MRPL20 Gene
protein-coding GIFtS: 46
GCID: GC01M001329
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|
mitochondrial ribosomal protein L20
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Aliases
for MRPL20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L201 2 | | L20mt2 3 | | MRP-L202 3 | | FLJ100241 | | 39S Ribosomal Protein L20, Mitochondrial2 |
Export aliases for MRPL20 gene to outside databasesPrevious GC identifers: GC01M000864 GC01M001089 GC01M001253 GC01M001288 GC01M001425 GC01M000614 |
Summaries
for MRPL20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL20:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.A pseudogene corresponding to this gene is found on chromosome 21q. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPL20
|
Genomic Views
for MRPL20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL20 gene promoter:
Max1 Pax-5 ATF-2 NCX/Ncx MyoD Lmo2 Gfi-1 CRE-BP1 Max c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.3-p36.2 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.3-p36.2MRPL20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001329: view genomic region
(about GC identifiers)
Start:
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1,337,276 bp from pter |
End:
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1,342,693 bp from pter |
Size:
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5,418 bases |
Orientation:
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minus strand |
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Proteins
for MRPL20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM20_HUMAN, Q9BYC9 (See
protein sequence)Recommended Name: 39S ribosomal protein L20, mitochondrial precursor Size: 149 amino acids; 17443 Da
Subunit: Interacts with OXA1L (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: B2RE41Explore the universe of human proteins at neXtProt for MRPL20: NX_Q9BYC9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYC9
MRPL20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060441.2
ENSEMBL proteins: ENSP00000341082 ENSP00000459994 ENSP00000460924
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPL20 for ontologies About GeneDecksing
MRPL20 Antibody Products:
Assay Products for MRPL20: |
Protein
Domains /
Families
for MRPL20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BYC9ProtoNet protein and cluster: Q9BYC9 1 Blocks protein family: IPB005812 Ribosomal protein L20
UniProtKB/Swiss-Prot: RM20_HUMAN, Q9BYC9Similarity: Belongs to the ribosomal protein L20P family |
Function
for MRPL20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MRPL20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL20 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MRPL20 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPL20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL20
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/256 Interacting proteins for MRPL20 (Q9BYC92, 3 ENSP000003410824) via UniProtKB, MINT, STRING, and/or I2D (see all 256)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPL20 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL20
Search CenterWatch for drugs/clinical trials and news about MRPL20 / RM20
|
Transcripts
for MRPL20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL20 gene: NM_017971.3 Unigene Cluster for MRPL20: Mitochondrial ribosomal protein L20 Hs.182698 [show with all ESTs]Unigene Representative Sequence: BF3408616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344843(uc001afo.4) ENST00000493287 ENST00000487659 ENST00000492508
ENST00000482352(uc010nyn.1) ENST00000477686
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL20 (NM_017971) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL20 |
Additional cDNA sequence: AB049644.1 AK301440.1 AK315794.1 BC009515.1 BC014316.1 BC059945.1 19 DOTS entries: DT.416674 DT.100728542 DT.100813868 DT.91757114 DT.91757115 DT.121375224 DT.100020329 DT.100813876 DT.95155953 DT.95155955 DT.121375152 DT.91757118 DT.91757120 DT.100813864 DT.100813874 DT.91711310 DT.91757119 DT.95232818 DT.97822337 24/244 AceView cDNA sequences (see all 244): CD674912 BM692759 AI282675 BU933472 CR619017 BE390332 BQ961898 AI214516 BQ688104 BU952126 BG680947 BM463735 BQ685249 AA603775 BM826043 F31560 BC009515 AW665517 BU190391 BU628224 AA721420 AB049644 AA699302 CB110365
GeneLoc Exon Structure
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Expression
for MRPL20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGTGTGA
About this image
See MRPL20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL20
SOURCE GeneReport for Unigene cluster: Hs.182698
SABiosciences Custom PCR Arrays for MRPL20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL20 |
Orthologs
for MRPL20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPL20 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for MRPL20 (if available)
TreeFam Gene Tree for MRPL20 (if available) |
Paralogs
for MRPL20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL20 gene
MRPL20 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL20
PGOHUM00000239173
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Genomic Variants
for MRPL20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL20 (1337276 - 1342693 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MRPL20
2 CNVs: 30362 3276 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MRPL20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL20 for disorders About GeneDecksing
OMIM gene information: 611833
OMIM disorders: --
4  diseases for MRPL20: About MalaCardspneumonia tuberculosis malaria mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRPL20 (1 document)
Export disorders for MRPL20 gene to outside databases
|
Publications
for MRPL20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL20 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MRPL20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
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External Searches for MRPL20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL20 gene:
Search GeneIP for patents involving MRPL20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL20 | | | OriGene Protein Over-expression Lysate for MRPL20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL20 | | OriGene 3'-UTR Clone for MRPL20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL20 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL20 |
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 | | | MRPL20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MRPL20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL20 |
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