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MRPL17 Gene

protein-coding   GIFtS: 53
GCID: GC11M006659

Mitochondrial Ribosomal Protein L17

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L171 2     39S Ribosomal Protein L17, Mitochondrial2
L17mt2 3     MRP-L262
LIP22 3     RPL17L2
MRP-L172 3     RPML262
LYST-Interacting Protein 22 3     LYST-Interacting Protein LIP22

External Ids:    HGNC: 140531   Entrez Gene: 638752   Ensembl: ENSG000001580427   OMIM: 6118305   UniProtKB: Q9NRX23   

Export aliases for MRPL17 gene to outside databases

Previous GC identifers: GC11M007445 GC11M007163 GC11M006661 GC11M006667 GC11M006360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL17 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
39S subunit protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPL17 Gene:
MRPL17 (mitochondrial ribosomal protein L17) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and protein domain specific binding.

Gene Wiki entry for MRPL17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL17 gene promoter:
         HOXA9   HOXA9B   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   NF-kappaB   POU3F2   FOXO4   Meis-1a   NF-kappaB1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL17 promoter sequence
   Search Chromatin IP Primers for MRPL17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.4

MRPL17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006659:  view genomic region     (about GC identifiers)

Start:
6,701,616 bp from pter      End:
6,704,632 bp from pter
Size:
3,017 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RM17_HUMAN, Q9NRX2 (See protein sequence)
Recommended Name: 39S ribosomal protein L17, mitochondrial precursor  
Size: 175 amino acids; 20050 Da
Sequence caution: Sequence=AAG49441.1; Type=Frameshift; Positions=8;
1 PDB 3D structure from and Proteopedia for MRPL17:
2CQM (3D)    
Secondary accessions: D3DQU3 Q6IAH8 Q96Q53 Q9C066

Explore the universe of human proteins at neXtProt for MRPL17: NX_Q9NRX2

Explore proteomics data for MRPL17 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRPL17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071344.1  
    ENSEMBL proteins: 
     ENSP00000288937   ENSP00000435294  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR000456 Ribosomal_L17

    Graphical View of Domain Structure for InterPro Entry Q9NRX2

    ProtoNet protein and cluster: Q9NRX2

    1 Blocks protein domain: IPB000456 Ribosomal protein L17

    UniProtKB/Swiss-Prot: RM17_HUMAN, Q9NRX2
    Similarity: Belongs to the ribosomal protein L17P family


    Find genes that share domains with MRPL17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0019904protein domain specific binding IPI11984006
         
    Find genes that share ontologies with MRPL17           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL17
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    miRNA
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    hsa-mir-32-5p (MIRT028314)

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    Selected qRT-PCR Assays for microRNAs that regulate MRPL17 (see all 18):
    hsa-miR-549 hsa-miR-3673 hsa-miR-4311 hsa-miR-216b hsa-miR-3167 hsa-miR-3125 hsa-miR-3916 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidMRPL17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRPL17

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RM17_HUMAN, Q9NRX2: Mitochondrion (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005840ribosome IEA--

    Find genes that share ontologies with MRPL17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPL17 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54


    Find genes that share SuperPaths with MRPL17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MRPL17):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL17
    Interactions:

        Search GeneGlobe Interaction Network for MRPL17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRPL17 (Q9NRX22, 3 ENSP000002889374) via UniProtKB, MINT, STRING, and/or I2D (see all 322)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MRPL11Q9Y3B72, ENSP000003088974MINT-8079030 STRING: ENSP00000308897
    MRPL16Q9NX202, ENSP000003001514MINT-8079030 STRING: ENSP00000300151
    MRPL2Q5T6532, ENSP000003734044MINT-8079030 STRING: ENSP00000373404
    MRPL19P494062, ENSP000003774864MINT-8079030 STRING: ENSP00000377486
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    Find genes that share ontologies with MRPL17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL17 (RM17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPL17 gene: 
    NM_022061.3  

    Unigene Cluster for MRPL17:

    Mitochondrial ribosomal protein L17
    Hs.523456  [show with all ESTs]
    Unigene Representative Sequence: NM_022061
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288937(uc001men.2) ENST00000532676 ENST00000529958 ENST00000532203

