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Aliases for MRPL18 Gene

Aliases for MRPL18 Gene

  • Mitochondrial Ribosomal Protein L18 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein UL18m 3 4
  • MRP-L18 3 4
  • L18mt 3 4
  • 39S Ribosomal Protein L18, Mitochondrial 3
  • HSPC071 3

External Ids for MRPL18 Gene

Previous GeneCards Identifiers for MRPL18 Gene

  • GC06P159650
  • GC06P160085
  • GC06P160043
  • GC06P160120
  • GC06P160181
  • GC06P157681
  • GC06P160210

Summaries for MRPL18 Gene

Entrez Gene Summary for MRPL18 Gene

  • This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL18 Gene

MRPL18 (Mitochondrial Ribosomal Protein L18) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and 5S rRNA binding.

UniProtKB/Swiss-Prot for MRPL18 Gene

  • Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Gene Wiki entry for MRPL18 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL18 Gene

Genomics for MRPL18 Gene

Regulatory Elements for MRPL18 Gene

Enhancers for MRPL18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G159787 1.2 ENCODE 64.1 +0.2 206 5.4 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A MRPL18 TCP1 PNLDC1
GH06G159725 1.4 ENCODE dbSUPER 39.8 -61.5 -61548 5.4 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MRPL18 PNLDC1 ACAT2 SOD2-OT1 SOD2 SNORA29 TCP1 SNORA20 WTAP IGF2R
GH06G159699 1.5 Ensembl ENCODE dbSUPER 35.9 -88.8 -88828 3.5 FOXA2 YY1 FOS SP3 REST TSHZ1 ZNF623 ZNF518A SMARCA4 MYNN MRPL18 WTAP PNLDC1 SOD2-OT1 SOD2 ACAT2 SNORA29 TCP1 GC06M159698 PIR54448
GH06G159714 1.9 FANTOM5 Ensembl ENCODE dbSUPER 27.9 -73.2 -73238 3.2 FOXA2 PKNOX1 ARNT MLX ARID4B DMAP1 YY1 ZNF143 FOS SP5 IGF2R MRPL18 SOD2 WTAP PNLDC1 RNU4ATAC18P HNRNPH1P1
GH06G159759 1.1 ENCODE 43.1 -28.2 -28225 4.0 HDGF PKNOX1 MLX ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 MRPL18 WTAP PNLDC1 SOD2-OT1 SOD2 ACAT2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL18 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206288 88 3001 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A

Genomic Location for MRPL18 Gene

Chromosome:
6
Start:
159,789,812 bp from pter
End:
159,798,436 bp from pter
Size:
8,625 bases
Orientation:
Plus strand

Genomic View for MRPL18 Gene

Genes around MRPL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL18 Gene

Proteins for MRPL18 Gene

  • Protein details for MRPL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0U6-RM18_HUMAN
    Recommended name:
    39S ribosomal protein L18, mitochondrial
    Protein Accession:
    Q9H0U6
    Secondary Accessions:
    • Q5TAP9
    • Q9NZW8

    Protein attributes for MRPL18 Gene

    Size:
    180 amino acids
    Molecular mass:
    20577 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL18 Gene

neXtProt entry for MRPL18 Gene

Post-translational modifications for MRPL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL18 Gene

Domains & Families for MRPL18 Gene

Gene Families for MRPL18 Gene

Protein Domains for MRPL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0U6

UniProtKB/Swiss-Prot:

RM18_HUMAN :
  • Belongs to the universal ribosomal protein uL18 family.
Family:
  • Belongs to the universal ribosomal protein uL18 family.
genes like me logo Genes that share domains with MRPL18: view

Function for MRPL18 Gene

Molecular function for MRPL18 Gene

UniProtKB/Swiss-Prot Function:
Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Gene Ontology (GO) - Molecular Function for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0008097 5S rRNA binding IDA 21685364
genes like me logo Genes that share ontologies with MRPL18: view

Phenotypes for MRPL18 Gene

GenomeRNAi human phenotypes for MRPL18:
genes like me logo Genes that share phenotypes with MRPL18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL18 Gene

Localization for MRPL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL18 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL18 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytoskeleton 2
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
genes like me logo Genes that share ontologies with MRPL18: view

Pathways & Interactions for MRPL18 Gene

genes like me logo Genes that share pathways with MRPL18: view

Gene Ontology (GO) - Biological Process for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006810 transport IEA --
GO:0035928 rRNA import into mitochondrion IDA 21685364
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL18: view

No data available for SIGNOR curated interactions for MRPL18 Gene

Drugs & Compounds for MRPL18 Gene

No Compound Related Data Available

Transcripts for MRPL18 Gene

Unigene Clusters for MRPL18 Gene

Mitochondrial ribosomal protein L18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL18 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPL18 Gene

GeneLoc Exon Structure for
MRPL18
ECgene alternative splicing isoforms for
MRPL18

Expression for MRPL18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL18 Gene

Protein differential expression in normal tissues from HIPED for MRPL18 Gene

This gene is overexpressed in Breast (10.4), Bone (7.6), Plasma (6.3), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL18 Gene



Protein tissue co-expression partners for MRPL18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL18 Gene:

MRPL18

SOURCE GeneReport for Unigene cluster for MRPL18 Gene:

Hs.416998

Evidence on tissue expression from TISSUES for MRPL18 Gene

  • Nervous system(4.7)
  • Blood(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with MRPL18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL18 Gene

Orthologs for MRPL18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL18 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia MRPL18 34 35
  • 87.41 (n)
cow
(Bos Taurus)
Mammalia MRPL18 34 35
  • 85.19 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl18 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Mrpl18 34 16 35
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL18 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL18 34 35
  • 63.52 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL18 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl18 34
  • 63.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69054 34
zebrafish
(Danio rerio)
Actinopterygii mrpl18 34 35
  • 53.51 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL18 34 35
  • 49.74 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004709 34
  • 48.56 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-18 35
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5697 35
  • 25 (a)
OneToOne
Species where no ortholog for MRPL18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL18 Gene

ENSEMBL:
Gene Tree for MRPL18 (if available)
TreeFam:
Gene Tree for MRPL18 (if available)

Paralogs for MRPL18 Gene

Pseudogenes.org Pseudogenes for MRPL18 Gene

genes like me logo Genes that share paralogs with MRPL18: view

No data available for Paralogs for MRPL18 Gene

Variants for MRPL18 Gene

Sequence variations from dbSNP and Humsavar for MRPL18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000015394 -- 159,794,782(+) TGTTA(A/G)GTGGA intron-variant
rs1000518769 -- 159,789,892(+) GGTTG(-/T)TAAGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000636122 -- 159,796,127(+) ATTTT(A/T)CTTTT intron-variant
rs1000860197 -- 159,790,878(+) AGAGC(C/G)GGTTC intron-variant, upstream-variant-2KB
rs1001093275 -- 159,796,033(+) TCCTG(A/C)CTCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL18 Gene

Variant ID Type Subtype PubMed ID
esv22776 CNV gain 19812545
esv2759483 CNV gain 17122850

Variation tolerance for MRPL18 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL18 Gene

Disorders for MRPL18 Gene

Relevant External Links for MRPL18

Genetic Association Database (GAD)
MRPL18
Human Genome Epidemiology (HuGE) Navigator
MRPL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL18

No disorders were found for MRPL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL18 Gene

Publications for MRPL18 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  4. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. (PMID: 21685364) Smirnov A. … Tarassov I. (Genes Dev. 2011) 3 4 64
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64

Products for MRPL18 Gene

Sources for MRPL18 Gene

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