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Aliases for MRPL14 Gene

Aliases for MRPL14 Gene

  • Mitochondrial Ribosomal Protein L14 2 3 5
  • 39S Ribosomal Protein L32, Mitochondrial 3 4
  • MRP-L14 3 4
  • MRP-L32 3 4
  • MRPL32 3 4
  • RPML32 3 4
  • L14mt 3 4
  • L32mt 3 4
  • 39S Ribosomal Protein L14, Mitochondrial 3
  • RMPL32 3

External Ids for MRPL14 Gene

Previous GeneCards Identifiers for MRPL14 Gene

  • GC06M044083
  • GC06M044128
  • GC06M043803

Summaries for MRPL14 Gene

Entrez Gene Summary for MRPL14 Gene

  • This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL14 Gene

MRPL14 (Mitochondrial Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL14 Gene

  • Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL14 Gene

Genomics for MRPL14 Gene

Regulatory Elements for MRPL14 Gene

Enhancers for MRPL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F044094 0.8 ENCODE 31.2 +32.5 32549 1.8 HDGF PKNOX1 MLX ARID4B DMAP1 SLC30A9 ZNF766 CBX5 ZNF143 FOS MRPL14 AARS2 TMEM63B CUL9 CAPN11 VEGFA SLC29A1 HSP90AB1 MIR4647 SLC35B2
GH06F044114 1 Ensembl ENCODE 21.7 +11.1 11064 4.6 ATF1 PKNOX1 FEZF1 RARA YY1 SMARCA5 ZNF362 CEBPB PPARG TGIF2 MRPL14 CAPN11 SLC29A1 HSP90AB1 TMEM63B NFKBIE MIR4647 SLC35B2 CRIP3 PIR46189
GH06F044132 0.5 Ensembl ENCODE 20.8 -6.2 -6239 3.1 HDGF CREB3L1 ARID4B FEZF1 ZNF48 GLIS2 GATA2 ZNF143 REST KAT8 MRPL14 LOC101929726 CAPN11 TMEM63B NFKBIE MIR4647 SLC35B2 CRIP3 PIR60878
GH06F044122 0.4 ENCODE 20.1 +4.0 3969 2.1 SOX13 ELF3 BCOR KLF1 ESRRA ZNF146 PKNOX1 SAP130 ZKSCAN1 ZNF664 MRPL14 TMEM63B PIR46189
GH06F044125 0.8 ENCODE 20.1 +0.1 90 3.3 HDGF PKNOX1 MLX SIN3A ARID4B DMAP1 YY1 SLC30A9 DEK ZNF263 MRPL14 TMEM63B AARS2 NFKBIE MIR4647 SLC35B2 TMEM151B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPL14 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001217366 -143 2801 HDGF PKNOX1 MLX SIN3A ARID4B DMAP1 YY1 SLC30A9 FOS DEK

Genomic Location for MRPL14 Gene

Chromosome:
6
Start:
44,113,454 bp from pter
End:
44,127,457 bp from pter
Size:
14,004 bases
Orientation:
Minus strand

Genomic View for MRPL14 Gene

Genes around MRPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL14 Gene

Proteins for MRPL14 Gene

  • Protein details for MRPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1L8-RM14_HUMAN
    Recommended name:
    39S ribosomal protein L14, mitochondrial
    Protein Accession:
    Q6P1L8
    Secondary Accessions:
    • B2R575
    • Q96Q72

    Protein attributes for MRPL14 Gene

    Size:
    145 amino acids
    Molecular mass:
    15948 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).

