Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MRPL22 Gene

protein-coding   GIFtS: 54
GCID: GC05P154300

Mitochondrial Ribosomal Protein L22

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitochondrial Ribosomal Protein L221 2     MRP-L252 3
39S Ribosomal Protein L25, Mitochondrial2 3     RPML252 3
L22mt2 3     39S Ribosomal Protein L22, Mitochondrial2
L25mt2 3     MRPL253
MRP-L222 3     

External Ids:    HGNC: 144801   Entrez Gene: 290932   Ensembl: ENSG000000825157   OMIM: 6118355   UniProtKB: Q9NWU53   

Export aliases for MRPL22 gene to outside databases

Previous GC identifers: GC05P154413 GC05P154916 GC05P154303 GC05P154349 GC05P149462


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MRPL22 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is
found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL22 Gene:
MRPL22 (mitochondrial ribosomal protein L22) is a protein-coding gene. Diseases associated with MRPL22 include malaria. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL22 gene promoter:
         Sox5   NF-1   AP-1   NRSF form 1   NRSF form 2   Cdc5   Evi-1   E47   FAC1   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL22 promoter sequence
   Search Chromatin IP Primers for MRPL22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.2   Ensembl cytogenetic band:  5q33.2   HGNC cytogenetic band: 5q33.2

MRPL22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL22 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P154300:  view genomic region     (about GC identifiers)

Start:
154,320,630 bp from pter      End:
154,348,971 bp from pter
Size:
28,342 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RM22_HUMAN, Q9NWU5 (See protein sequence)
Recommended Name: 39S ribosomal protein L22, mitochondrial precursor  
Size: 206 amino acids; 23641 Da
Sequence caution: Sequence=AAF29122.1; Type=Frameshift; Positions=197;
Secondary accessions: A6NGJ8 Q5H9Q1 Q96Q51 Q9P006
Alternative splicing: 3 isoforms:  Q9NWU5-1   Q9NWU5-2   Q9NWU5-3   

Explore the universe of human proteins at neXtProt for MRPL22: NX_Q9NWU5

Explore proteomics data for MRPL22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys191
  • Modification sites at PhosphoSitePlus

  • See MRPL22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014990.1  NP_054899.2  

    ENSEMBL proteins: 
     ENSP00000431040   ENSP00000265229   ENSP00000411177   ENSP00000429039   ENSP00000430648  

    MRPL22 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MRPL22
    GenScript Custom Purified and Recombinant Proteins Services for MRPL22
    Novus Biologicals MRPL22 Protein
    Novus Biologicals MRPL22 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPL22

    MRPL22 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MRPL22
    OriGene Custom Antibody Services for MRPL22
    Novus Biologicals MRPL22 Antibodies
    Abcam antibodies for MRPL22
    Cloud-Clone Corp. Antibodies for MRPL22
    Search ThermoFisher Antibodies for MRPL22
    LSBio Antibodies in human, mouse, rat for MRPL22

    MRPL22 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRPL22
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRPL22
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRPL22
    Cloud-Clone Corp. CLIAs for MRPL22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    2 InterPro protein domains:
     IPR005727 Ribosomal_L22_bac/chlpt-type
     IPR001063 Ribosomal_L22

    Graphical View of Domain Structure for InterPro Entry Q9NWU5

    ProtoNet protein and cluster: Q9NWU5

    1 Blocks protein domain: IPB001063 Ribosomal protein L22/L17

    UniProtKB/Swiss-Prot: RM22_HUMAN, Q9NWU5
    Similarity: Belongs to the ribosomal protein L22P family


    MRPL22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MRPL22 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL22
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRPL22

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRPL22
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPL22

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRPL22:
    hsa-mir-26b-5p (MIRT029465)

    Block miRNA regulation of human, mouse, rat MRPL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRPL22 (see all 12):
    hsa-miR-4306 hsa-miR-548o hsa-miR-218 hsa-miR-1205 hsa-miR-199a-5p hsa-miR-1323 hsa-miR-1909* hsa-miR-185
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRPL22
    Predesigned siRNA for gene silencing in human, mouse, rat MRPL22

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRPL22

    Clone
    Products:
         
