MRPL33 Gene
protein-coding GIFtS: 39
GCID: GC02P027994
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|
mitochondrial ribosomal protein L33
(Previous symbol: C2orf1)
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Aliases
for MRPL33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L331 2 | | C2orf11 2 3 | | RPL33L1 2 | | L33mt2 3 | | MRP-L332 3 | | 39S Ribosomal Protein L33, Mitochondrial2 |
Export aliases for MRPL33 gene to outside databasesPrevious GC identifers: GC02P027915 GC02P028087 GC02P027969 GC02P027906 GC02P027735 |
Summaries
for MRPL33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL33:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq, Jul2008)
Gene Wiki entry for MRPL33
|
Genomic Views
for MRPL33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL33 gene promoter:
AML1a LCR-F1 NF-kappaB AREB6 PPAR-gamma1 SEF-1 (1) PPAR-gamma2 Pax-4a NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p21 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p21MRPL33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P027994: view genomic region
(about GC identifiers)
Start:
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27,994,584 bp from pter |
End:
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28,210,954 bp from pter |
Size:
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216,371 bases |
Orientation:
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plus strand |
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Proteins
for MRPL33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM33_HUMAN, O75394 (See
protein sequence)Recommended Name: 39S ribosomal protein L33, mitochondrial Size: 65 amino acids; 7619 Da
Subcellular location: Mitochondrion
Secondary accessions: Q53RZ6 Q5FVE3 Q96Q50Alternative splicing: 2 isoforms: O75394-1 O75394-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MRPL33: NX_O75394
MRPL33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004882.1 NP_663303.1
ENSEMBL proteins: ENSP00000368988 ENSP00000296102 ENSP00000407385
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL33 for ontologies About GeneDecksing
MRPL33 Antibody Products:
Assay Products for MRPL33: |
Protein
Domains /
Families
for MRPL33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL33 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75394ProtoNet protein and cluster: O75394 1 Blocks protein family: IPB001705 Ribosomal protein L33
UniProtKB/Swiss-Prot: RM33_HUMAN, O75394Similarity: Belongs to the ribosomal protein L33P family |
Function
for MRPL33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL33 (NM_145330) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL33 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL33 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPL33 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPL33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL33
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for MRPL33 (ENSP000002961024) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPL33 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL33
Search CenterWatch for drugs/clinical trials and news about MRPL33 / RM33
|
Transcripts
for MRPL33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL33 gene (2 alternative transcripts): NM_004891.3 NM_145330.2 Unigene Cluster for MRPL33: Mitochondrial ribosomal protein L33 Hs.515879 [show with all ESTs]Unigene Representative Sequence: AK0944406 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379666 ENST00000296102(uc002rlm.1 uc002rln.1) ENST00000448427
ENST00000472192 ENST00000483992 ENST00000476552
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL33 (NM_145330) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL33 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL33 |
Additional cDNA sequence: AF047440.1 AK094440.1 BC009475.1 BC020834.1 BC087846.1 BC090047.1 CR456888.1 CR542117.1 13 DOTS entries: DT.117592 DT.92427906 DT.99942653 DT.92427905 DT.92427903 DT.121024167 DT.100036066 DT.92015093 DT.92427912 DT.95260337 DT.100723302 DT.92427911 DT.95146574 24/180 AceView cDNA sequences (see all 180): AA631119 AA894720 AI302407 AI312130 T31368 R16102 AA318851 AA594514 AA649214 AI095177 BM126407 F36024 CD672913 AI719533 BF516222 D52954 AA258212 AA826454 CR456888 CB143609 CK299389 CB130020 AA988588 BM739502
GeneLoc Exon Structure
|
Expression
for MRPL33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATCACTGC
About this image
See MRPL33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL33
SOURCE GeneReport for Unigene cluster: Hs.515879
SABiosciences Custom PCR Arrays for MRPL33
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL33 |
Orthologs
for MRPL33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRPL33 gene from 3/9 species (see all 9) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl331 , 5 |
mitochondrial ribosomal protein L331, 5 |
82.05(n)1
76.92(a)1 |
|
5 (17.27 cM)5
668451 NM_025796.31 NP_080072.21
315969355 |
chicken
(Gallus gallus) |
Aves |
MRPL336 |
Uncharacterized protein |
69(a) |
1 ↔ 1 |
3(28850977-28853271) |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
BX084669.12 |
-- |
79.69(n) |
|
BX084669.1 |
ENSEMBL Gene Tree for MRPL33 (if available)
TreeFam Gene Tree for MRPL33 (if available) |
Paralogs
for MRPL33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL33 (27994584 - 28210954 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL33: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL33 |
|
Disorders
/ Diseases
for MRPL33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL33 for disorders About MalaCards
MRPL33 for disorders About GeneDecksing
OMIM gene information: 610059
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL33 (1 document)
Export disorders for MRPL33 gene to outside databases
|
Publications
for MRPL33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL33 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MRPL33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for MRPL33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL33 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL33 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL33 gene:
Search GeneIP for patents involving MRPL33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL33 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL33 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for MRPL33 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL33 | | OriGene 3'-UTR Clone for MRPL33 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL33 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL33 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL33 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL33 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL33 |
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 | | | MRPL33 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MRPL33 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL33 |
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