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Aliases for MRPL24 Gene

Aliases for MRPL24 Gene

  • Mitochondrial Ribosomal Protein L24 2 3 5
  • MRP-L24 3 4
  • L24mt 3 4
  • MRP-L18 3

External Ids for MRPL24 Gene

Previous GeneCards Identifiers for MRPL24 Gene

  • GC01M154576
  • GC01M152472
  • GC01M153480
  • GC01M153923
  • GC01M153520
  • GC01M154973
  • GC01M156707
  • GC01M128064

Summaries for MRPL24 Gene

Entrez Gene Summary for MRPL24 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL24 Gene

MRPL24 (Mitochondrial Ribosomal Protein L24) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL24 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL24 Gene

Genomics for MRPL24 Gene

Regulatory Elements for MRPL24 Gene

Promoters for MRPL24 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL24 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL24 Gene

Chromosome:
1
Start:
156,737,302 bp from pter
End:
156,741,590 bp from pter
Size:
4,289 bases
Orientation:
Minus strand

Genomic View for MRPL24 Gene

Genes around MRPL24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL24 Gene

Proteins for MRPL24 Gene

  • Protein details for MRPL24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A35-RM24_HUMAN
    Recommended name:
    39S ribosomal protein L24, mitochondrial
    Protein Accession:
    Q96A35
    Secondary Accessions:
    • D3DVC8
    • Q53G65
    • Q53HT0
    • Q5SYZ9
    • Q5SZ00
    • Q5SZ02
    • Q96Q70
    • Q9H7G3

    Protein attributes for MRPL24 Gene

    Size:
    216 amino acids
    Molecular mass:
    24915 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL24 Gene

neXtProt entry for MRPL24 Gene

Proteomics data for MRPL24 Gene at MOPED

Post-translational modifications for MRPL24 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL24 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL24 Gene

Domains & Families for MRPL24 Gene

Gene Families for MRPL24 Gene

Suggested Antigen Peptide Sequences for MRPL24 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A35

UniProtKB/Swiss-Prot:

RM24_HUMAN :
  • Contains 1 KOW domain.
  • Belongs to the ribosomal protein L24P family.
Domain:
  • Contains 1 KOW domain.
Family:
  • Belongs to the ribosomal protein L24P family.
genes like me logo Genes that share domains with MRPL24: view

Function for MRPL24 Gene

genes like me logo Genes that share phenotypes with MRPL24: view

Animal Model Products

miRNA for MRPL24 Gene

miRTarBase miRNAs that target MRPL24

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL24 Gene

Localization for MRPL24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL24 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL24 Gene COMPARTMENTS Subcellular localization image for MRPL24 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL24: view

Pathways & Interactions for MRPL24 Gene

genes like me logo Genes that share pathways with MRPL24: view

Gene Ontology (GO) - Biological Process for MRPL24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL24: view

No data available for SIGNOR curated interactions for MRPL24 Gene

Drugs & Compounds for MRPL24 Gene

No Compound Related Data Available

Transcripts for MRPL24 Gene

Unigene Clusters for MRPL24 Gene

Mitochondrial ribosomal protein L24:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL24 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for MRPL24 Gene

GeneLoc Exon Structure for
MRPL24
ECgene alternative splicing isoforms for
MRPL24

Expression for MRPL24 Gene

mRNA expression in normal human tissues for MRPL24 Gene

Protein differential expression in normal tissues from HIPED for MRPL24 Gene

This gene is overexpressed in Breast (21.8), Pancreas (7.3), and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL24 Gene



SOURCE GeneReport for Unigene cluster for MRPL24 Gene Hs.418233

genes like me logo Genes that share expression patterns with MRPL24: view

Protein tissue co-expression partners for MRPL24 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL24 Gene

Orthologs for MRPL24 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL24 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL24 35
  • 88.58 (n)
  • 87.5 (a)
MRPL24 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL24 35
  • 88.12 (n)
  • 87.5 (a)
MRPL24 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl24 35
  • 84.88 (n)
  • 87.96 (a)
Mrpl24 36
  • 88 (a)
OneToOne
Mrpl24 16
chimpanzee
(Pan troglodytes)
Mammalia MRPL24 35
  • 100 (n)
  • 100 (a)
MRPL24 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MRPL24 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia mrpl24 35
  • 85.65 (n)
  • 88.89 (a)
chicken
(Gallus gallus)
Aves MRPL24 35
  • 63.8 (n)
  • 65.15 (a)
MRPL24 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL24 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rpl24-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10244 35
mrpl24 35
  • 66.51 (n)
  • 68.98 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.9429 35
mrpl24 35
  • 63.27 (n)
  • 65.28 (a)
mrpl24 36
  • 65 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10430 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL24 37
  • 47 (a)
mRpL24 35
  • 53.74 (n)
  • 50.51 (a)
mRpL24 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008405 35
  • 54.76 (n)
  • 47.96 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-24 35
  • 50 (n)
  • 43.6 (a)
mrpl-24 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10457 36
  • 34 (a)
OneToOne
Species with no ortholog for MRPL24:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL24 Gene

ENSEMBL:
Gene Tree for MRPL24 (if available)
TreeFam:
Gene Tree for MRPL24 (if available)

Paralogs for MRPL24 Gene

No data available for Paralogs for MRPL24 Gene

Variants for MRPL24 Gene

Sequence variations from dbSNP and Humsavar for MRPL24 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3806416 -- 156,741,445(+) GACAG(A/G)GCTAC upstream-variant-2KB
rs4459103 -- 156,739,829(+) GCTAA(A/T)TTTTT intron-variant
rs6670122 -- 156,737,983(+) ACTTT(G/T)TGGAC intron-variant
rs6670355 -- 156,737,583(+) ACTTT(C/T)ATTAA intron-variant
rs6682274 -- 156,739,142(+) AAAAG(G/T)TAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL24 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897

Variation tolerance for MRPL24 Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL24 Gene

HapMap Linkage Disequilibrium report
MRPL24

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL24 Gene

Disorders for MRPL24 Gene

Relevant External Links for MRPL24

Genetic Association Database (GAD)
MRPL24
Human Genome Epidemiology (HuGE) Navigator
MRPL24
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL24

No disorders were found for MRPL24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL24 Gene

Publications for MRPL24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPL24 Gene

Sources for MRPL24 Gene

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