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Aliases for MRPL16 Gene

Aliases for MRPL16 Gene

  • Mitochondrial Ribosomal Protein L16 2 3 5
  • MRP-L16 3 4
  • L16mt 3 4
  • 39S Ribosomal Protein L16, Mitochondrial 3
  • PNAS-111 3

External Ids for MRPL16 Gene

Previous GeneCards Identifiers for MRPL16 Gene

  • GC11M061967
  • GC11M061086
  • GC11M059348
  • GC11M059330
  • GC11M059573
  • GC11M055920

Summaries for MRPL16 Gene

Entrez Gene Summary for MRPL16 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL16 Gene

MRPL16 (Mitochondrial Ribosomal Protein L16) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

UniProtKB/Swiss-Prot for MRPL16 Gene

  • Component of the large subunit of mitochondrial ribosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL16 Gene

Genomics for MRPL16 Gene

Regulatory Elements for MRPL16 Gene

Enhancers for MRPL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRPL16 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL16 Gene

59,806,135 bp from pter
59,810,872 bp from pter
4,738 bases
Minus strand

Genomic View for MRPL16 Gene

Genes around MRPL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL16 Gene

Proteins for MRPL16 Gene

  • Protein details for MRPL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L16, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BYD0
    • Q9HB70

    Protein attributes for MRPL16 Gene

    251 amino acids
    Molecular mass:
    28449 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG23818.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL16 Gene

neXtProt entry for MRPL16 Gene

Post-translational modifications for MRPL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL16 Gene

Domains & Families for MRPL16 Gene

Gene Families for MRPL16 Gene

Protein Domains for MRPL16 Gene

Suggested Antigen Peptide Sequences for MRPL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L16P family.
  • Belongs to the ribosomal protein L16P family.
genes like me logo Genes that share domains with MRPL16: view

Function for MRPL16 Gene

Molecular function for MRPL16 Gene

UniProtKB/Swiss-Prot Function:
Component of the large subunit of mitochondrial ribosome.

Gene Ontology (GO) - Molecular Function for MRPL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0019843 rRNA binding IBA --
genes like me logo Genes that share ontologies with MRPL16: view

Phenotypes for MRPL16 Gene

genes like me logo Genes that share phenotypes with MRPL16: view

Animal Model Products

CRISPR Products

miRNA for MRPL16 Gene

miRTarBase miRNAs that target MRPL16

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL16 Gene

Localization for MRPL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL16 Gene


Subcellular locations from

Jensen Localization Image for MRPL16 Gene COMPARTMENTS Subcellular localization image for MRPL16 gene
Compartment Confidence
mitochondrion 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPL16: view

Pathways & Interactions for MRPL16 Gene

genes like me logo Genes that share pathways with MRPL16: view

Gene Ontology (GO) - Biological Process for MRPL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL16: view

No data available for SIGNOR curated interactions for MRPL16 Gene

Drugs & Compounds for MRPL16 Gene

No Compound Related Data Available

Transcripts for MRPL16 Gene

mRNA/cDNA for MRPL16 Gene

Unigene Clusters for MRPL16 Gene

Mitochondrial ribosomal protein L16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -

Relevant External Links for MRPL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL16 Gene

mRNA expression in normal human tissues for MRPL16 Gene

Protein differential expression in normal tissues from HIPED for MRPL16 Gene

This gene is overexpressed in Urine (18.1), Lung (6.5), and Neutrophil (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL16 Gene

Protein tissue co-expression partners for MRPL16 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPL16 Gene:


SOURCE GeneReport for Unigene cluster for MRPL16 Gene:

genes like me logo Genes that share expression patterns with MRPL16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL16 Gene

Orthologs for MRPL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL16 34
  • 84.06 (n)
  • 87.65 (a)
MRPL16 35
  • 88 (a)
(Canis familiaris)
Mammalia LOC100855841 34
  • 84.88 (n)
  • 91.19 (a)
-- 35
  • 88 (a)
-- 35
  • 85 (a)
(Mus musculus)
Mammalia Mrpl16 34
  • 85.52 (n)
  • 84.46 (a)
Mrpl16 16
Mrpl16 35
  • 84 (a)
(Pan troglodytes)
Mammalia MRPL16 34
  • 99.87 (n)
  • 99.6 (a)
MRPL16 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl16 34
  • 84.06 (n)
  • 83.67 (a)
(Monodelphis domestica)
Mammalia MRPL16 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL16 35
  • 69 (a)
(Gallus gallus)
Aves MRPL16 34
  • 66.82 (n)
  • 68.3 (a)
MRPL16 35
  • 64 (a)
(Anolis carolinensis)
Reptilia MRPL16 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731117 34
  • 60.47 (n)
  • 58.85 (a)
(Danio rerio)
Actinopterygii mrpl16 34
  • 63.41 (n)
  • 62.79 (a)
mrpl16 35
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10314 34
fruit fly
(Drosophila melanogaster)
Insecta mRpL16 36
  • 50 (a)
mRpL16 34
  • 50.84 (n)
  • 47.9 (a)
mRpL16 35
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004985 34
  • 52.49 (n)
  • 50.47 (a)
(Caenorhabditis elegans)
Secernentea mrpl-16 34
  • 45.05 (n)
  • 33.33 (a)
mrpl-16 35
  • 30 (a)
Species where no ortholog for MRPL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL16 Gene

Gene Tree for MRPL16 (if available)
Gene Tree for MRPL16 (if available)

Paralogs for MRPL16 Gene

No data available for Paralogs for MRPL16 Gene

Variants for MRPL16 Gene

Sequence variations from dbSNP and Humsavar for MRPL16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7122468 - 59,809,891(+) TACGC(C/T)AGCAC reference, missense, utr-variant-5-prime
rs12787462 - 59,806,507(+) CTTTT(C/T)GCATC reference, missense
rs491671 - 59,806,484(+) GTTAC(A/G)TTCTC reference, missense
rs1144728 -- 59,809,306(+) TTCAG(G/T)ttttt intron-variant
rs10400371 -- 59,811,755(+) gactg(C/T)tgtaa upstream-variant-2KB

Variation tolerance for MRPL16 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL16 Gene

Disorders for MRPL16 Gene

Relevant External Links for MRPL16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL16 Gene

Publications for MRPL16 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 65
  5. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4 65

Products for MRPL16 Gene

Sources for MRPL16 Gene

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