    OriGene clones in human, mouse for MRPL22 (see all 10)
    OriGene ORF clones in mouse, rat for MRPL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPL22 (NM_014180)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL22

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRPL22
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRPL22 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RM22_HUMAN, Q9NWU5: Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005840ribosome ----
    GO:0015934large ribosomal subunit IEA--

    MRPL22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MRPL22 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MRPL22):
        Ribosome


    MRPL22 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL22
    Interactions:

        Search GeneGlobe Interaction Network for MRPL22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRPL22 (Q9NWU52, 3 ENSP000004111774) via UniProtKB, MINT, STRING, and/or I2D (see all 428)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MCTS1Q9ULC43, ENSP000003603654I2D: score=5 STRING: ENSP00000360365
    MRPL16Q9NX202, ENSP000003001514MINT-8079030 STRING: ENSP00000300151
    MRPL2Q5T6532, ENSP000003734044MINT-8079030 STRING: ENSP00000373404
    MRPL4Q9BYD32, ENSP000002530994MINT-8079030 STRING: ENSP00000253099
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    MRPL22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL22 (RM22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MRPL22 gene (2 alternative transcripts): 
    NM_001014990.2  NM_014180.3  

    Unigene Cluster for MRPL22:

    Mitochondrial ribosomal protein L22
    Hs.483924  [show with all ESTs]
    Unigene Representative Sequence: NM_014180
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523037(uc003lvy.4 uc003lvz.4) ENST00000265229 ENST00000439747
    ENST00000522038 ENST00000519059 ENST00000520040 ENST00000518364
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRPL22 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRPL22 (see all 12):
    hsa-miR-4306 hsa-miR-548o hsa-miR-218 hsa-miR-1205 hsa-miR-199a-5p hsa-miR-1323 hsa-miR-1909* hsa-miR-185
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRPL22
    Predesigned siRNA for gene silencing in human, mouse, rat MRPL22
    Clone
    Products:
         
    OriGene clones in human, mouse for MRPL22 (see all 10)
    OriGene ORF clones in mouse, rat for MRPL22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPL22 (NM_014180)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL22
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRPL22
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL22
      QuantiTect SYBR Green Assays in human, mouse, rat MRPL22
      QuantiFast Probe-based Assays in human, mouse, rat MRPL22

    Additional mRNA sequence: 

    AF161507.1 AK000601.1 AK097880.1 AK302784.1 BC012565.1 CR933679.1 

    12 DOTS entries:

    DT.315890  DT.97845306  DT.92385210  DT.95276207  DT.97845308  DT.95276208  DT.95276209  DT.100760591 
    DT.91760095  DT.91760100  DT.95276211  DT.91760091 

    Selected AceView cDNA sequences (see all 228):

    AI214195 BX114909 AK097880 BM662504 BM839864 NM_014180 BQ101165 BG033093 
    BP372420 BQ100863 AK000601 BE326337 BM015731 BM844574 AA447170 BU165076 
    BE878577 CK823152 AI361130 AW404374 BM739889 AI138489 AI753664 BQ221495 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL22    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:              -                 -                                             
    SP2:              -           -     -                                             
    SP3:                                -                                             
    SP4:                          -     -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for MRPL22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MRPL22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAAGAGTA
    MRPL22 Expression
    About this image

    MRPL22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL22 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.483924
        Custom PCR Arrays for MRPL22
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MRPL22
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL22
    QuantiTect SYBR Green Assays in human, mouse, rat MRPL22
    QuantiFast Probe-based Assays in human, mouse, rat MRPL22
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MRPL22 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl221 , 5 mitochondrial ribosomal protein L221, 5 85.76(n)1
    89.32(a)1
      11 (35.89 cM)5
    2167671  NM_175001.31  NP_778166.21 
     581716615 
    chicken
    (Gallus gallus)
    Aves MRPL221 mitochondrial ribosomal protein L22 72.59(n)
    76.14(a)
      416253  XM_414573.4  XP_414573.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL226
    mitochondrial ribosomal protein L22
    72(a)
    1 ↔ 1
    GL343205.1(880990-896751)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.174242 Transcribed sequence with moderate similarity to protein more 78.13(n)    BX755661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139822 Transcribed sequence with moderate similarity to protein more 75.7(n)    CK396410.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL221 mitochondrial ribosomal protein L22 55.94(n)
    51.72(a)
      32662  NM_078655.3  NP_523379.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-221 mrpl-22 45.27(n)
    32.1(a)
      176482  NM_066939.4  NP_499340.1 


