Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL18 Gene

Aliases for MRPL18 Gene

  • Mitochondrial Ribosomal Protein L18 2 3
  • MRP-L18 3 4
  • L18mt 3 4
  • 39S Ribosomal Protein L18, Mitochondrial 3
  • HSPC071 3

External Ids for MRPL18 Gene

Previous GeneCards Identifiers for MRPL18 Gene

  • GC06P159650
  • GC06P160085
  • GC06P160043
  • GC06P160120
  • GC06P160181
  • GC06P157681
  • GC06P160210

Summaries for MRPL18 Gene

Entrez Gene Summary for MRPL18 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this gene, one of which is three nt in length which causes an extra aa near the N-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL18 Gene

MRPL18 (Mitochondrial Ribosomal Protein L18) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and 5S rRNA binding.

UniProtKB/Swiss-Prot for MRPL18 Gene

  • Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Gene Wiki entry for MRPL18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL18 Gene

Genomics for MRPL18 Gene

Regulatory Elements for MRPL18 Gene

Genomic Location for MRPL18 Gene

Start:
159,789,812 bp from pter
End:
159,798,436 bp from pter
Size:
8,625 bases
Orientation:
Plus strand

Genomic View for MRPL18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL18 Gene

Proteins for MRPL18 Gene

  • Protein details for MRPL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0U6-RM18_HUMAN
    Recommended name:
    39S ribosomal protein L18, mitochondrial
    Protein Accession:
    Q9H0U6
    Secondary Accessions:
    • Q5TAP9
    • Q9NZW8

    Protein attributes for MRPL18 Gene

    Size:
    180 amino acids
    Molecular mass:
    20577 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRPL18 Gene

Proteomics data for MRPL18 Gene at MOPED

Post-translational modifications for MRPL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL18 Gene

Domains for MRPL18 Gene

Gene Families for MRPL18 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0U6

UniProtKB/Swiss-Prot:

RM18_HUMAN :
  • Q9H0U6
Family:
  • Belongs to the ribosomal protein L18P family.
genes like me logo Genes that share domains with MRPL18: view

Function for MRPL18 Gene

Molecular function for MRPL18 Gene

UniProtKB/Swiss-Prot Function: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Gene Ontology (GO) - Molecular Function for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0008097 5S rRNA binding IDA 21685364
genes like me logo Genes that share ontologies with MRPL18: view

Phenotypes for MRPL18 Gene

GenomeRNAi human phenotypes for MRPL18:
genes like me logo Genes that share phenotypes with MRPL18: view

miRNA for MRPL18 Gene

miRTarBase miRNAs that target MRPL18

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL18 Gene

Localization for MRPL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL18 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL18 Gene COMPARTMENTS Subcellular localization image for MRPL18 gene
Compartment Confidence
mitochondrion 5
cytosol 2
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL18: view

Pathways for MRPL18 Gene

SuperPathways for MRPL18 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL18: view

Pathways by source for MRPL18 Gene

1 KEGG pathway for MRPL18 Gene

Gene Ontology (GO) - Biological Process for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0035928 rRNA import into mitochondrion IDA 21685364
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL18: view

Transcripts for MRPL18 Gene

Unigene Clusters for MRPL18 Gene

Mitochondrial ribosomal protein L18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL18 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPL18 Gene

GeneLoc Exon Structure for
MRPL18
ECgene alternative splicing isoforms for
MRPL18

Expression for MRPL18 Gene

mRNA expression in normal human tissues for MRPL18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL18 Gene

SOURCE GeneReport for Unigene cluster for MRPL18 Gene Hs.416998

genes like me logo Genes that share expressions with MRPL18: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL18 Gene

Orthologs for MRPL18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL18 35
  • 100 (n)
  • 100 (a)
MRPL18 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL18 35
  • 85.19 (n)
  • 85 (a)
MRPL18 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL18 35
  • 87.41 (n)
  • 90.56 (a)
MRPL18 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl18 35
  • 82.96 (n)
  • 83.33 (a)
Mrpl18 16
Mrpl18 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL18 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl18 35
  • 83.33 (n)
  • 81.11 (a)
chicken
(Gallus gallus)
Aves MRPL18 35
  • 63.52 (n)
  • 60 (a)
MRPL18 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL18 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69054 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl18 35
  • 63.56 (n)
  • 62.11 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl18 35
  • 53.51 (n)
  • 47.37 (a)
mrpl18 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004709 35
  • 48.56 (n)
  • 38.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL18 35
  • 49.74 (n)
  • 42.86 (a)
mRpL18 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-18 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5697 36
  • 25 (a)
OneToOne
Species with no ortholog for MRPL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL18 Gene

ENSEMBL:
Gene Tree for MRPL18 (if available)
TreeFam:
Gene Tree for MRPL18 (if available)

Paralogs for MRPL18 Gene

Pseudogenes.org Pseudogenes for MRPL18 Gene

genes like me logo Genes that share paralogs with MRPL18: view

No data available for Paralogs for MRPL18 Gene

Variants for MRPL18 Gene

Sequence variations from dbSNP and Humsavar for MRPL18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs927451 -- 159,792,404(+) ACTTG(A/C)TAGGC intron-variant
rs1322426 -- 159,792,023(-) CAAAT(A/G)TAAGT intron-variant
rs1853256 -- 159,791,812(-) ttctc(A/G)tgcct intron-variant
rs2093480 -- 159,795,545(-) tgaaa(C/T)acgtg intron-variant
rs2342479 -- 159,797,925(+) AAAAC(C/T)GTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL18 Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850
esv22776 CNV Gain 19812545

Relevant External Links for MRPL18 Gene

HapMap Linkage Disequilibrium report
MRPL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL18 Gene

Disorders for MRPL18 Gene

Relevant External Links for MRPL18

Genetic Association Database (GAD)
MRPL18
Human Genome Epidemiology (HuGE) Navigator
MRPL18
genes like me logo Genes that share disorders with MRPL18: view

No data available for UniProtKB/Swiss-Prot for MRPL18 Gene

Publications for MRPL18 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPL18 Gene

Sources for MRPL18 Gene

Back to Top

Content