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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL24 Gene

protein-coding   GIFtS: 55
GCID: GC01M156707

Mitochondrial Ribosomal Protein L24

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L241 2
L24mt2 3
MRP-L242 3
39S Ribosomal Protein L24, Mitochondrial2
MRP-L182

External Ids:    HGNC: 140371   Entrez Gene: 795902   Ensembl: ENSG000001433147   OMIM: 6118365   UniProtKB: Q96A353   

Export aliases for MRPL24 gene to outside databases

Previous GC identifers: GC01M154576 GC01M152472 GC01M153480 GC01M153923 GC01M153520 GC01M154973 GC01M128064


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL24 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis
identified two transcript variants that encode the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL24 Gene: 
MRPL24 (mitochondrial ribosomal protein L24) is a protein-coding gene. Diseases associated with MRPL24 include pneumonia, and tuberculosis, and among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL24 gene promoter:
         E2F-4   E2F-3a   STAT1   E2F-5   STAT6   E2F-2   STAT1alpha   E2F   E2F-1   Ik-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL24 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

MRPL24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL24 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156707:  view genomic region     (about GC identifiers)

Start:
156,707,094 bp from pter      End:
156,711,382 bp from pter
Size:
4,289 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RM24_HUMAN, Q96A35 (See protein sequence)
Recommended Name: 39S ribosomal protein L24, mitochondrial precursor  
Size: 216 amino acids; 24915 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: D3DVC8 Q53G65 Q53HT0 Q5SYZ9 Q5SZ00 Q5SZ02 Q96Q70 Q9H7G3

Explore the universe of human proteins at neXtProt for MRPL24: NX_Q96A35

Explore proteomics data for MRPL24 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A35

  • MRPL24 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPL24 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_078816.2  NP_663781.1  

    ENSEMBL proteins: 
     ENSP00000354525   ENSP00000357194   ENSP00000411369   ENSP00000406681   ENSP00000409803  

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    Cloud-Clone Corp. Proteins for MRPL24 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome IEA--

    MRPL24 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPL: Mitochondrial ribosomal proteins / large subunits

    5 InterPro protein domains:
     IPR005825 Ribosomal_L24/26_CS
     IPR008991 Translation_prot_SH3-like
     IPR005824 KOW
     IPR014722 Rib_L2_dom2
     IPR003256 Ribosomal_L24

    Graphical View of Domain Structure for InterPro Entry Q96A35

    ProtoNet protein and cluster: Q96A35

    2 Blocks protein domains:
    IPB003256 Ribosomal protein L24
    IPB006646 KOW (Kyprides


    UniProtKB/Swiss-Prot: RM24_HUMAN, Q96A35
    Similarity: Belongs to the ribosomal protein L24P family
    Similarity: Contains 1 KOW domain


    MRPL24 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    MRPL24 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPL24 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPL24):
        Ribosome


    MRPL24 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL24

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/255 Interacting proteins for MRPL24 (Q96A352, 3 ENSP000003545254) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    MRPL11Q9Y3B72, ENSP000003088974MINT-8079030 STRING: ENSP00000308897
    MRPL12P528152, ENSP000003338374MINT-8079030 STRING: ENSP00000333837
    MRPL19P494062, ENSP000003774864MINT-8079030 STRING: ENSP00000377486
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    MRPL24 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL24 (RM24)

    Search CenterWatch for drugs/clinical trials and news about MRPL24 / RM24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPL24 gene (2 alternative transcripts): 
    NM_024540.3  NM_145729.2  

    Unigene Cluster for MRPL24:

    Mitochondrial ribosomal protein L24
    Hs.418233  [show with all ESTs]
    Unigene Representative Sequence: BQ883105
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478899 ENST00000361531(uc001fpx.1) ENST00000368211(uc001fpw.1)
    ENST00000434558 ENST00000412846 ENST00000420938
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK024570.1 AK222500.1 AK223066.1 BC012440.1 BC016700.1 CR457329.1 

    10 DOTS entries:

    DT.455523  DT.95167633  DT.100754116  DT.97846659  DT.100754117  DT.40203738  DT.91742183  DT.95167635 
    DT.97788548  DT.102824841 

