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Aliases for MRPL3 Gene

Aliases for MRPL3 Gene

  • Mitochondrial Ribosomal Protein L3 2 3 5
  • MRP-L3 3 4
  • RPML3 3 4
  • L3mt 3 4
  • MRL3 3 4
  • Mitochondrial 60S Ribosomal Protein L3 3
  • COXPD9 3

External Ids for MRPL3 Gene

Previous HGNC Symbols for MRPL3 Gene

  • RPML3

Previous GeneCards Identifiers for MRPL3 Gene

  • GC03M128092
  • GC03M131922
  • GC03M132462
  • GC03M132501
  • GC03M132663
  • GC03M131181
  • GC03M128565

Summaries for MRPL3 Gene

Entrez Gene Summary for MRPL3 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL3 Gene

MRPL3 (Mitochondrial Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with MRPL3 include combined oxidative phosphorylation deficiency 9 and mitochondrial cardiomyopathy. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL3 Gene

Genomics for MRPL3 Gene

Regulatory Elements for MRPL3 Gene

Promoters for MRPL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL3 Gene

Chromosome:
3
Start:
131,462,201 bp from pter
End:
131,503,016 bp from pter
Size:
40,816 bases
Orientation:
Minus strand

Genomic View for MRPL3 Gene

Genes around MRPL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL3 Gene

Proteins for MRPL3 Gene

  • Protein details for MRPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09001-RM03_HUMAN
    Recommended name:
    39S ribosomal protein L3, mitochondrial
    Protein Accession:
    P09001
    Secondary Accessions:
    • Q6IBT2

    Protein attributes for MRPL3 Gene

    Size:
    348 amino acids
    Molecular mass:
    38633 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL3 Gene

neXtProt entry for MRPL3 Gene

Proteomics data for MRPL3 Gene at MOPED

Post-translational modifications for MRPL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL3 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL3 Gene

Domains & Families for MRPL3 Gene

Gene Families for MRPL3 Gene

Protein Domains for MRPL3 Gene

Suggested Antigen Peptide Sequences for MRPL3 Gene

Graphical View of Domain Structure for InterPro Entry

P09001

UniProtKB/Swiss-Prot:

RM03_HUMAN :
  • Belongs to the ribosomal protein L3P family.
Family:
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with MRPL3: view

Function for MRPL3 Gene

Gene Ontology (GO) - Molecular Function for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL3: view
genes like me logo Genes that share phenotypes with MRPL3: view

Human Phenotype Ontology for MRPL3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL3 Gene

Localization for MRPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL3 Gene COMPARTMENTS Subcellular localization image for MRPL3 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL3: view

Pathways & Interactions for MRPL3 Gene

genes like me logo Genes that share pathways with MRPL3: view

Gene Ontology (GO) - Biological Process for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,TAS 2891103
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL3: view

No data available for SIGNOR curated interactions for MRPL3 Gene

Drugs & Compounds for MRPL3 Gene

No Compound Related Data Available

Transcripts for MRPL3 Gene

Unigene Clusters for MRPL3 Gene

Mitochondrial ribosomal protein L3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6:
SP7:

Relevant External Links for MRPL3 Gene

GeneLoc Exon Structure for
MRPL3
ECgene alternative splicing isoforms for
MRPL3

Expression for MRPL3 Gene

mRNA expression in normal human tissues for MRPL3 Gene

Protein differential expression in normal tissues from HIPED for MRPL3 Gene

This gene is overexpressed in Pancreas (28.5), Platelet (7.1), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL3 Gene



SOURCE GeneReport for Unigene cluster for MRPL3 Gene Hs.205163

genes like me logo Genes that share expression patterns with MRPL3: view

Protein tissue co-expression partners for MRPL3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL3 Gene

Orthologs for MRPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL3 35
  • 87.55 (n)
  • 85.06 (a)
MRPL3 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL3 35
  • 89.72 (n)
  • 85.59 (a)
MRPL3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl3 35
  • 83.43 (n)
  • 82.18 (a)
Mrpl3 16
Mrpl3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL3 35
  • 99.52 (n)
  • 99.43 (a)
MRPL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl3 35
  • 83.14 (n)
  • 83.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL3 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL3 35
  • 69.18 (n)
  • 65.8 (a)
MRPL3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL3 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl3 35
  • 71.06 (n)
  • 69.16 (a)
Str.20499 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8380 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mrpl3 35
  • 66.78 (n)
  • 69.42 (a)
mrpl3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL3 37
  • 43 (a)
mRpL3 35
  • 49.55 (n)
  • 42.91 (a)
mRpL3 36
  • 36 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000857 35
  • 46.91 (n)
  • 43.43 (a)
worm
(Caenorhabditis elegans)
Secernentea C26E6.6 37
  • 40 (a)
mrps-18C 35
  • 49.93 (n)
  • 43.1 (a)
mrps-18C 36
  • 28 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL129W 35
  • 47.22 (n)
  • 37.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16039g 35
  • 44.79 (n)
  • 31.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL9 35
  • 50.33 (n)
  • 42.16 (a)
MRPL9 36
  • 34 (a)
OneToOne
MRPL9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL3P 35
  • 49.63 (n)
  • 41.85 (a)
rice
(Oryza sativa)
Liliopsida Os01g0251100 35
  • 51.52 (n)
  • 43.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06749 35
  • 45.13 (n)
  • 37.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl9 35
  • 49.54 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToOne
Species with no ortholog for MRPL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL3 Gene

ENSEMBL:
Gene Tree for MRPL3 (if available)
TreeFam:
Gene Tree for MRPL3 (if available)

Paralogs for MRPL3 Gene

Pseudogenes.org Pseudogenes for MRPL3 Gene

genes like me logo Genes that share paralogs with MRPL3: view

No data available for Paralogs for MRPL3 Gene

Variants for MRPL3 Gene

Sequence variations from dbSNP and Humsavar for MRPL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2291381 - 131,469,730(-) AAAAA(C/T)GGGAA reference, missense
VAR_066676 Combined oxidative phosphorylation deficiency 9 (COXPD9)
rs1027005 -- 131,485,029(+) TGACT(A/G)TCACT intron-variant
rs960971 -- 131,477,140(-) GTAAA(A/G)AAATA intron-variant
rs960972 -- 131,477,167(-) ATGCA(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL3 Gene

Variant ID Type Subtype PubMed ID
nsv829724 CNV Gain 17160897

Variation tolerance for MRPL3 Gene

Residual Variation Intolerance Score: 60.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL3 Gene

HapMap Linkage Disequilibrium report
MRPL3
Human Gene Mutation Database (HGMD)
MRPL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL3 Gene

Disorders for MRPL3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MRPL3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 9
  • coxpd9
mitochondrial cardiomyopathy
  • cardiomyopathy, maternally transmitted
tic disorder
- elite association - COSMIC cancer census association via MalaCards
Search MRPL3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RM03_HUMAN
  • Combined oxidative phosphorylation deficiency 9 (COXPD9) [MIM:614582]: A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases. {ECO:0000269 PubMed:21786366}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MRPL3

Genetic Association Database (GAD)
MRPL3
Human Genome Epidemiology (HuGE) Navigator
MRPL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL3
genes like me logo Genes that share disorders with MRPL3: view

No data available for Genatlas for MRPL3 Gene

Publications for MRPL3 Gene

  1. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PMID: 2891103) Ou J.-H. … Rutter W. (Nucleic Acids Res. 1987) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3

Products for MRPL3 Gene

Sources for MRPL3 Gene

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