    Three dimensional structures from OCA and Proteopedia for MRPL14 Gene

neXtProt entry for MRPL14 Gene

Post-translational modifications for MRPL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL14 Gene

No data available for DME Specific Peptides for MRPL14 Gene

Domains & Families for MRPL14 Gene

Gene Families for MRPL14 Gene

Protein Domains for MRPL14 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1L8

UniProtKB/Swiss-Prot:

RM14_HUMAN :
  • Belongs to the ribosomal protein L14P family.
Family:
  • Belongs to the ribosomal protein L14P family.
genes like me logo Genes that share domains with MRPL14: view

Function for MRPL14 Gene

Molecular function for MRPL14 Gene

UniProtKB/Swiss-Prot Function:
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

Gene Ontology (GO) - Molecular Function for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL14: view
genes like me logo Genes that share phenotypes with MRPL14: view

Animal Model Products

miRNA for MRPL14 Gene

miRTarBase miRNAs that target MRPL14

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL14 Gene

Localization for MRPL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL14 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL14 Gene COMPARTMENTS Subcellular localization image for MRPL14 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPL14: view

Pathways & Interactions for MRPL14 Gene

genes like me logo Genes that share pathways with MRPL14: view

Gene Ontology (GO) - Biological Process for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL14: view

No data available for SIGNOR curated interactions for MRPL14 Gene

Transcripts for MRPL14 Gene

mRNA/cDNA for MRPL14 Gene

Unigene Clusters for MRPL14 Gene

Mitochondrial ribosomal protein L14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for MRPL14 Gene

GeneLoc Exon Structure for
MRPL14
ECgene alternative splicing isoforms for
MRPL14

Expression for MRPL14 Gene

mRNA expression in normal human tissues for MRPL14 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL14 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for MRPL14 Gene

This gene is overexpressed in Bone (20.7) and Lung (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL14 Gene



Protein tissue co-expression partners for MRPL14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL14 Gene:

MRPL14

SOURCE GeneReport for Unigene cluster for MRPL14 Gene:

Hs.311190
genes like me logo Genes that share expression patterns with MRPL14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPL14 Gene

Orthologs for MRPL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL14 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia MRPL14 34 35
  • 89.2 (n)
cow
(Bos Taurus)
Mammalia MRPL14 34 35
  • 86.21 (n)
mouse
(Mus musculus)
Mammalia Mrpl14 34 16 35
  • 83.91 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl14 34
  • 83.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL14 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL14 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL14 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL14 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl14 34
  • 70.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13679 34
zebrafish
(Danio rerio)
Actinopterygii mrpl14 34 35
  • 68.46 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011148 34
  • 60.43 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL14 36 34 35
  • 60.1 (n)
Species where no ortholog for MRPL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL14 Gene

ENSEMBL:
Gene Tree for MRPL14 (if available)
TreeFam:
Gene Tree for MRPL14 (if available)

Paralogs for MRPL14 Gene

Pseudogenes.org Pseudogenes for MRPL14 Gene

genes like me logo Genes that share paralogs with MRPL14: view

No data available for Paralogs for MRPL14 Gene

Variants for MRPL14 Gene

Sequence variations from dbSNP and Humsavar for MRPL14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10085205 -- 44,117,146(+) GTACA(A/G)CTCAA intron-variant
rs10400 -- 44,114,147(+) CCAGG(G/T)CACTG reference, missense
rs1047555 -- 44,113,797(-) CAGTT(C/T)TGAGA utr-variant-3-prime
rs10625755 -- 44,122,721(+) AAGAG(-/AC)ACTGA intron-variant
rs111763940 -- 44,127,357(+) CCGCC(C/T)GGGAA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL14 Gene

Variant ID Type Subtype PubMed ID
nsv1073976 CNV deletion 25765185
nsv462935 CNV loss 19166990
nsv509132 CNV insertion 20534489
nsv603002 CNV loss 21841781

Variation tolerance for MRPL14 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL14 Gene

Disorders for MRPL14 Gene

Relevant External Links for MRPL14

Genetic Association Database (GAD)
MRPL14
Human Genome Epidemiology (HuGE) Navigator
MRPL14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL14

No disorders were found for MRPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL14 Gene

Publications for MRPL14 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A. … Ramakrishnan V. (Science 2014) 3 4 64
  2. RsfA (YbeB) proteins are conserved ribosomal silencing factors. (PMID: 22829778) Hauser R. … Uetz P. (PLoS Genet. 2012) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for MRPL14 Gene

Sources for MRPL14 Gene

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