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Aliases for MRPL30 Gene

Aliases for MRPL30 Gene

  • Mitochondrial Ribosomal Protein L30 2 3
  • 39S Ribosomal Protein L28, Mitochondrial 3 4
  • MRP-L28 3 4
  • MRP-L30 3 4
  • MRPL28 3 4
  • RPML28 3 4
  • L28mt 3 4
  • L30MT 3 4
  • MRPL28M 3

External Ids for MRPL30 Gene

Previous GeneCards Identifiers for MRPL30 Gene

  • GC02P097654
  • GC02P098225
  • GC02P099402
  • GC02P099418
  • GC02P099256
  • GC02P099137
  • GC02P099772
  • GC02P093563
  • GC02P099773
  • GC02P099800

Summaries for MRPL30 Gene

Entrez Gene Summary for MRPL30 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for MRPL30 Gene

MRPL30 (Mitochondrial Ribosomal Protein L30) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. An important paralog of this gene is ENSG00000273155.

Gene Wiki entry for MRPL30 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL30 Gene

Genomics for MRPL30 Gene

Regulatory Elements for MRPL30 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL30 Gene

Chromosome:
2
Start:
99,181,079 bp from pter
End:
99,199,557 bp from pter
Size:
18,479 bases
Orientation:
Plus strand

Genomic View for MRPL30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MRPL30 Gene

Proteins for MRPL30 Gene

  • Protein details for MRPL30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCC3-RM30_HUMAN
    Recommended name:
    39S ribosomal protein L30, mitochondrial
    Protein Accession:
    Q8TCC3
    Secondary Accessions:
    • A6NIC6
    • D3DVI0
    • D3DVI3
    • Q0D2Q7
    • Q6ZTP4
    • Q96Q69
    • Q9P0N0

    Protein attributes for MRPL30 Gene

    Size:
    161 amino acids
    Molecular mass:
    18546 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36169.1; Type=Frameshift; Positions=1, 36; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL30 Gene

    Alternative splice isoforms for MRPL30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL30 Gene

Proteomics data for MRPL30 Gene at MOPED

Post-translational modifications for MRPL30 Gene

  • Ubiquitination at Lys 87
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL30 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPL30 Gene

Domains & Families for MRPL30 Gene

Gene Families for MRPL30 Gene

Protein Domains for MRPL30 Gene

Suggested Antigen Peptide Sequences for MRPL30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCC3

UniProtKB/Swiss-Prot:

RM30_HUMAN :
  • Belongs to the ribosomal protein L30P family.
Family:
  • Belongs to the ribosomal protein L30P family.
genes like me logo Genes that share domains with MRPL30: view

Function for MRPL30 Gene

genes like me logo Genes that share phenotypes with MRPL30: view

Animal Model Products

miRNA for MRPL30 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL30 Gene

Localization for MRPL30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL30 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL30 Gene COMPARTMENTS Subcellular localization image for MRPL30 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MRPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL30: view

Pathways & Interactions for MRPL30 Gene

genes like me logo Genes that share pathways with MRPL30: view

Interacting Proteins for MRPL30 Gene

Gene Ontology (GO) - Biological Process for MRPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL30: view

No data available for SIGNOR curated interactions for MRPL30 Gene

Drugs & Compounds for MRPL30 Gene

No Compound Related Data Available

Transcripts for MRPL30 Gene

Unigene Clusters for MRPL30 Gene

Mitochondrial ribosomal protein L30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL30 Gene

No ASD Table

Relevant External Links for MRPL30 Gene

GeneLoc Exon Structure for
MRPL30
ECgene alternative splicing isoforms for
MRPL30

Expression for MRPL30 Gene

mRNA expression in normal human tissues for MRPL30 Gene

Protein differential expression in normal tissues from HIPED for MRPL30 Gene

This gene is overexpressed in Plasma (14.6), Rectum (14.4), and Lung (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL30 Gene



SOURCE GeneReport for Unigene cluster for MRPL30 Gene Hs.346736

genes like me logo Genes that share expression patterns with MRPL30: view

Protein tissue co-expression partners for MRPL30 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL30 Gene

Orthologs for MRPL30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL30 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL30 35
  • 86.71 (n)
  • 84.81 (a)
MRPL30 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRPL30 35
  • 89.23 (n)
  • 86.96 (a)
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mrpl30 35
  • 83.12 (n)
  • 83.54 (a)
Mrpl30 16
Mrpl30 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia MRPL30 35
  • 99.17 (n)
  • 98.76 (a)
MRPL30 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrpl30 35
  • 84.18 (n)
  • 86.08 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl30 35
  • 63.33 (n)
  • 61.25 (a)
Str.20361 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16980 35
mrpl30 35
  • 58.66 (n)
  • 59.74 (a)
C9H2orf15 36
  • 58 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4859 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL30 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4104 36
  • 18 (a)
OneToMany
Species with no ortholog for MRPL30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL30 Gene

ENSEMBL:
Gene Tree for MRPL30 (if available)
TreeFam:
Gene Tree for MRPL30 (if available)

Paralogs for MRPL30 Gene

Paralogs for MRPL30 Gene

Pseudogenes.org Pseudogenes for MRPL30 Gene

genes like me logo Genes that share paralogs with MRPL30: view

Variants for MRPL30 Gene

Sequence variations from dbSNP and Humsavar for MRPL30 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13798 -- 99,197,151(+) TATTT(C/T)AGATA utr-variant-3-prime, intron-variant
rs1044575 - 99,195,607(+) TTCCA(A/G)CAGAG missense, reference, nc-transcript-variant
rs1817645 -- 99,191,602(-) AAAGG(A/T)CTGAT intron-variant
rs1825771 -- 99,191,922(-) AAAGG(A/C)ACAGT intron-variant
rs1825772 -- 99,191,780(-) GGGGA(C/T)ACAGA intron-variant

Variation tolerance for MRPL30 Gene

Residual Variation Intolerance Score: 61.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL30 Gene

HapMap Linkage Disequilibrium report
MRPL30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL30 Gene

Disorders for MRPL30 Gene

Relevant External Links for MRPL30

Genetic Association Database (GAD)
MRPL30
Human Genome Epidemiology (HuGE) Navigator
MRPL30
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL30
genes like me logo Genes that share disorders with MRPL30: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL30 Gene

Publications for MRPL30 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for MRPL30 Gene

Sources for MRPL30 Gene

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