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Aliases for MRPL17 Gene

Aliases for MRPL17 Gene

  • Mitochondrial Ribosomal Protein L17 2 3
  • LYST-Interacting Protein 2 3 4
  • MRP-L17 3 4
  • L17mt 3 4
  • LIP2 3 4
  • 39S Ribosomal Protein L17, Mitochondrial 3
  • LYST-Interacting Protein LIP2 3
  • MRP-L26 3
  • RPL17L 3
  • RPML26 3

External Ids for MRPL17 Gene

Summaries for MRPL17 Gene

Entrez Gene Summary for MRPL17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL17 Gene

MRPL17 (Mitochondrial Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and protein domain specific binding.

Gene Wiki entry for MRPL17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL17 Gene

Genomics for MRPL17 Gene

Genomic Location for MRPL17 Gene

Start:
6,680,385 bp from pter
End:
6,683,401 bp from pter
Size:
3,017 bases
Orientation:
Minus strand

Genomic View for MRPL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL17 Gene

Proteins for MRPL17 Gene

  • Protein details for MRPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX2-RM17_HUMAN
    Recommended name:
    39S ribosomal protein L17, mitochondrial
    Protein Accession:
    Q9NRX2
    Secondary Accessions:
    • D3DQU3
    • Q6IAH8
    • Q96Q53
    • Q9C066

    Protein attributes for MRPL17 Gene

    Size:
    175 amino acids
    Molecular mass:
    20050 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG49441.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL17 Gene

neXtProt entry for MRPL17 Gene

Proteomics data for MRPL17 Gene at MOPED

Post-translational modifications for MRPL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL17 Gene

Domains for MRPL17 Gene

Gene Families for MRPL17 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL17 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX2

UniProtKB/Swiss-Prot:

RM17_HUMAN
Family:
  • Belongs to the ribosomal protein L17P family.:
    • Q9NRX2
genes like me logo Genes that share domains with MRPL17: view

Function for MRPL17 Gene

Gene Ontology (GO) - Molecular Function for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with MRPL17: view

miRNA for MRPL17 Gene

miRTarBase miRNAs that target MRPL17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL17 Gene

Localization for MRPL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL17 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL17 Gene COMPARTMENTS Subcellular localization image for MRPL17 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL17: view

Pathways for MRPL17 Gene

SuperPathways for MRPL17 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL17: view

Pathways by source for MRPL17 Gene

1 KEGG pathway for MRPL17 Gene

Gene Ontology (GO) - Biological Process for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IBA --
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL17: view

Transcripts for MRPL17 Gene

mRNA/cDNA for MRPL17 Gene

Unigene Clusters for MRPL17 Gene

Mitochondrial ribosomal protein L17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for MRPL17 Gene

GeneLoc Exon Structure for
MRPL17
ECgene alternative splicing isoforms for
MRPL17

Expression for MRPL17 Gene

mRNA expression in normal human tissues for MRPL17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL17 Gene

SOURCE GeneReport for Unigene cluster for MRPL17 Gene Hs.523456

mRNA Expression by UniProt/SwissProt for MRPL17 Gene

Q9NRX2-RM17_HUMAN
Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue.
genes like me logo Genes that share expressions with MRPL17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MRPL17 Gene

Orthologs for MRPL17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL17 35
  • 99.62 (n)
  • 99.43 (a)
MRPL17 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 59 (a)
OneToMany
MRPL17 35
  • 88.5 (n)
  • 89.47 (a)
MRPL17 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRPL17 35
  • 89.08 (n)
  • 91.81 (a)
MRPL17 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl17 35
  • 84.97 (n)
  • 85.55 (a)
Mrpl17 16
Mrpl17 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL17 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL17 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL17 35
  • 71.7 (n)
  • 76.73 (a)
MRPL17 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL17 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl17 35
  • 63.73 (n)
  • 70.44 (a)
Str.6257 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6245 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16017 35
mrpl17 35
  • 62.45 (n)
  • 69.62 (a)
mrpl17 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001865 35
  • 52.72 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL17 35
  • 50.71 (n)
  • 42.14 (a)
mRpL17 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-17 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL8 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7023 36
  • 36 (a)
OneToOne
Species with no ortholog for MRPL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL17 Gene

ENSEMBL:
Gene Tree for MRPL17 (if available)
TreeFam:
Gene Tree for MRPL17 (if available)

Paralogs for MRPL17 Gene

No data available for Paralogs for MRPL17 Gene

Variants for MRPL17 Gene

Sequence variations from dbSNP and Humsavar for MRPL17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8109 -- 6,682,103(+) TGCAG(A/G)CTCTT utr-variant-3-prime
rs13253 -- 6,682,259(+) GGGAG(A/G)CAATT reference, synonymous-codon
rs1044349 -- 6,682,111(-) TGGAT(C/T)TGAAG utr-variant-3-prime
rs1567135 -- 6,682,661(-) ATTAA(A/C)CTTGG intron-variant
rs1911276 -- 6,684,847(-) aaaac(A/G)acaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL17 Gene

Variant ID Type Subtype PubMed ID
nsv7658 CNV Insertion 18451855
nsv832060 CNV Gain 17160897

Relevant External Links for MRPL17 Gene

HapMap Linkage Disequilibrium report
MRPL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL17 Gene

Disorders for MRPL17 Gene

Relevant External Links for MRPL17

Genetic Association Database (GAD)
MRPL17
Human Genome Epidemiology (HuGE) Navigator
MRPL17
genes like me logo Genes that share disorders with MRPL17: view

No data available for UniProtKB/Swiss-Prot for MRPL17 Gene

Publications for MRPL17 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  3. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPL17 Gene

Sources for MRPL17 Gene

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