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Aliases for MRPL2 Gene

Aliases for MRPL2 Gene

  • Mitochondrial Ribosomal Protein L2 2 3 5
  • MRP-L2 3 4
  • L2mt 3 4
  • 39S Ribosomal Protein L2, Mitochondrial 3
  • MRP-L14 3
  • CGI-22 3
  • RPML14 3

External Ids for MRPL2 Gene

Previous GeneCards Identifiers for MRPL2 Gene

  • GC06M043023
  • GC06M043068
  • GC06M043129
  • GC06M042738
  • GC06M043021

Summaries for MRPL2 Gene

Entrez Gene Summary for MRPL2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPL2 Gene

MRPL2 (Mitochondrial Ribosomal Protein L2) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL2 Gene

Genomics for MRPL2 Gene

Regulatory Elements for MRPL2 Gene

Enhancers for MRPL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F042819 1.2 Ensembl ENCODE 10.8 +239.2 239161 2.9 CTCF RAD21 ZNF316 ZFHX2 POLR2A SCRT2 ZNF548 ZNF652 MAFK EGR2 GLTSCR1L RPL7L1 RNU6-890P POLH KLC4 MRPL2 UBR2 PPP2R5D KLHDC3 MEA1
GH06F043246 0.9 ENCODE 5.5 -187.0 -187001 1.8 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF263 SP3 ENSG00000271970 LOC101929726 RPL24P4 MRPL2 DNPH1 TTBK1 LOC105375064
GH06F043284 0.2 Ensembl 5.4 -225.3 -225342 1.4 GLIS2 EGR2 MRPL2 LOC105375064 SLC22A7
GH06F043266 1.4 FANTOM5 Ensembl ENCODE 5.4 -213.3 -213267 13.1 HDGF MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLH RPS2P29 RPS2P28 ENSG00000223469 RPL29P16 RRP36 KLC4 ENSG00000271754 DNPH1 LOC101929726
GH06F043058 0.5 ENCODE 0.8 0.0 -49 3.7 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GLTSCR1L RRP36 POLH RPL24P4 DNPH1 ENSG00000272223 MRPL2 ENSG00000272170
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPL2 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001495382 486 2201 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MRPL2 Gene

Chromosome:
6
Start:
43,054,029 bp from pter
End:
43,060,186 bp from pter
Size:
6,158 bases
Orientation:
Minus strand

Genomic View for MRPL2 Gene

Genes around MRPL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL2 Gene

Proteins for MRPL2 Gene

  • Protein details for MRPL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T653-RM02_HUMAN
    Recommended name:
    39S ribosomal protein L2, mitochondrial
    Protein Accession:
    Q5T653
    Secondary Accessions:
    • B2RC56
    • Q8WUL1
    • Q96Q56
    • Q9Y311

    Protein attributes for MRPL2 Gene

    Size:
    305 amino acids
    Molecular mass:
    33301 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    SequenceCaution:
    • Sequence=AAD27731.1; Type=Frameshift; Positions=274, 283; Evidence={ECO:0000305}; Sequence=CAI13780.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL2 Gene

neXtProt entry for MRPL2 Gene

Post-translational modifications for MRPL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL2 Gene

No data available for DME Specific Peptides for MRPL2 Gene

Domains & Families for MRPL2 Gene

Gene Families for MRPL2 Gene

Suggested Antigen Peptide Sequences for MRPL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T653

UniProtKB/Swiss-Prot:

RM02_HUMAN :
  • Belongs to the ribosomal protein L2P family.
Family:
  • Belongs to the ribosomal protein L2P family.
genes like me logo Genes that share domains with MRPL2: view

Function for MRPL2 Gene

Gene Ontology (GO) - Molecular Function for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0016740 transferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL2: view
genes like me logo Genes that share phenotypes with MRPL2: view

Animal Model Products

miRNA for MRPL2 Gene

miRTarBase miRNAs that target MRPL2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL2 Gene

Localization for MRPL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL2 Gene COMPARTMENTS Subcellular localization image for MRPL2 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA,IBA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL2: view

Pathways & Interactions for MRPL2 Gene

genes like me logo Genes that share pathways with MRPL2: view

Gene Ontology (GO) - Biological Process for MRPL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002181 NOT cytoplasmic translation IBA --
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL2: view

No data available for SIGNOR curated interactions for MRPL2 Gene

Transcripts for MRPL2 Gene

Unigene Clusters for MRPL2 Gene

Mitochondrial ribosomal protein L2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MRPL2 Gene

GeneLoc Exon Structure for
MRPL2
ECgene alternative splicing isoforms for
MRPL2

Expression for MRPL2 Gene

mRNA expression in normal human tissues for MRPL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL2 Gene

This gene is overexpressed in Breast (30.3) and Pancreas (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL2 Gene



Protein tissue co-expression partners for MRPL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL2 Gene:

MRPL2

SOURCE GeneReport for Unigene cluster for MRPL2 Gene:

Hs.55041
genes like me logo Genes that share expression patterns with MRPL2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL2 Gene

Orthologs for MRPL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL2 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia MRPL2 34 35
  • 88.63 (n)
dog
(Canis familiaris)
Mammalia MRPL2 34 35
  • 88.09 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl2 34
  • 85.7 (n)
mouse
(Mus musculus)
Mammalia Mrpl2 34 16 35
  • 85.14 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL2 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL2 34 35
  • 73.36 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL2 35
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21075 34
zebrafish
(Danio rerio)
Actinopterygii MRPL2 35
  • 68 (a)
OneToOne
im:6908224 34
  • 67.3 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8536 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL2 36 34 35
  • 56.86 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010450 34
  • 54.15 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-2 34 35
  • 50.57 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RML2 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for MRPL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPL2 Gene

ENSEMBL:
Gene Tree for MRPL2 (if available)
TreeFam:
Gene Tree for MRPL2 (if available)

Paralogs for MRPL2 Gene

Pseudogenes.org Pseudogenes for MRPL2 Gene

genes like me logo Genes that share paralogs with MRPL2: view

No data available for Paralogs for MRPL2 Gene

Variants for MRPL2 Gene

Sequence variations from dbSNP and Humsavar for MRPL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456521 -- 43,054,293(+) AAGCA(A/G)AAGGC upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs111613875 -- 43,054,981(+) GCTGA(A/G)GCAGA intron-variant, upstream-variant-2KB
rs111675957 -- 43,055,419(+) GGCAG(A/G)AAAGG intron-variant, upstream-variant-2KB
rs111832004 -- 43,054,400(+) AGCCA(C/G)CGGTT upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime
rs112364528 -- 43,054,561(+) CCTTG(C/G)GGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL2 Gene

Variant ID Type Subtype PubMed ID
dgv10640n54 CNV loss 21841781
nsv1017398 CNV gain 25217958
nsv462927 CNV loss 19166990
nsv462930 CNV loss 19166990
nsv602992 CNV loss 21841781

Variation tolerance for MRPL2 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL2 Gene

Disorders for MRPL2 Gene

Relevant External Links for MRPL2

Genetic Association Database (GAD)
MRPL2
Human Genome Epidemiology (HuGE) Navigator
MRPL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL2

No disorders were found for MRPL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL2 Gene

Publications for MRPL2 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4 64

Products for MRPL2 Gene

Sources for MRPL2 Gene

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