MRPL24 Gene
protein-coding GIFtS: 49
GCID: GC01M156707
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mitochondrial ribosomal protein L24
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Aliases
for MRPL24 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L241 2 | | MRP-L181 2 | | L24mt2 3 | | MRP-L242 3 | | 39S Ribosomal Protein L24, Mitochondrial2 |
Export aliases for MRPL24 gene to outside databasesPrevious GC identifers: GC01M154576 GC01M152472 GC01M153480 GC01M153923 GC01M153520 GC01M154973 GC01M128064 |
Summaries
for MRPL24 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL24:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit proteinwhich is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcriptvariants that encode the same protein. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPL24
|
Genomic Views
for MRPL24 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL24 gene promoter:
E2F-4 E2F-3a STAT1 E2F-5 STAT6 E2F-2 STAT1alpha E2F E2F-1 Ik-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL24
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL24 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q23.1 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q23.1MRPL24 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M156707: view genomic region
(about GC identifiers)
Start:
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156,707,094 bp from pter |
End:
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156,711,382 bp from pter |
Size:
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4,289 bases |
Orientation:
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minus strand |
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Proteins
for MRPL24 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM24_HUMAN, Q96A35 (See
protein sequence)Recommended Name: 39S ribosomal protein L24, mitochondrial precursor Size: 216 amino acids; 24915 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: D3DVC8 Q53G65 Q53HT0 Q5SYZ9 Q5SZ00 Q5SZ02 Q96Q70 Q9H7G3Explore the universe of human proteins at neXtProt for MRPL24: NX_Q96A35
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96A35
MRPL24 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_078816.2 NP_663781.1
ENSEMBL proteins: ENSP00000354525 ENSP00000357194 ENSP00000411369 ENSP00000406681 ENSP00000409803
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL24 for ontologies About GeneDecksing
MRPL24 Antibody Products:
Assay Products for MRPL24: |
Protein
Domains /
Families
for MRPL24 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL24 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96A35ProtoNet protein and cluster: Q96A35 2 Blocks protein families: IPB003256 Ribosomal protein L24 IPB006646 KOW (Kyprides
UniProtKB/Swiss-Prot: RM24_HUMAN, Q96A35Similarity: Belongs to the ribosomal protein L24P familySimilarity: Contains 1 KOW domain |
Function
for MRPL24 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL24 (NM_145729) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL24 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL24 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL24 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPL24 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPL24 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL24
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/241 Interacting proteins for MRPL24 (Q96A352, 3 ENSP000003545254) via UniProtKB, MINT, STRING, and/or I2D (see all 241)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPL24 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL24 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL24
Search CenterWatch for drugs/clinical trials and news about MRPL24 / RM24
|
Transcripts
for MRPL24 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL24 gene (2 alternative transcripts): NM_024540.3 NM_145729.2 Unigene Cluster for MRPL24: Mitochondrial ribosomal protein L24 Hs.418233 [show with all ESTs]Unigene Representative Sequence: BQ8831056 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478899 ENST00000361531(uc001fpx.1) ENST00000368211(uc001fpw.1)
ENST00000434558 ENST00000412846 ENST00000420938
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPL24 (NM_145729) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL24 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL24 |
Additional cDNA sequence: AK024570.1 AK222500.1 AK223066.1 BC012440.1 BC016700.1 CR457329.1 10 DOTS entries: DT.455523 DT.95167633 DT.100754116 DT.97846659 DT.100754117 DT.40203738 DT.91742183 DT.95167635 DT.97788548 DT.102824841 24/194 AceView cDNA sequences (see all 194): AI888327 BM464190 BU186912 AA312467 AI457174 NM_024540 BM853107 CA748574 BQ213895 BM781975 BE866662 BI855916 AI631373 BU681014 BM674120 BM825088 BM723869 BM314336 BU195299 AI927577 BM701213 CB156945 BM466842 BQ678120
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL24
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Expression
for MRPL24 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL24 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATCAAGG
About this image
See MRPL24 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL24
SOURCE GeneReport for Unigene cluster: Hs.418233
SABiosciences Custom PCR Arrays for MRPL24
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL24
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL24 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL24 |
Orthologs
for MRPL24 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPL24 gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for MRPL24 (if available)
TreeFam Gene Tree for MRPL24 (if available) |
Paralogs
for MRPL24 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL24 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL24 (156707094 - 156711382 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL24: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL24 |
|
Disorders
/ Diseases
for MRPL24 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL24 for disorders About GeneDecksing
OMIM gene information: 611836
OMIM disorders: --
4  diseases for MRPL24: About MalaCardspneumonia tuberculosis malaria mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRPL24 (1 document)
Export disorders for MRPL24 gene to outside databases
|
Publications
for MRPL24 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL24 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MRPL24) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
|
External Searches for MRPL24 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL24 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL24 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL24 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL24 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL24 gene:
Search GeneIP for patents involving MRPL24
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL24 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL24 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL24 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL24 | | | OriGene Protein Over-expression Lysate for MRPL24 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL24 | | OriGene 3'-UTR Clone for MRPL24 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL24 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL24 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL24 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL24 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL24 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL24 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL24 |
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| | | | Search Tocris compounds for MRPL24 |
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 | | | MRPL24 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL24 |
|  |  |  | | | | ThermoFisher Antibodies for MRPL24 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL24 |
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