Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL34 Gene

Aliases for MRPL34 Gene

  • Mitochondrial Ribosomal Protein L34 2 3 5
  • MRP-L34 3 4
  • L34mt 3 4
  • 39S Ribosomal Protein L34, Mitochondrial 3

External Ids for MRPL34 Gene

Previous GeneCards Identifiers for MRPL34 Gene

  • GC19P017910
  • GC19P017808
  • GC19P017258
  • GC19P017277
  • GC19P017416
  • GC19P016983
  • GC19P017499
  • GC19P017902
  • GC19P017294
  • GC19P017689
  • GC19P017715
  • GC19P018287

Summaries for MRPL34 Gene

Entrez Gene Summary for MRPL34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL34 Gene

MRPL34 (Mitochondrial Ribosomal Protein L34) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL34 Gene

Genomics for MRPL34 Gene

Regulatory Elements for MRPL34 Gene

Enhancers for MRPL34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017307 1.4 Ensembl ENCODE 42.3 +18.1 18119 5.6 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 MRPL34 MVB12A ENSG00000269578 ABHD8 PLVAP OCEL1 MED26 ENSG00000268087 ENSG00000267904 COLGALT1
GH19F017302 1.2 ENCODE 42.8 +11.9 11898 5.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 MRPL34 PLVAP ABHD8 MVB12A SIN3B ENSG00000268743 ENSG00000269427 ANO8 ENSG00000269439 ENSG00000269044
GH19F017326 1.1 Ensembl ENCODE 36.5 +35.9 35879 4.7 ATF1 CBX3 ZNF76 RAD21 GLIS2 EGR1 ZNF366 EGR2 ZNF263 SMARCA5 MRPL34 ABHD8 MVB12A BST2 PLVAP ANO8 PIR41076
GH19F017333 1.2 ENCODE 28.4 +41.7 41653 2.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ENSG00000268743 C19orf44 ENSG00000269578 SIN3B MRPL34 SMIM7 ENSG00000268087 ENSG00000267904 ENSG00000269427 ABHD8
GH19F017316 0.9 ENCODE 33 +24.9 24916 1.5 HDAC1 ATF1 KLF17 ZEB1 ZNF366 KLF7 FOS CREM SMARCC1 ZNF362 MRPL34 ENSG00000269578 C19orf44 ABHD8 ENSG00000268743 SIN3B ENSG00000268087 ENSG00000267904 SMIM7 PIR41076
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL34 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL34 Gene

17,292,609 bp from pter
17,306,847 bp from pter
14,239 bases
Plus strand

Genomic View for MRPL34 Gene

Genes around MRPL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL34 Gene

Proteins for MRPL34 Gene

  • Protein details for MRPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L34, mitochondrial
    Protein Accession:

    Protein attributes for MRPL34 Gene

    92 amino acids
    Molecular mass:
    10165 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL34 Gene

neXtProt entry for MRPL34 Gene

Post-translational modifications for MRPL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL34 Gene

No data available for DME Specific Peptides for MRPL34 Gene

Domains & Families for MRPL34 Gene

Gene Families for MRPL34 Gene

Protein Domains for MRPL34 Gene


Suggested Antigen Peptide Sequences for MRPL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L34P family.
  • Belongs to the ribosomal protein L34P family.
genes like me logo Genes that share domains with MRPL34: view

Function for MRPL34 Gene

Gene Ontology (GO) - Molecular Function for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL34: view
genes like me logo Genes that share phenotypes with MRPL34: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL34 Gene

Localization for MRPL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL34 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL34 gene
Compartment Confidence
mitochondrion 5
nucleus 3
extracellular 2
cytoskeleton 2
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
genes like me logo Genes that share ontologies with MRPL34: view

Pathways & Interactions for MRPL34 Gene

genes like me logo Genes that share pathways with MRPL34: view

Gene Ontology (GO) - Biological Process for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL34: view

No data available for SIGNOR curated interactions for MRPL34 Gene

Transcripts for MRPL34 Gene

Unigene Clusters for MRPL34 Gene

Mitochondrial ribosomal protein L34:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c
SP2: - -

Relevant External Links for MRPL34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL34 Gene

This gene is overexpressed in Breast (25.7), Lung (16.0), and Bone (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL34 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPL34 Gene:


SOURCE GeneReport for Unigene cluster for MRPL34 Gene:

genes like me logo Genes that share expression patterns with MRPL34: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MRPL34 Gene

Orthologs for MRPL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL34 34 35
  • 99.64 (n)
(Bos Taurus)
Mammalia MRPL34 34 35
  • 82.2 (n)
(Monodelphis domestica)
Mammalia MRPL34 35
  • 80 (a)
(Rattus norvegicus)
Mammalia Mrpl34 34
  • 78.02 (n)
(Mus musculus)
Mammalia Mrpl34 34 16 35
  • 77.9 (n)
(Canis familiaris)
Mammalia MRPL34 35
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL34 35
  • 58 (a)
(Danio rerio)
Actinopterygii mrpl34 35
  • 39 (a)
Species where no ortholog for MRPL34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL34 Gene

Gene Tree for MRPL34 (if available)
Gene Tree for MRPL34 (if available)

Paralogs for MRPL34 Gene

No data available for Paralogs for MRPL34 Gene

Variants for MRPL34 Gene

Sequence variations from dbSNP and Humsavar for MRPL34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10651952 -- 17,305,038(+) CCCTT(-/GGA)GGAGA intron-variant, upstream-variant-2KB
rs10709678 -- 17,304,790(+) ACTCC(-/T)TTTTT intron-variant, upstream-variant-2KB
rs11086066 -- 17,301,557(-) AACGC(C/T)GTGGG upstream-variant-2KB, reference, synonymous-codon
rs11086067 -- 17,301,590(-) GGTAT(C/T)TTCTG upstream-variant-2KB, reference, synonymous-codon
rs112118651 -- 17,305,878(+) CTGCG(A/G)GACCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL34 Gene

Variant ID Type Subtype PubMed ID
nsv470129 CNV loss 18288195
nsv515965 CNV loss 19592680

Variation tolerance for MRPL34 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL34 Gene

Disorders for MRPL34 Gene

Relevant External Links for MRPL34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL34 Gene

Publications for MRPL34 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 64
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 64

Products for MRPL34 Gene

Sources for MRPL34 Gene

Loading form....