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Aliases for MRPL2 Gene

Aliases for MRPL2 Gene

  • Mitochondrial Ribosomal Protein L2 2 3
  • MRP-L2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3
  • MRP-L14 3
  • CGI-22 3
  • RPML14 3

External Ids for MRPL2 Gene

Summaries for MRPL2 Gene

Entrez Gene Summary for MRPL2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPL2 Gene

MRPL2 (Mitochondrial Ribosomal Protein L2) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL2 Gene

Genomics for MRPL2 Gene

Genomic Location for MRPL2 Gene

Start:
43,054,029 bp from pter
End:
43,060,515 bp from pter
Size:
6,487 bases
Orientation:
Minus strand

Genomic View for MRPL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL2 Gene

Regulatory Elements for MRPL2 Gene

Proteins for MRPL2 Gene

  • Protein details for MRPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T653-RM02_HUMAN
    Recommended name:
    39S ribosomal protein L2, mitochondrial
    Protein Accession:
    Q5T653
    Secondary Accessions:
    • B2RC56
    • Q8WUL1
    • Q96Q56
    • Q9Y311

    Protein attributes for MRPL2 Gene

    Size:
    305 amino acids
    Molecular mass:
    33301 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27731.1; Type=Frameshift; Positions=274, 283; Evidence={ECO:0000305}; Sequence=CAI13780.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL2 Gene

neXtProt entry for MRPL2 Gene

Proteomics data for MRPL2 Gene at MOPED

Post-translational modifications for MRPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL2 Gene

No data available for DME Specific Peptides for MRPL2 Gene

Domains for MRPL2 Gene

Gene Families for MRPL2 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

UniProtKB/Swiss-Prot:

RM02_HUMAN
Family:
  • Belongs to the ribosomal protein L2P family.:
    • Q5T653
genes like me logo Genes that share domains with MRPL2: view

Function for MRPL2 Gene

Gene Ontology (GO) - Molecular Function for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL2: view

miRNA for MRPL2 Gene

miRTarBase miRNAs that target MRPL2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL2 Gene

Localization for MRPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL2 Gene COMPARTMENTS Subcellular localization image for MRPL2 gene
Compartment Confidence
mitochondrion 3
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL2: view

Pathways for MRPL2 Gene

SuperPathways for MRPL2 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL2: view

Pathways by source for MRPL2 Gene

1 KEGG pathway for MRPL2 Gene

Gene Ontology (GO) - Biological Process for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL2: view

Transcripts for MRPL2 Gene

Unigene Clusters for MRPL2 Gene

Mitochondrial ribosomal protein L2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MRPL2 Gene

GeneLoc Exon Structure for
MRPL2
ECgene alternative splicing isoforms for
MRPL2

Expression for MRPL2 Gene

mRNA expression in normal human tissues for MRPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL2 Gene

SOURCE GeneReport for Unigene cluster for MRPL2 Gene Hs.55041

genes like me logo Genes that share expressions with MRPL2: view

Orthologs for MRPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL2 36
  • 99.61 (n)
  • 99.22 (a)
MRPL2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL2 36
  • 88.63 (n)
  • 88.85 (a)
MRPL2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL2 36
  • 88.09 (n)
  • 89.18 (a)
MRPL2 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl2 36
  • 85.14 (n)
  • 84.26 (a)
Mrpl2 16
Mrpl2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL2 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL2 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl2 36
  • 85.7 (n)
  • 84.82 (a)
chicken
(Gallus gallus)
Aves MRPL2 36
  • 73.36 (n)
  • 82.91 (a)
MRPL2 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL2 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21075 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8536 36
zebrafish
(Danio rerio)
Actinopterygii im:6908224 36
  • 67.3 (n)
  • 74.14 (a)
MRPL2 37
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010450 36
  • 54.15 (n)
  • 51.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL2 36
  • 56.86 (n)
  • 52.04 (a)
mRpL2 37
  • 44 (a)
OneToOne
mRpL2 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-2 36
  • 50.57 (n)
  • 41.03 (a)
mrpl-2 37
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RML2 37
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToOne
Species with no ortholog for MRPL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPL2 Gene

ENSEMBL:
Gene Tree for MRPL2 (if available)
TreeFam:
Gene Tree for MRPL2 (if available)

Paralogs for MRPL2 Gene

Pseudogenes.org Pseudogenes for MRPL2 Gene

genes like me logo Genes that share paralogs with MRPL2: view

No data available for Paralogs for MRPL2 Gene

Variants for MRPL2 Gene

Sequence variations from dbSNP and Humsavar for MRPL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1214704 -- 43,057,173(+) caccc(A/G)gccGG intron-variant
rs9472000 -- 43,056,727(+) tggag(C/T)gcagt intron-variant
rs11970463 -- 43,057,244(+) ggtgc(A/G)atctc intron-variant
rs35707301 -- 43,057,037(+) AATAA(-/T)TTTCA intron-variant
rs114973901 -- 43,056,227(+) CAGAC(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL2 Gene

Variant ID Type Subtype PubMed ID
nsv462927 CNV Loss 19166990
nsv462930 CNV Loss 19166990

Relevant External Links for MRPL2 Gene

HapMap Linkage Disequilibrium report
MRPL2

Disorders for MRPL2 Gene

Relevant External Links for MRPL2

Genetic Association Database (GAD)
MRPL2
Human Genome Epidemiology (HuGE) Navigator
MRPL2
genes like me logo Genes that share disorders with MRPL2: view

No data available for UniProtKB/Swiss-Prot for MRPL2 Gene

Publications for MRPL2 Gene

  1. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. (PMID: 10593885) O'Brien T.W. … Graack H.R. (J. Biol. Chem. 1999) 3 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPL2 Gene

Sources for MRPL2 Gene

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