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Aliases for MRPL22 Gene

Aliases for MRPL22 Gene

  • Mitochondrial Ribosomal Protein L22 2 3
  • 39S Ribosomal Protein L25, Mitochondrial 3 4
  • MRP-L22 3 4
  • MRP-L25 3 4
  • RPML25 3 4
  • L22mt 3 4
  • L25mt 3 4
  • 39S Ribosomal Protein L22, Mitochondrial 3
  • HSPC158 3
  • MRPL25 4

External Ids for MRPL22 Gene

Previous GeneCards Identifiers for MRPL22 Gene

  • GC05P154413
  • GC05P154303
  • GC05P154349
  • GC05P154300
  • GC05P149462

Summaries for MRPL22 Gene

Entrez Gene Summary for MRPL22 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL22 Gene

MRPL22 (Mitochondrial Ribosomal Protein L22) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL22 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL22 Gene

Genomics for MRPL22 Gene

Regulatory Elements for MRPL22 Gene

Genomic Location for MRPL22 Gene

154,941,070 bp from pter
154,969,411 bp from pter
28,342 bases
Plus strand

Genomic View for MRPL22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL22 Gene

Proteins for MRPL22 Gene

  • Protein details for MRPL22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L22, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NGJ8
    • Q5H9Q1
    • Q96Q51
    • Q9P006

    Protein attributes for MRPL22 Gene

    206 amino acids
    Molecular mass:
    23641 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29122.1; Type=Frameshift; Positions=197; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPL22 Gene


neXtProt entry for MRPL22 Gene

Proteomics data for MRPL22 Gene at MOPED

Post-translational modifications for MRPL22 Gene

  • Ubiquitination at Lys191
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL22 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL22 Gene

Domains for MRPL22 Gene

Gene Families for MRPL22 Gene

Protein Domains for MRPL22 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L22P family.
  • Belongs to the ribosomal protein L22P family.
genes like me logo Genes that share domains with MRPL22: view

Function for MRPL22 Gene

Gene Ontology (GO) - Molecular Function for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL22: view

Animal Model Products

miRNA for MRPL22 Gene

miRTarBase miRNAs that target MRPL22

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL22 Gene

Localization for MRPL22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL22 Gene


Subcellular locations from

Jensen Localization Image for MRPL22 Gene COMPARTMENTS Subcellular localization image for MRPL22 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome --
GO:0015934 large ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPL22: view

Pathways for MRPL22 Gene

SuperPathways for MRPL22 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPL22: view

Pathways by source for MRPL22 Gene

1 KEGG pathway for MRPL22 Gene

Gene Ontology (GO) - Biological Process for MRPL22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL22: view

Transcripts for MRPL22 Gene

Unigene Clusters for MRPL22 Gene

Mitochondrial ribosomal protein L22:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL22 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for MRPL22 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL22 Gene

mRNA expression in normal human tissues for MRPL22 Gene

Protein differential expression in normal tissues for MRPL22 Gene

This gene is overexpressed in Lung (31.2) and Pancreas (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL22 Gene

SOURCE GeneReport for Unigene cluster for MRPL22 Gene Hs.483924

genes like me logo Genes that share expressions with MRPL22: view

Expression partners for MRPL22 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL22 Gene

Orthologs for MRPL22 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL22 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL22 35
  • 91.18 (n)
  • 90.69 (a)
MRPL22 36
  • 91 (a)
(Canis familiaris)
Mammalia MRPL22 35
  • 90.36 (n)
  • 91.18 (a)
MRPL22 36
  • 94 (a)
(Mus musculus)
Mammalia Mrpl22 35
  • 85.76 (n)
  • 89.32 (a)
Mrpl22 16
Mrpl22 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPL22 35
  • 99.51 (n)
  • 99.51 (a)
MRPL22 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl22 35
  • 85.6 (n)
  • 89.32 (a)
(Monodelphis domestica)
Mammalia MRPL22 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL22 36
  • 78 (a)
(Gallus gallus)
Aves MRPL22 35
  • 72.59 (n)
  • 76.14 (a)
MRPL22 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MRPL22 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl22 35
  • 67.67 (n)
  • 77 (a)
Str.17424 35
(Danio rerio)
Actinopterygii Dr.13982 35
mrpl22 35
  • 71.46 (n)
  • 75.29 (a)
mrpl22 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12520 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000508 35
  • 51.63 (n)
  • 49.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL22 35
  • 55.94 (n)
  • 51.72 (a)
mRpL22 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea mrpl-22 35
  • 45.27 (n)
  • 32.1 (a)
mrpl-22 36
  • 22 (a)
Species with no ortholog for MRPL22:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL22 Gene

Gene Tree for MRPL22 (if available)
Gene Tree for MRPL22 (if available)

Paralogs for MRPL22 Gene Pseudogenes for MRPL22 Gene

genes like me logo Genes that share paralogs with MRPL22: view

No data available for Paralogs for MRPL22 Gene

Variants for MRPL22 Gene

Sequence variations from dbSNP and Humsavar for MRPL22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs190829687 -- 154,962,189(+) AGAGT(A/C)TGATG intron-variant
rs190940400 -- 154,946,905(+) CTCCT(A/T)TCGTG intron-variant
rs190823351 -- 154,941,840(+) TAAAG(G/T)TTAGG intron-variant
rs190808654 -- 154,953,848(+) CGCCC(A/G)GCTAA intron-variant
rs190446268 -- 154,956,531(+) AATAA(A/G)AAAGA intron-variant

Relevant External Links for MRPL22 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL22 Gene

Disorders for MRPL22 Gene

Relevant External Links for MRPL22

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL22 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL22 Gene

Publications for MRPL22 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for MRPL22 Gene

Sources for MRPL22 Gene

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