MRPL14 Gene
protein-coding GIFtS: 46
GCID: GC06M044128
|
|
mitochondrial ribosomal protein L14
| |
Aliases
for MRPL14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L141 2 | | L14mt2 3 | | MRP-L321 2 3 | | L32mt2 3 | | RPML321 2 3 | | MRP-L142 3 | | MRPL322 3 5 | | 39S Ribosomal Protein L14, Mitochondrial2 | | 39S Ribosomal Protein L32, Mitochondrial2 3 | | RMPL322 |
Export aliases for MRPL14 gene to outside databasesPrevious GC identifers: GC06M044083 GC06M044189 GC06M043803 |
Summaries
for MRPL14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL14:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.A pseudogene corresponding to this gene is found at 17p13.3. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RM14_HUMAN, Q6P1L8Function: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridgeformation is blocked, preventing ribosome formation and repressing translation (Probable)
|
Genomic Views
for MRPL14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL14 gene promoter:
Max1 COUP NF-kappaB AP-2gamma AREB6 COUP-TF AP-2beta AP-2alpha c-Myc AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.3MRPL14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M044128: view genomic region
(about GC identifiers)
Start:
|
44,081,194 bp from pter |
End:
|
44,095,194 bp from pter |
Size:
|
14,001 bases |
Orientation:
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minus strand |
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Proteins
for MRPL14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM14_HUMAN, Q6P1L8 (See
protein sequence)Recommended Name: 39S ribosomal protein L14, mitochondrial precursor Size: 145 amino acids; 15948 Da
Subunit: Part of the mitochondrial ribosome large subunit (39S) (By similarity); associates with MALSU1
Subcellular location: Mitochondrion
Secondary accessions: B2R575 Q96Q72Explore the universe of human proteins at neXtProt for MRPL14: NX_Q6P1L8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P1L8
MRPL14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115487.2
ENSEMBL proteins: ENSP00000361084
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL14 for ontologies About GeneDecksing
MRPL14 Antibody Products:
Assay Products for MRPL14: |
Protein
Domains /
Families
for MRPL14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL14 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P1L8ProtoNet protein and cluster: Q6P1L8 UniProtKB/Swiss-Prot: RM14_HUMAN, Q6P1L8Similarity: Belongs to the ribosomal protein L14P family |
Function
for MRPL14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RM14_HUMAN, Q6P1L8Function: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridgeformation is blocked, preventing ribosome formation and repressing translation (Probable)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MRPL14 (NM_032111) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL14 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPL14 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MRPL14:
|
Pathways & Interactions
for MRPL14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL14
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/237 Interacting proteins for MRPL14 (Q6P1L82, 3 ENSP000003610844) via UniProtKB, MINT, STRING, and/or I2D (see all 237)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPL14 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL14
Search CenterWatch for drugs/clinical trials and news about MRPL14 / RM14
|
Transcripts
for MRPL14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL14 gene: NM_032111.2 Unigene Cluster for MRPL14: Mitochondrial ribosomal protein L14 Hs.311190 [show with all ESTs]Unigene Representative Sequence: BM9109351 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000372014(uc003owp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL14
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL14 (NM_032111) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL14 |
Additional cDNA sequence: AK312086.1 BC010416.2 BC065005.1 11 DOTS entries: DT.444126 DT.101982416 DT.100789156 DT.100046047 DT.100718876 DT.100046035 DT.100789159 DT.100789161 DT.99988927 DT.100789157 DT.40291638 24/211 AceView cDNA sequences (see all 211): BP369288 AA826784 BM966958 BG768994 BC065005 BQ632779 BU731679 CD364518 BE856287 BU177321 BC010416 BQ772010 BG231555 BU175571 AA192878 AA381278 BQ213469 CK823336 BQ644169 BQ329606 CR625056 BM694874 BM966948 BQ010785
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL14 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL14
|
Expression
for MRPL14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCTCCCT
About this image
See MRPL14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL14
SOURCE GeneReport for Unigene cluster: Hs.311190
SABiosciences Custom PCR Arrays for MRPL14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL14 |
Orthologs
for MRPL14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL14 gene from 6/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl141 , 5 |
mitochondrial ribosomal protein L141, 5 |
83.91(n)1
84.83(a)1 |
|
17 (22.59 cM)5
684631 NM_026732.21 NP_081008.11
456863225 |
chicken
(Gallus gallus) |
Aves |
MRPL141 |
mitochondrial ribosomal protein L14 |
71.43(n)
82.86(a) |
|
421443 XM_419494.3 XP_419494.2 |
lizard
(Anolis carolinensis) |
Reptilia |
MRPL146 |
-- |
74(a) |
1 ↔ 1 |
1(227360161-227368902) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.136792 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.15(n) |
|
BG408012.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC049041.12 |
-- |
75.32(n) |
|
394122 BC049041.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mRpL141 , 3 |
protein biosynthesis structural constituent
of more3
mitochondrial ribosomal protein L141 |
51(a)3
60.88(n)1
56.2(a)1 |
|
3A13
312221 NM_080309.31 NP_525048.11 |
ENSEMBL Gene Tree for MRPL14 (if available)
TreeFam Gene Tree for MRPL14 (if available) |
Paralogs
for MRPL14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL14 gene
MRPL14 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL14
PGOHUM00000237192
|
Genomic Variants
for MRPL14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL14 (44081194 - 44095194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL14: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL14 |
|
Disorders
/ Diseases
for MRPL14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL14 for disorders About MalaCards
MRPL14 for disorders About GeneDecksing
OMIM gene information: 611827
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL14 (1 document)
Export disorders for MRPL14 gene to outside databases
|
Publications
for MRPL14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL14 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MRPL14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- RsfA (YbeB) proteins are conserved ribosomal silencing factors. (PubMed id 22829778)2 Hauser R.... Uetz P. (2012)
- Identification of cis- and trans-acting genetic varia nts explaining up to half the variation in circulating vascular endothelial gro wth factor levels. (PubMed id 21757650)1 Debette S....Seshadri S. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for MRPL14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL14 gene:
Search GeneIP for patents involving MRPL14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL14 |
| |
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| |  |  |  |  | | | | |
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 |
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 | | | MRPL14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL14 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPL14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL14 |
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