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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL19 Gene

protein-coding   GIFtS: 53
GCID: GC02P075873

mitochondrial ribosomal protein L19

 Explore 1 disease affiliated with
MRPL19 via our new
 Human Malady Compendium 
Biological research products
for MRPL19
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein L191 2     39S Ribosomal Protein L15, Mitochondrial2 3
MRP-L151 2 3     L15mt2 3
KIAA01041 3 5     L19mt2 3
MRPL152 3 5     MRP-L192 3
RLX11 2     39S Ribosomal Protein L19, Mitochondrial2
RPML151 2     

External Ids:    HGNC: 140521   Entrez Gene: 98012   Ensembl: ENSG000001153647   OMIM: 6118325   UniProtKB: P494063   

Export aliases for MRPL19 gene to outside databases

Previous GC identifers: GC02P076011 GC02P075831 GC02P075848 GC02P075785 GC02P075727 GC02P075611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPL19:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
(provided by RefSeq, Jul 2008)

Gene Wiki entry for MRPL19


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL19 gene promoter:
         GR   ISGF-3   GR-beta   LUN-1   GATA-1   Zic1   FOXJ2 (long isoform)   GR-alpha   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL19 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.1-q11.2   Ensembl cytogenetic band:  2p12   HGNC cytogenetic band: 2p11.1-q11.2

MRPL19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL19 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P075873:  view genomic region     (about GC identifiers)

Start:
75,873,909 bp from pter      End:
75,917,977 bp from pter
Size:
44,069 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RM19_HUMAN, P49406 (See protein sequence)
Recommended Name: 39S ribosomal protein L19, mitochondrial precursor  
Size: 292 amino acids; 33535 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAY14972.1; Type=Erroneous initiation; Sequence=BAA03494.1; Type=Erroneous initiation;
Secondary accessions: Q53TX9 Q96Q52

Explore the universe of human proteins at neXtProt for MRPL19: NX_P49406

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49406

  • MRPL19 Protein expression data from MOPED and PaxDb:    About this image 
    MRPL19 Protein Expression
    REFSEQ proteins: NP_055578.2  
    ENSEMBL proteins: 
     ENSP00000377486   ENSP00000351639   ENSP00000387284   ENSP00000406267  

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    Uscn Proteins for MRPL19

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10942595
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome IEA--
    GO:0031965nuclear membrane IDA10942595

    MRPL19 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MRPL19 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008991 Translation_prot_SH3-like
     IPR001857 Ribosomal_L19

    Graphical View of Domain Structure for InterPro Entry P49406

    ProtoNet protein and cluster: P49406

    1 Blocks protein family: IPB001857 Ribosomal protein L19

    UniProtKB/Swiss-Prot: RM19_HUMAN, P49406
    Similarity: Belongs to the ribosomal protein L19P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
         
    MRPL19 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRPL19 

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    In Situ Assay
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synthesis of PB1-F2
    Cytoplasmic Ribosomal Proteins0.86


    1 BioSystems Pathway for MRPL19 
        Cytoplasmic Ribosomal Proteins


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL19

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/235 Interacting proteins for MRPL19 (P494062, 3 ENSP000003774864) via UniProtKB, MINT, STRING, and/or I2D (see all 235)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503950 I2D: score=1 STRING: ENSP00000262435
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503490 I2D: score=1 STRING: ENSP00000363390
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MAGEC1O607323, ENSP000002858794I2D: score=2 STRING: ENSP00000285879
    MRPL11Q9Y3B72, ENSP000003088974MINT-8079030 STRING: ENSP00000308897
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    MRPL19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL19
    Search CenterWatch for drugs/clinical trials and news about MRPL19 / RM19 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPL19 gene: 
    NM_014763.3  

    Unigene Cluster for MRPL19:

    Mitochondrial ribosomal protein L19
    Hs.44024  [show with all ESTs]
    Unigene Representative Sequence: NM_014763
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000493686 ENST00000393909(uc002snl.3) ENST00000358788 ENST00000409374
    ENST00000476622 ENST00000492255 ENST00000453233

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPL19
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPL19 (see all 12):
    hsa-miR-374b* hsa-miR-876-5p hsa-miR-513c hsa-miR-138-2* hsa-miR-373* hsa-miR-3167 hsa-miR-2116 hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL19
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    Additional cDNA sequence: 

