Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL3 Gene

protein-coding   GIFtS: 61
GCID: GC03M131181

Mitochondrial Ribosomal Protein L3


(Previous symbol: RPML3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L31 2     MRP-L32 3
RPML31 2 3     39S Ribosomal Protein L3, Mitochondrial2
L3mt2 3     COXPD92
MRL32 3     Mitochondrial 60S Ribosomal Protein L32

External Ids:    HGNC: 103791   Entrez Gene: 112222   Ensembl: ENSG000001146867   OMIM: 6071185   UniProtKB: P090013   

Export aliases for MRPL3 gene to outside databases

Previous GC identifers: GC03M128092 GC03M131922 GC03M132462 GC03M132501 GC03M132663 GC03M128565


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL3 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is
found on chromosome 13q. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL3 Gene: 
MRPL3 (mitochondrial ribosomal protein L3) is a protein-coding gene. Diseases associated with MRPL3 include mitochondrial cardiomyopathy, and hypertrophic cardiomyopathy, and among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and RNA binding.

Gene Wiki entry for MRPL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL3 gene promoter:
         p300   NF-AT   AREB6   NF-AT4   S8   NF-AT2   POU2F1   POU2F1a   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21-q23   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q21-q23

MRPL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M131181:  view genomic region     (about GC identifiers)

Start:
131,181,045 bp from pter      End:
131,221,860 bp from pter
Size:
40,816 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RM03_HUMAN, P09001 (See protein sequence)
Recommended Name: 39S ribosomal protein L3, mitochondrial  
Size: 348 amino acids; 38633 Da
Subcellular location: Mitochondrion
Secondary accessions: Q6IBT2

Explore the universe of human proteins at neXtProt for MRPL3: NX_P09001

Explore proteomics data for MRPL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09001

  • MRPL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPL3 Protein Expression
    REFSEQ proteins: NP_009139.1  
    ENSEMBL proteins: 
     ENSP00000264995   ENSP00000424107   ENSP00000398536   ENSP00000422419   ENSP00000422035  
     ENSP00000422622  

    Human Recombinant Protein Products for MRPL3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MRPL3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MRPL3
    GenScript Custom Purified and Recombinant Proteins Services for MRPL3
    Novus Biologicals MRPL3 Protein
    Novus Biologicals MRPL3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPL3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005762mitochondrial large ribosomal subunit IDA--
    GO:0005840ribosome ----

    MRPL3 for ontologies           About GeneDecksing



    MRPL3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MRPL3
    OriGene Custom Antibody Services for MRPL3
    GenScript Custom Superior Antibodies Services for MRPL3
    Novus Biologicals MRPL3 Antibodies
    Abcam antibodies for MRPL3
    Cloud-Clone Corp. Antibodies for MRPL3 
    ThermoFisher Antibodies for MRPL3
    LSBio Antibodies in human, mouse, rat for MRPL3 

    Assay Products for MRPL3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRPL3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRPL3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRPL3 
    Cloud-Clone Corp. CLIAs for MRPL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPL: Mitochondrial ribosomal proteins / large subunits

    4 InterPro protein domains:
     IPR019926 Ribosomal_L3_CS
     IPR009000 Transl_elong_init/rib_B-barrel
     IPR000597 Ribosomal_L3
     IPR019927 Ribosomal_L3_bac/org-type

    Graphical View of Domain Structure for InterPro Entry P09001

    ProtoNet protein and cluster: P09001

    1 Blocks protein domain: IPB000597 Ribosomal protein L3

    UniProtKB/Swiss-Prot: RM03_HUMAN, P09001
    Similarity: Belongs to the ribosomal protein L3P family


    MRPL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS2891103
    GO:0003735structural constituent of ribosome IEA--
         
    MRPL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPL3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPL3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRPL3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRPL3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPL3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPL3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPL3:
    hsa-miR-149 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMRPL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRPL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRPL3
    Sirion Biotech Customized adenovirus for overexpression of MRPL3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MRPL3 (see all 9)
    OriGene ORF clones in mouse, rat for MRPL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPL3 (NM_145330)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL3
    Sirion Biotech Customized lentivirus for stable overexpression of MRPL3 
                         Customized lentivirus expression plasmids for stable overexpression of MRPL3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRPL3
    Search LifeMap BioReagents cell lines for MRPL3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPL3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPL3):
        Ribosome


    MRPL3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/326 Interacting proteins for MRPL3 (P090012, 3 ENSP000002649954) via UniProtKB, MINT, STRING, and/or I2D (see all 326)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL11Q9Y3B72, 3, ENSP000003088974MINT-8079030 I2D: score=2 STRING: ENSP00000308897
    MRPL13Q9BYD12, 3, ENSP000003065484MINT-8079030 I2D: score=1 STRING: ENSP00000306548
    MRPL2Q5T6532, 3, ENSP000003734044MINT-8079030 I2D: score=1 STRING: ENSP00000373404
    PUS1Q9Y6062, 3MINT-8079030 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734 I2D: score=1 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    MRPL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL3 (RM03)