    24/194 AceView cDNA sequences (see all 194):

    CF130407 CF130269 BM853107 BM674120 BQ030430 BM314336 BM798601 CF529424 
    BM761551 BU687264 AI927577 BU682818 BM701213 BM466842 BE535342 CA429913 
    AA557627 BM694542 BU195299 BE866662 BQ948269 BG698167 BM851091 BM825088 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
    SP1:                          -               
    SP2:                                          


    ECgene alternative splicing isoforms for MRPL24

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGATCAAGG
    MRPL24 Expression
    About this image


    See MRPL24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL24

    SOURCE GeneReport for Unigene cluster: Hs.418233
        SABiosciences Custom PCR Arrays for MRPL24
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL24

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPL24 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl241 , 5 mitochondrial ribosomal protein L241, 5 84.88(n)1
    87.96(a)1
      3 (38.78 cM)5
    677071  NM_026591.31  NP_080867.21 
     879195065 
    chicken
    (Gallus gallus)
    Aves MRPL241 mitochondrial ribosomal protein L24 64.76(n)
    65.62(a)
      768957  XM_001232127.2  XP_001232128.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL246
    Uncharacterized protein
    67(a)
    1 ↔ 1
    GL343640.1(222232-228677)
    African clawed frog
    (Xenopus laevis)
    Amphibia rpl24-A2 ribosomal protein L24 73.2(n)    Y17113.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.94292 Transcribed sequence with weak similarity to protein more 74.96(n)    BQ617697.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL241 , 3 protein biosynthesis structural
    constituent of more3
    mitochondrial ribosomal protein L241
    47(a)3
    53.74(n)1
    50.51(a)1
      25B43
    337031  NM_078752.21  NP_523476.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-241 Protein MRPL-24 50.19(n)
    43.6(a)
      172204  NM_059212.2  NP_491613.1 


    ENSEMBL Gene Tree for MRPL24 (if available)
    TreeFam Gene Tree for MRPL24 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/118 SNPs in MRPL24 are shown (see all 118)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008705771,2
    C--156707368(+) CTTGCC/TAACTT 2 -- int10--------
    rs66703551,2
    C,F,H--156707375(+) ACTTTC/TATTAA 2 -- int110Minor allele frequency- T:0.01NS EA NA WA 1092
    rs2001594491,2
    C--156707393(+) TACTCT/CCACTC 2 -- int11Minor allele frequency- C:0.00EU 1323
    rs1122502791,2
    C--156707437(+) TCTCAC/G/TCAATC 2 -- spd11CSA 1
    rs1149411581,2
    C,F--156707553(+) CACTCG/CATCTC 4 /I /M mis12Minor allele frequency- C:0.01WA NA 4670
    rs1882859351,2
    C--156707572(+) TCCTGA/GTGGAT 2 -- int10--------
    rs2005739801,2
    C--156707582(+) TAGAAC/GAGGTG 2 -- int10--------
    rs115810441,2
    C,F,A,H--156707697(+) TACCCG/ACAGGG 2 -- int126Minor allele frequency- A:0.36NS EA NA WA 2714
    rs2020105501,2
    --156707773(+) GCACTC/TTTTGG 2 -- int10--------
    rs66701221,2
    C,F,H--156707775(+) ACTTTG/TTGGAC 2 -- int124Minor allele frequency- T:0.07NS EA NA WA CSA 1657

    HapMap Linkage Disequilibrium report for MRPL24 (156707094 - 156711382 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRPL24:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831648CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL24
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL24

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611836    OMIM disorders: --

    2 diseases for MRPL24:    About MalaCards
    pneumonia    tuberculosis


    MRPL24 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL24
    Human Genome Epidemiology (HuGE) Navigator: MRPL24 (1 document)

    Export disorders for MRPL24 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL24 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRPL24)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
    6. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79590 HGNC: 14037 AceView: MRPL24 Ensembl:ENSG00000143314 euGenes: HUgn79590
    ECgene: MRPL24 Kegg: 79590 H-InvDB: MRPL24

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL24 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPL24 gene:
    Search GeneIP for patents involving MRPL24

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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