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MRPL28 Gene

protein-coding   GIFtS: 57
GCID: GC16M000357

Mitochondrial Ribosomal Protein L28

(Previous name: melanoma-associated antigen recognised by cytotoxic T lymphocytes)
(Previous symbol: MAAT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L281 2     L28mt2 3
MAAT11 2 3 5     MRP-L282 3
Melanoma-Associated Antigen Recognised By Cytotoxic T Lymphocytes1 2     39S Ribosomal Protein L28, Mitochondrial2
Melanoma Antigen P152 3     Melanoma-Associated Antigen Recognized By T Lymphocytes2
Melanoma-Associated Antigen Recognized By T-Lymphocytes2 3     p152

External Ids:    HGNC: 144841   Entrez Gene: 105732   Ensembl: ENSG000000865047   OMIM: 6048535   UniProtKB: Q130843   

Export aliases for MRPL28 gene to outside databases

Previous GC identifers: GC00U990874 GC16M000438


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL28 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an
HLA-A24-restricted fashion. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL28 Gene:
MRPL28 (mitochondrial ribosomal protein L28) is a protein-coding gene. Diseases associated with MRPL28 include placental abruption, and melanoma. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL28 gene promoter:
         c-Fos   AP-1   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL28 promoter sequence
   Search Chromatin IP Primers for MRPL28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.12

MRPL28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL28 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000357:  view genomic region     (about GC identifiers)

Start:
417,384 bp from pter      End:
420,569 bp from pter
Size:
3,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RM28_HUMAN, Q13084 (See protein sequence)
Recommended Name: 39S ribosomal protein L28, mitochondrial precursor  
Size: 256 amino acids; 30157 Da
Subunit: Interacts with OXA1L (By similarity)
Miscellaneous: Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is
recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24
Sequence caution: Sequence=AAC50181.1; Type=Erroneous initiation; Sequence=AAK61226.1; Type=Erroneous gene model
prediction;
Secondary accessions: B2RCM4 D3DU46 Q4TT39 Q96S26 Q9BQD8 Q9BR04

Explore the universe of human proteins at neXtProt for MRPL28: NX_Q13084

Explore proteomics data for MRPL28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus

  • See MRPL28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006419.2  
    ENSEMBL proteins: 
     ENSP00000199706   ENSP00000414038   ENSP00000374326   ENSP00000398684   ENSP00000390399  
     ENSP00000395305  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR026569 Ribo_L28/L24

    Graphical View of Domain Structure for InterPro Entry Q13084

    ProtoNet protein and cluster: Q13084

    UniProtKB/Swiss-Prot: RM28_HUMAN, Q13084
    Similarity: Belongs to the ribosomal protein L28P family


    MRPL28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    MRPL28 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL28
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    miRNA
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    miRTarBase miRNAs that target MRPL28:
    hsa-mir-148b-3p (MIRT019287), hsa-mir-30a-5p (MIRT049955)

    Block miRNA regulation of human, mouse, rat MRPL28 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidMRPL28 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RM28_HUMAN, Q13084: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005761mitochondrial ribosome NAS11543634

    MRPL28 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPL28 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MRPL28):
        Ribosome


    MRPL28 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL28
    Interactions:

        Search GeneGlobe Interaction Network for MRPL28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for MRPL28 (Q130842, 3 ENSP000001997064) via UniProtKB, MINT, STRING, and/or I2D (see all 257)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    TUBB4AP043503, ENSP000002640714I2D: score=1 STRING: ENSP00000264071
    OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634

    MRPL28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL28 (RM28)

    4 Novoseek inferred chemical compound relationships for MRPL28 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chromium 14.8 1 12957571 (1)
    rantes 9.29 1 10917892 (1)
    tyrosine 0 1 19411300 (1)
    pge2 0 2 15618466 (1)



    MRPL28 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRPL28 gene: 
    NM_006428.4  

    Unigene Cluster for MRPL28:

    Mitochondrial ribosomal protein L28
    Hs.513230  [show with all ESTs]
    Unigene Representative Sequence: BM912866
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000199706 ENST00000483764 ENST00000481453 ENST00000429738 ENST00000461550
    ENST00000469744 ENST00000389675 ENST00000441883 ENST00000447696 ENST00000450882

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidMRPL28 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat MRPL28
      QuantiFast Probe-based Assays in human, mouse, rat MRPL28

    Additional mRNA sequence: 

    AK226042.1 AK315180.1 BC000507.2 BC000990.3 BC013829.1 BT009857.1 BX647501.1 CR541751.1 
    U19796.1 

    11 DOTS entries:

    DT.414482  DT.100819881  DT.91756489  DT.100819876  DT.40308781  DT.120692984  DT.97855303  DT.100819879 
    DT.120692878  DT.120692929  DT.95328794 

    Selected AceView cDNA sequences (see all 410):

    BM967214 BC013829 BF981794 BQ681910 BG395438 AW731625 BQ434907 BI862386 
    BE797996 BM912843 NM_006428 CR622823 BC000507 BU857340 BM970944 BM553370 
    BQ953693 BE277769 BM555936 BG757483 CR607877 BF343596 BQ679649 CB850620 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPL28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTTCCAG
    MRPL28 Expression
    About this image


    MRPL28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRPL28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513230

