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Aliases for MRPL28 Gene

Aliases for MRPL28 Gene

  • Mitochondrial Ribosomal Protein L28 2 3
  • MAAT1 3 4 6
  • Melanoma-Associated Antigen Recognised By Cytotoxic T Lymphocytes 2 3
  • Melanoma-Associated Antigen Recognized By T-Lymphocytes 3 4
  • Melanoma Antigen P15 3 4
  • MRP-L28 3 4
  • L28mt 3 4
  • Melanoma-Associated Antigen Recognized By T Lymphocytes 3
  • 39S Ribosomal Protein L28, Mitochondrial 3
  • P15 3

External Ids for MRPL28 Gene

Previous HGNC Symbols for MRPL28 Gene

  • MAAT1

Previous GeneCards Identifiers for MRPL28 Gene

  • GC00U990874
  • GC16M000438

Summaries for MRPL28 Gene

Entrez Gene Summary for MRPL28 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL28 Gene

MRPL28 (Mitochondrial Ribosomal Protein L28) is a Protein Coding gene. Diseases associated with MRPL28 include melanoma and hepatitis b. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL28 Gene

Genomics for MRPL28 Gene

Regulatory Elements for MRPL28 Gene

Transcription factor binding sites by QIAGEN in the MRPL28 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL28 Gene

Start:
367,384 bp from pter
End:
370,584 bp from pter
Size:
3,201 bases
Orientation:
Minus strand

Genomic View for MRPL28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL28 Gene

Proteins for MRPL28 Gene

  • Protein details for MRPL28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13084-RM28_HUMAN
    Recommended name:
    39S ribosomal protein L28, mitochondrial
    Protein Accession:
    Q13084
    Secondary Accessions:
    • B2RCM4
    • D3DU46
    • Q4TT39
    • Q96S26
    • Q9BQD8
    • Q9BR04

    Protein attributes for MRPL28 Gene

    Size:
    256 amino acids
    Molecular mass:
    30157 Da
    Quaternary structure:
    • Interacts with OXA1L.
    Miscellaneous:
    • Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24
    SequenceCaution:
    • Sequence=AAC50181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK61226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MRPL28 Gene

Proteomics data for MRPL28 Gene at MOPED

Post-translational modifications for MRPL28 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL28 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL28 Gene

Domains for MRPL28 Gene

Gene Families for MRPL28 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL28 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL28 Gene

Graphical View of Domain Structure for InterPro Entry

Q13084

UniProtKB/Swiss-Prot:

RM28_HUMAN :
  • Q13084
Family:
  • Belongs to the ribosomal protein L28P family.
genes like me logo Genes that share domains with MRPL28: view

Function for MRPL28 Gene

Gene Ontology (GO) - Molecular Function for MRPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0005515 protein binding IPI 20601428
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL28: view

Animal Model Products

CRISPR Products

miRNA for MRPL28 Gene

miRTarBase miRNAs that target MRPL28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL28

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL28 Gene

Localization for MRPL28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL28 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL28 Gene COMPARTMENTS Subcellular localization image for MRPL28 gene
Compartment Confidence
mitochondrion 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MRPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL28: view

Pathways for MRPL28 Gene

SuperPathways for MRPL28 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL28: view

Pathways by source for MRPL28 Gene

1 KEGG pathway for MRPL28 Gene

Gene Ontology (GO) - Biological Process for MRPL28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL28: view

Compounds for MRPL28 Gene

(4) Novoseek inferred chemical compound relationships for MRPL28 Gene

Compound -log(P) Hits PubMed IDs
chromium 14.8 1
rantes 9.29 1
tyrosine 0 1
pge2 0 1
genes like me logo Genes that share compounds with MRPL28: view

Transcripts for MRPL28 Gene

Unigene Clusters for MRPL28 Gene

Mitochondrial ribosomal protein L28:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL28

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL28 Gene

No ASD Table

Relevant External Links for MRPL28 Gene

GeneLoc Exon Structure for
MRPL28
ECgene alternative splicing isoforms for
MRPL28

