External Ids for MRPL18 Gene
Previous GeneCards Identifiers for MRPL18 Gene
This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]
GeneCards Summary for MRPL18 Gene
MRPL18 (Mitochondrial Ribosomal Protein L18) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome and 5S rRNA binding.
UniProtKB/Swiss-Prot for MRPL18 Gene
Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.