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Aliases for MRPL35 Gene

Aliases for MRPL35 Gene

  • Mitochondrial Ribosomal Protein L35 2 3
  • MRP-L35 3 4
  • L35mt 3 4
  • 39S Ribosomal Protein L35, Mitochondrial 3

External Ids for MRPL35 Gene

Summaries for MRPL35 Gene

Entrez Gene Summary for MRPL35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL35 Gene

MRPL35 (Mitochondrial Ribosomal Protein L35) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL35 Gene

Genomics for MRPL35 Gene

Genomic Location for MRPL35 Gene

Start:
86,199,355 bp from pter
End:
86,213,794 bp from pter
Size:
14,440 bases
Orientation:
Plus strand

Genomic View for MRPL35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL35 Gene

Regulatory Elements for MRPL35 Gene

Proteins for MRPL35 Gene

  • Protein details for MRPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZE8-RM35_HUMAN
    Recommended name:
    39S ribosomal protein L35, mitochondrial
    Protein Accession:
    Q9NZE8
    Secondary Accessions:
    • A6NKV6
    • B2RB93
    • Q658U7
    • Q8WWA2

    Protein attributes for MRPL35 Gene

    Size:
    188 amino acids
    Molecular mass:
    21514 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64263.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL35 Gene

    Alternative splice isoforms for MRPL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL35 Gene

Proteomics data for MRPL35 Gene at MOPED

Post-translational modifications for MRPL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL35 Gene

No data available for DME Specific Peptides for MRPL35 Gene

Domains for MRPL35 Gene

Gene Families for MRPL35 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL35 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RM35_HUMAN
Family:
  • Belongs to the ribosomal protein L35P family.:
    • Q9NZE8
genes like me logo Genes that share domains with MRPL35: view

Function for MRPL35 Gene

Gene Ontology (GO) - Molecular Function for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL35: view

Phenotypes for MRPL35 Gene

GenomeRNAi human phenotypes for MRPL35:
genes like me logo Genes that share phenotypes with MRPL35: view

miRNA for MRPL35 Gene

miRTarBase miRNAs that target MRPL35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL35 Gene

Localization for MRPL35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL35 Gene COMPARTMENTS Subcellular localization image for MRPL35 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL35: view

Pathways for MRPL35 Gene

SuperPathways for MRPL35 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL35: view

Pathways by source for MRPL35 Gene

1 KEGG pathway for MRPL35 Gene

Interacting Proteins for MRPL35 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338389%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000338389 for MRPL35 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL35: view

Transcripts for MRPL35 Gene

Unigene Clusters for MRPL35 Gene

Mitochondrial ribosomal protein L35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for MRPL35 Gene

GeneLoc Exon Structure for
MRPL35
ECgene alternative splicing isoforms for
MRPL35

Expression for MRPL35 Gene

mRNA expression in normal human tissues for MRPL35 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL35 Gene

SOURCE GeneReport for Unigene cluster for MRPL35 Gene Hs.433439

genes like me logo Genes that share expressions with MRPL35: view

Orthologs for MRPL35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL35 36
  • 99.29 (n)
  • 98.94 (a)
MRPL35 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL35 36
  • 84.57 (n)
  • 83.51 (a)
MRPL35 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL35 36
  • 85.59 (n)
  • 79.46 (a)
MRPL35 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl35 36
  • 81.56 (n)
  • 76.6 (a)
Mrpl35 16
Mrpl35 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL35 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL35 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl35 36
  • 79.61 (n)
  • 77.13 (a)
chicken
(Gallus gallus)
Aves MRPL35 36
  • 65.56 (n)
  • 64.9 (a)
MRPL35 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL35 37
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl35 36
  • 63.95 (n)
  • 70.07 (a)
Str.19278 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.888 36
zebrafish
(Danio rerio)
Actinopterygii Dr.15585 36
mrpl35 36
  • 58.87 (n)
  • 60.82 (a)
mrpl35 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL35 37
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToOne
Species with no ortholog for MRPL35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL35 Gene

ENSEMBL:
Gene Tree for MRPL35 (if available)
TreeFam:
Gene Tree for MRPL35 (if available)

Paralogs for MRPL35 Gene

Pseudogenes.org Pseudogenes for MRPL35 Gene

genes like me logo Genes that share paralogs with MRPL35: view

No data available for Paralogs for MRPL35 Gene

Variants for MRPL35 Gene

Sequence variations from dbSNP and Humsavar for MRPL35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10901 -- 86,206,117(-) CAGGG(A/G)CCGTA reference, missense
rs13353 -- 86,210,775(-) TTTAC(A/G)TATTC utr-variant-3-prime, intron-variant
rs1051944 -- 86,206,141(+) CTTCA(A/G)CCTAC reference, missense
rs1051949 - 86,206,148(+) CTACC(A/G)CAACT missense, reference
rs1051953 -- 86,206,149(+) TACCG(A/C)AACTG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for MRPL35 Gene

Variant ID Type Subtype PubMed ID
esv2751903 CNV Gain 17911159
nsv458563 CNV Gain 19166990
nsv458574 CNV Gain 19166990

Relevant External Links for MRPL35 Gene

HapMap Linkage Disequilibrium report
MRPL35

Disorders for MRPL35 Gene

Relevant External Links for MRPL35

Genetic Association Database (GAD)
MRPL35
Human Genome Epidemiology (HuGE) Navigator
MRPL35
genes like me logo Genes that share disorders with MRPL35: view

No data available for UniProtKB/Swiss-Prot for MRPL35 Gene

Publications for MRPL35 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MRPL35 Gene

Sources for MRPL35 Gene

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