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Aliases for MRPL2 Gene

Aliases for MRPL2 Gene

  • Mitochondrial Ribosomal Protein L2 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL2m 3 4
  • MRP-L2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3
  • MRP-L14 3
  • CGI-22 3
  • RPML14 3

External Ids for MRPL2 Gene

Previous GeneCards Identifiers for MRPL2 Gene

  • GC06M043023
  • GC06M043068
  • GC06M043129
  • GC06M042738
  • GC06M043021

Summaries for MRPL2 Gene

Entrez Gene Summary for MRPL2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPL2 Gene

MRPL2 (Mitochondrial Ribosomal Protein L2) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Additional gene information for MRPL2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL2 Gene

Genomics for MRPL2 Gene

Regulatory Elements for MRPL2 Gene

Enhancers for MRPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H043266 2 FANTOM5 Ensembl ENCODE dbSUPER 5.4 -213.3 -213267 13.1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 POLH ZNF318 GTPBP2 POLR1C RPS2P29 ABCC10 XPO5 CUL7 UBR2 RRP36
GH06H042819 0.8 Ensembl ENCODE 10.8 +239.2 239161 2.9 CTCF CEBPB PRDM1 RAD21 RPL7L1 RNU6-890P KLC4 MRPL2 PPP2R5D KLHDC3 MEA1 LOC401261
GH06H043246 1.1 ENCODE 5.5 -187.0 -187001 1.8 HDGF ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 ZNF143 SP3 MXD4 ZNF318 ENSG00000271970 CUL9 POLR1C POLH RPS2P29 TJAP1 XPO5 MRPL2 DNPH1
GH06H043058 1.4 Ensembl ENCODE 0.7 0.0 -49 3.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 BICRAL RRP36 POLH GTPBP2 DNPH1 ENSG00000272223 MRPL2 ENSG00000272170
GH06H043069 1 Ensembl ENCODE 0.4 -9.9 -9937 1 HDGF CTCF TBL1XR1 ARID4B ZNF384 RAD21 TEAD3 ZNF664 CC2D1A FOXK2 CUL7 ENSG00000272170 MRPL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL2 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197080 586 1601 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Locations for MRPL2 Gene

Genomic Locations for MRPL2 Gene
chr6:43,054,029-43,060,186
(GRCh38/hg38)
Size:
6,158 bases
Orientation:
Minus strand
chr6:43,021,767-43,027,544
(GRCh37/hg19)

Genomic View for MRPL2 Gene

Genes around MRPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL2 Gene

Proteins for MRPL2 Gene

  • Protein details for MRPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T653-RM02_HUMAN
    Recommended name:
    39S ribosomal protein L2, mitochondrial
    Protein Accession:
    Q5T653
    Secondary Accessions:
    • B2RC56
    • Q8WUL1
    • Q96Q56
    • Q9Y311

    Protein attributes for MRPL2 Gene

    Size:
    305 amino acids
    Molecular mass:
    33301 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAD27731.1; Type=Frameshift; Positions=274, 283; Evidence={ECO:0000305}; Sequence=CAI13780.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL2 Gene

neXtProt entry for MRPL2 Gene

Post-translational modifications for MRPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL2 Gene

No data available for DME Specific Peptides for MRPL2 Gene

Domains & Families for MRPL2 Gene

Gene Families for MRPL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T653

UniProtKB/Swiss-Prot:

RM02_HUMAN :
  • Belongs to the universal ribosomal protein uL2 family.
Family:
  • Belongs to the universal ribosomal protein uL2 family.
genes like me logo Genes that share domains with MRPL2: view

Function for MRPL2 Gene

Gene Ontology (GO) - Molecular Function for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003735 structural constituent of ribosome IEA,IBA --
genes like me logo Genes that share ontologies with MRPL2: view
genes like me logo Genes that share phenotypes with MRPL2: view

Animal Model Products

miRNA for MRPL2 Gene

miRTarBase miRNAs that target MRPL2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL2 Gene

Localization for MRPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL2 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL2: view

Pathways & Interactions for MRPL2 Gene

genes like me logo Genes that share pathways with MRPL2: view

Gene Ontology (GO) - Biological Process for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 NOT cytoplasmic translation IBA --
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL2: view

No data available for SIGNOR curated interactions for MRPL2 Gene

Drugs & Compounds for MRPL2 Gene

No Compound Related Data Available

Transcripts for MRPL2 Gene

Unigene Clusters for MRPL2 Gene

Mitochondrial ribosomal protein L2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MRPL2 Gene

GeneLoc Exon Structure for
MRPL2
ECgene alternative splicing isoforms for
MRPL2

Expression for MRPL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL2 Gene

This gene is overexpressed in Breast (30.3) and Pancreas (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL2 Gene



Protein tissue co-expression partners for MRPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL2 Gene:

MRPL2

SOURCE GeneReport for Unigene cluster for MRPL2 Gene:

Hs.55041

Evidence on tissue expression from TISSUES for MRPL2 Gene

  • Skin(4.2)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with MRPL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL2 Gene

Orthologs for MRPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL2 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia MRPL2 33 34
  • 88.63 (n)
dog
(Canis familiaris)
Mammalia MRPL2 33 34
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl2 33
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia Mrpl2 33 16 34
  • 85.14 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL2 34 33
  • 73.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL2 34
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21075 33
zebrafish
(Danio rerio)
Actinopterygii MRPL2 34
  • 68 (a)
OneToOne
im:6908224 33
  • 67.3 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8536 33
fruit fly
(Drosophila melanogaster)
Insecta mRpL2 35 33 34
  • 56.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010450 33
  • 54.15 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-2 33 34
  • 50.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RML2 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToOne
Species where no ortholog for MRPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPL2 Gene

ENSEMBL:
Gene Tree for MRPL2 (if available)
TreeFam:
Gene Tree for MRPL2 (if available)

Paralogs for MRPL2 Gene

Pseudogenes.org Pseudogenes for MRPL2 Gene

genes like me logo Genes that share paralogs with MRPL2: view

No data available for Paralogs for MRPL2 Gene

Variants for MRPL2 Gene

Sequence variations from dbSNP and Humsavar for MRPL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3737186 Likely benign 43,053,781(-) TCACG(C/T)GGGTG downstream-variant-500B, reference, synonymous-codon, utr-variant-5-prime
rs369727378 Uncertain significance 43,053,911(+) GCGGA(C/G)CCGAG downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs377101095 Uncertain significance 43,053,882(+) AAAGC(C/T)AGGGG downstream-variant-500B, utr-variant-5-prime
rs754072990 Uncertain significance 43,053,885(+) GCTAG(A/C/G)GGCCC downstream-variant-500B, utr-variant-5-prime
rs80311039 Uncertain significance 43,053,913(+) GGAGC(C/G)GAGGA downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL2 Gene

Variant ID Type Subtype PubMed ID
nsv602992 CNV loss 21841781
nsv462930 CNV loss 19166990
nsv462927 CNV loss 19166990
nsv1017398 CNV gain 25217958
dgv10640n54 CNV loss 21841781

Variation tolerance for MRPL2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL2 Gene

Disorders for MRPL2 Gene

Relevant External Links for MRPL2

Genetic Association Database (GAD)
MRPL2
Human Genome Epidemiology (HuGE) Navigator
MRPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL2

No disorders were found for MRPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL2 Gene

Publications for MRPL2 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4 60

Products for MRPL2 Gene

Sources for MRPL2 Gene

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