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MRPL18 Gene

protein-coding   GIFtS: 54
GCID: GC06P160210

Mitochondrial Ribosomal Protein L18

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L181 2
L18mt2 3
MRP-L182 3
39S Ribosomal Protein L18, Mitochondrial2

External Ids:    HGNC: 144771   Entrez Gene: 290742   Ensembl: ENSG000001121107   OMIM: 6118315   UniProtKB: Q9H0U63   

Export aliases for MRPL18 gene to outside databases

Previous GC identifers: GC06P159650 GC06P160085 GC06P160043 GC06P160120 GC06P160181 GC06P157681


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL18 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein that belongs to the L18P ribosomal protein family. Three polymorphic sites exist in this
gene, one of which is three nt in length which causes an extra aa near the N-terminus. (provided by RefSeq, Jul
2008)

GeneCards Summary for MRPL18 Gene:
MRPL18 (mitochondrial ribosomal protein L18) is a protein-coding gene. Diseases associated with MRPL18 include malaria. GO annotations related to this gene include structural constituent of ribosome and 5S rRNA binding.

UniProtKB/Swiss-Prot: RM18_HUMAN, Q9H0U6
Function: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the
cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an
import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms
are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA

Gene Wiki entry for MRPL18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL18 gene promoter:
         TBP   Egr-2   SRY   p53   USF-1   Lmo2   IRF-1   Nkx2-5   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL18 promoter sequence
   Search Chromatin IP Primers for MRPL18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

MRPL18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL18 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P160210:  view genomic region     (about GC identifiers)

Start:
160,210,844 bp from pter      End:
160,219,468 bp from pter
Size:
8,625 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RM18_HUMAN, Q9H0U6 (See protein sequence)
Recommended Name: 39S ribosomal protein L18, mitochondrial precursor  
Size: 180 amino acids; 20577 Da
Secondary accessions: Q5TAP9 Q9NZW8

Explore the universe of human proteins at neXtProt for MRPL18: NX_Q9H0U6

Explore proteomics data for MRPL18 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRPL18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054880.2  
    ENSEMBL proteins: 
     ENSP00000356001  

    MRPL18 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR005484 Ribosomal_L18/L5

    Graphical View of Domain Structure for InterPro Entry Q9H0U6

    ProtoNet protein and cluster: Q9H0U6

    UniProtKB/Swiss-Prot: RM18_HUMAN, Q9H0U6
    Similarity: Belongs to the ribosomal protein L18P family


    MRPL18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RM18_HUMAN, Q9H0U6
    Function: Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the
    cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an
    import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms
    are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
    GO:00080975S rRNA binding IDA--
         
    MRPL18 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPL18:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL18
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    miRNA
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    miRTarBase miRNAs that target MRPL18:
    hsa-mir-155-5p (MIRT020849), hsa-mir-26b-5p (MIRT029683)

    Block miRNA regulation of human, mouse, rat MRPL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRPL18
    SwitchGear 3'UTR luciferase reporter plasmidMRPL18 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: MRPL18 (NM_014161)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RM18_HUMAN, Q9H0U6: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    cytoskeleton1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA--
    GO:0005761mitochondrial ribosome NAS11543634
    GO:0005840ribosome ----

    MRPL18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPL18 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MRPL18):
        Ribosome


    MRPL18 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL18
    Interactions:

        Search GeneGlobe Interaction Network for MRPL18

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for MRPL18 (Q9H0U62, 3 ENSP000003560014) via UniProtKB, MINT, STRING, and/or I2D (see all 247)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PAX9P557713I2D: score=3 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634
    GO:0035928rRNA import into mitochondrion IDA--

    MRPL18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL18 (RM18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRPL18 gene: 
    NM_014161.3  

    Unigene Cluster for MRPL18:

    Mitochondrial ribosomal protein L18
    Hs.416998  [show with all ESTs]
    Unigene Representative Sequence: BF204687
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476826 ENST00000479638 ENST00000367034(uc003qsw.4) ENST00000480842(uc010kkb.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat MRPL18 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRPL18
    SwitchGear 3'UTR luciferase reporter plasmidMRPL18 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MRPL18
    Predesigned siRNA for gene silencing in human, mouse, rat MRPL18
    Clone
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    OriGene clones in human, mouse for MRPL18 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRPL18 (NM_014161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL18
    Primer
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    OriGene qPCR primer pairs and template standards for MRPL18
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL18
      QuantiTect SYBR Green Assays in human, mouse, rat MRPL18
      QuantiFast Probe-based Assays in human, mouse, rat MRPL18

    Additional mRNA sequence: 

