Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL30 Gene

Aliases for MRPL30 Gene

  • Mitochondrial Ribosomal Protein L30 2 3
  • MRPL28 3 4 6
  • 39S Ribosomal Protein L28, Mitochondrial 3 4
  • MRP-L28 3 4
  • MRP-L30 3 4
  • RPML28 3 4
  • L28mt 3 4
  • L30MT 3 4
  • 39S Ribosomal Protein L30, Mitochondrial 3
  • MRPL28M 3

External Ids for MRPL30 Gene

Previous GeneCards Identifiers for MRPL30 Gene

  • GC02P097654
  • GC02P098225
  • GC02P099402
  • GC02P099418
  • GC02P099256
  • GC02P099137
  • GC02P099772
  • GC02P093563
  • GC02P099773
  • GC02P099800

Summaries for MRPL30 Gene

Entrez Gene Summary for MRPL30 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. Read-through transcription also exists between this gene and the neighboring upstream lipoyltransferase 1 (LIPT1) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for MRPL30 Gene

MRPL30 (Mitochondrial Ribosomal Protein L30) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). An important paralog of this gene is ENSG00000273155.

Gene Wiki entry for MRPL30 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL30 Gene

Genomics for MRPL30 Gene

Regulatory Elements for MRPL30 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL30 Gene

Start:
99,181,079 bp from pter
End:
99,199,557 bp from pter
Size:
18,479 bases
Orientation:
Plus strand

Genomic View for MRPL30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL30 Gene

Proteins for MRPL30 Gene

  • Protein details for MRPL30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCC3-RM30_HUMAN
    Recommended name:
    39S ribosomal protein L30, mitochondrial
    Protein Accession:
    Q8TCC3
    Secondary Accessions:
    • A6NIC6
    • D3DVI0
    • D3DVI3
    • Q0D2Q7
    • Q6ZTP4
    • Q96Q69
    • Q9P0N0

    Protein attributes for MRPL30 Gene

    Size:
    161 amino acids
    Molecular mass:
    18546 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36169.1; Type=Frameshift; Positions=1, 36; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL30 Gene

    Alternative splice isoforms for MRPL30 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL30 Gene

Proteomics data for MRPL30 Gene at MOPED

Post-translational modifications for MRPL30 Gene

  • Ubiquitination at Lys87
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL30 Gene

Domains for MRPL30 Gene

Gene Families for MRPL30 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL30 Gene

Suggested Antigen Peptide Sequences for MRPL30 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCC3

UniProtKB/Swiss-Prot:

RM30_HUMAN :
  • Q8TCC3
Family:
  • Belongs to the ribosomal protein L30P family.
genes like me logo Genes that share domains with MRPL30: view

Function for MRPL30 Gene

Phenotypes for MRPL30 Gene

GenomeRNAi human phenotypes for MRPL30:
genes like me logo Genes that share phenotypes with MRPL30: view

Animal Model Products

CRISPR Products

miRNA for MRPL30 Gene

miRTarBase miRNAs that target MRPL30

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL30 Gene

Localization for MRPL30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL30 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for MRPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL30: view

No data available for Subcellular locations from COMPARTMENTS for MRPL30 Gene

Pathways for MRPL30 Gene

SuperPathways for MRPL30 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL30: view

Pathways by source for MRPL30 Gene

1 KEGG pathway for MRPL30 Gene

Interacting Proteins for MRPL30 Gene

Gene Ontology (GO) - Biological Process for MRPL30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL30: view

Transcripts for MRPL30 Gene

Unigene Clusters for MRPL30 Gene

Mitochondrial ribosomal protein L30:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL30

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL30 Gene

No ASD Table

Relevant External Links for MRPL30 Gene

GeneLoc Exon Structure for
MRPL30
ECgene alternative splicing isoforms for
MRPL30

Expression for MRPL30 Gene

mRNA expression in normal human tissues for MRPL30 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL30 Gene

SOURCE GeneReport for Unigene cluster for MRPL30 Gene Hs.346736

genes like me logo Genes that share expressions with MRPL30: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL30 Gene

Orthologs for MRPL30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL30 35
  • 99.17 (n)
  • 98.76 (a)
MRPL30 36
  • 83 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRPL30 35
  • 86.71 (n)
  • 84.81 (a)
MRPL30 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 87 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
MRPL30 35
  • 89.23 (n)
  • 86.96 (a)
mouse
(Mus musculus)
Mammalia Mrpl30 35
  • 83.12 (n)
  • 83.54 (a)
Mrpl30 16
Mrpl30 36
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrpl30 35
  • 84.18 (n)
  • 86.08 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl30 35
  • 63.33 (n)
  • 61.25 (a)
Str.20361 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4859 35
zebrafish
(Danio rerio)
Actinopterygii C9H2orf15 36
  • 58 (a)
OneToMany
Dr.16980 35
mrpl30 35
  • 58.66 (n)
  • 59.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL30 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4104 36
  • 18 (a)
OneToMany
Species with no ortholog for MRPL30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL30 Gene

ENSEMBL:
Gene Tree for MRPL30 (if available)
TreeFam:
Gene Tree for MRPL30 (if available)

Paralogs for MRPL30 Gene

Paralogs for MRPL30 Gene

Pseudogenes.org Pseudogenes for MRPL30 Gene

genes like me logo Genes that share paralogs with MRPL30: view

Variants for MRPL30 Gene

Sequence variations from dbSNP and Humsavar for MRPL30 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs13798 -- 99,197,151(+) TATTT(C/T)AGATA utr-variant-3-prime, intron-variant
rs1044575 - 99,195,607(+) TTCCA(A/G)CAGAG missense, reference, nc-transcript-variant
rs1210870 -- 99,198,556(-) CCCTT(C/T)CTTGA utr-variant-3-prime, nc-transcript-variant
rs1817645 -- 99,191,602(-) AAAGG(A/T)CTGAT intron-variant
rs1825771 -- 99,191,922(-) AAAGG(A/C)ACAGT intron-variant

Relevant External Links for MRPL30 Gene

HapMap Linkage Disequilibrium report
MRPL30

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL30 Gene

Disorders for MRPL30 Gene

Relevant External Links for MRPL30

Genetic Association Database (GAD)
MRPL30
Human Genome Epidemiology (HuGE) Navigator
MRPL30
genes like me logo Genes that share disorders with MRPL30: view

No data available for UniProtKB/Swiss-Prot for MRPL30 Gene

Publications for MRPL30 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for MRPL30 Gene

Sources for MRPL30 Gene

Back to Top

Content