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Aliases for MRPL14 Gene

Aliases for MRPL14 Gene

  • Mitochondrial Ribosomal Protein L14 2 3 5
  • 39S Ribosomal Protein L32, Mitochondrial 3 4
  • MRP-L14 3 4
  • MRP-L32 3 4
  • MRPL32 3 4
  • RPML32 3 4
  • L14mt 3 4
  • L32mt 3 4
  • RMPL32 3

External Ids for MRPL14 Gene

Previous GeneCards Identifiers for MRPL14 Gene

  • GC06M044083
  • GC06M044128
  • GC06M043803

Summaries for MRPL14 Gene

Entrez Gene Summary for MRPL14 Gene

  • This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]

GeneCards Summary for MRPL14 Gene

MRPL14 (Mitochondrial Ribosomal Protein L14) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

UniProtKB/Swiss-Prot for MRPL14 Gene

  • Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL14 Gene

Genomics for MRPL14 Gene

Regulatory Elements for MRPL14 Gene

Promoters for MRPL14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL14 Gene

Chromosome:
6
Start:
44,113,454 bp from pter
End:
44,127,457 bp from pter
Size:
14,004 bases
Orientation:
Minus strand

Genomic View for MRPL14 Gene

Genes around MRPL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL14 Gene

Proteins for MRPL14 Gene

  • Protein details for MRPL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1L8-RM14_HUMAN
    Recommended name:
    39S ribosomal protein L14, mitochondrial
    Protein Accession:
    Q6P1L8
    Secondary Accessions:
    • B2R575
    • Q96Q72

    Protein attributes for MRPL14 Gene

    Size:
    145 amino acids
    Molecular mass:
    15948 Da
    Quaternary structure:
    • Part of the mitochondrial ribosome large subunit (39S) (By similarity); associates with MALSU1.

    Three dimensional structures from OCA and Proteopedia for MRPL14 Gene

neXtProt entry for MRPL14 Gene

Proteomics data for MRPL14 Gene at MOPED

Post-translational modifications for MRPL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL14 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL14 Gene

Domains & Families for MRPL14 Gene

Gene Families for MRPL14 Gene

Protein Domains for MRPL14 Gene

Suggested Antigen Peptide Sequences for MRPL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P1L8

UniProtKB/Swiss-Prot:

RM14_HUMAN :
  • Belongs to the ribosomal protein L14P family.
Family:
  • Belongs to the ribosomal protein L14P family.
genes like me logo Genes that share domains with MRPL14: view

Function for MRPL14 Gene

Molecular function for MRPL14 Gene

UniProtKB/Swiss-Prot Function:
Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).
genes like me logo Genes that share phenotypes with MRPL14: view

Animal Model Products

miRNA for MRPL14 Gene

miRTarBase miRNAs that target MRPL14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL14 Gene

Localization for MRPL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL14 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL14 Gene COMPARTMENTS Subcellular localization image for MRPL14 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL14: view

Pathways & Interactions for MRPL14 Gene

genes like me logo Genes that share pathways with MRPL14: view

Gene Ontology (GO) - Biological Process for MRPL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL14: view

No data available for SIGNOR curated interactions for MRPL14 Gene

Drugs & Compounds for MRPL14 Gene

No Compound Related Data Available

Transcripts for MRPL14 Gene

mRNA/cDNA for MRPL14 Gene

Unigene Clusters for MRPL14 Gene

Mitochondrial ribosomal protein L14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL14 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5: -

Relevant External Links for MRPL14 Gene

GeneLoc Exon Structure for
MRPL14
ECgene alternative splicing isoforms for
MRPL14

Expression for MRPL14 Gene

mRNA expression in normal human tissues for MRPL14 Gene

mRNA differential expression in normal tissues according to GTEx for MRPL14 Gene

This gene is overexpressed in Muscle - Skeletal (x5.2).

Protein differential expression in normal tissues from HIPED for MRPL14 Gene

This gene is overexpressed in Bone (20.7) and Lung (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL14 Gene



SOURCE GeneReport for Unigene cluster for MRPL14 Gene Hs.311190

genes like me logo Genes that share expression patterns with MRPL14: view

Protein tissue co-expression partners for MRPL14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPL14 Gene

Orthologs for MRPL14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL14 35
  • 86.21 (n)
  • 86.9 (a)
MRPL14 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL14 35
  • 89.2 (n)
  • 87.59 (a)
MRPL14 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl14 35
  • 83.91 (n)
  • 84.83 (a)
Mrpl14 16
Mrpl14 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL14 35
  • 99.08 (n)
  • 98.62 (a)
MRPL14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl14 35
  • 83.45 (n)
  • 84.14 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL14 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL14 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL14 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL14 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl14 35
  • 70.56 (n)
  • 75.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13679 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
mrpl14 35
  • 68.46 (n)
  • 74.62 (a)
mrpl14 36
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL14 37
  • 51 (a)
mRpL14 35
  • 60.1 (n)
  • 53.54 (a)
mRpL14 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011148 35
  • 60.43 (n)
  • 53.66 (a)
Species with no ortholog for MRPL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL14 Gene

ENSEMBL:
Gene Tree for MRPL14 (if available)
TreeFam:
Gene Tree for MRPL14 (if available)

Paralogs for MRPL14 Gene

Pseudogenes.org Pseudogenes for MRPL14 Gene

genes like me logo Genes that share paralogs with MRPL14: view

No data available for Paralogs for MRPL14 Gene

Variants for MRPL14 Gene

Sequence variations from dbSNP and Humsavar for MRPL14 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6883 -- 44,113,981(-) AGATT(C/T)GACTC reference, synonymous-codon
rs10400 -- 44,114,147(+) CCAGG(G/T)CACTG reference, missense
rs713049 -- 44,124,107(+) ATACA(C/T)AATTC intron-variant
rs713050 -- 44,124,392(+) ACTCA(G/T)GTAAG intron-variant
rs700006 -- 44,113,773(-) TAAGG(A/G)AGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL14 Gene

Variant ID Type Subtype PubMed ID
nsv462935 CNV Loss 19166990
nsv509132 CNV Insertion 20534489

Variation tolerance for MRPL14 Gene

Residual Variation Intolerance Score: 29.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL14 Gene

HapMap Linkage Disequilibrium report
MRPL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL14 Gene

Disorders for MRPL14 Gene

Relevant External Links for MRPL14

Genetic Association Database (GAD)
MRPL14
Human Genome Epidemiology (HuGE) Navigator
MRPL14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL14

No disorders were found for MRPL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL14 Gene

Publications for MRPL14 Gene

  1. RsfA (YbeB) proteins are conserved ribosomal silencing factors. (PMID: 22829778) Hauser R. … Uetz P. (PLoS Genet. 2012) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The conserved interaction of C7orf30 with MRPL14 promotes biogenesis of the mitochondrial large ribosomal subunit and mitochondrial translation. (PMID: 23171548) Fung S. … Shoubridge E.A. (Mol. Biol. Cell 2013) 3
  5. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3

Products for MRPL14 Gene

Sources for MRPL14 Gene

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