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Aliases for MRPL27 Gene

Aliases for MRPL27 Gene

  • Mitochondrial Ribosomal Protein L27 2 3
  • MRP-L27 3 4
  • L27mt 3 4
  • 39S Ribosomal Protein L27, Mitochondrial 3

External Ids for MRPL27 Gene

Summaries for MRPL27 Gene

Entrez Gene Summary for MRPL27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL27 Gene

MRPL27 (Mitochondrial Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL27 Gene

Genomics for MRPL27 Gene

Genomic Location for MRPL27 Gene

Start:
50,367,857 bp from pter
End:
50,373,214 bp from pter
Size:
5,358 bases
Orientation:
Minus strand

Genomic View for MRPL27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL27 Gene

Regulatory Elements for MRPL27 Gene

Proteins for MRPL27 Gene

  • Protein details for MRPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M9-RM27_HUMAN
    Recommended name:
    39S ribosomal protein L27, mitochondrial
    Protein Accession:
    Q9P0M9
    Secondary Accessions:
    • B2RE14

    Protein attributes for MRPL27 Gene

    Size:
    148 amino acids
    Molecular mass:
    16073 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL27 Gene

neXtProt entry for MRPL27 Gene

Proteomics data for MRPL27 Gene at MOPED

Post-translational modifications for MRPL27 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys122

Other Protein References for MRPL27 Gene

No data available for DME Specific Peptides for MRPL27 Gene

Domains for MRPL27 Gene

Gene Families for MRPL27 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL27 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RM27_HUMAN
Family:
  • Belongs to the ribosomal protein L27P family.:
    • Q9P0M9
genes like me logo Genes that share domains with MRPL27: view

Function for MRPL27 Gene

Gene Ontology (GO) - Molecular Function for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279069
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL27: view

Phenotypes for MRPL27 Gene

GenomeRNAi human phenotypes for MRPL27:
genes like me logo Genes that share phenotypes with MRPL27: view

miRNA for MRPL27 Gene

miRTarBase miRNAs that target MRPL27

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL27 Gene

Localization for MRPL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL27 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL27 Gene COMPARTMENTS Subcellular localization image for MRPL27 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit NAS 11279069
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL27: view

Pathways for MRPL27 Gene

SuperPathways for MRPL27 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL27: view

Pathways by source for MRPL27 Gene

1 KEGG pathway for MRPL27 Gene

Gene Ontology (GO) - Biological Process for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279069
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL27: view

Transcripts for MRPL27 Gene

Unigene Clusters for MRPL27 Gene

Mitochondrial ribosomal protein L27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL27 Gene

No ASD Table

Relevant External Links for MRPL27 Gene

GeneLoc Exon Structure for
MRPL27
ECgene alternative splicing isoforms for
MRPL27

Expression for MRPL27 Gene

mRNA expression in normal human tissues for MRPL27 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MRPL27 Gene

SOURCE GeneReport for Unigene cluster for MRPL27 Gene Hs.7736

genes like me logo Genes that share expressions with MRPL27: view

Orthologs for MRPL27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL27 36
  • 99.55 (n)
  • 99.32 (a)
MRPL27 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL27 36
  • 88.06 (n)
  • 85.81 (a)
MRPL27 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL27 36
  • 85.81 (n)
  • 82.43 (a)
MRPL27 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl27 36
  • 83.56 (n)
  • 83.11 (a)
Mrpl27 16
Mrpl27 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL27 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL27 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl27 36
  • 81.98 (n)
  • 81.08 (a)
chicken
(Gallus gallus)
Aves MRPL27 36
  • 62.37 (n)
  • 69.7 (a)
lizard
(Anolis carolinensis)
Reptilia MRPL27 37
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8174 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl27 36
  • 61.87 (n)
  • 61.87 (a)
Str.16304 36
zebrafish
(Danio rerio)
Actinopterygii mrpl27 36
  • 64.37 (n)
  • 69.66 (a)
mrpl27 37
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002470 36
  • 48.78 (n)
  • 43.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL27 36
  • 46.15 (n)
  • 41.88 (a)
mRpL27 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP7 37
  • 12 (a)
OneToOne
MRP7 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4967 37
  • 34 (a)
OneToOne
Species with no ortholog for MRPL27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL27 Gene

ENSEMBL:
Gene Tree for MRPL27 (if available)
TreeFam:
Gene Tree for MRPL27 (if available)

Paralogs for MRPL27 Gene

No data available for Paralogs for MRPL27 Gene

Variants for MRPL27 Gene

Sequence variations from dbSNP and Humsavar for MRPL27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1043916 -- 50,367,986(-) GAGGT(C/T)TGCTT utr-variant-3-prime
rs1043924 -- 50,367,958(-) AGACT(C/T)TGAAG utr-variant-3-prime
rs2586438 -- 50,368,338(-) ACCTC(A/G)CTGAC intron-variant
rs4638629 -- 50,368,731(+) ATATA(A/G)ACCAA intron-variant
rs4793651 -- 50,369,764(+) ACACC(A/G)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL27 Gene

Variant ID Type Subtype PubMed ID
nsv833475 CNV Loss 17160897
nsv833476 CNV Loss 17160897
nsv519530 CNV Loss 19592680

Relevant External Links for MRPL27 Gene

HapMap Linkage Disequilibrium report
MRPL27

Disorders for MRPL27 Gene

Relevant External Links for MRPL27

Genetic Association Database (GAD)
MRPL27
Human Genome Epidemiology (HuGE) Navigator
MRPL27
genes like me logo Genes that share disorders with MRPL27: view

No data available for UniProtKB/Swiss-Prot for MRPL27 Gene

Publications for MRPL27 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for MRPL27 Gene

Sources for MRPL27 Gene

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