Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL19 Gene

Aliases for MRPL19 Gene

  • Mitochondrial Ribosomal Protein L19 2 3
  • MRPL15 3 4 6
  • 39S Ribosomal Protein L15, Mitochondrial 3 4
  • KIAA0104 4 6
  • MRP-L15 3 4
  • MRP-L19 3 4
  • L15mt 3 4
  • L19mt 3 4
  • 39S Ribosomal Protein L19, Mitochondrial 3
  • 39S Ribosomal Protein L19 2
  • RPML15 3
  • RLX1 3

External Ids for MRPL19 Gene

Summaries for MRPL19 Gene

Entrez Gene Summary for MRPL19 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL19 Gene

MRPL19 (Mitochondrial Ribosomal Protein L19) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations) and CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL19 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL19 Gene

Genomics for MRPL19 Gene

Genomic Location for MRPL19 Gene

Start:
75,613,881 bp from pter
End:
75,690,851 bp from pter
Size:
76,971 bases
Orientation:
Plus strand

Genomic View for MRPL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL19 Gene

Regulatory Elements for MRPL19 Gene

Proteins for MRPL19 Gene

  • Protein details for MRPL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49406-RM19_HUMAN
    Recommended name:
    39S ribosomal protein L19, mitochondrial
    Protein Accession:
    P49406
    Secondary Accessions:
    • Q53TX9
    • Q96Q52

    Protein attributes for MRPL19 Gene

    Size:
    292 amino acids
    Molecular mass:
    33535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY14972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03494.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL19 Gene

neXtProt entry for MRPL19 Gene

Proteomics data for MRPL19 Gene at MOPED

Post-translational modifications for MRPL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL19 Gene

No data available for DME Specific Peptides for MRPL19 Gene

Domains for MRPL19 Gene

Gene Families for MRPL19 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL19 Gene

Suggested Antigen Peptide Sequences for MRPL19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49406

UniProtKB/Swiss-Prot:

RM19_HUMAN
Family:
  • Belongs to the ribosomal protein L19P family.:
    • P49406
genes like me logo Genes that share domains with MRPL19: view

Function for MRPL19 Gene

Gene Ontology (GO) - Molecular Function for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL19: view

miRNA for MRPL19 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL19 Gene

Localization for MRPL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL19 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL19 Gene COMPARTMENTS Subcellular localization image for MRPL19 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 10942595
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL19: view

Pathways for MRPL19 Gene

genes like me logo Genes that share pathways with MRPL19: view

Pathways by source for MRPL19 Gene

1 BioSystems pathway for MRPL19 Gene
1 KEGG pathway for MRPL19 Gene

Gene Ontology (GO) - Biological Process for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL19: view

Transcripts for MRPL19 Gene

Unigene Clusters for MRPL19 Gene

Mitochondrial ribosomal protein L19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL19 Gene

No ASD Table

Relevant External Links for MRPL19 Gene

GeneLoc Exon Structure for
MRPL19
ECgene alternative splicing isoforms for
MRPL19

Expression for MRPL19 Gene

mRNA expression in normal human tissues for MRPL19 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL19 Gene

SOURCE GeneReport for Unigene cluster for MRPL19 Gene Hs.44024

genes like me logo Genes that share expressions with MRPL19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL19 Gene

Orthologs for MRPL19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL19 35
  • 99.89 (n)
  • 99.66 (a)
MRPL19 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL19 35
  • 87.44 (n)
  • 83.9 (a)
MRPL19 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL19 35
  • 87.41 (n)
  • 84.53 (a)
MRPL19 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl19 35
  • 79.79 (n)
  • 81.51 (a)
Mrpl19 16
Mrpl19 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL19 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL19 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl19 35
  • 80.14 (n)
  • 80.82 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 72 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
MRPL19 35
  • 73.76 (n)
  • 75.74 (a)
lizard
(Anolis carolinensis)
Reptilia MRPL19 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22445 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496116 35
  • 67.76 (n)
  • 69.39 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl19 35
  • 61.9 (n)
  • 63.21 (a)
mrpl19 36
  • 62 (a)
OneToOne
wufc01c05 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001139 35
  • 48.95 (n)
  • 44.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL19 35
  • 54.98 (n)
  • 52.34 (a)
mRpL19 36
  • 38 (a)
OneToOne
mRpL19 37
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-19 35
  • 56.42 (n)
  • 48.96 (a)
mrpl-19 36
  • 36 (a)
OneToOne
Y119C1B.4 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
Species with no ortholog for MRPL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL19 Gene

ENSEMBL:
Gene Tree for MRPL19 (if available)
TreeFam:
Gene Tree for MRPL19 (if available)

Paralogs for MRPL19 Gene

Pseudogenes.org Pseudogenes for MRPL19 Gene

genes like me logo Genes that share paralogs with MRPL19: view

No data available for Paralogs for MRPL19 Gene

Variants for MRPL19 Gene

Sequence variations from dbSNP and Humsavar for MRPL19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11847 -- 75,655,450(+) GTTTA(C/T)TACTC utr-variant-3-prime, nc-transcript-variant
rs714479 -- 75,620,578(+) CCAGT(A/C)AAAAA intron-variant
rs757916 -- 75,651,317(+) CTCTC(C/T)TCGAC intron-variant
rs757917 -- 75,651,492(+) ATCTC(A/G)GTTAC intron-variant
rs875754 -- 75,617,707(-) GGAGC(A/G)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL19 Gene

Variant ID Type Subtype PubMed ID
dgv1201e1 CNV Complex 17122850
dgv1202e1 CNV Complex 17122850
dgv5n43 CNV Gain 19587683
dgv4169n71 CNV Gain 21882294
esv260037 OTHER Complex 20981092
dgv152e55 CNV Gain 17911159
nsv441762 CNV CNV 18776908
dgv20n14 CNV Gain 18776910
nsv438356 CNV Loss 16468122
nsv834263 CNV Gain 17160897
nsv514988 CNV Complex 21397061
nsv874307 CNV Gain 21882294

Relevant External Links for MRPL19 Gene

HapMap Linkage Disequilibrium report
MRPL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL19 Gene

Disorders for MRPL19 Gene

(1) University of Copenhagen DISEASES for MRPL19 Gene

Relevant External Links for MRPL19

Genetic Association Database (GAD)
MRPL19
Human Genome Epidemiology (HuGE) Navigator
MRPL19
genes like me logo Genes that share disorders with MRPL19: view

No data available for UniProtKB/Swiss-Prot for MRPL19 Gene

Publications for MRPL19 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. (PMID: 17309879) Anthoni H. … Peyrard-Janvid M. (Hum. Mol. Genet. 2007) 2 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for MRPL19 Gene

Sources for MRPL19 Gene

Back to Top

Content