    Search CenterWatch for drugs/clinical trials and news about MRPL3 / RM03

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPL3 gene: 
    NM_007208.3  

    Unigene Cluster for MRPL3:

    Mitochondrial ribosomal protein L3
    Hs.205163  [show with all ESTs]
    Unigene Representative Sequence: BM541805
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264995(uc011blo.2 uc003eoh.3 uc011blp.2) ENST00000511168
    ENST00000510043 ENST00000425847 ENST00000507669 ENST00000506487 ENST00000512877
    ENST00000506946 ENST00000510923 ENST00000510154
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPL3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPL3:
    hsa-miR-149 hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidMRPL3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRPL3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL3
    Clone
    Products:
         
    OriGene clones in human, mouse for MRPL3 (see all 9)
    OriGene ORF clones in mouse, rat for MRPL3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPL3 (NM_145330)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL3
    Sirion Biotech Customized lentivirus for stable overexpression of MRPL3 
                         Customized lentivirus expression plasmids for stable overexpression of MRPL3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRPL3
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL3

    Additional mRNA sequence: 

    AK296626.1 AK301377.1 BC003375.2 CR456720.1 X06323.1 

    23 DOTS entries:

    DT.100825086  DT.418330  DT.405054  DT.100802507  DT.120887835  DT.95365260  DT.100825075  DT.120763362 
    DT.100665460  DT.100825069  DT.100825081  DT.120887825  DT.95365277  DT.95365283  DT.120763358  DT.120887807 
    DT.120887845  DT.91874583  DT.91945429  DT.92455866  DT.100030423  DT.120887830  DT.92455872 

    24/497 AceView cDNA sequences (see all 497):

    BG286927 CR604372 AV647648 BF594507 CR601545 BM763636 CR595603 BM992835 
    AA868029 BQ130866 BU855641 BX418081 BG759348 BX096711 BM543299 CB143224 
    CR611567 BQ218412 BQ230191 CR456720 BU621197 BG260440 BP376069 BQ959830 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                        -           -           -                                       
    SP2:                                                        -                       -                                       
    SP3:                                -                       -           -           -                                       
    SP4:                          -     -                       -                                                               
    SP5:                                                  -     -           -                                                   


    ECgene alternative splicing isoforms for MRPL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAAGGCCG
    MRPL3 Expression
    About this image


    See MRPL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL3

    SOURCE GeneReport for Unigene cluster: Hs.205163
        SABiosciences Custom PCR Arrays for MRPL3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MRPL3
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRPL3 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl31 , 5 mitochondrial ribosomal protein L31, 5 83.43(n)1
    82.18(a)1
      9 (56.61 cM)5
    940621  NM_053159.31  NP_444389.21 
     1050532395 
    chicken
    (Gallus gallus)
    Aves MRPL31 mitochondrial ribosomal protein L3 69.18(n)
    65.8(a)
      420686  NM_001006366.1  NP_001006366.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL36
    Uncharacterized protein
    62(a)
    1 ↔ 1
    6(37466508-37502160)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83802 Xenopus laevis transcribed sequence with weak similarity more 78.8(n)    CA984954.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC055650.12   -- 75.61(n)   336283  BC055650.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL31 , 3 protein biosynthesis structural
    constituent of more3
    mitochondrial ribosomal protein L31
    43(a)3
    49.27(n)1
    42.42(a)1
      13E143
    325231  NM_078611.31  NP_511166.21 
    worm
    (Caenorhabditis elegans)
    Secernentea C26E6.63
    mrps-18C1
    Ribosomal protein L33
    Protein MRPS-18C1
    40(a)3
    50.28(n)1
    43.59(a)1
      III(5007433-5008859)3
    1756661  NM_065644.31  NP_498045.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRPL9(YGR220C)4
    MRPL91
    Mitochondrial ribosomal protein of the large subunit4
    Mrpl9p1
    50.33(n)1
    42.16(a)1
      7(936883-936074)4
    8531351, 4  NP_011736.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RPL3P1 50S ribosomal protein L3-2 49.63(n)
    41.85(a)
      821011  NM_112626.2  NP_566579.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g02511001 hypothetical protein 51.52(n)
    43.29(a)
      4327104  NM_001049134.1  NP_001042599.1 


    ENSEMBL Gene Tree for MRPL3 (if available)
    TreeFam Gene Tree for MRPL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPL3 gene

    MRPL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPL3
    PGOHUM00000248307


