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Aliases for MRPL17 Gene

Aliases for MRPL17 Gene

  • Mitochondrial Ribosomal Protein L17 2 3 5
  • LYST-Interacting Protein 2 3 4
  • MRP-L17 3 4
  • L17mt 3 4
  • LIP2 3 4
  • 39S Ribosomal Protein L17, Mitochondrial 3
  • LYST-Interacting Protein LIP2 3
  • MRP-L26 3
  • RPL17L 3
  • RPML26 3

External Ids for MRPL17 Gene

Previous GeneCards Identifiers for MRPL17 Gene

  • GC11M007445
  • GC11M007163
  • GC11M006661
  • GC11M006667
  • GC11M006360

Summaries for MRPL17 Gene

Entrez Gene Summary for MRPL17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL17 Gene

MRPL17 (Mitochondrial Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include protein domain specific binding and structural constituent of ribosome.

Gene Wiki entry for MRPL17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL17 Gene

Genomics for MRPL17 Gene

Regulatory Elements for MRPL17 Gene

Enhancers for MRPL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F006568 1.2 Ensembl ENCODE 10.6 +114.8 114800 0.8 HDAC1 PKNOX1 SIN3A CHAMP1 FOS ZNF263 ZBTB2 NCOA1 ZEB2 CREB3 ILK RRP8 MRPL17 RPL21P94 ENSG00000254400 APBB1 SMPD1 PIR42127 DNHD1
GH11F006634 1.1 Ensembl ENCODE 11.1 +47.7 47665 3.1 CBX3 RAD21 RARA ZNF366 ETV6 CREM EGR2 NR2F2 SMARCA4 PBX2 ILK MRPL17 RPL21P94 RRP8 DCHS1 ENSG00000255410
GH11F006616 1.1 ENCODE 10.7 +65.0 64984 3.6 PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS LOC644169 MRPL17 RPL21P94 DCHS1 ILK ENSG00000255680 TAF10
GH11F006680 1.1 ENCODE 10.2 +0.9 852 3.4 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 OLFML1 TIMM10B MRPL17 ZNF214 ILK GC11P006674
GH11F006598 1 ENCODE 10.7 +84.0 83963 2.3 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF143 ZNF263 RRP8 MRPL17 RPL21P94 ENSG00000255410 PIR55036 PIR42127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL17 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107640 301 1801 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143
ENSR00001766072 1501 201

Genomic Location for MRPL17 Gene

6,680,385 bp from pter
6,683,401 bp from pter
3,017 bases
Minus strand

Genomic View for MRPL17 Gene

Genes around MRPL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL17 Gene

Proteins for MRPL17 Gene

  • Protein details for MRPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L17, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • D3DQU3
    • Q6IAH8
    • Q96Q53
    • Q9C066

    Protein attributes for MRPL17 Gene

    175 amino acids
    Molecular mass:
    20050 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG49441.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL17 Gene

neXtProt entry for MRPL17 Gene

Post-translational modifications for MRPL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL17 Gene

Domains & Families for MRPL17 Gene

Gene Families for MRPL17 Gene

Protein Domains for MRPL17 Gene


Suggested Antigen Peptide Sequences for MRPL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L17P family.
  • Belongs to the ribosomal protein L17P family.
genes like me logo Genes that share domains with MRPL17: view

Function for MRPL17 Gene

Gene Ontology (GO) - Molecular Function for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA,IBA --
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with MRPL17: view

Phenotypes for MRPL17 Gene

GenomeRNAi human phenotypes for MRPL17:
genes like me logo Genes that share phenotypes with MRPL17: view

Animal Model Products

miRNA for MRPL17 Gene

miRTarBase miRNAs that target MRPL17

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL17 Gene

Localization for MRPL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL17 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL17 gene
Compartment Confidence
mitochondrion 5
nucleus 3
golgi apparatus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA,IBA 25278503
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL17: view

Pathways & Interactions for MRPL17 Gene

genes like me logo Genes that share pathways with MRPL17: view

Gene Ontology (GO) - Biological Process for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IBA --
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL17: view

No data available for SIGNOR curated interactions for MRPL17 Gene

Transcripts for MRPL17 Gene

Unigene Clusters for MRPL17 Gene

Mitochondrial ribosomal protein L17:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for MRPL17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPL17 Gene

Protein differential expression in normal tissues from HIPED for MRPL17 Gene

This gene is overexpressed in Bone (21.8) and Pancreas (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL17 Gene

Protein tissue co-expression partners for MRPL17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL17 Gene:


SOURCE GeneReport for Unigene cluster for MRPL17 Gene:


mRNA Expression by UniProt/SwissProt for MRPL17 Gene:

Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue.
genes like me logo Genes that share expression patterns with MRPL17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MRPL17 Gene

Orthologs for MRPL17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL17 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia MRPL17 34 35
  • 89.08 (n)
(Bos Taurus)
Mammalia MRPL17 34 35
  • 88.5 (n)
-- 35
  • 59 (a)
(Mus musculus)
Mammalia Mrpl17 34 16 35
  • 84.97 (n)
(Monodelphis domestica)
Mammalia MRPL17 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL17 35
  • 67 (a)
(Gallus gallus)
Aves MRPL17 34 35
  • 71.7 (n)
(Anolis carolinensis)
Reptilia MRPL17 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl17 34
  • 63.73 (n)
Str.6257 34
(Danio rerio)
Actinopterygii mrpl17 34 35
  • 62.45 (n)
Dr.16017 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6245 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001865 34
  • 52.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL17 34 35
  • 50.71 (n)
(Caenorhabditis elegans)
Secernentea mrpl-17 35
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL8 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7023 35
  • 36 (a)
Species where no ortholog for MRPL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL17 Gene

Gene Tree for MRPL17 (if available)
Gene Tree for MRPL17 (if available)

Paralogs for MRPL17 Gene

No data available for Paralogs for MRPL17 Gene

Variants for MRPL17 Gene

Sequence variations from dbSNP and Humsavar for MRPL17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1044349 -- 6,682,111(-) TGGAT(C/T)TGAAG utr-variant-3-prime
rs11040956 -- 6,680,960(+) GAATA(A/G)TTCGT utr-variant-3-prime
rs11040957 -- 6,681,967(+) GCAAA(C/G)AGAGG utr-variant-3-prime
rs111323609 -- 6,684,063(+) TGTCT(C/T)CCCCA upstream-variant-2KB
rs111534432 -- 6,682,403(+) TTCTC(C/G/T)TAGAG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL17 Gene

Variant ID Type Subtype PubMed ID
nsv1035138 CNV gain 25217958
nsv7658 CNV insertion 18451855
nsv832060 CNV gain 17160897

Variation tolerance for MRPL17 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL17 Gene

Disorders for MRPL17 Gene

Relevant External Links for MRPL17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL17 Gene

Publications for MRPL17 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. (PMID: 11984006) Tchernev V.T. … Kingsmore S.F. (Mol. Med. 2002) 3 4 64
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4 64

Products for MRPL17 Gene

Sources for MRPL17 Gene

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