Expression for MRPL28 Gene

mRNA expression in normal human tissues for MRPL28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL28 Gene

SOURCE GeneReport for Unigene cluster for MRPL28 Gene Hs.513230

mRNA Expression by UniProt/SwissProt for MRPL28 Gene

Q13084-RM28_HUMAN
Tissue specificity: Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue
genes like me logo Genes that share expressions with MRPL28: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MRPL28 Gene

Orthologs for MRPL28 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL28 35
  • 93.31 (n)
  • 91.34 (a)
cow
(Bos Taurus)
Mammalia MRPL28 35
  • 85.04 (n)
  • 86.61 (a)
MRPL28 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL28 35
  • 78.61 (n)
  • 76.77 (a)
MRPL28 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl28 35
  • 83.46 (n)
  • 85.04 (a)
Mrpl28 16
Mrpl28 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL28 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL28 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl28 35
  • 83.07 (n)
  • 84.65 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 68 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
MRPL28 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MRPL28 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl28 35
  • 62.98 (n)
  • 69.17 (a)
Str.15480 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10905 35
zebrafish
(Danio rerio)
Actinopterygii mrpl28 35
  • 68.65 (n)
  • 67.06 (a)
mrpl28 36
  • 67 (a)
OneToOne
wufa96b11 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL28 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-28 35
  • 47.67 (n)
  • 44.93 (a)
mrpl-28 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3134 36
  • 40 (a)
OneToOne
Species with no ortholog for MRPL28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL28 Gene

ENSEMBL:
Gene Tree for MRPL28 (if available)
TreeFam:
Gene Tree for MRPL28 (if available)

Paralogs for MRPL28 Gene

No data available for Paralogs for MRPL28 Gene

Variants for MRPL28 Gene

Sequence variations from dbSNP and Humsavar for MRPL28 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs13226 - 367,757(-) GATCT(A/G)TGTGG reference, missense
rs394991 -- 367,183(+) CTGGG(C/T)GACTG downstream-variant-500B
rs424224 -- 369,636(-) GTGGG(A/G)GAGGC intron-variant
rs1053604 -- 367,693(-) CAGAA(A/G)AGAGC synonymous-codon, reference
rs1053623 -- 367,536(-) CATGC(A/C)CCTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL28 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2466n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2472n71 CNV Loss 21882294
dgv2473n71 CNV Loss 21882294
nsv904699 CNV Loss 21882294
nsv904700 CNV Loss 21882294
nsv904707 CNV Loss 21882294
nsv517471 CNV Loss 19592680
nsv827478 CNV Gain 20364138
dgv2474n71 CNV Loss 21882294
nsv513440 CNV Insertion 21212237
esv1353875 CNV Insertion 17803354

Relevant External Links for MRPL28 Gene

HapMap Linkage Disequilibrium report
MRPL28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL28 Gene

Disorders for MRPL28 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MRPL28 Gene including...

Search for MRPL28 Gene in MalaCards »

(16) Novoseek inferred disease relationships for MRPL28 Gene

Disease -log(P) Hits PubMed IDs
melanoma 48.5 13
tumors 45.5 19
cancer 35 12
autoimmune diseases 29.6 3
immunodeficiency 27.1 1

Relevant External Links for MRPL28

Genetic Association Database (GAD)
MRPL28
Human Genome Epidemiology (HuGE) Navigator
MRPL28
genes like me logo Genes that share disorders with MRPL28: view

No data available for UniProtKB/Swiss-Prot for MRPL28 Gene

Publications for MRPL28 Gene

  1. Cloning of a new gene encoding an antigen recognized by melanoma- specific HLA-A24-restricted tumor-infiltrating lymphocytes. (PMID: 7751637) Robbins P.F. … Rosenberg S.A. (J. Immunol. 1995) 3 4 23
  2. Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. (PMID: 19753307) Chen Y. … Denko N.C. (PLoS ONE 2009) 2 3 23
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  4. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MRPL28 Gene

Sources for MRPL28 Gene

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