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Aliases for MRPL13 Gene

Aliases for MRPL13 Gene

  • Mitochondrial Ribosomal Protein L13 2 3
  • MRP-L13 3 4
  • L13mt 3 4
  • 39S Ribosomal Protein L13, Mitochondrial 3
  • RPML13 3
  • RPL13 3
  • L13A 3
  • L13 3

External Ids for MRPL13 Gene

Previous GeneCards Identifiers for MRPL13 Gene

  • GC08M121466
  • GC08M121076
  • GC08M121364
  • GC08M121477
  • GC08M116728
  • GC08M121393

Summaries for MRPL13 Gene

Entrez Gene Summary for MRPL13 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL13 Gene

MRPL13 (Mitochondrial Ribosomal Protein L13) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL13 Gene

Genomics for MRPL13 Gene

Regulatory Elements for MRPL13 Gene

Genomic Location for MRPL13 Gene

120,380,761 bp from pter
120,445,407 bp from pter
64,647 bases
Minus strand

Genomic View for MRPL13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL13 Gene

Proteins for MRPL13 Gene

  • Protein details for MRPL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L13, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R4R8
    • Q9UI04

    Protein attributes for MRPL13 Gene

    178 amino acids
    Molecular mass:
    20692 Da
    Quaternary structure:
    • Interacts with OXA1L.
    • Sequence=AAF17202.1; Type=Frameshift; Positions=160; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL13 Gene

neXtProt entry for MRPL13 Gene

Proteomics data for MRPL13 Gene at MOPED

Post-translational modifications for MRPL13 Gene

  • Ubiquitination at Lys114
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL13 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL13 Gene

Domains for MRPL13 Gene

Gene Families for MRPL13 Gene

Protein Domains for MRPL13 Gene

Suggested Antigen Peptide Sequences for MRPL13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L13P family.
  • Belongs to the ribosomal protein L13P family.
genes like me logo Genes that share domains with MRPL13: view

Function for MRPL13 Gene

Gene Ontology (GO) - Molecular Function for MRPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279069
GO:0005515 protein binding IPI 20601428
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL13: view

Phenotypes for MRPL13 Gene

genes like me logo Genes that share phenotypes with MRPL13: view

Animal Model Products

miRNA for MRPL13 Gene

miRTarBase miRNAs that target MRPL13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL13

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL13 Gene

Localization for MRPL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL13 Gene


Subcellular locations from

Jensen Localization Image for MRPL13 Gene COMPARTMENTS Subcellular localization image for MRPL13 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IDA 20601428
GO:0005762 mitochondrial large ribosomal subunit NAS 11279069
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL13: view

Pathways for MRPL13 Gene

genes like me logo Genes that share pathways with MRPL13: view

Pathways by source for MRPL13 Gene

1 KEGG pathway for MRPL13 Gene
1 GeneGo (Thomson Reuters) pathway for MRPL13 Gene

Gene Ontology (GO) - Biological Process for MRPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279069
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL13: view

Transcripts for MRPL13 Gene

Unigene Clusters for MRPL13 Gene

Mitochondrial ribosomal protein L13:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for MRPL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL13 Gene

mRNA expression in normal human tissues for MRPL13 Gene

Protein differential expression in normal tissues for MRPL13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Breast (11.0), Cervix (10.6), and Pancreas (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL13 Gene

SOURCE GeneReport for Unigene cluster for MRPL13 Gene Hs.333823

genes like me logo Genes that share expressions with MRPL13: view

Expression partners for MRPL13 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL13 Gene

Orthologs for MRPL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL13 35
  • 88.95 (n)
  • 89.89 (a)
MRPL13 36
  • 89 (a)
(Canis familiaris)
Mammalia MRPL13 35
  • 90.45 (n)
  • 91.01 (a)
MRPL13 36
  • 88 (a)
(Mus musculus)
Mammalia Mrpl13 35
  • 87.08 (n)
  • 89.33 (a)
Mrpl13 16
Mrpl13 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPL13 35
  • 99.25 (n)
  • 99.44 (a)
MRPL13 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl13 35
  • 86.52 (n)
  • 89.33 (a)
(Monodelphis domestica)
Mammalia MRPL13 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL13 36
  • 84 (a)
(Gallus gallus)
Aves MRPL13 35
  • 73.97 (n)
  • 77.53 (a)
MRPL13 36
  • 76 (a)
(Anolis carolinensis)
Reptilia MRPL13 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl13 35
  • 68.94 (n)
  • 73.3 (a)
Str.13427 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33171 35
(Danio rerio)
Actinopterygii mrpl13 35
  • 70.22 (n)
  • 77.53 (a)
mrpl13 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8416 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL13 37
  • 47 (a)
mRpL13 35
  • 51.14 (n)
  • 47.16 (a)
mRpL13 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009908 35
  • 53.53 (n)
  • 47.65 (a)
(Caenorhabditis elegans)
Secernentea mrpl-13 35
  • 52.78 (n)
  • 39.88 (a)
mrpl-13 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR403W 35
  • 46.43 (n)
  • 38.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02508g 35
  • 49.86 (n)
  • 38.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL23 35
  • 47.32 (n)
  • 39.16 (a)
MRPL23 36
  • 34 (a)
MRPL23 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1473 35
  • 48.95 (n)
  • 34.23 (a)
(Oryza sativa)
Liliopsida Os01g0749200 35
  • 51.44 (n)
  • 33.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07852 35
  • 40.91 (n)
  • 35.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl23 35
  • 48.06 (n)
  • 35.83 (a)
Species with no ortholog for MRPL13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL13 Gene

Gene Tree for MRPL13 (if available)
Gene Tree for MRPL13 (if available)

Paralogs for MRPL13 Gene

No data available for Paralogs for MRPL13 Gene

Variants for MRPL13 Gene

Sequence variations from dbSNP and Humsavar for MRPL13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs77647897 -- 120,430,362(+) CAGGA(C/G)TGAAT intron-variant
rs77560353 -- 120,434,806(+) GCCAG(A/G)TAAGC intron-variant
rs77315654 -- 120,415,841(+) GTCAG(A/G)TATTT intron-variant
rs77125238 -- 120,428,148(+) AAAAA(A/C)CAGAC intron-variant
rs77123221 -- 120,431,741(+) ATGAA(C/T)TACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL13 Gene

Variant ID Type Subtype PubMed ID
dgv7872n71 CNV Gain 21882294
esv996748 CNV Deletion 20482838
nsv470235 CNV Loss 18288195

Relevant External Links for MRPL13 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL13 Gene

Disorders for MRPL13 Gene

Relevant External Links for MRPL13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPL13 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL13 Gene

Publications for MRPL13 Gene

  1. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (PMID: 18995835) Mukhopadhyay R. … Fox P.L. (Mol. Cell 2008) 3

Products for MRPL13 Gene

Sources for MRPL13 Gene

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