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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL34 Gene

protein-coding   GIFtS: 48
GCID: GC19P017499

Mitochondrial Ribosomal Protein L34

  Search for MRPL34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L341 2
L34mt2 3
MRP-L342 3
39S Ribosomal Protein L34, Mitochondrial2

External Ids:    HGNC: 144881   Entrez Gene: 649812   Ensembl: ENSG000001303127   OMIM: 6118405   UniProtKB: Q9BQ483   

Export aliases for MRPL34 gene to outside databases

Previous GC identifers: GC19P017910 GC19P017808 GC19P017258 GC19P017277 GC19P017416 GC19P016983


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL34 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL34 Gene: 
MRPL34 (mitochondrial ribosomal protein L34) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL34 gene promoter:
         SRF   C/EBPbeta   AML1a   p53   MAZR   SRF (504 AA)   Olf-1   E47   GATA-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL34 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

MRPL34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL34 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017499:  view genomic region     (about GC identifiers)

Start:
17,403,418 bp from pter      End:
17,417,652 bp from pter
Size:
14,235 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RM34_HUMAN, Q9BQ48 (See protein sequence)
Recommended Name: 39S ribosomal protein L34, mitochondrial precursor  
Size: 92 amino acids; 10165 Da
Subcellular location: Mitochondrion (By similarity)

Explore the universe of human proteins at neXtProt for MRPL34: NX_Q9BQ48

Explore proteomics data for MRPL34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQ48

  • MRPL34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPL34 Protein Expression
    REFSEQ proteins: NP_076426.1  
    ENSEMBL proteins: 
     ENSP00000472266   ENSP00000469581   ENSP00000471820   ENSP00000252602   ENSP00000471089  

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    Cloud-Clone Corp. Proteins for MRPL34 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005761mitochondrial ribosome NAS11543634
    GO:0005840ribosome ----

    MRPL34 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR000271 Ribosomal_L34

    Graphical View of Domain Structure for InterPro Entry Q9BQ48

    ProtoNet protein and cluster: Q9BQ48

    1 Blocks protein domain: IPB000271 Ribosomal protein L34

    UniProtKB/Swiss-Prot: RM34_HUMAN, Q9BQ48
    Similarity: Belongs to the ribosomal protein L34P family


    MRPL34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
         
    MRPL34 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPL34:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPL34 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPL34 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPL34):
        Ribosome


    MRPL34 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL34

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/12 Interacting proteins for MRPL34 (ENSP000002526024) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL13ENSP000003065484STRING: ENSP00000306548
    MRPL11ENSP000003088974STRING: ENSP00000308897
    MRPL22ENSP000004111774STRING: ENSP00000411177
    MRPL2ENSP000003734044STRING: ENSP00000373404
    MRPL24ENSP000003545254STRING: ENSP00000354525
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634

    MRPL34 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL34 (RM34)

    Search CenterWatch for drugs/clinical trials and news about MRPL34 / RM34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPL34 gene: 
    NM_023937.3  

    Unigene Cluster for MRPL34:

    Mitochondrial ribosomal protein L34
    Hs.515242  [show with all ESTs]
    Unigene Representative Sequence: BM467434
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000595444 ENST00000600434 ENST00000597996 ENST00000594999 ENST00000252602(uc002ngc.1)
    ENST00000602206
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL34
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL34

    Additional mRNA sequence: 

    AB049652.1 BC000071.2 BC021801.1 

    8 DOTS entries:

    DT.453794  DT.121465024  DT.100024944  DT.92425654  DT.121465059  DT.100713893  DT.100784417  DT.91801157 

    24/153 AceView cDNA sequences (see all 153):

    AW410648 AI934890 AI827403 BM685872 AA649155 AA961542 NM_023937 BM832209 
    AI918166 AI972761 CA842850 BQ928709 BM982574 AI479793 BC000071 AA975981 
    BE295816 CA495342 BQ011592 CA848792 AA769250 BM719828 AA456665 BE615280 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL34    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c
    SP1:                                    
    SP2:              -     -               


    ECgene alternative splicing isoforms for MRPL34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCATCGC
    MRPL34 Expression
    About this image


    See MRPL34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL34

    SOURCE GeneReport for Unigene cluster: Hs.515242
        SABiosciences Custom PCR Arrays for MRPL34
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL34

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MRPL34 gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl341 , 5 mitochondrial ribosomal protein L341, 5 77.9(n)1
    75(a)1
      8 (34.43 cM)5
    940651  NM_053162.21  NP_444392.11 
     714649265 
    zebrafish
    (Danio rerio)
    Actinopterygii AI106331.12   -- 76.64(n)    AI106331.1 


    ENSEMBL Gene Tree for MRPL34 (if available)
    TreeFam Gene Tree for MRPL34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/48 SNPs in MRPL34 are shown (see all 48)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116687551,2
    C,F,H--17416357(+) GCTGCG/ACCCGG 1 -- us2k118Minor allele frequency- A:0.22EA NS NA WA 1806
    rs1383456791,2
    C--17416416(+) CAGCTA/GCCAGC 1 -- us2k10--------
    rs1147259191,2
    F--17416418(+) GCTGCC/TAGCTG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1428389441,2
    C--17416570(+) ACTTCA/GGGGTT 1 -- ut510--------
    rs32173291,2
    C--17416591(-) AAAAA-/AGAGGC 1 -- ut51 trp32Minor allele frequency- A:0.00NA CSA 4
    rs1453156941,2
    F--17416701(+) GCGGAT/CATGGC 1 -- ut511Minor allele frequency- C:0.00NA 4510
    rs1458510841,2
    --17416707(+) TGGCT-/GGGGG 
     GGGGGGG
    GTCTT
    1 GGGGV cds10--------
    rs2013903771,2
    --17416726(+) CCCTGC/TTGGGC 2 L syn10--------
    rs2009172881,2
    --17416940(+) GCCCCG/TTCTGA 1 -- int10--------
    rs1891348201,2
    --17417040(+) GCAGGA/CCCGGG 2 D A mis10--------

    HapMap Linkage Disequilibrium report for MRPL34 (17403418 - 17417652 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for MRPL34:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv515965CNV Loss19592680
    nsv911185CNV Loss21882294
    nsv911200CNV Loss21882294
    nsv470129CNV Loss18288195
    dgv3758n71CNV Loss21882294
    dgv3759n71CNV Loss21882294
    nsv911186CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL34
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPL34 for disorders           About MalaCards
    OMIM gene information: 611840    OMIM disorders: --


    MRPL34 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL34
    Human Genome Epidemiology (HuGE) Navigator: MRPL34 (1 document)

    Export disorders for MRPL34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL34 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MRPL34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N....Tanaka T. (2001)
    4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. (PubMed id 10600119)1 Graack H.R.... O'Brien T.W. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64981 HGNC: 14488 AceView: MRPL34 Ensembl:ENSG00000130312 euGenes: HUgn64981
    ECgene: MRPL34 Kegg: 64981 H-InvDB: MRPL34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPL34 gene:
    Search GeneIP for patents involving MRPL34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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