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Aliases for MRPL32 Gene

Aliases for MRPL32 Gene

  • Mitochondrial Ribosomal Protein L32 2 3
  • MRP-L32 3 4
  • L32mt 3 4
  • 39S Ribosomal Protein L32, Mitochondrial 3
  • BMRP-59b 3
  • HSPC283 3

External Ids for MRPL32 Gene

Summaries for MRPL32 Gene

Entrez Gene Summary for MRPL32 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL32 Gene

MRPL32 (Mitochondrial Ribosomal Protein L32) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL32 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL32 Gene

Genomics for MRPL32 Gene

Genomic Location for MRPL32 Gene

Start:
42,932,200 bp from pter
End:
42,948,958 bp from pter
Size:
16,759 bases
Orientation:
Plus strand

Genomic View for MRPL32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL32 Gene

Regulatory Elements for MRPL32 Gene

Proteins for MRPL32 Gene

  • Protein details for MRPL32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC8-RM32_HUMAN
    Recommended name:
    39S ribosomal protein L32, mitochondrial
    Protein Accession:
    Q9BYC8
    Secondary Accessions:
    • Q96Q68
    • Q9P098

    Protein attributes for MRPL32 Gene

    Size:
    188 amino acids
    Molecular mass:
    21405 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL32 Gene

neXtProt entry for MRPL32 Gene

Proteomics data for MRPL32 Gene at MOPED

Post-translational modifications for MRPL32 Gene

No Post-translational modifications

Other Protein References for MRPL32 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL32 Gene

Domains for MRPL32 Gene

Gene Families for MRPL32 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL32 Gene

UniProtKB/Swiss-Prot:

RM32_HUMAN
Family:
  • Belongs to the ribosomal protein L32P family.:
    • Q9BYC8
genes like me logo Genes that share domains with MRPL32: view

Function for MRPL32 Gene

Gene Ontology (GO) - Molecular Function for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL32: view

miRNA for MRPL32 Gene

miRTarBase miRNAs that target MRPL32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL32 Gene

Localization for MRPL32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL32 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL32 Gene COMPARTMENTS Subcellular localization image for MRPL32 gene
Compartment Confidence
mitochondrion 5
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005840 ribosome --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPL32: view

Pathways for MRPL32 Gene

SuperPathways for MRPL32 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL32: view

Pathways by source for MRPL32 Gene

1 KEGG pathway for MRPL32 Gene

Gene Ontology (GO) - Biological Process for MRPL32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL32: view

Transcripts for MRPL32 Gene

mRNA/cDNA for MRPL32 Gene

Unigene Clusters for MRPL32 Gene

Mitochondrial ribosomal protein L32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL32 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for MRPL32 Gene

GeneLoc Exon Structure for
MRPL32
ECgene alternative splicing isoforms for
MRPL32

Expression for MRPL32 Gene

mRNA expression in normal human tissues for MRPL32 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL32 Gene

SOURCE GeneReport for Unigene cluster for MRPL32 Gene Hs.50252

genes like me logo Genes that share expressions with MRPL32: view

Orthologs for MRPL32 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL32 36
  • 99.11 (n)
  • 98.4 (a)
MRPL32 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL32 36
  • 84.93 (n)
  • 84.57 (a)
MRPL32 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL32 36
  • 86.52 (n)
  • 87.77 (a)
MRPL32 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6578 37
  • 61 (a)
OneToMany
Mrpl32 36
  • 79.32 (n)
  • 72.73 (a)
Mrpl32 16
Mrpl32 37
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MRPL32 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL32 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl32 36
  • 80.04 (n)
  • 73.26 (a)
chicken
(Gallus gallus)
Aves MRPL32 36
  • 62.68 (n)
  • 60.87 (a)
MRPL32 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL32 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7971 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl32 36
  • 62.76 (n)
  • 66.21 (a)
Str.6331 36
zebrafish
(Danio rerio)
Actinopterygii Dr.19923 36
mrpl32 36
  • 64.07 (n)
  • 59.28 (a)
mrpl32 37
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL32 37
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-32 37
  • 25 (a)
OneToOne
Species with no ortholog for MRPL32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL32 Gene

ENSEMBL:
Gene Tree for MRPL32 (if available)
TreeFam:
Gene Tree for MRPL32 (if available)

Paralogs for MRPL32 Gene

Pseudogenes.org Pseudogenes for MRPL32 Gene

genes like me logo Genes that share paralogs with MRPL32: view

No data available for Paralogs for MRPL32 Gene

Variants for MRPL32 Gene

Sequence variations from dbSNP and Humsavar for MRPL32 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7432 -- 42,937,743(+) AACTC(C/T)GAAAA utr-variant-3-prime, nc-transcript-variant
rs598810 -- 42,934,741(+) GATCC(A/G)CTAAG intron-variant
rs601057 -- 42,935,228(+) TTATT(A/C)TCAGA intron-variant
rs615770 -- 42,936,258(+) TCTGA(A/G)GGAAT intron-variant
rs627435 -- 42,936,536(+) ATCAA(C/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL32 Gene

Variant ID Type Subtype PubMed ID
nsv830979 CNV Gain 17160897

Relevant External Links for MRPL32 Gene

HapMap Linkage Disequilibrium report
MRPL32

Disorders for MRPL32 Gene

Relevant External Links for MRPL32

Genetic Association Database (GAD)
MRPL32
Human Genome Epidemiology (HuGE) Navigator
MRPL32
genes like me logo Genes that share disorders with MRPL32: view

No data available for UniProtKB/Swiss-Prot for MRPL32 Gene

Publications for MRPL32 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  5. Tissue inhibitor of metalloproteinases-1 stimulates gene expression in MDA-MB-435 human breast cancer cells by means of its ability to inhibit metalloproteinases. (PMID: 16142437) Porter J.F. … Denhardt D.T. (Breast Cancer Res. Treat. 2005) 23

Products for MRPL32 Gene

Sources for MRPL32 Gene

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