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Aliases for MRPL19 Gene

Aliases for MRPL19 Gene

  • Mitochondrial Ribosomal Protein L19 2 3
  • 39S Ribosomal Protein L15, Mitochondrial 3 4
  • MRP-L15 3 4
  • MRP-L19 3 4
  • MRPL15 3 4
  • L15mt 3 4
  • L19mt 3 4
  • 39S Ribosomal Protein L19 2
  • KIAA0104 4
  • RPML15 3
  • RLX1 3

External Ids for MRPL19 Gene

Previous GeneCards Identifiers for MRPL19 Gene

  • GC02P076011
  • GC02P075831
  • GC02P075848
  • GC02P075785
  • GC02P075727
  • GC02P075873
  • GC02P075611

Summaries for MRPL19 Gene

Entrez Gene Summary for MRPL19 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL19 Gene

MRPL19 (Mitochondrial Ribosomal Protein L19) is a Protein Coding gene. Diseases associated with MRPL19 include reading disorder and speech and communication disorders. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL19 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL19 Gene

Genomics for MRPL19 Gene

Regulatory Elements for MRPL19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL19 Gene

Chromosome:
2
Start:
75,646,783 bp from pter
End:
75,690,851 bp from pter
Size:
44,069 bases
Orientation:
Plus strand

Genomic View for MRPL19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MRPL19 Gene

Proteins for MRPL19 Gene

  • Protein details for MRPL19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49406-RM19_HUMAN
    Recommended name:
    39S ribosomal protein L19, mitochondrial
    Protein Accession:
    P49406
    Secondary Accessions:
    • Q53TX9
    • Q96Q52

    Protein attributes for MRPL19 Gene

    Size:
    292 amino acids
    Molecular mass:
    33535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY14972.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA03494.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL19 Gene

neXtProt entry for MRPL19 Gene

Proteomics data for MRPL19 Gene at MOPED

Post-translational modifications for MRPL19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL19 Gene

No data available for DME Specific Peptides for MRPL19 Gene

Domains & Families for MRPL19 Gene

Gene Families for MRPL19 Gene

Protein Domains for MRPL19 Gene

Suggested Antigen Peptide Sequences for MRPL19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49406

UniProtKB/Swiss-Prot:

RM19_HUMAN :
  • Belongs to the ribosomal protein L19P family.
Family:
  • Belongs to the ribosomal protein L19P family.
genes like me logo Genes that share domains with MRPL19: view

Function for MRPL19 Gene

Gene Ontology (GO) - Molecular Function for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPL19: view

Phenotypes for MRPL19 Gene

GenomeRNAi human phenotypes for MRPL19:
genes like me logo Genes that share phenotypes with MRPL19: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL19 Gene

Localization for MRPL19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL19 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL19 Gene COMPARTMENTS Subcellular localization image for MRPL19 gene
Compartment Confidence
nucleus 5
mitochondrion 4

Gene Ontology (GO) - Cellular Components for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 10942595
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPL19: view

Pathways & Interactions for MRPL19 Gene

genes like me logo Genes that share pathways with MRPL19: view

Pathways by source for MRPL19 Gene

Gene Ontology (GO) - Biological Process for MRPL19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL19: view

No data available for SIGNOR curated interactions for MRPL19 Gene

Drugs & Compounds for MRPL19 Gene

No Compound Related Data Available

Transcripts for MRPL19 Gene

mRNA/cDNA for MRPL19 Gene

Unigene Clusters for MRPL19 Gene

Mitochondrial ribosomal protein L19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL19 Gene

No ASD Table

Relevant External Links for MRPL19 Gene

GeneLoc Exon Structure for
MRPL19
ECgene alternative splicing isoforms for
MRPL19

Expression for MRPL19 Gene

mRNA expression in normal human tissues for MRPL19 Gene

Protein differential expression in normal tissues from HIPED for MRPL19 Gene

This gene is overexpressed in Pancreas (12.5), Bone marrow stromal cell (9.6), Peripheral blood mononuclear cells (9.3), and Bone (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL19 Gene



