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Aliases for MRPL34 Gene

Aliases for MRPL34 Gene

  • Mitochondrial Ribosomal Protein L34 2 3 5
  • MRP-L34 3 4
  • L34mt 3 4

External Ids for MRPL34 Gene

Previous GeneCards Identifiers for MRPL34 Gene

  • GC19P017910
  • GC19P017808
  • GC19P017258
  • GC19P017277
  • GC19P017416
  • GC19P016983
  • GC19P017499
  • GC19P017902
  • GC19P017294
  • GC19P017689

Summaries for MRPL34 Gene

Entrez Gene Summary for MRPL34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL34 Gene

MRPL34 (Mitochondrial Ribosomal Protein L34) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL34 Gene

Genomics for MRPL34 Gene

Regulatory Elements for MRPL34 Gene

Enhancers for MRPL34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL34 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL34 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL34 Gene

17,292,609 bp from pter
17,306,847 bp from pter
14,239 bases
Plus strand

Genomic View for MRPL34 Gene

Genes around MRPL34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL34 Gene

Proteins for MRPL34 Gene

  • Protein details for MRPL34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L34, mitochondrial
    Protein Accession:

    Protein attributes for MRPL34 Gene

    92 amino acids
    Molecular mass:
    10165 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL34 Gene

neXtProt entry for MRPL34 Gene

Proteomics data for MRPL34 Gene at MOPED

Post-translational modifications for MRPL34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL34 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL34 Gene

Domains & Families for MRPL34 Gene

Gene Families for MRPL34 Gene

Protein Domains for MRPL34 Gene


Suggested Antigen Peptide Sequences for MRPL34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L34P family.
  • Belongs to the ribosomal protein L34P family.
genes like me logo Genes that share domains with MRPL34: view

Function for MRPL34 Gene

genes like me logo Genes that share phenotypes with MRPL34: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL34 Gene

Localization for MRPL34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL34 Gene


Subcellular locations from

Jensen Localization Image for MRPL34 Gene COMPARTMENTS Subcellular localization image for MRPL34 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytoskeleton 2
extracellular 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL34: view

Pathways & Interactions for MRPL34 Gene

genes like me logo Genes that share pathways with MRPL34: view

Interacting Proteins for MRPL34 Gene

Gene Ontology (GO) - Biological Process for MRPL34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL34: view

No data available for SIGNOR curated interactions for MRPL34 Gene

Drugs & Compounds for MRPL34 Gene

No Compound Related Data Available

Transcripts for MRPL34 Gene

Unigene Clusters for MRPL34 Gene

Mitochondrial ribosomal protein L34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c
SP2: - -

Relevant External Links for MRPL34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL34 Gene

mRNA expression in normal human tissues for MRPL34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL34 Gene

This gene is overexpressed in Breast (25.7), Lung (16.0), and Bone (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL34 Gene

SOURCE GeneReport for Unigene cluster for MRPL34 Gene Hs.515242

genes like me logo Genes that share expression patterns with MRPL34: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MRPL34 Gene

Orthologs for MRPL34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL34 35
  • 82.2 (n)
  • 80.68 (a)
MRPL34 36
  • 76 (a)
(Mus musculus)
Mammalia Mrpl34 35
  • 77.9 (n)
  • 75 (a)
Mrpl34 16
Mrpl34 36
  • 75 (a)
(Pan troglodytes)
Mammalia MRPL34 35
  • 99.64 (n)
  • 100 (a)
MRPL34 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl34 35
  • 78.02 (n)
  • 74.73 (a)
(Canis familiaris)
Mammalia MRPL34 36
  • 76 (a)
(Monodelphis domestica)
Mammalia MRPL34 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL34 36
  • 58 (a)
(Danio rerio)
Actinopterygii mrpl34 36
  • 39 (a)
Species with no ortholog for MRPL34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL34 Gene

Gene Tree for MRPL34 (if available)
Gene Tree for MRPL34 (if available)

Paralogs for MRPL34 Gene

No data available for Paralogs for MRPL34 Gene

Variants for MRPL34 Gene

Sequence variations from dbSNP and Humsavar for MRPL34 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs71334700 -- 17,290,987(+) AAAAA(-/CAAA)CAAAC upstream-variant-2KB
rs8109198 -- 17,307,015(+) cacgc(C/T)cggct downstream-variant-500B
rs8109328 -- 17,307,146(+) cactg(C/T)gctct downstream-variant-500B
rs72485424 -- 17,291,287(+) TCTCG(-/T)TTTTT upstream-variant-2KB
rs34302193 -- 17,290,839(+) GGAGC(-/T)CTGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL34 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
nsv911185 CNV Loss 21882294
nsv911186 CNV Gain 21882294
dgv3759n71 CNV Loss 21882294
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv515965 CNV Loss 19592680
nsv911200 CNV Loss 21882294

Variation tolerance for MRPL34 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL34 Gene

Disorders for MRPL34 Gene

Relevant External Links for MRPL34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL34 Gene

Publications for MRPL34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3

Products for MRPL34 Gene

Sources for MRPL34 Gene