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/900 SNPs in MRPL3 are shown (see all 900)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0666764
    Combined oxidative phosphorylation deficiency 9 (COXPD9)4--see VAR_0666762 P R mis40--------
    rs1911590121,2
    --131166649(+) ATACAA/CTTAAA 1 -- ds50010--------
    rs1825285161,2
    --131166681(+) CATTTC/TGATTA 1 -- ds50010--------
    rs345808311,2
    C,F--131166740(+) AAATTC/ATTTTT 1 -- ds50013Minor allele frequency- A:0.05NA 124
    rs1493631671,2
    --131166752(+) AAAGGC/TAGACT 1 -- ds50010--------
    rs1474777551,2
    --131166765(+) GTGCAC/GTGGCT 1 -- ds50010--------
    rs1868581921,2
    --131166915(+) ACCTAC/TAGTCC 1 -- ds50010--------
    rs1931934781,2
    --131166992(+) AGATCA/GCACCA 1 -- ds50010--------
    rs747728751,2
    C--131167025(+) CAACAG/AAGCAA 1 -- ds50013Minor allele frequency- A:0.00NA 6
    rs1384259891,2
    --131167033(+) CAAAAA/CCCTGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MRPL3 (131181045 - 131221860 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRPL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829724CNV Gain17160897


    Human Gene Mutation Database (HGMD): MRPL3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL3
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607118    OMIM disorders: --

    UniProtKB/Swiss-Prot: RM03_HUMAN, P09001
  • Combined oxidative phosphorylation deficiency 9 (COXPD9) [MIM:614582]: A mitochondrial disease
    characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor
    retardation. Death in infancy has been observed in some cases. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 4 diseases for MRPL3:    About MalaCards
    mitochondrial cardiomyopathy    hypertrophic cardiomyopathy    pneumonia    tuberculosis

    1 disease from the University of Copenhagen DISEASES database for MRPL3:
    Gilles de la Tourette syndrome

    MRPL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL3
    Human Genome Epidemiology (HuGE) Navigator: MRPL3 (1 document)

    Export disorders for MRPL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL3 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with MRPL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells. (PubMed id 2891103)1, 2, 3 Ou J.-H.... Rutter W. (1987)
    2. Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy. (PubMed id 21786366)1, 2 Galmiche L.... Rotig A. (2011)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria. (PubMed id 23892058)1 Dujeancourt L....Herbert C.J. (2013)
    6. p32/gC1qR is indispensable for fetal development and m itochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (2012)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Analysis of the MRPL3, DNAJC13 and OFCC1 variants in C hinese Han patients with TS-CTD. (PubMed id 22507240)1 Guo Y....Deng H. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11222 HGNC: 10379 AceView: MRPL3 Ensembl:ENSG00000114686 euGenes: HUgn11222
    ECgene: MRPL3 Kegg: 11222 H-InvDB: MRPL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPL3 gene:
    Search GeneIP for patents involving MRPL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRPL3   OriGene RNAi products in human, mouse, rat for MRPL3  
     OriGene qPCR primer pairs and template standards for MRPL3   OriGene Protein Over-expression Lysate for MRPL3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MRPL3  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRPL3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MRPL3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRPL3   OriGene Custom Protein Services for MRPL3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL3
     QIAGEN SeqTarget long-range PCR primers for resequencing MRPL3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL3
     GenScript Custom Purified and Recombinant Proteins Services for MRPL3 GenScript cDNA clones with any tag delivered in your preferred vector for MRPL3
     GenScript Custom Assay Services for MRPL3 GenScript Custom Superior Antibodies Services for MRPL3
     GenScript Custom overexpressing Cell Line Services for MRPL3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MRPL3 promoter
     Search Chromatin IP Primers for MRPL3
     RT2 qPCR Primer Assay in human, mouse, rat MRPL3
     Search GNC Networks for MRPL3
     SABiosciences Custom PCR Arrays for MRPL3
     Search Tocris compounds for MRPL3 (RM03)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MRPL3 antibodies
     MRPL3 proteins
     MRPL3 lysates
     Antibodies for MRPL3
     See all of Abcam's Antibodies, Kits and Proteins for MRPL3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MRPL3
     Antibodies for MRPL3
     ELISAs for MRPL3
     CLIAs for MRPL3
     Search LifeMap BioReagents cell lines for MRPL3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL3
     SwitchGear 3'UTR luciferase reporter plasmids for MRPL3
     SwitchGear Promoter luciferase reporter plasmids for MRPL3
     ThermoFisher Antibodies for MRPL3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPL3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRPL3
    Customized:
     lentivirus for stable overexpression of MRPL3
     lentivirus expression plasmids for stable overexpression of MRPL3
     adenovirus for overexpression of MRPL3
     LSBio Antibodies in human, mouse, rat for MRPL3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRPL3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4