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRPL17 (see all 18):
    hsa-miR-549 hsa-miR-3673 hsa-miR-4311 hsa-miR-216b hsa-miR-3167 hsa-miR-3125 hsa-miR-3916 hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidMRPL17 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL17
      QuantiTect SYBR Green Assays in human, mouse, rat MRPL17
      QuantiFast Probe-based Assays in human, mouse, rat MRPL17

    Additional mRNA sequence: 

    AF141338.1 AF164797.1 AK026857.1 BC012306.1 CR457177.1 

    4 DOTS entries:

    DT.445172  DT.95084012  DT.100778773  DT.92434904 

    Selected AceView cDNA sequences (see all 233):

    BQ059555 AI080041 AA706164 BX364628 BP381749 F16320 NM_022061 AA928915 
    BQ015729 BG612831 BQ772306 AK026857 AI360359 CD672538 AA098801 AA435579 
    BU634058 BQ574818 AW672992 BE073472 AW451443 AI088159 BM925090 CR607645 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL17    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for MRPL17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPL17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCACAGGCC
    MRPL17 Expression
    About this image

    MRPL17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523456

    UniProtKB/Swiss-Prot: RM17_HUMAN, Q9NRX2
    Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPL17 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl171 , 5 mitochondrial ribosomal protein L171, 5 84.97(n)1
    85.55(a)1
      7 (55.98 cM)5
    273971  NM_025301.21  NP_079577.11 
     1058066585 
    chicken
    (Gallus gallus)
    Aves MRPL171 mitochondrial ribosomal protein L17 71.7(n)
    76.73(a)
      769700  XM_001232122.3  XP_001232123.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL176
    mitochondrial ribosomal protein L17
    69(a)
    1 ↔ 1
    GL343859.1(67710-76914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.62572 Transcribed sequence with weak similarity to protein more 77.49(n)    142019542 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.160172 Transcribed sequence with weak similarity to protein more 72.71(n)    BM572163.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL171 mitochondrial ribosomal protein L17 50.71(n)
    42.14(a)
      38046  NM_079146.3  NP_523870.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-176
    Protein MRPL-17 (mrpl-17) mRNA, complete cds
    25(a)
    1 ↔ 1
    I(3162813-3163649) WBGene00021829


    ENSEMBL Gene Tree for MRPL17 (if available)
    TreeFam Gene Tree for MRPL17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPL17 (see all 166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896906061,2
    --6701123(+) AAGACA/GGTGGG 1 -- ds50010--------
    rs1424772181,2
    --6701152(+) TCTTGG/TGTTTG 1 -- ds50010--------
    rs1819351371,2
    --6701187(+) TGGACC/TTGGGG 1 -- ds50010--------
    rs1863525231,2
    --6701241(+) GTAAAA/GTTCTT 1 -- ds50010--------
    rs2019371531,2
    --6701244(+) AATTC-/TTTTTT 1 -- ds50010--------
    rs1919339491,2
    --6701307(+) CTCAGC/TTCACT 1 -- ds50010--------
    rs753742121,2
    C--6701514(+) ACAGGC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1405314881,2
    --6701552(+) ATGCTC/GTTACT 1 -- ds50010--------
    rs1504579701,2
    --6701678(+) GGCCTC/GTTATT 1 -- ut310--------
    rs1835747751,2
    --6701813(+) AACTGC/TTGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MRPL17 (6701616 - 6704632 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRPL17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7658CNV Insertion18451855
    nsv832060CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL17
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611830    OMIM disorders: --


    Find genes that share disorders with MRPL17           About GenesLikeMe

    Genetic Association Database (GAD): MRPL17
    Human Genome Epidemiology (HuGE) Navigator: MRPL17 (1 document)

    Export disorders for MRPL17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPL17 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MRPL17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PubMed id 11984006)1, 2 Tchernev V.T.... Kingsmore S.F. (Mol. Med. 2002)
    5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N.... Tanaka T. (Genomics 2001)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63875 HGNC: 14053 AceView: MRPL17 Ensembl:ENSG00000158042 euGenes: HUgn63875
    ECgene: MRPL17 Kegg: 63875 H-InvDB: MRPL17

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPL17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPL17 gene:
    Search GeneIP for patents involving MRPL17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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