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Aliases for MRPL32 Gene

Aliases for MRPL32 Gene

  • Mitochondrial Ribosomal Protein L32 2 3
  • MRP-L32 3 4
  • L32mt 3 4
  • BMRP-59b 3
  • HSPC283 3

External Ids for MRPL32 Gene

Previous GeneCards Identifiers for MRPL32 Gene

  • GC07P042618
  • GC07P042712
  • GC07P042745
  • GC07P042938

Summaries for MRPL32 Gene

Entrez Gene Summary for MRPL32 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL32 Gene

MRPL32 (Mitochondrial Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL32 Gene

Genomics for MRPL32 Gene

Regulatory Elements for MRPL32 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL32 Gene

Chromosome:
7
Start:
42,932,200 bp from pter
End:
42,948,958 bp from pter
Size:
16,759 bases
Orientation:
Plus strand

Genomic View for MRPL32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL32 Gene

Proteins for MRPL32 Gene

  • Protein details for MRPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC8-RM32_HUMAN
    Recommended name:
    39S ribosomal protein L32, mitochondrial
    Protein Accession:
    Q9BYC8
    Secondary Accessions:
    • Q96Q68
    • Q9P098

    Protein attributes for MRPL32 Gene

    Size:
    188 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL32 Gene

neXtProt entry for MRPL32 Gene

Proteomics data for MRPL32 Gene at MOPED

Post-translational modifications for MRPL32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL32 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPL32 Gene

Domains & Families for MRPL32 Gene

Gene Families for MRPL32 Gene

Protein Domains for MRPL32 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYC8

UniProtKB/Swiss-Prot:

RM32_HUMAN :
  • Belongs to the ribosomal protein L32P family.
Family:
  • Belongs to the ribosomal protein L32P family.
genes like me logo Genes that share domains with MRPL32: view

Function for MRPL32 Gene

Gene Ontology (GO) - Molecular Function for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL32: view
genes like me logo Genes that share phenotypes with MRPL32: view

Animal Model Products

miRNA for MRPL32 Gene

miRTarBase miRNAs that target MRPL32

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL32

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL32 Gene

Localization for MRPL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL32 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL32 Gene COMPARTMENTS Subcellular localization image for MRPL32 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IBA --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL32: view

Pathways & Interactions for MRPL32 Gene

genes like me logo Genes that share pathways with MRPL32: view

Gene Ontology (GO) - Biological Process for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL32: view

No data available for SIGNOR curated interactions for MRPL32 Gene

Drugs & Compounds for MRPL32 Gene

No Compound Related Data Available

Transcripts for MRPL32 Gene

mRNA/cDNA for MRPL32 Gene

Unigene Clusters for MRPL32 Gene

Mitochondrial ribosomal protein L32:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL32

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for MRPL32 Gene

GeneLoc Exon Structure for
MRPL32
ECgene alternative splicing isoforms for
MRPL32

Expression for MRPL32 Gene

mRNA expression in normal human tissues for MRPL32 Gene

Protein differential expression in normal tissues from HIPED for MRPL32 Gene

This gene is overexpressed in Lung (28.4) and Pancreas (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL32 Gene



SOURCE GeneReport for Unigene cluster for MRPL32 Gene Hs.50252

genes like me logo Genes that share expression patterns with MRPL32: view

Protein tissue co-expression partners for MRPL32 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL32 Gene

Orthologs for MRPL32 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL32 35
  • 84.93 (n)
  • 84.57 (a)
MRPL32 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL32 35
  • 86.52 (n)
  • 87.77 (a)
MRPL32 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl32 35
  • 79.32 (n)
  • 72.73 (a)
Mrpl32 16
Gm6578 36
  • 61 (a)
OneToMany
Mrpl32 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MRPL32 35
  • 99.11 (n)
  • 98.4 (a)
MRPL32 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl32 35
  • 80.04 (n)
  • 73.26 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL32 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL32 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL32 35
  • 62.68 (n)
  • 60.87 (a)
MRPL32 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL32 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl32 35
  • 62.76 (n)
  • 66.21 (a)
Str.6331 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7971 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19923 35
mrpl32 35
  • 64.07 (n)
  • 59.28 (a)
mrpl32 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL32 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-32 36
  • 25 (a)
OneToOne
Species with no ortholog for MRPL32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL32 Gene

ENSEMBL:
Gene Tree for MRPL32 (if available)
TreeFam:
Gene Tree for MRPL32 (if available)

Paralogs for MRPL32 Gene

Pseudogenes.org Pseudogenes for MRPL32 Gene

genes like me logo Genes that share paralogs with MRPL32: view

No data available for Paralogs for MRPL32 Gene

Variants for MRPL32 Gene

Sequence variations from dbSNP and Humsavar for MRPL32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7432 -- 42,937,743(+) AACTC(C/T)GAAAA utr-variant-3-prime, nc-transcript-variant
rs598810 -- 42,934,741(+) GATCC(A/G)CTAAG intron-variant
rs601057 -- 42,935,228(+) TTATT(A/C)TCAGA intron-variant
rs615770 -- 42,936,258(+) TCTGA(A/G)GGAAT intron-variant
rs627435 -- 42,936,536(+) ATCAA(C/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL32 Gene

Variant ID Type Subtype PubMed ID
nsv830979 CNV Gain 17160897

Variation tolerance for MRPL32 Gene

Residual Variation Intolerance Score: 78.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL32 Gene

HapMap Linkage Disequilibrium report
MRPL32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL32 Gene

Disorders for MRPL32 Gene

Relevant External Links for MRPL32

Genetic Association Database (GAD)
MRPL32
Human Genome Epidemiology (HuGE) Navigator
MRPL32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL32
genes like me logo Genes that share disorders with MRPL32: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL32 Gene

Publications for MRPL32 Gene

  1. Tissue inhibitor of metalloproteinases-1 stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases. (PMID: 16142437) Porter J.F. … Denhardt D.T. (Breast Cancer Res. Treat. 2005) 23 67
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for MRPL32 Gene

Sources for MRPL32 Gene

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