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Aliases for MRPL14 Gene

Aliases for MRPL14 Gene

  • Mitochondrial Ribosomal Protein L14 2 3
  • MRPL32 3 4 6
  • 39S Ribosomal Protein L32, Mitochondrial 3 4
  • MRP-L32 3 4
  • MRP-L14 3 4
  • RPML32 3 4
  • L32mt 3 4
  • L14mt 3 4
  • 39S Ribosomal Protein L14, Mitochondrial 3
  • RMPL32 3

External Ids for MRPL14 Gene

Previous GeneCards Identifiers for MRPL14 Gene

  • GC06M044083
  • GC06M044128
  • GC06M043803

Summaries for MRPL14 Gene

Entrez Gene Summary for MRPL14 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found at 17p13.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL14 Gene

MRPL14 (Mitochondrial Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL14 Gene

  • Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL14 Gene

Genomics for MRPL14 Gene

Regulatory Elements for MRPL14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL14 Gene

44,113,454 bp from pter
44,127,457 bp from pter
14,004 bases
Minus strand

Genomic View for MRPL14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL14 Gene

Proteins for MRPL14 Gene

  • Protein details for MRPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L14, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R575
    • Q96Q72

    Protein attributes for MRPL14 Gene

    145 amino acids
    Molecular mass:
    15948 Da
    Quaternary structure:
    • Part of the mitochondrial ribosome large subunit (39S) (By similarity); associates with MALSU1.

    Three dimensional structures from OCA and Proteopedia for MRPL14 Gene

neXtProt entry for MRPL14 Gene

Proteomics data for MRPL14 Gene at MOPED

Post-translational modifications for MRPL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL14 Gene

Domains for MRPL14 Gene

Gene Families for MRPL14 Gene

  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL14 Gene

Suggested Antigen Peptide Sequences for MRPL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6P1L8
  • Belongs to the ribosomal protein L14P family.
genes like me logo Genes that share domains with MRPL14: view

Function for MRPL14 Gene

Molecular function for MRPL14 Gene

UniProtKB/Swiss-Prot Function: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

Gene Ontology (GO) - Molecular Function for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL14: view

Phenotypes for MRPL14 Gene

GenomeRNAi human phenotypes for MRPL14:
genes like me logo Genes that share phenotypes with MRPL14: view

Animal Model Products

CRISPR Products

miRNA for MRPL14 Gene

miRTarBase miRNAs that target MRPL14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL14 Gene

Localization for MRPL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL14 Gene


Subcellular locations from

Jensen Localization Image for MRPL14 Gene COMPARTMENTS Subcellular localization image for MRPL14 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL14: view

Pathways for MRPL14 Gene

SuperPathways for MRPL14 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPL14: view

Pathways by source for MRPL14 Gene

1 KEGG pathway for MRPL14 Gene

Gene Ontology (GO) - Biological Process for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL14: view

Transcripts for MRPL14 Gene

mRNA/cDNA for MRPL14 Gene

Unigene Clusters for MRPL14 Gene

Mitochondrial ribosomal protein L14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP5: -

Relevant External Links for MRPL14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL14 Gene

mRNA expression in normal human tissues for MRPL14 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL14 Gene

This gene is overexpressed in Muscle - Skeletal (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL14 Gene

SOURCE GeneReport for Unigene cluster for MRPL14 Gene Hs.311190

genes like me logo Genes that share expressions with MRPL14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPL14 Gene

Orthologs for MRPL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPL14 35
  • 99.08 (n)
  • 98.62 (a)
MRPL14 36
  • 99 (a)
(Bos Taurus)
Mammalia MRPL14 35
  • 86.21 (n)
  • 86.9 (a)
MRPL14 36
  • 87 (a)
(Canis familiaris)
Mammalia MRPL14 35
  • 89.2 (n)
  • 87.59 (a)
MRPL14 36
  • 88 (a)
(Mus musculus)
Mammalia Mrpl14 35
  • 83.91 (n)
  • 84.83 (a)
Mrpl14 16
Mrpl14 36
  • 85 (a)
(Monodelphis domestica)
Mammalia MRPL14 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL14 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Mrpl14 35
  • 83.45 (n)
  • 84.14 (a)
(Gallus gallus)
Aves MRPL14 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MRPL14 36
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13679 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl14 35
  • 70.56 (n)
  • 75.18 (a)
(Danio rerio)
Actinopterygii -- 35
mrpl14 35
  • 68.46 (n)
  • 74.62 (a)
mrpl14 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011148 35
  • 60.43 (n)
  • 53.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL14 35
  • 60.1 (n)
  • 53.54 (a)
mRpL14 36
  • 44 (a)
mRpL14 37
  • 51 (a)
Species with no ortholog for MRPL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL14 Gene

Gene Tree for MRPL14 (if available)
Gene Tree for MRPL14 (if available)

Paralogs for MRPL14 Gene Pseudogenes for MRPL14 Gene

genes like me logo Genes that share paralogs with MRPL14: view

No data available for Paralogs for MRPL14 Gene

Variants for MRPL14 Gene

Sequence variations from dbSNP and Humsavar for MRPL14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6883 -- 44,113,981(-) AGATT(C/T)GACTC reference, synonymous-codon
rs10400 -- 44,114,147(+) CCAGG(G/T)CACTG missense, reference
rs700006 -- 44,113,773(-) TAAGG(A/G)AGCTT utr-variant-3-prime
rs713049 -- 44,124,107(+) ATACA(C/T)AATTC intron-variant
rs713050 -- 44,124,392(+) ACTCA(G/T)GTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL14 Gene

Variant ID Type Subtype PubMed ID
nsv462935 CNV Loss 19166990
nsv509132 CNV Insertion 20534489

Relevant External Links for MRPL14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL14 Gene

Disorders for MRPL14 Gene

Relevant External Links for MRPL14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRPL14: view

No data available for UniProtKB/Swiss-Prot for MRPL14 Gene

Publications for MRPL14 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MRPL14 Gene

  • antibodies-online proteins for MRPL14
  • antibodies-online antibodies for MRPL14
  • antibodies-online kits for MRPL14

Sources for MRPL14 Gene

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