    AF161556.1 AK311391.1 AL136633.1 BC001623.1 CR533491.1 

    Selected DOTS entries (see all 25):

    DT.100799612  DT.448597  DT.121327058  DT.100818219  DT.85104442  DT.100818226  DT.100033444  DT.92442042 
    DT.92442052  DT.121326983  DT.95114435  DT.99989299  DT.100036974  DT.121326963  DT.121327022  DT.92442053 
    DT.100818220  DT.102822064  DT.121327057  DT.95096176  DT.121326720  DT.92442043  DT.95152535  DT.100818225 

    Selected AceView cDNA sequences (see all 344):

    CR593311 AI802307 BM693115 BF589255 CA442761 CR611649 H42540 AA961341 
    AA995960 AA494475 BF196654 BE253074 CD675657 BM904111 AA928855 CA412411 
    BF064215 AA461154 BM664823 BI059774 AA412637 AI272863 H42541 AA777290 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRPL18 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:        -     -     -     -     -     -     -     -                 -                                                               
    SP2:                                -     -     -     -                 -                                                               
    SP3:                                -     -     -     -                 -           -     -                                             
    SP4:                                -     -     -     -           -     -                                                               
    SP5:                                -     -     -     -                 -                 -                                             


    ECgene alternative splicing isoforms for MRPL18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPL18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATATAAA
    MRPL18 Expression
    About this image

    MRPL18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.416998
        Custom PCR Arrays for MRPL18
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPL18 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl181 , 5 mitochondrial ribosomal protein L181, 5 82.96(n)1
    83.33(a)1
      17 (8.72 cM)5
    676811  NM_026310.31  NP_080586.11 
     129113495 
    chicken
    (Gallus gallus)
    Aves MRPL181 mitochondrial ribosomal protein L18 63.52(n)
    60(a)
      421585  XM_419623.3  XP_419623.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL186
    mitochondrial ribosomal protein L18
    58(a)
    1 ↔ 1
    1(212178006-212179826)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690542 hypothetical protein MGC69054 70.98(n)    BC056073.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrpl181 mitochondrial ribosomal protein L18 53.51(n)
    47.37(a)
      768187  NM_001077330.1  NP_001070798.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL181 mitochondrial ribosomal protein L18 49.74(n)
    42.86(a)
      36406  NM_136974.2  NP_610818.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-186
    Protein MRPL-18 (mrpl-18) mRNA, complete cds
    29(a)
    1 ↔ 1
    III(8145015-8145986) WBGene00017044


    ENSEMBL Gene Tree for MRPL18 (if available)
    TreeFam Gene Tree for MRPL18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPL18 gene

    MRPL18 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPL18
    PGOHUM00000248723


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPL18 (see all 177)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909013931,2
    --160212764(+) AAACCC/GCGTCT 1 -- int10--------
    rs1167761331,2
    F--160212790(+) AAATTA/GGAGGG 1 -- int11Minor allele frequency- G:0.03WA 118
    rs18532561,2
    C,F,A,H--160212844(-) ttctcG/Atgcct 1 -- int15Minor allele frequency- A:0.50NA 10
    rs13224261,2
    C,F,A,H--160213055(-) CAAATG/ATAAGT 1 -- int118Minor allele frequency- A:0.30NA NS EA WA CSA 931
    rs74503321,2
    H--160213083(+) tgcttT/Catatg 1 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1807155291,2
    --160213118(+) TTACAC/TCATGA 1 -- int10--------
    rs1501381821,2
    --160213223(+) TTAACG/TGACCT 1 -- int10--------
    rs1862461821,2
    --160213229(+) GACCTC/GAGAGC 1 -- int10--------
    rs28803691,2
    F--160213241(+) aggacG/Actagg 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1910935251,2
    --160213258(+) CCACTA/GTACTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRPL18 (160210844 - 160219468 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRPL18:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv22776CNV Gain19812545
    dgv2023e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL18
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611831    OMIM disorders: --

    1 disease for MRPL18:    About MalaCards
    malaria


    MRPL18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPL18
    Human Genome Epidemiology (HuGE) Navigator: MRPL18 (1 document)

    Export disorders for MRPL18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPL18 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with MRPL18)
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    1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    6. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    7. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. (PubMed id 21685364)2 Smirnov A.... Tarassov I. (Genes Dev. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29074 HGNC: 14477 AceView: MRPL18 Ensembl:ENSG00000112110 euGenes: HUgn29074
    ECgene: MRPL18 Kegg: 29074 H-InvDB: MRPL18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPL18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPL18 gene:
    Search GeneIP for patents involving MRPL18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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