Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL3 Gene

Aliases for MRPL3 Gene

  • Mitochondrial Ribosomal Protein L3 2 3
  • MRL3 3 4 6
  • MRP-L3 3 4
  • COXPD9 3 6
  • RPML3 3 4
  • L3mt 3 4
  • 39S Ribosomal Protein L3, Mitochondrial 3
  • Mitochondrial 60S Ribosomal Protein L3 3

External Ids for MRPL3 Gene

Previous HGNC Symbols for MRPL3 Gene

  • RPML3

Previous GeneCards Identifiers for MRPL3 Gene

  • GC03M128092
  • GC03M131922
  • GC03M132462
  • GC03M132501
  • GC03M132663
  • GC03M131181
  • GC03M128565

Summaries for MRPL3 Gene

Entrez Gene Summary for MRPL3 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL3 Gene

MRPL3 (Mitochondrial Ribosomal Protein L3) is a Protein Coding gene. Diseases associated with MRPL3 include combined oxidative phosphorylation deficiency 9 and mitochondrial cardiomyopathy. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL3 Gene

Genomics for MRPL3 Gene

Regulatory Elements for MRPL3 Gene

Genomic Location for MRPL3 Gene

131,462,201 bp from pter
131,503,016 bp from pter
40,816 bases
Minus strand

Genomic View for MRPL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL3 Gene

Proteins for MRPL3 Gene

  • Protein details for MRPL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L3, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6IBT2

    Protein attributes for MRPL3 Gene

    348 amino acids
    Molecular mass:
    38633 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL3 Gene

neXtProt entry for MRPL3 Gene

Proteomics data for MRPL3 Gene at MOPED

Post-translational modifications for MRPL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL3 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL3 Gene

Domains for MRPL3 Gene

Gene Families for MRPL3 Gene

Protein Domains for MRPL3 Gene

Suggested Antigen Peptide Sequences for MRPL3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L3P family.
  • Belongs to the ribosomal protein L3P family.
genes like me logo Genes that share domains with MRPL3: view

Function for MRPL3 Gene

Gene Ontology (GO) - Molecular Function for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 2891103
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL3: view

Phenotypes for MRPL3 Gene

GenomeRNAi human phenotypes for MRPL3:
genes like me logo Genes that share phenotypes with MRPL3: view

Animal Model Products

miRNA for MRPL3 Gene

miRTarBase miRNAs that target MRPL3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL3 Gene

Localization for MRPL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL3 Gene


Subcellular locations from

Jensen Localization Image for MRPL3 Gene COMPARTMENTS Subcellular localization image for MRPL3 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 20186120
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL3: view

Pathways for MRPL3 Gene

SuperPathways for MRPL3 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPL3: view

Pathways by source for MRPL3 Gene

1 KEGG pathway for MRPL3 Gene

Gene Ontology (GO) - Biological Process for MRPL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 2891103
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL3: view

Transcripts for MRPL3 Gene

Unigene Clusters for MRPL3 Gene

Mitochondrial ribosomal protein L3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - -

Relevant External Links for MRPL3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL3 Gene

mRNA expression in normal human tissues for MRPL3 Gene

Protein differential expression in normal tissues for MRPL3 Gene

This gene is overexpressed in Pancreas (28.5), Platelet (7.1), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL3 Gene

SOURCE GeneReport for Unigene cluster for MRPL3 Gene Hs.205163

genes like me logo Genes that share expressions with MRPL3: view

Expression partners for MRPL3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL3 Gene

Orthologs for MRPL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL3 35
  • 87.55 (n)
  • 85.06 (a)
MRPL3 36
  • 85 (a)
(Canis familiaris)
Mammalia MRPL3 35
  • 89.72 (n)
  • 85.59 (a)
MRPL3 36
  • 85 (a)
(Mus musculus)
Mammalia Mrpl3 35
  • 83.43 (n)
  • 82.18 (a)
Mrpl3 16
Mrpl3 36
  • 82 (a)
(Pan troglodytes)
Mammalia MRPL3 35
  • 99.52 (n)
  • 99.43 (a)
MRPL3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl3 35
  • 83.14 (n)
  • 83.05 (a)
(Monodelphis domestica)
Mammalia MRPL3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL3 36
  • 77 (a)
(Gallus gallus)
Aves MRPL3 35
  • 69.18 (n)
  • 65.8 (a)
MRPL3 36
  • 66 (a)
(Anolis carolinensis)
Reptilia MRPL3 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl3 35
  • 71.06 (n)
  • 69.16 (a)
Str.20499 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8380 35
(Danio rerio)
Actinopterygii -- 35
mrpl3 35
  • 66.78 (n)
  • 69.42 (a)
mrpl3 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL3 37
  • 43 (a)
mRpL3 35
  • 49.55 (n)
  • 42.91 (a)
mRpL3 36
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000857 35
  • 46.91 (n)
  • 43.43 (a)
(Caenorhabditis elegans)
Secernentea C26E6.6 37
  • 40 (a)
mrps-18C 35
  • 49.93 (n)
  • 43.1 (a)
mrps-18C 36
  • 28 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL129W 35
  • 47.22 (n)
  • 37.5 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E16039g 35
  • 44.79 (n)
  • 31.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL9 35
  • 50.33 (n)
  • 42.16 (a)
MRPL9 36
  • 34 (a)
MRPL9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RPL3P 35
  • 49.63 (n)
  • 41.85 (a)
(Oryza sativa)
Liliopsida Os01g0251100 35
  • 51.52 (n)
  • 43.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06749 35
  • 45.13 (n)
  • 37.61 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl9 35
  • 49.54 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for MRPL3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL3 Gene

Gene Tree for MRPL3 (if available)
Gene Tree for MRPL3 (if available)

Paralogs for MRPL3 Gene Pseudogenes for MRPL3 Gene

genes like me logo Genes that share paralogs with MRPL3: view

No data available for Paralogs for MRPL3 Gene

Variants for MRPL3 Gene

Sequence variations from dbSNP and Humsavar for MRPL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs960971 -- 131,477,140(-) GTAAA(A/G)AAATA intron-variant
rs960972 -- 131,477,167(-) ATGCA(A/G)TGAAA intron-variant
rs963801 -- 131,501,016(-) AGTTA(C/T)CAAAA intron-variant
rs1027005 -- 131,485,029(+) TGACT(A/G)TCACT intron-variant
rs1352109 -- 131,497,355(-) TTTAT(C/T)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL3 Gene

Variant ID Type Subtype PubMed ID
nsv829724 CNV Gain 17160897

Relevant External Links for MRPL3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL3 Gene

Disorders for MRPL3 Gene

(1) OMIM Diseases for MRPL3 Gene (607118)


  • Combined oxidative phosphorylation deficiency 9 (COXPD9) [MIM:614582]: A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases. {ECO:0000269 PubMed:21786366}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MRPL3 Gene

Relevant External Links for MRPL3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRPL3: view

No data available for Novoseek inferred disease relationships and Genatlas for MRPL3 Gene

Publications for MRPL3 Gene

  1. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PMID: 2891103) Ou J.-H. … Rutter W. (Nucleic Acids Res. 1987) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy. (PMID: 21786366) Galmiche L. … Rotig A. (Hum. Mutat. 2011) 3 4
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for MRPL3 Gene

Sources for MRPL3 Gene

Back to Top