE8
MRPL35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_057706.2 NP_663619.1
ENSEMBL proteins: ENSP00000254644 ENSP00000338389 ENSP00000386255
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPL35 for ontologies About GeneDecksing
MRPL35 Antibody Products:
Assay Products for MRPL35: |
Protein
Domains /
Families
for MRPL35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL35 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NZE8ProtoNet protein and cluster: Q9NZE8 UniProtKB/Swiss-Prot: RM35_HUMAN, Q9NZE8Similarity: Belongs to the ribosomal protein L35P family |
Function
for MRPL35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL35 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL35 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL35 (NM_016622) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL35 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 11543634 |
MRPL35 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRPL35:
|
Pathways & Interactions
for MRPL35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL35
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPL35 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL35
Search CenterWatch for drugs/clinical trials and news about MRPL35 / RM35
|
Transcripts
for MRPL35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL35 gene (2 alternative transcripts): NM_016622.3 NM_145644.2 Unigene Cluster for MRPL35: Mitochondrial ribosomal protein L35 Hs.433439 [show with all ESTs]Unigene Representative Sequence: NM_0166223 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254644 ENST00000337109(uc002srf.4 uc002srg.4) ENST00000409180
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL35 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL35 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL35 (NM_016622) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL35 |
Additional cDNA sequence: AF208849.1 AK026220.1 AK074352.1 AK314555.1 AK314577.1 AL832982.1 BC020651.1 10 DOTS entries: DT.99988876 DT.119122 DT.95200003 DT.119125 DT.121003936 DT.95237046 DT.100058614 DT.121003894 DT.95276899 DT.97855388 24/267 AceView cDNA sequences (see all 267): AI277139 AA806482 BM802035 CB265242 BG030594 BQ011851 AA906163 NM_016622 AI041326 AI955106 H11039 BM985369 CB159640 BQ011822 AI919266 AA385267 AI758899 BG231895 BU181958 BE673007 AI161215 BM548350 AA678059 AI032939
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL35 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL35
|
Expression
for MRPL35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGTCTTTAT
About this image
See MRPL35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL35
SOURCE GeneReport for Unigene cluster: Hs.433439
SABiosciences Custom PCR Arrays for MRPL35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL35 |
Orthologs
for MRPL35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL35 gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl351 , 5 |
mitochondrial ribosomal protein L351, 5 |
81.56(n)1
76.6(a)1 |
|
6 (32.21 cM)5
662231 NM_025430.31 NP_079706.11
718130035 |
chicken
(Gallus gallus) |
Aves |
MRPL351 |
mitochondrial ribosomal protein L35 |
61.39(n)
58.86(a) |
|
422914 XM_420855.3 XP_420855.3 |
lizard
(Anolis carolinensis) |
Reptilia |
MRPL356 |
-- |
76(a) |
1 ↔ 1 |
6(60655146-60655949) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.192782 |
Transcribed sequence with weak similarity to protein more |
72.38(n) |
|
AL859208.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.155852 |
Transcribed sequence with weak similarity to protein more |
74.37(n) |
|
AL910944.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mRpL351 |
mitochondrial ribosomal protein L35 |
45.9(n)
47.69(a) |
|
42588 NM_142744.2 NP_651001.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
mrpl-356 |
Probable 39S ribosomal protein L35, mitochondrial |
20(a) |
1 ↔ 1 |
III(3510224-3510959) |
ENSEMBL Gene Tree for MRPL35 (if available)
TreeFam Gene Tree for MRPL35 (if available) |
Paralogs
for MRPL35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL35 gene
MRPL35 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for MRPL35
PGOHUM00000238501 PGOHUM00000238844 PGOHUM00000243490 PGOHUM00000241191
|
Genomic Variants
for MRPL35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL35 (86426556 - 86440917 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRPL35
1 CNV: 8380 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MRPL35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL35 for disorders About MalaCards
MRPL35 for disorders About GeneDecksing
OMIM gene information: 611841
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL35 (1 document)
Export disorders for MRPL35 gene to outside databases
|
Publications
for MRPL35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL35 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MRPL35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C....Spremulli L.L. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
|
External Searches for MRPL35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL35 gene:
Search GeneIP for patents involving MRPL35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL35 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL35 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL35 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL35 |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL35 |
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