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Aliases for MRPL34 Gene

Aliases for MRPL34 Gene

  • Mitochondrial Ribosomal Protein L34 2 3
  • MRP-L34 3 4
  • L34mt 3 4
  • 39S Ribosomal Protein L34, Mitochondrial 3

External Ids for MRPL34 Gene

Previous GeneCards Identifiers for MRPL34 Gene

  • GC19P017910
  • GC19P017808
  • GC19P017258
  • GC19P017277
  • GC19P017416
  • GC19P016983
  • GC19P017499
  • GC19P017902

Summaries for MRPL34 Gene

Entrez Gene Summary for MRPL34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL34 Gene

MRPL34 (Mitochondrial Ribosomal Protein L34) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL34 Gene

Genomics for MRPL34 Gene

Regulatory Elements for MRPL34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL34 Gene

17,292,609 bp from pter
17,306,843 bp from pter
14,235 bases
Plus strand

Genomic View for MRPL34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL34 Gene

Proteins for MRPL34 Gene

  • Protein details for MRPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L34, mitochondrial
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MRPL34 Gene

    92 amino acids
    Molecular mass:
    10165 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL34 Gene

neXtProt entry for MRPL34 Gene

Proteomics data for MRPL34 Gene at MOPED

Post-translational modifications for MRPL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL34 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL34 Gene

Domains for MRPL34 Gene

Gene Families for MRPL34 Gene

Protein Domains for MRPL34 Gene


Suggested Antigen Peptide Sequences for MRPL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L34P family.
  • Belongs to the ribosomal protein L34P family.
genes like me logo Genes that share domains with MRPL34: view

Function for MRPL34 Gene

Gene Ontology (GO) - Molecular Function for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL34: view

Phenotypes for MRPL34 Gene

GenomeRNAi human phenotypes for MRPL34:
genes like me logo Genes that share phenotypes with MRPL34: view

Animal Model Products

miRNA for MRPL34 Gene

miRTarBase miRNAs that target MRPL34

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL34

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL34 Gene

Localization for MRPL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL34 Gene


Subcellular locations from

Jensen Localization Image for MRPL34 Gene COMPARTMENTS Subcellular localization image for MRPL34 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL34: view

Pathways for MRPL34 Gene

SuperPathways for MRPL34 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPL34: view

Pathways by source for MRPL34 Gene

1 KEGG pathway for MRPL34 Gene

Interacting Proteins for MRPL34 Gene

Gene Ontology (GO) - Biological Process for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL34: view

Transcripts for MRPL34 Gene

Unigene Clusters for MRPL34 Gene

Mitochondrial ribosomal protein L34:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL34

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c
SP2: - -

Relevant External Links for MRPL34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL34 Gene

mRNA expression in normal human tissues for MRPL34 Gene

Protein differential expression in normal tissues for MRPL34 Gene

This gene is overexpressed in Breast (25.7), Lung (16.0), and Bone (13.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL34 Gene

SOURCE GeneReport for Unigene cluster for MRPL34 Gene Hs.515242

genes like me logo Genes that share expressions with MRPL34: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for MRPL34 Gene

Orthologs for MRPL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL34 35
  • 82.2 (n)
  • 80.68 (a)
MRPL34 36
  • 76 (a)
(Mus musculus)
Mammalia Mrpl34 35
  • 77.9 (n)
  • 75 (a)
Mrpl34 16
Mrpl34 36
  • 75 (a)
(Pan troglodytes)
Mammalia MRPL34 35
  • 99.64 (n)
  • 100 (a)
MRPL34 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl34 35
  • 78.02 (n)
  • 74.73 (a)
(Canis familiaris)
Mammalia MRPL34 36
  • 76 (a)
(Monodelphis domestica)
Mammalia MRPL34 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL34 36
  • 58 (a)
(Danio rerio)
Actinopterygii mrpl34 36
  • 39 (a)
Species with no ortholog for MRPL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL34 Gene

Gene Tree for MRPL34 (if available)
Gene Tree for MRPL34 (if available)

Paralogs for MRPL34 Gene

No data available for Paralogs for MRPL34 Gene

Variants for MRPL34 Gene

Sequence variations from dbSNP and Humsavar for MRPL34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs578144449 -- 17,306,706(+) TTCTT(C/G)TGTAA utr-variant-3-prime
rs578076403 -- 17,307,089(+) ACCTC(A/G)GGTGA downstream-variant-500B
rs577152875 -- 17,305,614(+) CAGCT(C/G)ACCGC upstream-variant-2KB
rs577046279 -- 17,305,991(+) ATCAG(G/T)GAATA intron-variant
rs574441113 -- 17,305,589(+) GGAGA(C/G)AGAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL34 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294
dgv3759n71 CNV Loss 21882294
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv515965 CNV Loss 19592680
nsv911200 CNV Loss 21882294

Relevant External Links for MRPL34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL34 Gene

Disorders for MRPL34 Gene

Relevant External Links for MRPL34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL34 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL34 Gene

Publications for MRPL34 Gene

  1. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for MRPL34 Gene

Sources for MRPL34 Gene

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