    ENSEMBL Gene Tree for MRPL22 (if available)
    TreeFam Gene Tree for MRPL22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MRPL22 gene

    MRPL22 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPL22
    PGOHUM00000245538


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MRPL22 (see all 548)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs792512341,2
    F--154319810(+) ATGCCT/CTGTTG 2 -- us2k11Minor allele frequency- C:0.04EA 120
    rs1852577711,2
    --154319834(+) AATAAA/GTGAGA 2 -- us2k10--------
    rs3487501,2
    C,F,A,H--154319892(+) ATAAAT/CTCATT 2 -- us2k1 tfbs323Minor allele frequency- C:0.21NS EA NA WA CSA 2352
    rs1135026751,2
    F--154320006(+) CTAATC/TCTAGC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1899122491,2
    C--154320056(+) GAATTC/TGAGAT 2 -- us2k10--------
    rs1443947461,2
    --154320322(+) CCTAAA/GGTTAG 2 -- us2k10--------
    rs777683611,2
    C,F--154320404(+) TTCTAG/CTTTGT 2 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1811815931,2
    --154320407(+) TAGTTC/TGTGAG 2 -- us2k10--------
    rs738072091,2
    C,F--154320570(+) TAAGTA/GCTGCT 2 -- us2k12Minor allele frequency- G:0.05WA 120
    rs283726881,2
    C,F--154320596(+) CAGGAA/GATCCA 2 -- us2k18Minor allele frequency- G:0.09MN EA NA WA EU 2180

    HapMap Linkage Disequilibrium report for MRPL22 (154320630 - 154348971 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MRPL22: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL22
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611835    OMIM disorders: --

    1 disease for MRPL22:    
    About MalaCards
    malaria


    MRPL22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL22
    Human Genome Epidemiology (HuGE) Navigator: MRPL22 (2 documents)

    Export disorders for MRPL22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MRPL22 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MRPL22)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N.... Tanaka T. (Genomics 2001)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)
    8. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29093 HGNC: 14480 AceView: MRPL22 Ensembl:ENSG00000082515 euGenes: HUgn29093
    ECgene: MRPL22 Kegg: 29093 H-InvDB: MRPL22

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MRPL22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MRPL22 gene:
    Search GeneIP for patents involving MRPL22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRPL22   OriGene RNAi products in human, mouse, rat for MRPL22  
     OriGene qPCR primer pairs and template standards for MRPL22   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MRPL22  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRPL22   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MRPL22   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRPL22   OriGene Custom Protein Services for MRPL22  

     
     
     Block miRNA regulation of human, mouse, rat MRPL22 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRPL22
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL22 Predesigned siRNA for gene silencing in human, mouse, rat MRPL22
     QuantiFast Probe-based Assays in human, mouse, rat MRPL22 QuantiTect SYBR Green Assays in human, mouse, rat MRPL22
     Custom PCR Arrays for MRPL22 Search Chromatin IP Primers for MRPL22
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL22  Search GeneGlobe Interaction Network for MRPL22
     Regulatory tfbs in MRPL22 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MRPL22 GenScript cDNA clones with any tag delivered in your preferred vector for MRPL22
     GenScript Custom Assay Services for MRPL22 GenScript Custom overexpressing Cell Line Services for MRPL22
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MRPL22 (RM22)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MRPL22 antibodies
     MRPL22 proteins
     MRPL22 lysates
     Antibodies for MRPL22
     See all of Abcam's Antibodies, Kits and Proteins for MRPL22
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MRPL22
     Antibodies for MRPL22
     ELISAs for MRPL22
     CLIAs for MRPL22



     Browse ESI BIO Cell Lines and PureStem Progenitors for MRPL22
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL22
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MRPL22
     SwitchGear Promoter luciferase reporter plasmids for MRPL22
     Search ThermoFisher Antibodies for MRPL22
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL22
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL22
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRPL22
     LSBio Antibodies in human, mouse, rat for MRPL22
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRPL22 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4