MRPL2 Gene
protein-coding GIFtS : 47
GCID: GC06 M043068
mitochondrial ribosomal protein L2
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Aliasesfor MRPL2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mitochondrial Ribosomal Protein L2 1 2 MRP-L22 3 MRP-L141 2 CGI-221 RPML141 2 39S Ribosomal Protein L2, Mitochondrial2 L2mt2 3
Export aliases for MRPL2 gene to outside databases Previous GC identifers: GC06M043023 GC06M043129 GC06M042738
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Summariesfor MRPL2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MRPL2 : Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. (provided by RefSeq, Jul 2008)
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Genomic Viewsfor MRPL2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPL2 gene promoter: GR E2F-4 E2F-3a E2F-5 Sox5 Bach2 E2F-2 E2F E2F-1 GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for MRPL2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPL2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.3 MRPL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M043068: view genomic region
(about GC identifiers )
Start:
43,021,767 bp from pter
End:
43,027,544 bp from pter
Size:
5,778 bases
Orientation:
minus strand
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Proteinsfor MRPL2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RM02_HUMAN, Q5T653 (See
protein sequence )Recommended Name: 39S ribosomal protein L2, mitochondrial precursor Size : 305 amino acids; 33301 Da
Subcellular location : Mitochondrion (By similarity)
Sequence caution : Sequence=AAD27731.1; Type=Frameshift; Positions=274, 283; Sequence=CAI13780.1; Type=Erroneous genemodel prediction;
Secondary accessions : B2RC56 Q8WUL1 Q96Q56 Q9Y311Explore the universe of human proteins at neXtProt for MRPL2: NX_Q5T653 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5T653 MRPL2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_057034.2 ENSEMBL proteins: ENSP00000373404 ENSP00000230413 ENSP00000419753 ENSP00000417101 ENSP00000419710 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
MRPL2 for ontologies About GeneDecksing MRPL2 Antibody Products: Assay Products for MRPL2:
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Protein
Domains / Familiesfor MRPL2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MRPL2 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q5T653 ProtoNet protein and cluster: Q5T653
UniProtKB/Swiss-Prot: RM02_HUMAN, Q5T653 Similarity : Belongs to the ribosomal protein L2P family
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Functionfor MRPL2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPL2 (NM_021134 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPL2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL2
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003735 structural constituent of ribosome
IEA --
MRPL2 for ontologies About GeneDecksing
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Pathways & Interactionsfor MRPL2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL2 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/414 Interacting proteins for MRPL2 (Q5T653 2 , 3 ENSP00000373404 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 414 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006412 translation
IEA --
MRPL2 for ontologies About GeneDecksing
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Drugs & Compoundsfor MRPL2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MRPL2 Search CenterWatch for drugs/clinical trials and news about MRPL2 / RM02
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Transcriptsfor MRPL2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MRPL2 gene: NM_015950.3 Unigene Cluster for MRPL2:
Mitochondrial ribosomal protein L2 Hs.55041 [show with all ESTs ] Unigene Representative Sequence: NM_015950 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000388752 (uc003ots.1 ) ENST00000230413 ENST00000485654 ENST00000489623 ENST00000470667 ENST00000491898 (uc011dvc.2 ) ENST00000480286 ENST00000487429 (uc010jyi.3 uc003ott.4 )ENST00000468957 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPL2 (NM_021134 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPL2
Additional cDNA sequence: AF086160.1 AF132956.1 AK301041.1 AK307208.1 AK314948.1 BC013685.1 BC020212.1
12 DOTS entries : DT.100783352 DT.101972501
DT.314883 DT.121374918 DT.75101705 DT.121374949 DT.102836930 DT.100783351 DT.121374938 DT.121374922 DT.95159384 DT.97819493 24/156 AceView cDNA sequences (see all 156 ):
BM558772 BQ681996 CB157285 AJ712925 BM313091 AI499025 BM474838 AI342982 CB139607 BM914880 AI283794 AW160610 NM_015950 BU161496 BQ939927 BQ223798 BM458798 CA454108 AI185677 BM553982 AF086160 BM693034 BQ221175 AI701608 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL2 (see all 7 ) About this scheme ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c SP1 :         -     -   -           -           SP2 :         -     -   -           -   -         SP3 :         -     -   -                     SP4 :         -     -   -                     SP5 :         -     -   -   -   -   -   -   -   -        
ECgene alternative splicing isoforms for MRPL2
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Expression for MRPL2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MRPL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AAGAGTTACG
About this image See MRPL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPL2 SOURCE GeneReport for Unigene cluster: Hs.55041 SABiosciences Custom PCR Arrays for MRPL2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPL2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MRPL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPL2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL2
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Orthologsfor MRPL2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPL2 gene from 9/31 species (see all 31 ) About this table
ENSEMBL Gene Tree for MRPL2 (if available)TreeFam Gene Tree for MRPL2 (if available)
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Paralogsfor MRPL2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MRPL2 gene
MRPL2 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for MRPL2 PGOHUM00000239886
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Genomic Variantsfor MRPL2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MRPL2 (43021767 - 43027544 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPL2: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPL2
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Disorders
/ Diseasesfor MRPL2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MRPL2 for disorders About GeneDecksing
OMIM gene information: 611822
OMIM disorders : --4 diseases for MRPL2 : About MalaCards pneumonia tuberculosis malaria mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: MRPL2 (1 document)Export disorders for MRPL2 gene to outside databases
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Publicationsfor MRPL2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MRPL2 gene, integrated from 9 sources (see all 17 ): (articles sorted by number of sources associating them with MRPL2) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 1 , 2 Mungall A.J.... Beck S. (2003) The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634) 1 , 2 Kenmochi N....Tanaka T. (2001) Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093) 1 , 2 Lai C.H....Lin W. (2000) Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. (PubMed id 10593885) 1 , 9 O'Brien T.W.... Graack H.R. (1999) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120) 1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
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External Searches for MRPL2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MRPL2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MRPL2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MRPL2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MRPL2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MRPL2 gene: Search GeneIP for patents involving MRPL2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MRPL2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MRPL2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MRPL2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPL2 OriGene Protein Over-expression Lysate for MRPL2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MRPL2 OriGene 3'-UTR Clone for MRPL2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPL2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MRPL2 OriGene Custom Protein Services for MRPL2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPL2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPL2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MRPL2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPL2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPL2
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MRPL2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPL2
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Aliases for MRPL2
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Expression for MRPL2
Function for MRPL2
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