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Aliases for MRPL32 Gene

Aliases for MRPL32 Gene

  • Mitochondrial Ribosomal Protein L32 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL32m 3 4
  • MRP-L32 3 4
  • L32mt 3 4
  • 39S Ribosomal Protein L32, Mitochondrial 3
  • BMRP-59b 3
  • HSPC283 3

External Ids for MRPL32 Gene

Previous GeneCards Identifiers for MRPL32 Gene

  • GC07P042618
  • GC07P042712
  • GC07P042745
  • GC07P042938

Summaries for MRPL32 Gene

Entrez Gene Summary for MRPL32 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL32 Gene

MRPL32 (Mitochondrial Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL32 Gene

Genomics for MRPL32 Gene

Regulatory Elements for MRPL32 Gene

Enhancers for MRPL32 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G042911 1.1 ENCODE 9.2 -20.0 -20008 2.3 HDGF HNRNPUL1 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 C7orf25 MRPL32 ENSG00000261019
GH07G042913 1.1 FANTOM5 Ensembl ENCODE 9.2 -17.8 -17775 1.4 ZNF121 POLR2A JUN FOS C7orf25 MRPL32 LOC105375252
GH07G042940 1 Ensembl ENCODE 9.2 +9.2 9183 0.9 CTCF MXI1 CBX3 WRNIP1 MAX ZNF2 RAD21 SCRT2 ZNF143 SMC3 C7orf25 MRPL32 PSMA2 LOC105375253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL32 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211624 100 3001 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207

Genomic Location for MRPL32 Gene

42,932,200 bp from pter
42,948,958 bp from pter
16,759 bases
Plus strand

Genomic View for MRPL32 Gene

Genes around MRPL32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL32 Gene

Proteins for MRPL32 Gene

  • Protein details for MRPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L32, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q96Q68
    • Q9P098

    Protein attributes for MRPL32 Gene

    188 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bL32m has a zinc binding site.

    Three dimensional structures from OCA and Proteopedia for MRPL32 Gene

neXtProt entry for MRPL32 Gene

Post-translational modifications for MRPL32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL32 Gene

Domains & Families for MRPL32 Gene

Gene Families for MRPL32 Gene

Protein Domains for MRPL32 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the bacterial ribosomal protein bL32 family.
  • Belongs to the bacterial ribosomal protein bL32 family.
genes like me logo Genes that share domains with MRPL32: view

Function for MRPL32 Gene

Gene Ontology (GO) - Molecular Function for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL32: view
genes like me logo Genes that share phenotypes with MRPL32: view

Animal Model Products

CRISPR Products

miRNA for MRPL32 Gene

miRTarBase miRNAs that target MRPL32

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL32 Gene

Localization for MRPL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL32 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL32 gene
Compartment Confidence
mitochondrion 5
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL32: view

Pathways & Interactions for MRPL32 Gene

genes like me logo Genes that share pathways with MRPL32: view

Gene Ontology (GO) - Biological Process for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for SIGNOR curated interactions for MRPL32 Gene

Drugs & Compounds for MRPL32 Gene

No Compound Related Data Available

Transcripts for MRPL32 Gene

Unigene Clusters for MRPL32 Gene

Mitochondrial ribosomal protein L32:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - -

Relevant External Links for MRPL32 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL32 Gene

Protein differential expression in normal tissues from HIPED for MRPL32 Gene

This gene is overexpressed in Lung (28.4) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL32 Gene

Protein tissue co-expression partners for MRPL32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL32 Gene:


SOURCE GeneReport for Unigene cluster for MRPL32 Gene:


Evidence on tissue expression from TISSUES for MRPL32 Gene

  • Blood(4.1)
  • Heart(2)
  • Kidney(2)
  • Liver(2)
genes like me logo Genes that share expression patterns with MRPL32: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL32 Gene

Orthologs for MRPL32 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL32 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL32 34 35
  • 99.11 (n)
(Canis familiaris)
Mammalia MRPL32 34 35
  • 86.52 (n)
(Bos Taurus)
Mammalia MRPL32 34 35
  • 84.93 (n)
(Rattus norvegicus)
Mammalia Mrpl32 34
  • 80.04 (n)
(Mus musculus)
Mammalia Mrpl32 34 16 35
  • 79.32 (n)
Gm6578 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL32 35
  • 63 (a)
(Monodelphis domestica)
Mammalia MRPL32 35
  • 58 (a)
(Gallus gallus)
Aves MRPL32 34 35
  • 62.68 (n)
(Anolis carolinensis)
Reptilia MRPL32 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl32 34
  • 62.76 (n)
Str.6331 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7971 34
(Danio rerio)
Actinopterygii mrpl32 34 35
  • 64.07 (n)
Dr.19923 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL32 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea mrpl-32 35
  • 25 (a)
Species where no ortholog for MRPL32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL32 Gene

Gene Tree for MRPL32 (if available)
Gene Tree for MRPL32 (if available)

Paralogs for MRPL32 Gene Pseudogenes for MRPL32 Gene

genes like me logo Genes that share paralogs with MRPL32: view

No data available for Paralogs for MRPL32 Gene

Variants for MRPL32 Gene

Sequence variations from dbSNP and Humsavar for MRPL32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000138292 -- 42,932,316(+) CGAGG(C/T)TTGCC nc-transcript-variant, upstream-variant-2KB
rs1000299247 -- 42,932,186(+) CAGCC(A/G/T)CACAC upstream-variant-2KB, utr-variant-5-prime
rs1000526844 -- 42,937,974(+) TTGGT(A/G)TTGTT downstream-variant-500B
rs1000596877 -- 42,936,599(+) CCTAC(A/G)TCTAG intron-variant
rs1000629327 -- 42,936,945(+) TTTCC(C/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL32 Gene

Variant ID Type Subtype PubMed ID
nsv606715 CNV gain 21841781
nsv830979 CNV gain 17160897

Variation tolerance for MRPL32 Gene

Residual Variation Intolerance Score: 78.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL32 Gene

Disorders for MRPL32 Gene

Relevant External Links for MRPL32

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL32 Gene

Publications for MRPL32 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 64
  2. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 64

Products for MRPL32 Gene

Sources for MRPL32 Gene

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