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Aliases for MRPL16 Gene

Aliases for MRPL16 Gene

  • Mitochondrial Ribosomal Protein L16 2 3 5
  • MRP-L16 3 4
  • L16mt 3 4
  • PNAS-111 3

External Ids for MRPL16 Gene

Previous GeneCards Identifiers for MRPL16 Gene

  • GC11M061967
  • GC11M061086
  • GC11M059348
  • GC11M059330
  • GC11M059573
  • GC11M055920

Summaries for MRPL16 Gene

Entrez Gene Summary for MRPL16 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL16 Gene

MRPL16 (Mitochondrial Ribosomal Protein L16) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

UniProtKB/Swiss-Prot for MRPL16 Gene

  • Component of the large subunit of mitochondrial ribosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL16 Gene

Genomics for MRPL16 Gene

Regulatory Elements for MRPL16 Gene

Enhancers for MRPL16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL16 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL16 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL16 Gene

59,806,135 bp from pter
59,810,872 bp from pter
4,738 bases
Minus strand

Genomic View for MRPL16 Gene

Genes around MRPL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL16 Gene

Proteins for MRPL16 Gene

  • Protein details for MRPL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L16, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BYD0
    • Q9HB70

    Protein attributes for MRPL16 Gene

    251 amino acids
    Molecular mass:
    28449 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG23818.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL16 Gene

neXtProt entry for MRPL16 Gene

Proteomics data for MRPL16 Gene at MOPED

Post-translational modifications for MRPL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL16 Gene

Domains & Families for MRPL16 Gene

Gene Families for MRPL16 Gene

Protein Domains for MRPL16 Gene

Suggested Antigen Peptide Sequences for MRPL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L16P family.
  • Belongs to the ribosomal protein L16P family.
genes like me logo Genes that share domains with MRPL16: view

Function for MRPL16 Gene

Molecular function for MRPL16 Gene

UniProtKB/Swiss-Prot Function:
Component of the large subunit of mitochondrial ribosome.

Phenotypes for MRPL16 Gene

genes like me logo Genes that share phenotypes with MRPL16: view

Animal Model Products

miRNA for MRPL16 Gene

miRTarBase miRNAs that target MRPL16

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL16 Gene

Localization for MRPL16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL16 Gene


Subcellular locations from

Jensen Localization Image for MRPL16 Gene COMPARTMENTS Subcellular localization image for MRPL16 gene
Compartment Confidence
mitochondrion 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL16: view

Pathways & Interactions for MRPL16 Gene

genes like me logo Genes that share pathways with MRPL16: view

Gene Ontology (GO) - Biological Process for MRPL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL16: view

No data available for SIGNOR curated interactions for MRPL16 Gene

Drugs & Compounds for MRPL16 Gene

No Compound Related Data Available

Transcripts for MRPL16 Gene

Unigene Clusters for MRPL16 Gene

Mitochondrial ribosomal protein L16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL16 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - - - -
SP2: - - - - -
SP3: - -
SP4: - -

Relevant External Links for MRPL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL16 Gene

mRNA expression in normal human tissues for MRPL16 Gene

Protein differential expression in normal tissues from HIPED for MRPL16 Gene

This gene is overexpressed in Urine (18.1), Lung (6.5), and Neutrophil (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL16 Gene

SOURCE GeneReport for Unigene cluster for MRPL16 Gene Hs.530734

genes like me logo Genes that share expression patterns with MRPL16: view

Protein tissue co-expression partners for MRPL16 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL16 Gene

Orthologs for MRPL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL16 35
  • 84.06 (n)
  • 87.65 (a)
MRPL16 36
  • 88 (a)
(Canis familiaris)
Mammalia LOC100855841 35
  • 84.88 (n)
  • 91.19 (a)
-- 36
  • 88 (a)
-- 36
  • 85 (a)
(Mus musculus)
Mammalia Mrpl16 35
  • 85.52 (n)
  • 84.46 (a)
Mrpl16 16
Mrpl16 36
  • 84 (a)
(Pan troglodytes)
Mammalia MRPL16 35
  • 99.87 (n)
  • 99.6 (a)
MRPL16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrpl16 35
  • 84.06 (n)
  • 83.67 (a)
(Monodelphis domestica)
Mammalia MRPL16 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL16 36
  • 69 (a)
(Gallus gallus)
Aves MRPL16 35
  • 66.82 (n)
  • 68.3 (a)
MRPL16 36
  • 64 (a)
(Anolis carolinensis)
Reptilia MRPL16 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731117 35
  • 60.47 (n)
  • 58.85 (a)
(Danio rerio)
Actinopterygii mrpl16 35
  • 63.41 (n)
  • 62.79 (a)
mrpl16 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10314 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL16 37
  • 50 (a)
mRpL16 35
  • 50.84 (n)
  • 47.9 (a)
mRpL16 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004985 35
  • 52.49 (n)
  • 50.47 (a)
(Caenorhabditis elegans)
Secernentea mrpl-16 35
  • 45.05 (n)
  • 33.33 (a)
mrpl-16 36
  • 30 (a)
Species with no ortholog for MRPL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL16 Gene

Gene Tree for MRPL16 (if available)
Gene Tree for MRPL16 (if available)

Paralogs for MRPL16 Gene

No data available for Paralogs for MRPL16 Gene

Variants for MRPL16 Gene

Sequence variations from dbSNP and Humsavar for MRPL16 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7122468 - 59,809,891(+) TACGC(C/T)AGCAC reference, missense, utr-variant-5-prime
rs12787462 - 59,806,507(+) CTTTT(C/T)GCATC reference, missense
rs491671 - 59,806,484(+) GTTAC(A/G)TTCTC reference, missense
rs519445 -- 59,809,230(+) TTAAC(A/C)AATTA intron-variant
rs568270 -- 59,807,650(+) GATTT(C/G/T)GTTAT intron-variant

Variation tolerance for MRPL16 Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPL16 Gene

Disorders for MRPL16 Gene

Relevant External Links for MRPL16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL16 Gene

Publications for MRPL16 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for MRPL16 Gene

Sources for MRPL16 Gene