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Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL24m 3 4
  • MRP-L24 3 4
  • L24mt 3 4
  • 39S Ribosomal Protein L24, Mitochondrial 3
  • MRP-L18 3

External Ids for MRPL24 Gene

Previous GeneCards Identifiers for MRPL24 Gene

  • GC01M154576
  • GC01M152472
  • GC01M153480
  • GC01M153923
  • GC01M153520
  • GC01M154973
  • GC01M156707
  • GC01M128064

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

Additional gene information for MRPL24 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

Regulatory Elements for MRPL24 Gene

Enhancers for MRPL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156765 1.7 Ensembl ENCODE dbSUPER 18.9 -26.4 -26356 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RRNAD1 GON4L KIAA0907 LOC246784 ISG20L2 CCT3 MRPL24 LRRC71 ENSG00000229961 ENSG00000233712
GH01H156804 1.3 FANTOM5 Ensembl dbSUPER 14.8 -63.1 -63111 0 MAZ ZBTB11 CEBPB MAFG ZNF398 ZNF316 ZBTB48 ZNF341 IKZF1 NFE2 MRPL24 INSRR PEAR1 LRRC71 ISG20L2 RRNAD1 HDGF MIR765 ARHGEF11 C1orf61
GH01H156456 1.8 FANTOM5 ENCODE dbSUPER 9.2 +284.2 284214 2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KIAA0907 GON4L ENSG00000271267 LOC246784 RRNAD1 ASH1L LMNA MSTO2P DAP3P1 ENSG00000229961
GH01H156740 1.9 FANTOM5 ENCODE dbSUPER 8.6 -5.3 -5273 13 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D SSRP1 GON4L RRNAD1 KIAA0907 LOC246784 CCT3 SYT11 HDGF ISG20L2 LMNA TSACC
GH01H156801 0.9 ENCODE dbSUPER 16.2 -60.0 -60014 0 CTCF ZNF654 STAT1 REST JUND POLR2A IKZF1 FOXP2 RCOR1 MRPL24 INSRR PEAR1 LRRC71 HDGF PRCC ISG20L2 RRNAD1 ENSG00000223356 MIR765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL24 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014245 790 1201 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MRPL24 Gene

Chromosome:
1
Start:
156,737,302 bp from pter
End:
156,741,590 bp from pter
Size:
4,289 bases
Orientation:
Minus strand

Genomic View for MRPL24 Gene

Genes around MRPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A35-RM24_HUMAN
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Q96A35
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    Size:
    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

No data available for DME Specific Peptides for MRPL24 Gene

Domains & Families for MRPL24 Gene

Gene Families for MRPL24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A35

UniProtKB/Swiss-Prot:

RM24_HUMAN :
  • Belongs to the universal ribosomal protein uL24 family.
Family:
  • Belongs to the universal ribosomal protein uL24 family.
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

Phenotypes From GWAS Catalog for MRPL24 Gene

Gene Ontology (GO) - Molecular Function for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view
genes like me logo Genes that share phenotypes with MRPL24: view

Animal Model Products

CRISPR Products

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 5
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL24 Gene

Pathways & Interactions for MRPL24 Gene

genes like me logo Genes that share pathways with MRPL24: view

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for SIGNOR curated interactions for MRPL24 Gene

Drugs & Compounds for MRPL24 Gene

No Compound Related Data Available

Transcripts for MRPL24 Gene

Unigene Clusters for MRPL24 Gene

Mitochondrial ribosomal protein L24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL24
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
MRPL24
ECgene alternative splicing isoforms for
MRPL24

Expression for MRPL24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL24 Gene

Protein differential expression in normal tissues from HIPED for MRPL24 Gene

This gene is overexpressed in Breast (21.8), Pancreas (7.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL24 Gene



Protein tissue co-expression partners for MRPL24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL24 Gene:

MRPL24

SOURCE GeneReport for Unigene cluster for MRPL24 Gene:

Hs.418233

Evidence on tissue expression from TISSUES for MRPL24 Gene

  • Bone marrow(4.2)
  • Nervous system(2.3)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with MRPL24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL24 Gene

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL24 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia MRPL24 33 34
  • 88.58 (n)
dog
(Canis familiaris)
Mammalia MRPL24 33 34
  • 88.12 (n)
rat
(Rattus norvegicus)
Mammalia mrpl24 33
  • 85.65 (n)
mouse
(Mus musculus)
Mammalia Mrpl24 33 16 34
  • 84.88 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL24 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 64 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves MRPL24 33 34
  • 63.8 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL24 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl24 33
  • 66.51 (n)
Str.10244 33
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 33
zebrafish
(Danio rerio)
Actinopterygii mrpl24 33 34
  • 63.27 (n)
Dr.9429 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 33
  • 54.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 35 33 34
  • 53.74 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-24 33 34
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 34
  • 34 (a)
OneToOne
Species where no ortholog for MRPL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

ENSEMBL:
Gene Tree for MRPL24 (if available)
TreeFam:
Gene Tree for MRPL24 (if available)

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Sequence variations from dbSNP and Humsavar for MRPL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000389800 -- 156,740,947(+) TTCCG(A/G)TGCAA intron-variant, utr-variant-5-prime
rs1000464108 -- 156,741,091(+) CATGG(A/G)CCCTC intron-variant, utr-variant-5-prime
rs1000659619 -- 156,737,793(+) AAGAG(-/GT)GAGCC intron-variant
rs1001011810 -- 156,738,048(+) TCCAC(A/C)AGTTT reference, synonymous-codon
rs1001253811 -- 156,741,351(+) TGGAG(C/G)CCGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for MRPL24 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL24 Gene

Disorders for MRPL24 Gene

Relevant External Links for MRPL24

Genetic Association Database (GAD)
MRPL24
Human Genome Epidemiology (HuGE) Navigator
MRPL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL24

No disorders were found for MRPL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL24 Gene

Publications for MRPL24 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for MRPL24 Gene

Sources for MRPL24 Gene

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