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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL32 Gene

protein-coding   GIFtS: 53
GCID: GC07P042971

Mitochondrial Ribosomal Protein L32

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L321 2
L32mt2 3
MRP-L322 3
39S Ribosomal Protein L32, Mitochondrial2
bMRP-59b2

External Ids:    HGNC: 140351   Entrez Gene: 649832   Ensembl: ENSG000001065917   OMIM: 6118395   UniProtKB: Q9BYC83   

Export aliases for MRPL32 gene to outside databases

Previous GC identifers: GC07P042618 GC07P042712 GC07P042745 GC07P042938


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL32 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is
found on chromosome Xp. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL32 Gene: 
MRPL32 (mitochondrial ribosomal protein L32) is a protein-coding gene. Diseases associated with MRPL32 include gastric cancer, and breast cancer, and among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL32 gene promoter:
         AREB6   AP-2rep   MEF-2A   AML1a   aMEF-2   POU3F2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MRPL32 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p14

MRPL32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL32 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P042971:  view genomic region     (about GC identifiers)

Start:
42,971,799 bp from pter      End:
42,988,557 bp from pter
Size:
16,759 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 43,011,437-43,016,951     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RM32_HUMAN, Q9BYC8 (See protein sequence)
Recommended Name: 39S ribosomal protein L32, mitochondrial precursor  
Size: 188 amino acids; 21405 Da
Subcellular location: Mitochondrion
Secondary accessions: Q96Q68 Q9P098

Explore the universe of human proteins at neXtProt for MRPL32: NX_Q9BYC8

Explore proteomics data for MRPL32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYC8

  • MRPL32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPL32 Protein Expression
    REFSEQ proteins: NP_114109.1  
    ENSEMBL proteins: 
     ENSP00000223324   ENSP00000415581   ENSP00000391562  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPL32 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005761mitochondrial ribosome NAS11543634
    GO:0005840ribosome ----
    GO:0015934large ribosomal subunit IEA--

    MRPL32 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR002677 Ribosomal_L32p

    Graphical View of Domain Structure for InterPro Entry Q9BYC8

    ProtoNet protein and cluster: Q9BYC8

    1 Blocks protein domain: IPB002677 Ribosomal L32p protein

    UniProtKB/Swiss-Prot: RM32_HUMAN, Q9BYC8
    Similarity: Belongs to the ribosomal protein L32P family


    MRPL32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
         
    MRPL32 for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPL32 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPL32):
        Ribosome


    MRPL32 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL32

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/244 Interacting proteins for MRPL32 (Q9BYC82, 3 ENSP000002233244) via UniProtKB, MINT, STRING, and/or I2D (see all 244)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    ACAD9Q9H8452MINT-8079030
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634

    MRPL32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL32 (RM32)

    Search CenterWatch for drugs/clinical trials and news about MRPL32 / RM32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPL32 gene: 
    NM_031903.2  

    Unigene Cluster for MRPL32:

    Mitochondrial ribosomal protein L32
    Hs.50252  [show with all ESTs]
    Unigene Representative Sequence: AK090551
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223324(uc003tia.3) ENST00000432845(uc003tib.3) ENST00000413995
    ENST00000496564
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AB049649.1 AF161401.1 AK090551.1 AK313393.1 BC013147.1 

    8 DOTS entries:

    DT.453357  DT.100818090  DT.100801495  DT.100818088  DT.95248419  DT.213526  DT.121091212  DT.95328466 

    24/170 AceView cDNA sequences (see all 170):

    AA371238 AA354801 BI521527 AA308008 BM701372 BM848494 CR599793 CR593442 
    AA166925 BF718654 CB161336 AA984245 BI715354 BU927763 BU631987 BU674201 
    CK004754 CB991745 BI792807 CA774475 BC013147 BI830131 AW029331 BF794977 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
    SP1:                          -     -                     
    SP2:                          -     -                     
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for MRPL32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL32 expression in normal human tissues (normalized intensities)      MRPL32 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTTGTGC
    MRPL32 Expression
    About this image


    MRPL32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See MRPL32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL32

    SOURCE GeneReport for Unigene cluster: Hs.50252
        SABiosciences Custom PCR Arrays for MRPL32
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPL32 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl321 , 5 mitochondrial ribosomal protein L321, 5 79.42(n)1
    73.22(a)1
      13 (5.36 cM)5
    753981  NM_029271.21  NP_083547.11 
     146103015 
    chicken
    (Gallus gallus)
    Aves MRPL321 mitochondrial ribosomal protein L32 62.68(n)
    60.87(a)
      420773  XM_418869.3  XP_418869.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL326
    Uncharacterized protein
    65(a)
    1 ↔ 1
    6(50532163-50544542)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.79712 Xenopus laevis transcribed sequence with weak similarity more 74.27(n)    48054696 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.199232 Transcribed sequence with weak similarity to protein more 75.87(n)    BU710305.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL326
    mitochondrial ribosomal protein L32
    28(a)
    1 ↔ 1
    3R(27078603-27079408)
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-326
    Probable 39S ribosomal protein L32, mitochondrial
    24(a)
    1 ↔ 1
    III(8449757-8450510)


    ENSEMBL Gene Tree for MRPL32 (if available)
    TreeFam Gene Tree for MRPL32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPL32 gene

    MRPL32 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MRPL32
    PGOHUM00000241288 PGOHUM00000241786


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 SNPs in MRPL32 are shown (see all 98)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20331701,2
    C--42973815(+) TGAGCC/TGAGGT 1 -- int12Minor allele frequency- T:0.00NA 4
    rs1458938101,2
    C--42973867(+) GTCTC-/AAAAAAA 1 -- int10--------
    rs30287631,2
    C--42973882(+) aaaaa-/A/AA  
            
    GTATG
    1 -- int11NA 2
    rs1140157791,2
    C,F--42973902(+) AAGAAA/GTAGCA 1 -- int11Minor allele frequency- G:0.01WA 118
    rs1441031671,2
    --42974264(+) GTTAGA/GTGCCT 1 -- int10--------
    rs5988101,2
    C,F,H--42974340(+) GATCCA/GCTAAG 1 -- int125Minor allele frequency- G:0.10NS EA NA WA CSA 1039
    rs747427581,2
    F--42974447(+) AGTTTT/GTGTGT 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1842282071,2
    --42974461(+) TGTATC/GTTTGA 1 -- int10--------
    rs771698241,2
    C--42974531(+) TCTGTA/GTCTCT 1 -- int11Minor allele frequency- G:0.01WA 118
    rs2007924081,2
    --42974610(+) ATACCA/CGTGGA 2 S R mis10--------

    HapMap Linkage Disequilibrium report for MRPL32 (42971799 - 42988557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRPL32:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830979CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing MRPL32
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611839    OMIM disorders: --

    2 diseases for MRPL32:    About MalaCards
    gastric cancer    breast cancer


    MRPL32 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL32
    Human Genome Epidemiology (HuGE) Navigator: MRPL32 (1 document)

    Export disorders for MRPL32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL32 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRPL32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64983 HGNC: 14035 AceView: MRPL32 Ensembl:ENSG00000106591 euGenes: HUgn64983
    ECgene: MRPL32 Kegg: 64983 H-InvDB: MRPL32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPL32 gene:
    Search GeneIP for patents involving MRPL32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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