    UniProtKB/Swiss-Prot: RM28_HUMAN, Q13084
    Tissue specificity: Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain,
    adrenal, lung and retinal tissue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPL28 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl281 , 5 mitochondrial ribosomal protein L281, 5 83.46(n)1
    85.04(a)1
      17 (13.07 cM)5
    686111  NM_024227.31  NP_077189.21 
     261235205 
    chicken
    (Gallus gallus)
    Aves --
    MRPL286
    (see all 3)
    Uncharacterized protein
    Gallus gallus mitochondrial ribosomal protein L28 ...
    (see all 3)
    68(a)
    67(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    AADN03010586.1(1774-5343)
    14(12121979-12125813)
    lizard
    (Anolis carolinensis)
    Reptilia MRPL286
    mitochondrial ribosomal protein L28
    64(a)
    1 ↔ 1
    GL344563.1(6021-9421)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154802 Transcribed sequence with moderate similarity to protein more 72.61(n)    141998683 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96b112 Transcribed sequence with weak similarity to protein more 72.16(n)    CK397037.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL286
    mitochondrial ribosomal protein L28
    28(a)
    1 ↔ 1
    2L(4973976-4975316)
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-281 mrpl-28 47.67(n)
    44.93(a)
      173400  NM_061271.4  NP_493672.1 


    ENSEMBL Gene Tree for MRPL28 (if available)
    TreeFam Gene Tree for MRPL28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPL28 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822746931,2
    --416888(+) CTACAA/CCAGAC 1 -- ds50010--------
    rs1878477061,2
    --416962(+) CAACAC/TTTTGG 1 -- ds50010--------
    rs1460227831,2
    C--417035(+) AAACCC/TCTTCT 1 -- ds50010--------
    rs1169817541,2
    F--417072(+) GATAGC/TGGGGT 1 -- ds50011Minor allele frequency- T:0.02EA 120
    rs1929834771,2
    --417073(+) ATAGCA/GGGGTG 1 -- ds50010--------
    rs1138491771,2
    C,F--417099(+) ACTCAG/AGAGGC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs734903051,2
    C--417115(+) CAGGAC/GAATCA 1 -- ds50014Minor allele frequency- G:0.07WA CSA NA 124
    rs1488939321,2
    --417140(+) GTGGAA/GGTTGT 1 -- ds50010--------
    rs1833433581,2
    --417159(+) CAGATA/CGTGCC 1 -- ds50010--------
    rs3949911,2
    C,A,H--417183(+) CTGGGC/TGACTG 1 -- ds500110Minor allele frequency- T:0.00NA WA CSA 19

    HapMap Linkage Disequilibrium report for MRPL28 (417384 - 420569 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MRPL28 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv513440CNV Insertion21212237
    esv1353875CNV Insertion17803354
    dgv2472n71CNV Loss21882294
    nsv904707CNV Loss21882294
    dgv2473n71CNV Loss21882294
    nsv904699CNV Loss21882294
    dgv2474n71CNV Loss21882294
    dgv2469n71CNV Loss21882294
    dgv32n68CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL28
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604853    OMIM disorders: --

    Selected diseases for MRPL28 (see all 29):    
    About MalaCards
    placental abruption    melanoma    hepatitis b virus infection    vaccinia
    hepatitis b    bronchitis    influenza    malaria
    hodgkin's lymphoma    hepatitis c    non-hodgkin lymphoma    hepatitis
    endometriosis    acute myeloid leukemia    lymphoblastic leukemia    inflammatory bowel disease
    osteosarcoma    myeloid leukemia    pancreatic cancer    rheumatoid arthritis


    MRPL28 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MRPL28 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 48.5 16 11565838 (1), 7541714 (1), 15386406 (1), 15289358 (1) (see all 13)
    tumors 45.5 21 1958033 (1), 14704996 (1), 19561536 (1), 11983105 (1) (see all 19)
    cancer 35 12 19738905 (1), 14722670 (1), 20490265 (1), 9286413 (1) (see all 12)
    autoimmune diseases 29.6 3 15592805 (1), 16373368 (1), 20138855 (1)
    immunodeficiency 27.1 1 12437858 (1)
    virus infection 24.5 6 14704996 (1), 18627014 (1), 10466628 (1), 9012587 (1) (see all 6)
    leukemia 20.5 1 11874628 (1)
    autoimmunity 12.1 1 16373368 (1)
    influenza 11.8 2 10421792 (1), 10335482 (1)
    hepatitis b chronic 2.44 1 17064461 (1)

    Genetic Association Database (GAD): MRPL28
    Human Genome Epidemiology (HuGE) Navigator: MRPL28 (1 document)

    Export disorders for MRPL28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPL28 gene, integrated from 10 sources (see all 159):
    (articles sorted by number of sources associating them with MRPL28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    2. Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. (PubMed id 19753307)1, 3, 9 Chen Y....Denko N.C. (PLoS ONE 2009)
    3. Cloning of a new gene encoding an antigen recognized by melanoma- specific HLA-A24-restricted tumor-infiltrating lymphocytes. (PubMed id 7751637)1, 2, 9 Robbins P.F.... Rosenberg S.A. (J. Immunol. 1995)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    9. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10573 HGNC: 14484 AceView: MRPL28 Ensembl:ENSG00000086504 euGenes: HUgn10573
    ECgene: MRPL28 Kegg: 10573 H-InvDB: MRPL28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPL28 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRPL28 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPL28 gene:
    Search GeneIP for patents involving MRPL28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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