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Aliases for MRPL17 Gene

Aliases for MRPL17 Gene

  • Mitochondrial Ribosomal Protein L17 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL17m 3 4
  • LYST-Interacting Protein 2 3 4
  • MRP-L17 3 4
  • L17mt 3 4
  • LIP2 3 4
  • 39S Ribosomal Protein L17, Mitochondrial 3
  • LYST-Interacting Protein LIP2 3
  • MRP-L26 3
  • RPL17L 3
  • RPML26 3

External Ids for MRPL17 Gene

Previous GeneCards Identifiers for MRPL17 Gene

  • GC11M007445
  • GC11M007163
  • GC11M006661
  • GC11M006667
  • GC11M006360

Summaries for MRPL17 Gene

Entrez Gene Summary for MRPL17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL17 Gene

MRPL17 (Mitochondrial Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include protein domain specific binding and structural constituent of ribosome.

Gene Wiki entry for MRPL17 Gene

Additional gene information for MRPL17 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL17 Gene

Genomics for MRPL17 Gene

Regulatory Elements for MRPL17 Gene

Enhancers for MRPL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H006680 1.4 ENCODE dbSUPER 10.1 +0.9 852 3 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 MRPL17 ILK GC11P006674
GH11H006616 1.3 ENCODE dbSUPER 10.7 +65.0 64984 3 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS RRP8 OLFML1 MRPL17 RPL21P94 LOC644169 TIMM10B DCHS1 ILK ENSG00000255680 TAF10
GH11H006634 1.1 Ensembl ENCODE 11.1 +47.7 47665 3 RAD21 RARA EGR1 ETV6 CREM EGR2 REST NR2F2 ZNF592 SMARCA4 ILK MRPL17 RPL21P94 RRP8 DCHS1 ENSG00000255410
GH11H006703 1 ENCODE dbSUPER 11.7 -20.3 -20264 0 ELF3 CTCF NFIB CEBPG RAD21 RFX5 IRF9 ZNF366 HSF1 SMC3 MRPL17 CAVIN3 RRP8 GVINP2 GC11P006694 PIR51504
GH11H006598 1 ENCODE dbSUPER 10.7 +84.0 83963 2 DRAP1 SAP130 ARID4B MAX ZNF644 ZSCAN9 RAD21 YY1 HNF4G MIXL1 RRP8 MRPL17 RPL21P94 ENSG00000255410 PIR42127 PIR55036
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL17 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036327 301 1801 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for MRPL17 Gene

Chromosome:
11
Start:
6,680,385 bp from pter
End:
6,683,401 bp from pter
Size:
3,017 bases
Orientation:
Minus strand

Genomic View for MRPL17 Gene

Genes around MRPL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL17 Gene

Proteins for MRPL17 Gene

  • Protein details for MRPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX2-RM17_HUMAN
    Recommended name:
    39S ribosomal protein L17, mitochondrial
    Protein Accession:
    Q9NRX2
    Secondary Accessions:
    • D3DQU3
    • Q6IAH8
    • Q96Q53
    • Q9C066

    Protein attributes for MRPL17 Gene

    Size:
    175 amino acids
    Molecular mass:
    20050 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAG49441.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL17 Gene

neXtProt entry for MRPL17 Gene

Post-translational modifications for MRPL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL17 Gene

Domains & Families for MRPL17 Gene

Gene Families for MRPL17 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX2

UniProtKB/Swiss-Prot:

RM17_HUMAN :
  • Belongs to the bacterial ribosomal protein bL17 family.
Family:
  • Belongs to the bacterial ribosomal protein bL17 family.
genes like me logo Genes that share domains with MRPL17: view

Function for MRPL17 Gene

Phenotypes From GWAS Catalog for MRPL17 Gene

Gene Ontology (GO) - Molecular Function for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA,IEA --
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with MRPL17: view

