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Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3 5
  • MRP-L24 3 4
  • L24mt 3 4
  • 39S Ribosomal Protein L24, Mitochondrial 3
  • MRP-L18 3

External Ids for MRPL24 Gene

Previous GeneCards Identifiers for MRPL24 Gene

  • GC01M154576
  • GC01M152472
  • GC01M153480
  • GC01M153923
  • GC01M153520
  • GC01M154973
  • GC01M156707
  • GC01M128064

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

Regulatory Elements for MRPL24 Gene

Enhancers for MRPL24 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRPL24 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL24 Gene

156,737,302 bp from pter
156,741,590 bp from pter
4,289 bases
Minus strand

Genomic View for MRPL24 Gene

Genes around MRPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

No data available for DME Specific Peptides for MRPL24 Gene

Domains & Families for MRPL24 Gene

Gene Families for MRPL24 Gene

Suggested Antigen Peptide Sequences for MRPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L24P family.
  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L24P family.
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

Gene Ontology (GO) - Molecular Function for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view
genes like me logo Genes that share phenotypes with MRPL24: view

Animal Model Products

CRISPR Products

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene


Subcellular locations from

Jensen Localization Image for MRPL24 Gene COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

Pathways & Interactions for MRPL24 Gene

genes like me logo Genes that share pathways with MRPL24: view

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for SIGNOR curated interactions for MRPL24 Gene

Drugs & Compounds for MRPL24 Gene

No Compound Related Data Available

Transcripts for MRPL24 Gene

Unigene Clusters for MRPL24 Gene

Mitochondrial ribosomal protein L24:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL24 Gene

mRNA expression in normal human tissues for MRPL24 Gene

Protein differential expression in normal tissues from HIPED for MRPL24 Gene

This gene is overexpressed in Breast (21.8), Pancreas (7.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL24 Gene

Protein tissue co-expression partners for MRPL24 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL24 Gene:


SOURCE GeneReport for Unigene cluster for MRPL24 Gene:

genes like me logo Genes that share expression patterns with MRPL24: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL24 Gene

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL24 34
  • 88.58 (n)
  • 87.5 (a)
MRPL24 35
  • 88 (a)
(Canis familiaris)
Mammalia MRPL24 34
  • 88.12 (n)
  • 87.5 (a)
MRPL24 35
  • 86 (a)
(Mus musculus)
Mammalia Mrpl24 34
  • 84.88 (n)
  • 87.96 (a)
Mrpl24 16
Mrpl24 35
  • 88 (a)
(Pan troglodytes)
Mammalia MRPL24 34
  • 100 (n)
  • 100 (a)
MRPL24 35
  • 100 (a)
(Rattus norvegicus)
Mammalia mrpl24 34
  • 85.65 (n)
  • 88.89 (a)
(Monodelphis domestica)
Mammalia MRPL24 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
-- 35
  • 61 (a)
(Gallus gallus)
Aves MRPL24 34
  • 63.8 (n)
  • 65.15 (a)
MRPL24 35
  • 65 (a)
(Anolis carolinensis)
Reptilia MRPL24 35
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl24 34
  • 66.51 (n)
  • 68.98 (a)
Str.10244 34
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 34
(Danio rerio)
Actinopterygii Dr.9429 34
mrpl24 34
  • 63.27 (n)
  • 65.28 (a)
mrpl24 35
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 36
  • 47 (a)
mRpL24 34
  • 53.74 (n)
  • 50.51 (a)
mRpL24 35
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 34
  • 54.76 (n)
  • 47.96 (a)
(Caenorhabditis elegans)
Secernentea mrpl-24 34
  • 50 (n)
  • 43.6 (a)
mrpl-24 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 35
  • 34 (a)
Species where no ortholog for MRPL24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

Gene Tree for MRPL24 (if available)
Gene Tree for MRPL24 (if available)

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Sequence variations from dbSNP and Humsavar for MRPL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3806416 -- 156,741,445(+) GACAG(A/G)GCTAC upstream-variant-2KB
rs4459103 -- 156,739,829(+) GCTAA(A/T)TTTTT intron-variant
rs6676980 -- 156,739,939(+) tggga(G/T)tacag intron-variant
rs6682274 -- 156,739,142(+) AAAAG(G/T)TAGGC intron-variant
rs6670122 -- 156,737,983(+) ACTTT(G/T)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
esv3578200 CNV loss 25503493
nsv831648 CNV loss 17160897

Variation tolerance for MRPL24 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL24 Gene

Disorders for MRPL24 Gene

Relevant External Links for MRPL24

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL24 Gene

Publications for MRPL24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4 65

Products for MRPL24 Gene

Sources for MRPL24 Gene

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