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Aliases for MRPL18 Gene

Aliases for MRPL18 Gene

  • Mitochondrial Ribosomal Protein L18 2 3 5
  • MRP-L18 3 4
  • L18mt 3 4
  • HSPC071 3

External Ids for MRPL18 Gene

Previous GeneCards Identifiers for MRPL18 Gene

  • GC06P159650
  • GC06P160085
  • GC06P160043
  • GC06P160120
  • GC06P160181
  • GC06P157681
  • GC06P160210

Summaries for MRPL18 Gene

Entrez Gene Summary for MRPL18 Gene

  • This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL18 Gene

MRPL18 (Mitochondrial Ribosomal Protein L18) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome and 5S rRNA binding.

UniProtKB/Swiss-Prot for MRPL18 Gene

  • Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Gene Wiki entry for MRPL18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL18 Gene

Genomics for MRPL18 Gene

Regulatory Elements for MRPL18 Gene

Enhancers for MRPL18 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL18 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL18 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL18 Gene

Chromosome:
6
Start:
159,789,812 bp from pter
End:
159,798,436 bp from pter
Size:
8,625 bases
Orientation:
Plus strand

Genomic View for MRPL18 Gene

Genes around MRPL18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL18 Gene

Proteins for MRPL18 Gene

  • Protein details for MRPL18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0U6-RM18_HUMAN
    Recommended name:
    39S ribosomal protein L18, mitochondrial
    Protein Accession:
    Q9H0U6
    Secondary Accessions:
    • Q5TAP9
    • Q9NZW8

    Protein attributes for MRPL18 Gene

    Size:
    180 amino acids
    Molecular mass:
    20577 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL18 Gene

neXtProt entry for MRPL18 Gene

Proteomics data for MRPL18 Gene at MOPED

Post-translational modifications for MRPL18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPL18 Gene

Domains & Families for MRPL18 Gene

Gene Families for MRPL18 Gene

Protein Domains for MRPL18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL18 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0U6

UniProtKB/Swiss-Prot:

RM18_HUMAN :
  • Belongs to the ribosomal protein L18P family.
Family:
  • Belongs to the ribosomal protein L18P family.
genes like me logo Genes that share domains with MRPL18: view

Function for MRPL18 Gene

Molecular function for MRPL18 Gene

UniProtKB/Swiss-Prot Function:
Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Phenotypes for MRPL18 Gene

GenomeRNAi human phenotypes for MRPL18:
genes like me logo Genes that share phenotypes with MRPL18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL18 Gene

Localization for MRPL18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL18 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL18 Gene COMPARTMENTS Subcellular localization image for MRPL18 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytoskeleton 2
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL18: view

Pathways & Interactions for MRPL18 Gene

genes like me logo Genes that share pathways with MRPL18: view

Gene Ontology (GO) - Biological Process for MRPL18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL18: view

No data available for SIGNOR curated interactions for MRPL18 Gene

Drugs & Compounds for MRPL18 Gene

No Compound Related Data Available

Transcripts for MRPL18 Gene

Unigene Clusters for MRPL18 Gene

Mitochondrial ribosomal protein L18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL18 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPL18 Gene

GeneLoc Exon Structure for
MRPL18
ECgene alternative splicing isoforms for
MRPL18

Expression for MRPL18 Gene

mRNA expression in normal human tissues for MRPL18 Gene

Protein differential expression in normal tissues from HIPED for MRPL18 Gene

This gene is overexpressed in Breast (10.4), Bone (7.6), Plasma (6.3), and Tlymphocyte (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL18 Gene



SOURCE GeneReport for Unigene cluster for MRPL18 Gene Hs.416998

genes like me logo Genes that share expression patterns with MRPL18: view

Protein tissue co-expression partners for MRPL18 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL18 Gene

Orthologs for MRPL18 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL18 35
  • 85.19 (n)
  • 85 (a)
MRPL18 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL18 35
  • 87.41 (n)
  • 90.56 (a)
MRPL18 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl18 35
  • 82.96 (n)
  • 83.33 (a)
Mrpl18 16
Mrpl18 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL18 35
  • 100 (n)
  • 100 (a)
MRPL18 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl18 35
  • 83.33 (n)
  • 81.11 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL18 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL18 35
  • 63.52 (n)
  • 60 (a)
MRPL18 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL18 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl18 35
  • 63.56 (n)
  • 62.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69054 35
zebrafish
(Danio rerio)
Actinopterygii mrpl18 35
  • 53.51 (n)
  • 47.37 (a)
mrpl18 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004709 35
  • 48.56 (n)
  • 38.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL18 35
  • 49.74 (n)
  • 42.86 (a)
mRpL18 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-18 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5697 36
  • 25 (a)
OneToOne
Species with no ortholog for MRPL18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL18 Gene

ENSEMBL:
Gene Tree for MRPL18 (if available)
TreeFam:
Gene Tree for MRPL18 (if available)

Paralogs for MRPL18 Gene

Pseudogenes.org Pseudogenes for MRPL18 Gene

genes like me logo Genes that share paralogs with MRPL18: view

No data available for Paralogs for MRPL18 Gene

Variants for MRPL18 Gene

Sequence variations from dbSNP and Humsavar for MRPL18 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_024609 -
rs1322426 -- 159,792,023(-) CAAAT(A/G)TAAGT intron-variant
rs6907203 -- 159,792,840(+) gctct(A/G)tcacc intron-variant
rs6907384 -- 159,792,949(+) caggc(A/T)cacac intron-variant
rs6908128 -- 159,796,917(+) gttcc(A/G)tctta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL18 Gene

Variant ID Type Subtype PubMed ID
dgv2023e1 CNV Complex 17122850
esv22776 CNV Gain 19812545

Variation tolerance for MRPL18 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL18 Gene

Disorders for MRPL18 Gene

Relevant External Links for MRPL18

Genetic Association Database (GAD)
MRPL18
Human Genome Epidemiology (HuGE) Navigator
MRPL18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL18

No disorders were found for MRPL18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL18 Gene

Publications for MRPL18 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPL18 Gene

Sources for MRPL18 Gene

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