    AK024792.1 AK291250.1 AK295578.1 AL157503.1 BC021051.1 BC030144.2 D14660.1 

    8 DOTS entries:

    DT.443679  DT.100696898  DT.209978  DT.100700294  DT.120989994  DT.91985133  DT.75147675  DT.97784999 

    24/282 AceView cDNA sequences (see all 282):

    BP367733 CA424138 BF724430 BQ050355 AA514876 BQ188262 AA740496 BX506786 
    BX107291 BC030144 BX475084 D14660 AA768402 CR605824 BQ185704 BF797747 
    CR593472 BF448769 N29454 AI371880 BP380003 BX499968 NM_014763 AI186994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    MRPL19 Expression
    About this image
    See MRPL19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL19

    SOURCE GeneReport for Unigene cluster: Hs.44024
        SABiosciences Custom PCR Arrays for MRPL19

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPL19 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl191 , 5 mitochondrial ribosomal protein L191, 5 79.79(n)1
    81.51(a)1
      6 (35.81 cM)5
    562841  NM_026490.21  NP_080766.11 
     819578515 
    chicken
    (Gallus gallus)
    Aves MRPL191 mitochondrial ribosomal protein L19 74.07(n)
    76.07(a)
      422066  XM_420071.3  XP_420071.3 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL196
    --
    59(a)
    1 ↔ 1
    1(137762557-137769264)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.224452 Xenopus laevis transcribed sequence with moderate similarity more 73.8(n)    BI444821.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc01c052 Transcribed sequence with weak similarity to protein more 73.17(n)    CA471078.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL191 , 3 protein biosynthesis structural constituent
    of more3
    mitochondrial ribosomal protein L191
    48(a)3
    54.98(n)1
    52.34(a)1
      85A53
    410281  NM_079560.41  NP_524284.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y119C1B.43
    mrpl-191
    Protein MRPL-191 42(a)3
    52.3(n)1
    44.89(a)1
      I(4509051-4511125)3
    1720521  NM_058980.31  NP_491381.11 


    ENSEMBL Gene Tree for MRPL19 (if available)
    TreeFam Gene Tree for MRPL19 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPL19 gene

    MRPL19 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPL19
    PGOHUM00000245995


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in MRPL19 are shown (see all 347    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10018941,2
    C,F,O,A--75871946(-) ATTAGA/TACAAG 1 -- us2k114Minor allele frequency- T:0.32EA NA WA 710
    rs1815019121,2
    --75871965(+) CTAGAG/TTTAAA 1 -- us2k10--------
    rs1857678651,2
    --75871978(+) AGAAGA/GCCCTG 1 -- us2k10--------
    rs1901373081,2
    --75872147(+) ACAGTA/CAGGCT 1 -- us2k10--------
    rs1157402121,2
    F--75872149(+) AGTAAG/AGCTTT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs729160311,2
    C--75872191(+) TTTCTG/AAGCCA 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs10018931,2
    C,F,A,H--75872246(-) TTAGTC/TTTCTT 1 -- us2k116Minor allele frequency- T:0.14NS EA NA WA 2326
    rs1483419091,2
    --75872356(+) CCTGAG/TATATT 1 -- us2k10--------
    rs1809807331,2
    --75872365(+) TTTGAC/TGGTGT 1 -- us2k10--------
    rs1852598491,2
    --75872366(+) TTGACA/GGTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRPL19 (75873909 - 75917977 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for MRPL19
         9 CNVs: 8376 37592 59605 3367 37536 2392 1585 37800 59004

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPL19 for disorders           About GeneDecksing

    OMIM gene information: 611832    OMIM disorders: --

    1 disease for MRPL19:    About MalaCards
    dyslexia

    1 disease from the University of Copenhagen DISEASES database for MRPL19:
    Dyslexia
    Human Genome Epidemiology (HuGE) Navigator: MRPL19 (4 documents)

    Export disorders for MRPL19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL19 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MRPL19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
    2. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. (PubMed id 17309879)1, 3 Anthoni H....Peyrard-Janvid M. (2007)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle. (PubMed id 10600119)1, 2 Graack H.R.... O'Brien T.W. (1999)
    6. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9801 HGNC: 14052 AceView: MRPL19 Ensembl:ENSG00000115364 euGenes: HUgn9801
    ECgene: MRPL19 H-InvDB: MRPL19

    (According to HUGE)
    About This Section
    HUGE: KIAA0104

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPL19 gene:
    Search GeneIP for patents involving MRPL19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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