MRPL12 Gene
protein-coding GIFtS: 49
GCID: GC17P079670
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mitochondrial ribosomal protein L12
(Previous symbol: RPML12)
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Aliases
for MRPL12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L121 2 | | L12mt2 3 | | RPML121 2 3 5 | | MRP-L122 3 | | MRPL71 2 | | 39S Ribosomal Protein L12, Mitochondrial2 | | MRPL7/L121 2 | | MRP-L31/342 | | 5c5-22 3 | | |
Export aliases for MRPL12 gene to outside databasesPrevious GC identifers: GC17U990085 GC17P080228 GC17P080366 GC17P077280 GC17P075116 |
Summaries
for MRPL12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL12:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit proteinwhich forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.(provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPL12
|
Genomic Views
for MRPL12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL12 gene promoter:
USF1 AML1a NRSF form 1 Lmo2 AP-4 NRSF form 2 Roaz HEN1 USF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25MRPL12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P079670: view genomic region
(about GC identifiers)
Start:
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79,670,387 bp from pter |
End:
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79,674,556 bp from pter |
Size:
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4,170 bases |
Orientation:
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plus strand |
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Proteins
for MRPL12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM12_HUMAN, P52815 (See
protein sequence)Recommended Name: 39S ribosomal protein L12, mitochondrial precursor Size: 198 amino acids; 21348 Da
Subunit: Interacts with NOA1
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAD16894.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q969U0 Q9HCA2 Q9UQJ3Explore the universe of human proteins at neXtProt for MRPL12: NX_P52815
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52815
MRPL12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002940.2
ENSEMBL proteins: ENSP00000333837
Human Recombinant Protein Products for MRPL12:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- | | GO:0005762 | mitochondrial large ribosomal subunit |
IDA | -- |
MRPL12 for ontologies About GeneDecksing
MRPL12 Antibody Products:
Assay Products for MRPL12: |
Protein
Domains /
Families
for MRPL12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52815ProtoNet protein and cluster: P52815 1 Blocks protein family: IPB000206 Ribosomal protein L7/L12
UniProtKB/Swiss-Prot: RM12_HUMAN, P52815Similarity: Belongs to the ribosomal protein L7/L12P family |
Function
for MRPL12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
MRPL12 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MRPL12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL12 |
|
Pathways & Interactions
for MRPL12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRPL12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/273 Interacting proteins for MRPL12 (P528152, 3 ENSP000003338374) via UniProtKB, MINT, STRING, and/or I2D (see all 273)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
MRPL12 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL12
Search CenterWatch for drugs/clinical trials and news about MRPL12 / RM12
|
Transcripts
for MRPL12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL12 gene: NM_002949.3 Unigene Cluster for MRPL12: Mitochondrial ribosomal protein L12 Hs.109059 [show with all ESTs]Unigene Representative Sequence: BM5575121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333676(uc002kbh.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL12 (NM_002949) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL12 |
Additional cDNA sequence: AF105278.1 BC002344.2 BC007497.2 EF036488.1 U25041.1 X79865.1 6 DOTS entries: DT.99957736 DT.116243 DT.95194105 DT.92469503 DT.92469583 DT.92469591 24/715 AceView cDNA sequences (see all 715): BM719190 BQ927283 NM_002949 CA307884 AW163544 AW629684 AL539358 AI362004 AI888921 BM971991 CN482479 BU855778 AW249230 BU527054 BT009754 CA455421 BE408682 BE905808 BG055782 BM794188 BQ278969 BM911608 BF219688 AI870114
GeneLoc Exon Structure
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Expression
for MRPL12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCTGTGCC
About this image
See MRPL12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL12
SOURCE GeneReport for Unigene cluster: Hs.109059
SABiosciences Custom PCR Arrays for MRPL12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL12 |
Orthologs
for MRPL12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPL12 gene from 11/36 species (see all 36) About this table
ENSEMBL Gene Tree for MRPL12 (if available)
TreeFam Gene Tree for MRPL12 (if available) |
Paralogs
for MRPL12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL12 (79670387 - 79674556 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MRPL12
3 CNVs: 30036 73071 30034 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL12 |
|
Disorders
/ Diseases
for MRPL12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL12 for disorders About GeneDecksing
OMIM gene information: 602375
OMIM disorders: --
2  diseases for MRPL12: About MalaCardsprostate cancer prostatitis
Human Genome Epidemiology (HuGE) Navigator: MRPL12 (1 document)
Export disorders for MRPL12 gene to outside databases
|
Publications
for MRPL12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL12 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with MRPL12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein. (PubMed id 8626705)1, 2, 3, 9 Marty L. and Fort P. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12. (PubMed id 9169145)1, 3 Marty L....Fort P. (1997)
- Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. (PubMed id 17337445)1, 9 Wang Z....Shadel G.S. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for MRPL12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPL12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL12 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPL12 gene:
Search GeneIP for patents involving MRPL12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL12 | | | OriGene Protein Over-expression Lysate for MRPL12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL12 | | OriGene 3'-UTR Clone for MRPL12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPL12 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MRPL12 Proteins, Antibodies, CLIAs, and ELISAs |
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