Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL12 Gene

Aliases for MRPL12 Gene

  • Mitochondrial Ribosomal Protein L12 2 3 5
  • MRP-L12 3 4
  • RPML12 3 4
  • 5c5-2 3 4
  • L12mt 3 4
  • MRP-L31/34 3
  • MRPL7/L12 3
  • MRPL7 3

External Ids for MRPL12 Gene

Previous HGNC Symbols for MRPL12 Gene

  • RPML12

Previous GeneCards Identifiers for MRPL12 Gene

  • GC17U990085
  • GC17P080228
  • GC17P080366
  • GC17P077280
  • GC17P079670
  • GC17P075116

Summaries for MRPL12 Gene

Entrez Gene Summary for MRPL12 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL12 Gene

MRPL12 (Mitochondrial Ribosomal Protein L12) is a Protein Coding gene. Diseases associated with MRPL12 include Brain Glioblastoma Multiforme and Autosomal Dominant Nonsyndromic Deafness. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL12 Gene

Genomics for MRPL12 Gene

Regulatory Elements for MRPL12 Gene

Enhancers for MRPL12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL12 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL12 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL12 Gene

81,703,357 bp from pter
81,707,526 bp from pter
4,170 bases
Plus strand

Genomic View for MRPL12 Gene

Genes around MRPL12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL12 Gene

Proteins for MRPL12 Gene

  • Protein details for MRPL12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L12, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q969U0
    • Q9HCA2
    • Q9UQJ3

    Protein attributes for MRPL12 Gene

    198 amino acids
    Molecular mass:
    21348 Da
    Quaternary structure:
    • Interacts with NOA1.
    • Sequence=AAD16894.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MRPL12 Gene

Proteomics data for MRPL12 Gene at MOPED

Post-translational modifications for MRPL12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL12 Gene

Domains & Families for MRPL12 Gene

Gene Families for MRPL12 Gene

Suggested Antigen Peptide Sequences for MRPL12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L7/L12P family.
  • Belongs to the ribosomal protein L7/L12P family.
genes like me logo Genes that share domains with MRPL12: view

Function for MRPL12 Gene

genes like me logo Genes that share phenotypes with MRPL12: view

Animal Model Products

miRNA for MRPL12 Gene

miRTarBase miRNAs that target MRPL12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL12 Gene

Localization for MRPL12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL12 Gene


Subcellular locations from

Jensen Localization Image for MRPL12 Gene COMPARTMENTS Subcellular localization image for MRPL12 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL12: view

Pathways & Interactions for MRPL12 Gene

genes like me logo Genes that share pathways with MRPL12: view

Gene Ontology (GO) - Biological Process for MRPL12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 17337445
genes like me logo Genes that share ontologies with MRPL12: view

No data available for SIGNOR curated interactions for MRPL12 Gene

Drugs & Compounds for MRPL12 Gene

No Compound Related Data Available

Transcripts for MRPL12 Gene

mRNA/cDNA for MRPL12 Gene

Unigene Clusters for MRPL12 Gene

Mitochondrial ribosomal protein L12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL12 Gene

No ASD Table

Relevant External Links for MRPL12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL12 Gene

mRNA expression in normal human tissues for MRPL12 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPL12 Gene

SOURCE GeneReport for Unigene cluster for MRPL12 Gene Hs.109059

genes like me logo Genes that share expression patterns with MRPL12: view

Protein tissue co-expression partners for MRPL12 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL12 Gene

Orthologs for MRPL12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL12 35
  • 86.2 (n)
  • 85.86 (a)
(Canis familiaris)
Mammalia MRPL12 35
  • 87.37 (n)
  • 87.88 (a)
(Mus musculus)
Mammalia Mrpl12 35
  • 83.67 (n)
  • 84.85 (a)
Mrpl12 16
Mrpl12 36
  • 84 (a)
(Pan troglodytes)
Mammalia MRPL12 35
  • 99.66 (n)
  • 99.49 (a)
(Rattus norvegicus)
Mammalia Mrpl12 35
  • 82.83 (n)
  • 82.83 (a)
(Monodelphis domestica)
Mammalia MRPL12 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL12 36
  • 34 (a)
(Gallus gallus)
Aves MRPL12 35
  • 70.78 (n)
  • 69.14 (a)
(Anolis carolinensis)
Reptilia MRPL12 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl12 35
  • 64.27 (n)
  • 64.67 (a)
Str.1933 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24066 35
(Danio rerio)
Actinopterygii Dr.9805 35
mrpl12 35
  • 64.51 (n)
  • 61.76 (a)
mrpl12 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011581 35
  • 53.53 (n)
  • 43.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL12 35
  • 54.64 (n)
  • 39.85 (a)
mRpL12 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrpl-12 35
  • 52.17 (n)
  • 45.65 (a)
mrpl-12 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL089C 35
  • 56.57 (n)
  • 47.73 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03212g 35
  • 52.32 (n)
  • 46.36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNP1 35
  • 52.97 (n)
  • 49.61 (a)
MNP1 36
  • 38 (a)
MNP1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU06469 35
  • 55.77 (n)
  • 46.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC4B3.09c 35
  • 46.56 (n)
  • 40.46 (a)
Species with no ortholog for MRPL12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL12 Gene

Gene Tree for MRPL12 (if available)
Gene Tree for MRPL12 (if available)

Paralogs for MRPL12 Gene

(2) SIMAP similar genes for MRPL12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRPL12: view

No data available for Paralogs for MRPL12 Gene

Variants for MRPL12 Gene

Sequence variations from dbSNP and Humsavar for MRPL12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11546280 - 81,704,684(+) TGATG(C/T)CTGGG reference, missense
rs10560 -- 81,707,345(+) GGAGC(C/T)GTTTG utr-variant-3-prime
rs1132802 -- 81,703,243(+) AAACC(C/T)GGCGG upstream-variant-2KB
rs1132803 -- 81,703,356(+) GAGGT(A/G)CGGCT upstream-variant-2KB
rs7503103 -- 81,707,606(+) GCTGC(A/G)GGGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL12 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909116 CNV Loss 21882294
dgv3334n71 CNV Loss 21882294
dgv3335n71 CNV Loss 21882294
dgv3336n71 CNV Loss 21882294
nsv909126 CNV Loss 21882294

Variation tolerance for MRPL12 Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL12 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL12 Gene

Disorders for MRPL12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MRPL12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
autosomal dominant nonsyndromic deafness
  • autosomal dominant deafness
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MRPL12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRPL12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPL12 Gene

Publications for MRPL12 Gene

  1. A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein. (PMID: 8626705) Marty L. … Fort P. (J. Biol. Chem. 1996) 2 3 4 23 67
  2. Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression. (PMID: 17337445) Wang Z. … Shadel G.S. (J. Biol. Chem. 2007) 3 23
  3. Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12. (PMID: 9169145) Marty L. … Fort P. (Genomics 1997) 2 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair. (PMID: 25921070) Ui A. … Yasui A. (Mol. Cell 2015) 3

Products for MRPL12 Gene

Sources for MRPL12 Gene