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Aliases for MRPL20 Gene

Aliases for MRPL20 Gene

  • Mitochondrial Ribosomal Protein L20 2 3 5
  • MRP-L20 3 4
  • L20mt 3 4

External Ids for MRPL20 Gene

Previous GeneCards Identifiers for MRPL20 Gene

  • GC01M000864
  • GC01M001089
  • GC01M001253
  • GC01M001288
  • GC01M001425
  • GC01M001329
  • GC01M000614

Summaries for MRPL20 Gene

Entrez Gene Summary for MRPL20 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL20 Gene

MRPL20 (Mitochondrial Ribosomal Protein L20) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and rRNA binding.

Gene Wiki entry for MRPL20 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL20 Gene

Genomics for MRPL20 Gene

Regulatory Elements for MRPL20 Gene

Promoters for MRPL20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL20 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL20 Gene

Chromosome:
1
Start:
1,401,896 bp from pter
End:
1,407,834 bp from pter
Size:
5,939 bases
Orientation:
Minus strand

Genomic View for MRPL20 Gene

Genes around MRPL20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL20 Gene

Proteins for MRPL20 Gene

  • Protein details for MRPL20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC9-RM20_HUMAN
    Recommended name:
    39S ribosomal protein L20, mitochondrial
    Protein Accession:
    Q9BYC9
    Secondary Accessions:
    • B2RE41
    • B7Z746

    Protein attributes for MRPL20 Gene

    Size:
    149 amino acids
    Molecular mass:
    17443 Da
    Quaternary structure:
    • Interacts with OXA1L.

    Three dimensional structures from OCA and Proteopedia for MRPL20 Gene

    Alternative splice isoforms for MRPL20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL20 Gene

Proteomics data for MRPL20 Gene at MOPED

Post-translational modifications for MRPL20 Gene

  • Ubiquitination at Lys 82, Lys 100, Lys 111, and Lys 114
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL20 Gene

No data available for DME Specific Peptides for MRPL20 Gene

Domains & Families for MRPL20 Gene

Gene Families for MRPL20 Gene

Protein Domains for MRPL20 Gene

Suggested Antigen Peptide Sequences for MRPL20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYC9

UniProtKB/Swiss-Prot:

RM20_HUMAN :
  • Belongs to the ribosomal protein L20P family.
Family:
  • Belongs to the ribosomal protein L20P family.
genes like me logo Genes that share domains with MRPL20: view

Function for MRPL20 Gene

Animal Model Products

miRNA for MRPL20 Gene

miRTarBase miRNAs that target MRPL20

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL20 Gene

Localization for MRPL20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL20 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL20 Gene COMPARTMENTS Subcellular localization image for MRPL20 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL20: view

Pathways & Interactions for MRPL20 Gene

genes like me logo Genes that share pathways with MRPL20: view

Gene Ontology (GO) - Biological Process for MRPL20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation IEA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with MRPL20: view

No data available for SIGNOR curated interactions for MRPL20 Gene

Drugs & Compounds for MRPL20 Gene

No Compound Related Data Available

Transcripts for MRPL20 Gene

Unigene Clusters for MRPL20 Gene

Mitochondrial ribosomal protein L20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL20 Gene

No ASD Table

Relevant External Links for MRPL20 Gene

GeneLoc Exon Structure for
MRPL20
ECgene alternative splicing isoforms for
MRPL20

Expression for MRPL20 Gene

mRNA expression in normal human tissues for MRPL20 Gene

Protein differential expression in normal tissues from HIPED for MRPL20 Gene

This gene is overexpressed in Breast (24.4), Lung (15.1), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL20 Gene



SOURCE GeneReport for Unigene cluster for MRPL20 Gene Hs.182698

genes like me logo Genes that share expression patterns with MRPL20: view

Protein tissue co-expression partners for MRPL20 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL20 Gene

Orthologs for MRPL20 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL20 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL20 36
  • 85 (a)
OneToOne
MRPL20 35
  • 83 (n)
  • 85.23 (a)
dog
(Canis familiaris)
Mammalia MRPL20 35
  • 85.91 (n)
  • 88.59 (a)
MRPL20 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl20 36
  • 88 (a)
OneToOne
Mrpl20 16
Mrpl20 35
  • 82.33 (n)
  • 87.92 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL20 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl20 35
  • 81.21 (n)
  • 86.58 (a)
chicken
(Gallus gallus)
Aves MRPL20 35
  • 69.8 (n)
  • 74.5 (a)
MRPL20 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL20 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.34799 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl20 35
  • 66.67 (n)
  • 73.15 (a)
Str.20421 35
zebrafish
(Danio rerio)
Actinopterygii mrpl20 35
  • 59.51 (n)
  • 61.74 (a)
wufa27e09 35
mrpl20 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001311 35
  • 49.08 (n)
  • 41.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL20 35
  • 49.86 (n)
  • 39.02 (a)
mRpL20 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G16740 35
  • 49.83 (n)
  • 42.42 (a)
rice
(Oryza sativa)
Liliopsida Os01g0734100 35
  • 51.82 (n)
  • 41.82 (a)
Species with no ortholog for MRPL20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL20 Gene

ENSEMBL:
Gene Tree for MRPL20 (if available)
TreeFam:
Gene Tree for MRPL20 (if available)

Paralogs for MRPL20 Gene

Pseudogenes.org Pseudogenes for MRPL20 Gene

genes like me logo Genes that share paralogs with MRPL20: view

No data available for Paralogs for MRPL20 Gene

Variants for MRPL20 Gene

Sequence variations from dbSNP and Humsavar for MRPL20 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1240713 -- 1,409,623(+) agaaa(C/T)ggagt upstream-variant-2KB
rs17160975 -- 1,403,216(+) GACCT(G/T)TATGC intron-variant
rs17363048 -- 1,403,593(+) AGTCA(A/G)ACCTC intron-variant
rs28418680 -- 1,408,286(+) AATAA(A/G)AAGTT upstream-variant-2KB
rs34442823 -- 1,407,565(-) GGTCC(A/G/T)CTGCC upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL20 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
dgv2n67 CNV Gain 20364138
dgv10n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
dgv25n71 CNV Loss 21882294
dgv30n71 CNV Gain 21882294
dgv31n71 CNV Gain 21882294
dgv32n71 CNV Gain+Loss 21882294
dgv33n71 CNV Loss 21882294
dgv34n71 CNV Loss 21882294
dgv38n71 CNV Loss 21882294
nsv871837 CNV Loss 21882294
nsv871690 CNV Gain 21882294
essv5472 CNV CNV 17122850
dgv9e1 CNV Complex 17122850
dgv40n71 CNV Loss 21882294

Variation tolerance for MRPL20 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL20 Gene

HapMap Linkage Disequilibrium report
MRPL20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL20 Gene

Disorders for MRPL20 Gene

Relevant External Links for MRPL20

Genetic Association Database (GAD)
MRPL20
Human Genome Epidemiology (HuGE) Navigator
MRPL20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL20

No disorders were found for MRPL20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL20 Gene

Publications for MRPL20 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz A.G. … Landthaler M. (Mol. Cell 2012) 3

Products for MRPL20 Gene

Sources for MRPL20 Gene

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