Phenotypes for MRPL17 Gene

GenomeRNAi human phenotypes for MRPL17:
genes like me logo Genes that share phenotypes with MRPL17: view

Animal Model Products

CRISPR Products

miRNA for MRPL17 Gene

miRTarBase miRNAs that target MRPL17

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL17 Gene

Localization for MRPL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL17 gene
Compartment Confidence
mitochondrion 5
nucleus 3
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL17: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRPL17 Gene

Pathways & Interactions for MRPL17 Gene

genes like me logo Genes that share pathways with MRPL17: view

Gene Ontology (GO) - Biological Process for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IBA --
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL17: view

No data available for SIGNOR curated interactions for MRPL17 Gene

Drugs & Compounds for MRPL17 Gene

No Compound Related Data Available

Transcripts for MRPL17 Gene

Unigene Clusters for MRPL17 Gene

Mitochondrial ribosomal protein L17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for MRPL17 Gene

GeneLoc Exon Structure for
MRPL17
ECgene alternative splicing isoforms for
MRPL17

Expression for MRPL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL17 Gene

Protein differential expression in normal tissues from HIPED for MRPL17 Gene

This gene is overexpressed in Bone (21.8) and Pancreas (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL17 Gene



Protein tissue co-expression partners for MRPL17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL17 Gene:

MRPL17

SOURCE GeneReport for Unigene cluster for MRPL17 Gene:

Hs.523456

mRNA Expression by UniProt/SwissProt for MRPL17 Gene:

Q9NRX2-RM17_HUMAN
Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue.

Evidence on tissue expression from TISSUES for MRPL17 Gene

  • Adrenal gland(4.3)
genes like me logo Genes that share expression patterns with MRPL17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL17 Gene

Orthologs for MRPL17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL17 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia MRPL17 33 34
  • 89.08 (n)
cow
(Bos Taurus)
Mammalia MRPL17 33 34
  • 88.5 (n)
-- 34
  • 59 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrpl17 33 16 34
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL17 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL17 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL17 33 34
  • 71.7 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL17 34
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl17 33
  • 63.73 (n)
Str.6257 33
zebrafish
(Danio rerio)
Actinopterygii mrpl17 33 34
  • 62.45 (n)
Dr.16017 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6245 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001865 33
  • 52.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL17 33 34
  • 50.71 (n)
worm
(Caenorhabditis elegans)
Secernentea mrpl-17 34
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL8 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7023 34
  • 36 (a)
OneToOne
Species where no ortholog for MRPL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL17 Gene

ENSEMBL:
Gene Tree for MRPL17 (if available)
TreeFam:
Gene Tree for MRPL17 (if available)

Paralogs for MRPL17 Gene

No data available for Paralogs for MRPL17 Gene

Variants for MRPL17 Gene

Sequence variations from dbSNP and Humsavar for MRPL17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000018626 -- 6,681,222(+) GGGAA(C/T)GGCAG utr-variant-3-prime
rs1000046549 -- 6,681,463(+) CCCCT(C/T)TGGCC utr-variant-3-prime
rs1001069451 -- 6,682,367(+) GGGGC(-/CAGT)ACTTG reference, frameshift-variant
rs1001473790 -- 6,680,455(+) ATTGT(G/T)AGCTC utr-variant-3-prime
rs1001631815 -- 6,680,780(+) AGAAG(C/G)AGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL17 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv7658 CNV insertion 18451855
nsv832060 CNV gain 17160897

Variation tolerance for MRPL17 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL17 Gene

Disorders for MRPL17 Gene

Relevant External Links for MRPL17

Genetic Association Database (GAD)
MRPL17
Human Genome Epidemiology (HuGE) Navigator
MRPL17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL17

No disorders were found for MRPL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL17 Gene

Publications for MRPL17 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev VT … Kingsmore SF (Molecular medicine (Cambridge, Mass.) 2002) 3 4 60

Products for MRPL17 Gene

Sources for MRPL17 Gene

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