SOURCE GeneReport for Unigene cluster for MRPL19 Gene Hs.44024

genes like me logo Genes that share expression patterns with MRPL19: view

Protein tissue co-expression partners for MRPL19 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL19 Gene

Orthologs for MRPL19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL19 35
  • 87.44 (n)
  • 83.9 (a)
MRPL19 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL19 35
  • 87.41 (n)
  • 84.53 (a)
MRPL19 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl19 35
  • 79.79 (n)
  • 81.51 (a)
Mrpl19 16
Mrpl19 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL19 35
  • 99.89 (n)
  • 99.66 (a)
MRPL19 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl19 35
  • 80.14 (n)
  • 80.82 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL19 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL19 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL19 35
  • 73.76 (n)
  • 75.74 (a)
-- 36
  • 72 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MRPL19 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496116 35
  • 67.76 (n)
  • 69.39 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22445 35
zebrafish
(Danio rerio)
Actinopterygii mrpl19 35
  • 61.9 (n)
  • 63.21 (a)
wufc01c05 35
mrpl19 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL19 37
  • 48 (a)
mRpL19 35
  • 54.98 (n)
  • 52.34 (a)
mRpL19 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001139 35
  • 48.95 (n)
  • 44.88 (a)
worm
(Caenorhabditis elegans)
Secernentea Y119C1B.4 37
  • 42 (a)
mrpl-19 35
  • 56.42 (n)
  • 48.96 (a)
mrpl-19 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
Species with no ortholog for MRPL19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL19 Gene

ENSEMBL:
Gene Tree for MRPL19 (if available)
TreeFam:
Gene Tree for MRPL19 (if available)

Paralogs for MRPL19 Gene

Pseudogenes.org Pseudogenes for MRPL19 Gene

genes like me logo Genes that share paralogs with MRPL19: view

No data available for Paralogs for MRPL19 Gene

Variants for MRPL19 Gene

Sequence variations from dbSNP and Humsavar for MRPL19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11847 -- 75,655,450(+) GTTTA(C/T)TACTC utr-variant-3-prime
rs757916 -- 75,651,317(+) CTCTC(C/T)TCGAC intron-variant
rs757917 -- 75,651,492(+) ATCTC(A/G)GTTAC intron-variant
rs917236 -- 75,656,264(+) TATAA(G/T)CACAC utr-variant-3-prime
rs1001893 -- 75,645,120(-) TTAGT(C/T)TTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL19 Gene

Variant ID Type Subtype PubMed ID
dgv1201e1 CNV Complex 17122850
dgv1202e1 CNV Complex 17122850
dgv5n43 CNV Gain 19587683
dgv4169n71 CNV Gain 21882294
esv260037 OTHER Complex 20981092
dgv152e55 CNV Gain 17911159
nsv441762 CNV CNV 18776908
dgv20n14 CNV Gain 18776910
nsv438356 CNV Loss 16468122
nsv834263 CNV Gain 17160897
nsv514988 CNV Complex 21397061
nsv874307 CNV Gain 21882294

Variation tolerance for MRPL19 Gene

Residual Variation Intolerance Score: 49.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL19 Gene

HapMap Linkage Disequilibrium report
MRPL19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL19 Gene

Disorders for MRPL19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MRPL19 Gene - From: DISEASES

Disorder Aliases PubMed IDs
reading disorder
  • dyslexia
speech and communication disorders
  • communication disorder
- elite association

Relevant External Links for MRPL19

Genetic Association Database (GAD)
MRPL19
Human Genome Epidemiology (HuGE) Navigator
MRPL19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL19
genes like me logo Genes that share disorders with MRPL19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL19 Gene

Publications for MRPL19 Gene

  1. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. (PMID: 17309879) Anthoni H. … Peyrard-Janvid M. (Hum. Mol. Genet. 2007) 2 67
  2. Statistical modeling for selecting housekeeper genes. (PMID: 15287981) Szabo A. … Bernard P.S. (Genome Biol. 2004) 23 67
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67

Products for MRPL19 Gene

Sources for MRPL19 Gene

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