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Aliases for MRPL27 Gene

Aliases for MRPL27 Gene

  • Mitochondrial Ribosomal Protein L27 2 3 5
  • MRP-L27 3 4
  • L27mt 3 4

External Ids for MRPL27 Gene

Previous GeneCards Identifiers for MRPL27 Gene

  • GC17M048158
  • GC17M050926
  • GC17M048787
  • GC17M048919
  • GC17M045800
  • GC17M048445
  • GC17M043813

Summaries for MRPL27 Gene

Entrez Gene Summary for MRPL27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL27 Gene

MRPL27 (Mitochondrial Ribosomal Protein L27) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL27 Gene

Genomics for MRPL27 Gene

Regulatory Elements for MRPL27 Gene

Promoters for MRPL27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL27 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL27 Gene

Chromosome:
17
Start:
50,367,857 bp from pter
End:
50,373,214 bp from pter
Size:
5,358 bases
Orientation:
Minus strand

Genomic View for MRPL27 Gene

Genes around MRPL27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL27 Gene

Proteins for MRPL27 Gene

  • Protein details for MRPL27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M9-RM27_HUMAN
    Recommended name:
    39S ribosomal protein L27, mitochondrial
    Protein Accession:
    Q9P0M9
    Secondary Accessions:
    • B2RE14

    Protein attributes for MRPL27 Gene

    Size:
    148 amino acids
    Molecular mass:
    16073 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL27 Gene

neXtProt entry for MRPL27 Gene

Proteomics data for MRPL27 Gene at MOPED

Post-translational modifications for MRPL27 Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL27 Gene

No data available for DME Specific Peptides for MRPL27 Gene

Domains & Families for MRPL27 Gene

Gene Families for MRPL27 Gene

Protein Domains for MRPL27 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P0M9

UniProtKB/Swiss-Prot:

RM27_HUMAN :
  • Belongs to the ribosomal protein L27P family.
Family:
  • Belongs to the ribosomal protein L27P family.
genes like me logo Genes that share domains with MRPL27: view

Function for MRPL27 Gene

Phenotypes for MRPL27 Gene

genes like me logo Genes that share phenotypes with MRPL27: view

Animal Model Products

miRNA for MRPL27 Gene

miRTarBase miRNAs that target MRPL27

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL27 Gene

Localization for MRPL27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL27 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL27 Gene COMPARTMENTS Subcellular localization image for MRPL27 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL27: view

Pathways & Interactions for MRPL27 Gene

genes like me logo Genes that share pathways with MRPL27: view

Gene Ontology (GO) - Biological Process for MRPL27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279069
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL27: view

No data available for SIGNOR curated interactions for MRPL27 Gene

Drugs & Compounds for MRPL27 Gene

No Compound Related Data Available

Transcripts for MRPL27 Gene

Unigene Clusters for MRPL27 Gene

Mitochondrial ribosomal protein L27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL27 Gene

No ASD Table

Relevant External Links for MRPL27 Gene

GeneLoc Exon Structure for
MRPL27
ECgene alternative splicing isoforms for
MRPL27

Expression for MRPL27 Gene

mRNA expression in normal human tissues for MRPL27 Gene

Protein differential expression in normal tissues from HIPED for MRPL27 Gene

This gene is overexpressed in Lung (21.5), Breast (16.1), and Liver (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPL27 Gene



SOURCE GeneReport for Unigene cluster for MRPL27 Gene Hs.7736

genes like me logo Genes that share expression patterns with MRPL27: view

Protein tissue co-expression partners for MRPL27 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL27 Gene

Orthologs for MRPL27 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL27 35
  • 99.55 (n)
  • 99.32 (a)
MRPL27 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL27 36
  • 86 (a)
OneToOne
MRPL27 35
  • 88.06 (n)
  • 85.81 (a)
dog
(Canis familiaris)
Mammalia MRPL27 35
  • 85.81 (n)
  • 82.43 (a)
MRPL27 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl27 36
  • 83 (a)
OneToOne
Mrpl27 16
Mrpl27 35
  • 83.56 (n)
  • 83.11 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL27 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL27 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl27 35
  • 81.98 (n)
  • 81.08 (a)
chicken
(Gallus gallus)
Aves MRPL27 35
  • 62.37 (n)
  • 69.7 (a)
lizard
(Anolis carolinensis)
Reptilia MRPL27 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8174 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl27 35
  • 61.87 (n)
  • 61.87 (a)
Str.16304 35
zebrafish
(Danio rerio)
Actinopterygii mrpl27 35
  • 64.37 (n)
  • 69.66 (a)
mrpl27 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002470 35
  • 48.78 (n)
  • 43.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL27 35
  • 46.15 (n)
  • 41.88 (a)
mRpL27 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP7 36
  • 12 (a)
OneToOne
MRP7 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4967 36
  • 34 (a)
OneToOne
Species with no ortholog for MRPL27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL27 Gene

ENSEMBL:
Gene Tree for MRPL27 (if available)
TreeFam:
Gene Tree for MRPL27 (if available)

Paralogs for MRPL27 Gene

No data available for Paralogs for MRPL27 Gene

Variants for MRPL27 Gene

Sequence variations from dbSNP and Humsavar for MRPL27 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17776919 - 50,370,557(+) AGCTG(C/T)AGCCG reference, missense
rs4793651 -- 50,369,764(+) ACACC(A/G)GGGCA intron-variant
rs4638629 -- 50,368,731(+) ATATA(A/G)ACCAA intron-variant
rs7212696 -- 50,369,546(+) CCTAA(C/T)TCCTG intron-variant
rs9911773 -- 50,370,038(+) TGGGC(A/C)CCTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MRPL27 Gene

Variant ID Type Subtype PubMed ID
nsv833475 CNV Loss 17160897
nsv833476 CNV Loss 17160897
nsv519530 CNV Loss 19592680

Variation tolerance for MRPL27 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL27 Gene

HapMap Linkage Disequilibrium report
MRPL27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL27 Gene

Disorders for MRPL27 Gene

Relevant External Links for MRPL27

Genetic Association Database (GAD)
MRPL27
Human Genome Epidemiology (HuGE) Navigator
MRPL27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL27

No disorders were found for MRPL27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL27 Gene

Publications for MRPL27 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for MRPL27 Gene

Sources for MRPL27 Gene

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