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Aliases for MRPL35 Gene

Aliases for MRPL35 Gene

  • Mitochondrial Ribosomal Protein L35 2 3 5
  • MRP-L35 3 4
  • L35mt 3 4
  • 39S Ribosomal Protein L35, Mitochondrial 3

External Ids for MRPL35 Gene

Previous GeneCards Identifiers for MRPL35 Gene

  • GC02P086321
  • GC02P086720
  • GC02P086401
  • GC02P086338
  • GC02P086426

Summaries for MRPL35 Gene

Entrez Gene Summary for MRPL35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL35 Gene

MRPL35 (Mitochondrial Ribosomal Protein L35) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL35 Gene

Genomics for MRPL35 Gene

Regulatory Elements for MRPL35 Gene

Enhancers for MRPL35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F086222 1.4 FANTOM5 Ensembl ENCODE 43.4 +25.4 25368 4.6 HDGF CTCF ZIC2 RAD21 ZFHX2 POLR2A SCRT2 EED CREM EGR2 MRPL35 IMMT POLR1A REEP1 ENSG00000251974 ENSG00000202537 ENSG00000273080 RNF103 RMND5A GC02M086172
GH02F086221 0.7 Ensembl 46.1 +22.0 22046 0.8 CTCF ESRRA ARNT TBL1XR1 ZNF384 RAD21 NFYB ZNF143 SMC3 PRDM10 MRPL35 ENSG00000251974 REEP1 IMMT ENSG00000202537 POLR1A GC02M086172
GH02F086201 1.1 Ensembl ENCODE 28 +2.7 2746 0.6 HDGF HDAC1 PKNOX1 ARNT TBL1XR1 ZBTB2 HCFC1 REST RAD51 SMARCA4 MRPL35 ENSG00000202537 POLR1A GC02M086172
GH02F086243 0.8 Ensembl ENCODE 36.1 +44.9 44946 1.0 CTCF MTA2 IKZF1 NBN JUNB BCL6 MRPL35 REEP1 ENSG00000202537 IMMT GC02M086172 GC02M086283
GH02F086249 1 Ensembl ENCODE 25.5 +50.7 50717 1.6 CTCF WRNIP1 BMI1 RAD21 RFX5 POLR2A SMC3 FOS CREM MAFK MRPL35 IMMT PLGLB1 GC02M086172 GC02M086283
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL35 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001544142 645 2401 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 ZHX2 MXD4

Genomic Location for MRPL35 Gene

Chromosome:
2
Start:
86,199,355 bp from pter
End:
86,213,794 bp from pter
Size:
14,440 bases
Orientation:
Plus strand

Genomic View for MRPL35 Gene

Genes around MRPL35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL35 Gene

Proteins for MRPL35 Gene

  • Protein details for MRPL35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZE8-RM35_HUMAN
    Recommended name:
    39S ribosomal protein L35, mitochondrial
    Protein Accession:
    Q9NZE8
    Secondary Accessions:
    • A6NKV6
    • B2RB93
    • Q658U7
    • Q8WWA2

    Protein attributes for MRPL35 Gene

    Size:
    188 amino acids
    Molecular mass:
    21514 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    SequenceCaution:
    • Sequence=AAF64263.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL35 Gene

    Alternative splice isoforms for MRPL35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL35 Gene

Post-translational modifications for MRPL35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL35 Gene

No data available for DME Specific Peptides for MRPL35 Gene

Domains & Families for MRPL35 Gene

Gene Families for MRPL35 Gene

Protein Domains for MRPL35 Gene

Suggested Antigen Peptide Sequences for MRPL35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NZE8

UniProtKB/Swiss-Prot:

RM35_HUMAN :
  • Belongs to the ribosomal protein L35P family.
Family:
  • Belongs to the ribosomal protein L35P family.
genes like me logo Genes that share domains with MRPL35: view

Function for MRPL35 Gene

Gene Ontology (GO) - Molecular Function for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL35: view
genes like me logo Genes that share phenotypes with MRPL35: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL35 Gene

Localization for MRPL35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL35 gene
Compartment Confidence
mitochondrion 5
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
genes like me logo Genes that share ontologies with MRPL35: view

Pathways & Interactions for MRPL35 Gene

genes like me logo Genes that share pathways with MRPL35: view

Interacting Proteins for MRPL35 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338389%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9NZE8-RM35_HUMAN ENSP00000338389 for MRPL35 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MRPL35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL35: view

No data available for SIGNOR curated interactions for MRPL35 Gene

Transcripts for MRPL35 Gene

Unigene Clusters for MRPL35 Gene

Mitochondrial ribosomal protein L35:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for MRPL35 Gene

GeneLoc Exon Structure for
MRPL35
ECgene alternative splicing isoforms for
MRPL35

Expression for MRPL35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL35 Gene

This gene is overexpressed in Breast (34.3), Lung (10.2), Pancreatic juice (8.8), and Pancreas (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MRPL35 Gene



Protein tissue co-expression partners for MRPL35 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPL35 Gene:

MRPL35

SOURCE GeneReport for Unigene cluster for MRPL35 Gene:

Hs.433439
genes like me logo Genes that share expression patterns with MRPL35: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL35 Gene

Orthologs for MRPL35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL35 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia MRPL35 34 35
  • 85.59 (n)
cow
(Bos Taurus)
Mammalia MRPL35 34 35
  • 84.57 (n)
mouse
(Mus musculus)
Mammalia Mrpl35 34 16 35
  • 81.56 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl35 34
  • 79.61 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL35 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL35 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL35 34 35
  • 65.56 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL35 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl35 34
  • 63.95 (n)
Str.19278 34
zebrafish
(Danio rerio)
Actinopterygii mrpl35 34 35
  • 58.87 (n)
Dr.15585 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.888 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL35 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToOne
Species where no ortholog for MRPL35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL35 Gene

ENSEMBL:
Gene Tree for MRPL35 (if available)
TreeFam:
Gene Tree for MRPL35 (if available)

Paralogs for MRPL35 Gene

Pseudogenes.org Pseudogenes for MRPL35 Gene

genes like me logo Genes that share paralogs with MRPL35: view

No data available for Paralogs for MRPL35 Gene

Variants for MRPL35 Gene

Sequence variations from dbSNP and Humsavar for MRPL35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10170676 -- 86,197,989(+) gagcc(A/G)agatc upstream-variant-2KB
rs10184462 -- 86,202,452(+) ATTTC(A/G)TAGGT intron-variant
rs10187875 -- 86,203,525(+) atttc(A/G)tgttt intron-variant
rs10208602 -- 86,202,761(+) ATCTC(A/G)GCTCA intron-variant
rs1051944 -- 86,206,141(+) CTTCA(A/G)CCTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRPL35 Gene

Variant ID Type Subtype PubMed ID
nsv582372 CNV gain 21841781
nsv458574 CNV gain 19166990
nsv458563 CNV gain 19166990
esv3591540 CNV gain 21293372
esv2751903 CNV gain 17911159
dgv713e214 CNV gain 21293372
dgv6946n54 CNV gain 21841781
dgv3885n100 CNV gain 25217958

Variation tolerance for MRPL35 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.27; 88.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL35 Gene

Disorders for MRPL35 Gene

Relevant External Links for MRPL35

Genetic Association Database (GAD)
MRPL35
Human Genome Epidemiology (HuGE) Navigator
MRPL35
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL35

No disorders were found for MRPL35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL35 Gene

Publications for MRPL35 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPL35 Gene

Sources for MRPL35 Gene

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