MRPL16 Gene
protein-coding GIFtS: 48
GCID: GC11M059573
|
|
mitochondrial ribosomal protein L16
| |
Aliases
for MRPL16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L161 2 | | L16mt2 3 | | MRP-L162 3 | | FLJ204841 | | PNAS-1111 | | 39S Ribosomal Protein L16, Mitochondrial2 |
Export aliases for MRPL16 gene to outside databasesPrevious GC identifers: GC11M061967 GC11M061086 GC11M059824 GC11M059348 GC11M059330 GC11M055920 |
Summaries
for MRPL16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL16:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.(provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RM16_HUMAN, Q9NX20Function: Component of the large subunit of mitochondrial ribosome
|
Genomic Views
for MRPL16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL16 gene promoter:
AML1a NF-E2 p45 Roaz FOXO1a TGIF Zic3 Pax-4a NF-E2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1MRPL16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M059573: view genomic region
(about GC identifiers)
Start:
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59,573,608 bp from pter |
End:
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59,578,345 bp from pter |
Size:
|
4,738 bases |
Orientation:
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minus strand |
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Proteins
for MRPL16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM16_HUMAN, Q9NX20 (See
protein sequence)Recommended Name: 39S ribosomal protein L16, mitochondrial precursor Size: 251 amino acids; 28449 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG23818.1; Type=Erroneous initiation;
Secondary accessions: Q9BYD0 Q9HB70Explore the universe of human proteins at neXtProt for MRPL16: NX_Q9NX20
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NX20
MRPL16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060310.1
ENSEMBL proteins: ENSP00000300151 ENSP00000436592
Human Recombinant Protein Products for MRPL16:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL16 for ontologies About GeneDecksing
MRPL16 Antibody Products:
Assay Products for MRPL16: |
Protein
Domains /
Families
for MRPL16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL16 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NX20ProtoNet protein and cluster: Q9NX20 1 Blocks protein family: IPB000114 Ribosomal protein L16
UniProtKB/Swiss-Prot: RM16_HUMAN, Q9NX20Similarity: Belongs to the ribosomal protein L16P family |
Function
for MRPL16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RM16_HUMAN, Q9NX20Function: Component of the large subunit of mitochondrial ribosome Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- | | GO:0019843 | rRNA binding |
IEA | -- |
MRPL16 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MRPL16:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPL16 (NM_017840) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL16 |
|
Pathways & Interactions
for MRPL16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/242 Interacting proteins for MRPL16 (Q9NX202, 3 ENSP000003001514) via UniProtKB, MINT, STRING, and/or I2D (see all 242)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPL16 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL16
Search CenterWatch for drugs/clinical trials and news about MRPL16 / RM16
|
Transcripts
for MRPL16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL16 gene: NM_017840.3 Unigene Cluster for MRPL16: Mitochondrial ribosomal protein L16 Hs.530734 [show with all ESTs]Unigene Representative Sequence: BQ0581304 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300151(uc001noh.2) ENST00000534340 ENST00000525470 ENST00000531802
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL16 (NM_017840) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL16 |
Additional cDNA sequence: AB049642.1 AF183428.1 AF275806.1 AK000491.1 BC001040.2 BC019269.1 CR457117.1 9 DOTS entries: DT.449288 DT.40106681 DT.91943376 DT.100704146 DT.120739611 DT.40191988 DT.95322920 DT.100787435 DT.40197039 24/309 AceView cDNA sequences (see all 309): W72710 AA344599 AA782838 BQ013470 AI277135 BG770888 AI870777 BU628964 AI271905 CA439833 BM711171 BF001979 CA430658 AF275806 AL555807 AW953499 N20797 BF684100 CB164384 BM668215 BQ446517 CB157721 AI423087 AW027043
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL16 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | - | | - | | | | - | | - | | - | | | | - | | | | | | |
| SP2: | | | | | | | - | | | | - | | - | | - | | | | - | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL16
|
Expression
for MRPL16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAAACGTG
About this image
See MRPL16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL16
SOURCE GeneReport for Unigene cluster: Hs.530734
SABiosciences Custom PCR Arrays for MRPL16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL16 |
Orthologs
for MRPL16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL16 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for MRPL16 (if available)
TreeFam Gene Tree for MRPL16 (if available) |
Paralogs
for MRPL16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL16 (59573608 - 59578345 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL16: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL16 |
|
Disorders
/ Diseases
for MRPL16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL16 for disorders About MalaCards
MRPL16 for disorders About GeneDecksing
OMIM gene information: 611829
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL16 (1 document)
Export disorders for MRPL16 gene to outside databases
|
Publications
for MRPL16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL16 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with MRPL16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2 Koc E.C....Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for MRPL16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL16 gene:
Search GeneIP for patents involving MRPL16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL16 | | | OriGene Protein Over-expression Lysate for MRPL16 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL16 | | OriGene 3'-UTR Clone for MRPL16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | | Search Tocris compounds for MRPL16 |
| |  |  |  |  | | | | |
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 | | | MRPL16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL16 |
|  |  |  |  | | | | ThermoFisher Antibody for MRPL16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL16 |
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