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Aliases for MRPL13 Gene

Aliases for MRPL13 Gene

  • Mitochondrial Ribosomal Protein L13 2 3 5
  • MRP-L13 3 4
  • L13mt 3 4
  • RPML13 3
  • RPL13 3
  • L13A 3
  • L13 3

External Ids for MRPL13 Gene

Previous GeneCards Identifiers for MRPL13 Gene

  • GC08M121466
  • GC08M121076
  • GC08M121364
  • GC08M121477
  • GC08M116728
  • GC08M121393

Summaries for MRPL13 Gene

Entrez Gene Summary for MRPL13 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL13 Gene

MRPL13 (Mitochondrial Ribosomal Protein L13) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL13 Gene

Genomics for MRPL13 Gene

Regulatory Elements for MRPL13 Gene

Enhancers for MRPL13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL13 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL13 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL13 Gene

120,380,761 bp from pter
120,445,407 bp from pter
64,647 bases
Minus strand

Genomic View for MRPL13 Gene

Genes around MRPL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL13 Gene

Proteins for MRPL13 Gene

  • Protein details for MRPL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L13, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R4R8
    • Q9UI04

    Protein attributes for MRPL13 Gene

    178 amino acids
    Molecular mass:
    20692 Da
    Quaternary structure:
    • Interacts with OXA1L.
    • Sequence=AAF17202.1; Type=Frameshift; Positions=160; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL13 Gene

neXtProt entry for MRPL13 Gene

Proteomics data for MRPL13 Gene at MOPED

Post-translational modifications for MRPL13 Gene

  • Ubiquitination at Lys 114
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL13 Gene

No data available for DME Specific Peptides for MRPL13 Gene

Domains & Families for MRPL13 Gene

Gene Families for MRPL13 Gene

Protein Domains for MRPL13 Gene

Suggested Antigen Peptide Sequences for MRPL13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L13P family.
  • Belongs to the ribosomal protein L13P family.
genes like me logo Genes that share domains with MRPL13: view

Function for MRPL13 Gene

genes like me logo Genes that share phenotypes with MRPL13: view

Animal Model Products

miRNA for MRPL13 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL13 Gene

Localization for MRPL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL13 Gene


Subcellular locations from

Jensen Localization Image for MRPL13 Gene COMPARTMENTS Subcellular localization image for MRPL13 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL13: view

Pathways & Interactions for MRPL13 Gene

genes like me logo Genes that share pathways with MRPL13: view

Gene Ontology (GO) - Biological Process for MRPL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279069
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL13: view

No data available for SIGNOR curated interactions for MRPL13 Gene

Drugs & Compounds for MRPL13 Gene

No Compound Related Data Available

Transcripts for MRPL13 Gene

Unigene Clusters for MRPL13 Gene

Mitochondrial ribosomal protein L13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL13 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for MRPL13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL13 Gene

mRNA expression in normal human tissues for MRPL13 Gene

Protein differential expression in normal tissues from HIPED for MRPL13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.7), Breast (11.0), Cervix (10.6), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL13 Gene

SOURCE GeneReport for Unigene cluster for MRPL13 Gene Hs.333823

genes like me logo Genes that share expression patterns with MRPL13: view

Protein tissue co-expression partners for MRPL13 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL13 Gene

Orthologs for MRPL13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL13 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL13 35
  • 88.95 (n)
  • 89.89 (a)
MRPL13 36
  • 89 (a)
(Canis familiaris)
Mammalia MRPL13 35
  • 90.45 (n)
  • 91.01 (a)
MRPL13 36
  • 88 (a)
(Mus musculus)
Mammalia Mrpl13 35
  • 87.08 (n)
  • 89.33 (a)
Mrpl13 16
Mrpl13 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPL13 35
  • 99.25 (n)
  • 99.44 (a)
MRPL13 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl13 35
  • 86.52 (n)
  • 89.33 (a)
(Monodelphis domestica)
Mammalia MRPL13 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL13 36
  • 84 (a)
(Gallus gallus)
Aves MRPL13 35
  • 73.97 (n)
  • 77.53 (a)
MRPL13 36
  • 76 (a)
(Anolis carolinensis)
Reptilia MRPL13 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl13 35
  • 68.94 (n)
  • 73.3 (a)
Str.13427 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33171 35
(Danio rerio)
Actinopterygii mrpl13 35
  • 70.22 (n)
  • 77.53 (a)
mrpl13 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8416 35
fruit fly
(Drosophila melanogaster)
Insecta mRpL13 37
  • 47 (a)
mRpL13 35
  • 51.14 (n)
  • 47.16 (a)
mRpL13 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009908 35
  • 53.53 (n)
  • 47.65 (a)
(Caenorhabditis elegans)
Secernentea mrpl-13 35
  • 52.78 (n)
  • 39.88 (a)
mrpl-13 36
  • 33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR403W 35
  • 46.43 (n)
  • 38.57 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02508g 35
  • 49.86 (n)
  • 38.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL23 35
  • 47.32 (n)
  • 39.16 (a)
MRPL23 36
  • 34 (a)
MRPL23 38
thale cress
(Arabidopsis thaliana)
eudicotyledons emb1473 35
  • 48.95 (n)
  • 34.23 (a)
(Oryza sativa)
Liliopsida Os01g0749200 35
  • 51.44 (n)
  • 33.07 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07852 35
  • 40.91 (n)
  • 35.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl23 35
  • 48.06 (n)
  • 35.83 (a)
Species with no ortholog for MRPL13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL13 Gene

Gene Tree for MRPL13 (if available)
Gene Tree for MRPL13 (if available)

Paralogs for MRPL13 Gene

No data available for Paralogs for MRPL13 Gene

Variants for MRPL13 Gene

Sequence variations from dbSNP and Humsavar for MRPL13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2311338 -- 120,428,809(-) TTATC(A/C/G)CCATT intron-variant
rs2507722 -- 120,400,676(+) aatga(A/T)tccag intron-variant
rs7838344 -- 120,405,502(+) GTTTA(C/T)GGACC intron-variant
rs7844850 -- 120,397,728(+) gggat(A/G)gagcc intron-variant
rs9297616 -- 120,420,984(+) CAGAC(A/G)TACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL13 Gene

Variant ID Type Subtype PubMed ID
dgv7872n71 CNV Gain 21882294
esv996748 CNV Deletion 20482838
nsv470235 CNV Loss 18288195

Variation tolerance for MRPL13 Gene

Residual Variation Intolerance Score: 52.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL13 Gene

Disorders for MRPL13 Gene

Relevant External Links for MRPL13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL13 Gene

Publications for MRPL13 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPL13 Gene

Sources for MRPL13 Gene