Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL15 Gene

Aliases for MRPL15 Gene

  • Mitochondrial Ribosomal Protein L15 2 3 5
  • MRP-L15 3 4
  • L15mt 3 4
  • HSPC145 3
  • MRP-L7 3
  • RPML7 3

External Ids for MRPL15 Gene

Previous GeneCards Identifiers for MRPL15 Gene

  • GC08P054319
  • GC08P054987
  • GC08P054770
  • GC08P055097
  • GC08P055210
  • GC08P050515

Summaries for MRPL15 Gene

Entrez Gene Summary for MRPL15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL15 Gene

MRPL15 (Mitochondrial Ribosomal Protein L15) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL15 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL15 Gene

Genomics for MRPL15 Gene

Regulatory Elements for MRPL15 Gene

Enhancers for MRPL15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL15 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL15 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL15 Gene

54,135,210 bp from pter
54,148,514 bp from pter
13,305 bases
Plus strand

Genomic View for MRPL15 Gene

Genes around MRPL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL15 Gene

Proteins for MRPL15 Gene

  • Protein details for MRPL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q96Q54
    • Q9H0Y1

    Protein attributes for MRPL15 Gene

    296 amino acids
    Molecular mass:
    33420 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL15 Gene

neXtProt entry for MRPL15 Gene

Proteomics data for MRPL15 Gene at MOPED

Post-translational modifications for MRPL15 Gene

  • Ubiquitination at Lys 28 and Lys 80
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL15 Gene

Domains & Families for MRPL15 Gene

Gene Families for MRPL15 Gene

Protein Domains for MRPL15 Gene

Suggested Antigen Peptide Sequences for MRPL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L15P family.
  • Belongs to the ribosomal protein L15P family.
genes like me logo Genes that share domains with MRPL15: view

Function for MRPL15 Gene

genes like me logo Genes that share phenotypes with MRPL15: view

Animal Model Products

miRNA for MRPL15 Gene

miRTarBase miRNAs that target MRPL15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL15 Gene

Localization for MRPL15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL15 Gene


Subcellular locations from

Jensen Localization Image for MRPL15 Gene COMPARTMENTS Subcellular localization image for MRPL15 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
genes like me logo Genes that share ontologies with MRPL15: view

Pathways & Interactions for MRPL15 Gene

genes like me logo Genes that share pathways with MRPL15: view

Gene Ontology (GO) - Biological Process for MRPL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL15: view

No data available for SIGNOR curated interactions for MRPL15 Gene

Drugs & Compounds for MRPL15 Gene

No Compound Related Data Available

Transcripts for MRPL15 Gene

mRNA/cDNA for MRPL15 Gene

Unigene Clusters for MRPL15 Gene

Mitochondrial ribosomal protein L15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL15 Gene

No ASD Table

Relevant External Links for MRPL15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL15 Gene

mRNA expression in normal human tissues for MRPL15 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL15 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPL15 Gene

This gene is overexpressed in Breast (35.6) and Lung (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL15 Gene

SOURCE GeneReport for Unigene cluster for MRPL15 Gene Hs.18349

genes like me logo Genes that share expression patterns with MRPL15: view

Protein tissue co-expression partners for MRPL15 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPL15 Gene

Orthologs for MRPL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL15 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL15 35
  • 83.22 (n)
  • 90.88 (a)
MRPL15 36
  • 91 (a)
(Canis familiaris)
Mammalia MRPL15 35
  • 90.54 (n)
  • 94.59 (a)
MRPL15 36
  • 95 (a)
(Mus musculus)
Mammalia Mrpl15 35
  • 85.76 (n)
  • 90.17 (a)
Mrpl15 16
Mrpl15 36
  • 90 (a)
(Pan troglodytes)
Mammalia MRPL15 35
  • 99.77 (n)
  • 100 (a)
MRPL15 36
  • 100 (a)
(Monodelphis domestica)
Mammalia MRPL15 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL15 36
  • 80 (a)
(Gallus gallus)
Aves MRPL15 35
  • 74.77 (n)
  • 81.08 (a)
MRPL15 36
  • 83 (a)
(Anolis carolinensis)
Reptilia MRPL15 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl15 35
  • 70.23 (n)
  • 76.21 (a)
Str.7141 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19285 35
(Danio rerio)
Actinopterygii Dr.18509 35
mrpl15 35
  • 65.16 (n)
  • 69.44 (a)
mrpl15 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.652 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL15 37
  • 54 (a)
mRpL15 35
  • 53.41 (n)
  • 54.38 (a)
mRpL15 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011946 35
  • 52.55 (n)
  • 52.92 (a)
(Caenorhabditis elegans)
Secernentea Y92H12BR.8 37
  • 37 (a)
mrpl-15 35
  • 45.18 (n)
  • 37.98 (a)
mrpl-15 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL10 36
  • 25 (a)
MRPL10 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
Species with no ortholog for MRPL15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL15 Gene

Gene Tree for MRPL15 (if available)
Gene Tree for MRPL15 (if available)

Paralogs for MRPL15 Gene Pseudogenes for MRPL15 Gene

genes like me logo Genes that share paralogs with MRPL15: view

No data available for Paralogs for MRPL15 Gene

Variants for MRPL15 Gene

Sequence variations from dbSNP and Humsavar for MRPL15 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2271567 -- 54,136,695(-) GGGGA(A/C)CTGTA intron-variant
rs2292589 -- 54,135,159(-) CGGGA(C/G)TCGGG upstream-variant-2KB
rs2292590 -- 54,135,146(-) GAGGC(C/G)TGGGA upstream-variant-2KB
rs2375696 -- 54,135,803(-) GCTCA(C/T)GCCTG intron-variant
rs7830051 -- 54,137,487(+) tagac(A/G)gagtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL15 Gene

Variant ID Type Subtype PubMed ID
dgv7798n71 CNV Loss 21882294
nsv820132 CNV Gain 19587683
nsv510147 CNV Loss 20534489

Variation tolerance for MRPL15 Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.89% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL15 Gene

Disorders for MRPL15 Gene

Relevant External Links for MRPL15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL15 Gene

Publications for MRPL15 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPL15 Gene

Sources for MRPL15 Gene