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Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3
  • MRP-L24 3 4
  • L24mt 3 4
  • 39S Ribosomal Protein L24, Mitochondrial 3
  • MRP-L18 3

External Ids for MRPL24 Gene

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

Genomic Location for MRPL24 Gene

Start:
156,737,302 bp from pter
End:
156,741,590 bp from pter
Size:
4,289 bases
Orientation:
Minus strand

Genomic View for MRPL24 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Regulatory Elements for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A35-RM24_HUMAN
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Q96A35
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    Size:
    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Proteomics data for MRPL24 Gene at MOPED

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

No data available for DME Specific Peptides for MRPL24 Gene

Domains for MRPL24 Gene

Gene Families for MRPL24 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

UniProtKB/Swiss-Prot:

RM24_HUMAN
Domain:
  • Contains 1 KOW domain.:
    • Q96A35
Family:
  • Belongs to the ribosomal protein L24P family.:
    • Q96A35
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

Gene Ontology (GO) - Molecular Function for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL24 Gene COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL24: view

Pathways for MRPL24 Gene

SuperPathways for MRPL24 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL24: view

Pathways by source for MRPL24 Gene

1 KEGG pathway for MRPL24 Gene

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL24: view

Transcripts for MRPL24 Gene

Unigene Clusters for MRPL24 Gene

Mitochondrial ribosomal protein L24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
MRPL24
ECgene alternative splicing isoforms for
MRPL24

Expression for MRPL24 Gene

mRNA expression in normal human tissues for MRPL24 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL24 Gene

SOURCE GeneReport for Unigene cluster for MRPL24 Gene Hs.418233

genes like me logo Genes that share expressions with MRPL24: view

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL24 36
  • 100 (n)
  • 100 (a)
MRPL24 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL24 36
  • 88.58 (n)
  • 87.5 (a)
MRPL24 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL24 36
  • 88.12 (n)
  • 87.5 (a)
MRPL24 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl24 36
  • 84.88 (n)
  • 87.96 (a)
Mrpl24 16
Mrpl24 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL24 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia mrpl24 36
  • 85.65 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves MRPL24 36
  • 63.8 (n)
  • 65.15 (a)
MRPL24 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL24 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl24 36
  • 66.51 (n)
  • 68.98 (a)
Str.10244 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 36
zebrafish
(Danio rerio)
Actinopterygii Dr.9429 36
mrpl24 36
  • 63.27 (n)
  • 65.28 (a)
mrpl24 37
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 36
  • 54.76 (n)
  • 47.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 36
  • 53.74 (n)
  • 50.51 (a)
mRpL24 37
  • 44 (a)
OneToOne
mRpL24 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-24 36
  • 50 (n)
  • 43.6 (a)
mrpl-24 37
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 37
  • 34 (a)
OneToOne
Species with no ortholog for MRPL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

ENSEMBL:
Gene Tree for MRPL24 (if available)
TreeFam:
Gene Tree for MRPL24 (if available)

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Sequence variations from dbSNP and Humsavar for MRPL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3806416 -- 156,741,445(+) GACAG(A/G)GCTAC upstream-variant-2KB
rs4459103 -- 156,739,829(+) GCTAA(A/T)TTTTT intron-variant
rs6670122 -- 156,737,983(+) ACTTT(G/T)TGGAC intron-variant
rs6670355 -- 156,737,583(+) ACTTT(C/T)ATTAA intron-variant
rs6676980 -- 156,739,939(+) tggga(G/T)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897

Relevant External Links for MRPL24 Gene

HapMap Linkage Disequilibrium report
MRPL24

Disorders for MRPL24 Gene

Relevant External Links for MRPL24

Genetic Association Database (GAD)
MRPL24
Human Genome Epidemiology (HuGE) Navigator
MRPL24
genes like me logo Genes that share disorders with MRPL24: view

No data available for UniProtKB/Swiss-Prot for MRPL24 Gene

Publications for MRPL24 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for MRPL24 Gene

Sources for MRPL24 Gene

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