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Aliases for MRPL21 Gene

Aliases for MRPL21 Gene

  • Mitochondrial Ribosomal Protein L21 2 3 5
  • MRP-L21 3 4
  • L21mt 3 4

External Ids for MRPL21 Gene

Previous GeneCards Identifiers for MRPL21 Gene

  • GC00U990877
  • GC11M068434
  • GC11M068415
  • GC11M068658
  • GC11M064998

Summaries for MRPL21 Gene

Entrez Gene Summary for MRPL21 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL21 Gene

MRPL21 (Mitochondrial Ribosomal Protein L21) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL21 Gene

Genomics for MRPL21 Gene

Regulatory Elements for MRPL21 Gene

Enhancers for MRPL21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL21 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL21 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL21 Gene

Chromosome:
11
Start:
68,891,272 bp from pter
End:
68,903,835 bp from pter
Size:
12,564 bases
Orientation:
Minus strand

Genomic View for MRPL21 Gene

Genes around MRPL21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL21 Gene

Proteins for MRPL21 Gene

  • Protein details for MRPL21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z2W9-RM21_HUMAN
    Recommended name:
    39S ribosomal protein L21, mitochondrial
    Protein Accession:
    Q7Z2W9
    Secondary Accessions:
    • A6NKU0
    • C9JPR2

    Protein attributes for MRPL21 Gene

    Size:
    205 amino acids
    Molecular mass:
    22815 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH55088.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL21 Gene

    Alternative splice isoforms for MRPL21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL21 Gene

Proteomics data for MRPL21 Gene at MOPED

Post-translational modifications for MRPL21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL21 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL21 Gene

Domains & Families for MRPL21 Gene

Gene Families for MRPL21 Gene

Protein Domains for MRPL21 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z2W9

UniProtKB/Swiss-Prot:

RM21_HUMAN :
  • Belongs to the ribosomal protein L21P family.
Family:
  • Belongs to the ribosomal protein L21P family.
genes like me logo Genes that share domains with MRPL21: view

Function for MRPL21 Gene

Animal Model Products

miRNA for MRPL21 Gene

miRTarBase miRNAs that target MRPL21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL21 Gene

Localization for MRPL21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL21 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL21 Gene COMPARTMENTS Subcellular localization image for MRPL21 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL21: view

Pathways & Interactions for MRPL21 Gene

genes like me logo Genes that share pathways with MRPL21: view

Gene Ontology (GO) - Biological Process for MRPL21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL21: view

No data available for SIGNOR curated interactions for MRPL21 Gene

Drugs & Compounds for MRPL21 Gene

No Compound Related Data Available

Transcripts for MRPL21 Gene

Unigene Clusters for MRPL21 Gene

Mitochondrial ribosomal protein L21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL21 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e ^ 7
SP1: - - - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - -
SP5: - - -
SP6: - - - - - -
SP7: -
SP8: - - -

Relevant External Links for MRPL21 Gene

GeneLoc Exon Structure for
MRPL21
ECgene alternative splicing isoforms for
MRPL21

Expression for MRPL21 Gene

mRNA expression in normal human tissues for MRPL21 Gene

Protein differential expression in normal tissues from HIPED for MRPL21 Gene

This gene is overexpressed in Pancreas (9.8), Peripheral blood mononuclear cells (7.4), Lung (6.8), and Breast (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL21 Gene



SOURCE GeneReport for Unigene cluster for MRPL21 Gene Hs.503047

genes like me logo Genes that share expression patterns with MRPL21: view

Protein tissue co-expression partners for MRPL21 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL21 Gene

Orthologs for MRPL21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL21 35
  • 83.58 (n)
  • 82.41 (a)
MRPL21 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL21 35
  • 84.46 (n)
  • 82.38 (a)
MRPL21 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl21 35
  • 84.69 (n)
  • 82.56 (a)
Mrpl21 16
Mrpl21 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL21 35
  • 99.19 (n)
  • 98.54 (a)
MRPL21 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl21 35
  • 82.93 (n)
  • 80.98 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL21 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL21 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL21 35
  • 70.24 (n)
  • 72.88 (a)
MRPL21 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL21 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl21 35
  • 62.18 (n)
  • 64.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10281 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13693 35
mrpl21 35
  • 59.22 (n)
  • 60.41 (a)
mrpl21 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14177 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012030 35
  • 48.63 (n)
  • 41.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL21 35
  • 49.05 (n)
  • 42.28 (a)
mRpL21 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-21 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11033 36
  • 35 (a)
OneToOne
Species with no ortholog for MRPL21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL21 Gene

ENSEMBL:
Gene Tree for MRPL21 (if available)
TreeFam:
Gene Tree for MRPL21 (if available)

Paralogs for MRPL21 Gene

Pseudogenes.org Pseudogenes for MRPL21 Gene

genes like me logo Genes that share paralogs with MRPL21: view

No data available for Paralogs for MRPL21 Gene

Variants for MRPL21 Gene

Sequence variations from dbSNP and Humsavar for MRPL21 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs535559 -- 68,891,742(-) CTCTC(A/G)TGTAC intron-variant
rs545528 -- 68,893,802(+) GGTGC(A/G)GTGGC intron-variant
rs552645 -- 68,897,417(-) ATTCC(A/G)TGCGA intron-variant
rs569445 -- 68,894,107(-) GACAC(A/G)ATGGT intron-variant
rs573267 -- 68,894,555(-) CCTGT(A/T)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL21 Gene

Variant ID Type Subtype PubMed ID
nsv428261 CNV Gain 18775914
nsv509423 CNV Insertion 20534489
nsv374 CNV Insertion 18451855
esv996248 CNV Insertion 20482838

Variation tolerance for MRPL21 Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL21 Gene

HapMap Linkage Disequilibrium report
MRPL21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL21 Gene

Disorders for MRPL21 Gene

Relevant External Links for MRPL21

Genetic Association Database (GAD)
MRPL21
Human Genome Epidemiology (HuGE) Navigator
MRPL21
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL21

No disorders were found for MRPL21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL21 Gene

Publications for MRPL21 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRPL21 Gene

Sources for MRPL21 Gene

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