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Aliases for MRPL11 Gene

Aliases for MRPL11 Gene

  • Mitochondrial Ribosomal Protein L11 2 3 5
  • MRP-L11 3 4
  • L11MT 3 4
  • 39S Ribosomal Protein L11, Mitochondrial 3
  • CGI-113 3

External Ids for MRPL11 Gene

Previous GeneCards Identifiers for MRPL11 Gene

  • GC11M068737
  • GC11M067883
  • GC11M065978
  • GC11M065959
  • GC11M066202
  • GC11M062530

Summaries for MRPL11 Gene

Entrez Gene Summary for MRPL11 Gene

  • This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

GeneCards Summary for MRPL11 Gene

MRPL11 (Mitochondrial Ribosomal Protein L11) is a Protein Coding gene. Among its related pathways are Translational Control and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL11 Gene

Genomics for MRPL11 Gene

Regulatory Elements for MRPL11 Gene

Enhancers for MRPL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRPL11 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL11 Gene

Chromosome:
11
Start:
66,435,075 bp from pter
End:
66,466,738 bp from pter
Size:
31,664 bases
Orientation:
Minus strand

Genomic View for MRPL11 Gene

Genes around MRPL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL11 Gene

Proteins for MRPL11 Gene

  • Protein details for MRPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3B7-RM11_HUMAN
    Recommended name:
    39S ribosomal protein L11, mitochondrial
    Protein Accession:
    Q9Y3B7
    Secondary Accessions:
    • A6NLT0
    • A8K219
    • Q32P46
    • Q96Q73

    Protein attributes for MRPL11 Gene

    Size:
    192 amino acids
    Molecular mass:
    20683 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL11 Gene

    Alternative splice isoforms for MRPL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL11 Gene

Post-translational modifications for MRPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL11 Gene

No data available for DME Specific Peptides for MRPL11 Gene

Domains & Families for MRPL11 Gene

Gene Families for MRPL11 Gene

Protein Domains for MRPL11 Gene

Suggested Antigen Peptide Sequences for MRPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3B7

UniProtKB/Swiss-Prot:

RM11_HUMAN :
  • Belongs to the ribosomal protein L11P family.
Family:
  • Belongs to the ribosomal protein L11P family.
genes like me logo Genes that share domains with MRPL11: view

Function for MRPL11 Gene

Gene Ontology (GO) - Molecular Function for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0005515 protein binding IPI 22190034
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL11: view

Phenotypes for MRPL11 Gene

genes like me logo Genes that share phenotypes with MRPL11: view

Animal Model Products

CRISPR Products

miRNA for MRPL11 Gene

miRTarBase miRNAs that target MRPL11

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL11 Gene

Localization for MRPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL11 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL11 Gene COMPARTMENTS Subcellular localization image for MRPL11 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPL11: view

Pathways & Interactions for MRPL11 Gene

genes like me logo Genes that share pathways with MRPL11: view

Pathways by source for MRPL11 Gene

Gene Ontology (GO) - Biological Process for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0006412 translation NAS 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL11: view

No data available for SIGNOR curated interactions for MRPL11 Gene

Drugs & Compounds for MRPL11 Gene

No Compound Related Data Available

Transcripts for MRPL11 Gene

Unigene Clusters for MRPL11 Gene

Mitochondrial ribosomal protein L11:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1:
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for MRPL11 Gene

GeneLoc Exon Structure for
MRPL11
ECgene alternative splicing isoforms for
MRPL11

Expression for MRPL11 Gene

mRNA expression in normal human tissues for MRPL11 Gene

Protein differential expression in normal tissues from HIPED for MRPL11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Lung (7.4), and Breast (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL11 Gene



Protein tissue co-expression partners for MRPL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL11 Gene:

MRPL11

SOURCE GeneReport for Unigene cluster for MRPL11 Gene:

Hs.418450
genes like me logo Genes that share expression patterns with MRPL11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL11 Gene

Orthologs for MRPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL11 34
  • 89.07 (n)
  • 91.67 (a)
MRPL11 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL11 34
  • 89.07 (n)
  • 93.33 (a)
MRPL11 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl11 34
  • 85.24 (n)
  • 87.5 (a)
Mrpl11 16
Mrpl11 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL11 34
  • 99.48 (n)
  • 100 (a)
MRPL11 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia mrpl11 34
  • 83.99 (n)
  • 87.15 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL11 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL11 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl11 34
  • 63 (n)
  • 66.49 (a)
Str.19345 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6453 34
zebrafish
(Danio rerio)
Actinopterygii Dr.27215 34
mrpl11 34
  • 65.07 (n)
  • 67.02 (a)
mrpl11 35
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8314 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002332 34
  • 55.69 (n)
  • 47.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL11 34
  • 54.22 (n)
  • 44.3 (a)
mRpL11 35
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0303.15 36
  • 46 (a)
mrpl-11 34
  • 50.94 (n)
  • 48.88 (a)
mrpl-11 35
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL144C 34
  • 46.81 (n)
  • 42.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08437g 34
  • 49.75 (n)
  • 47.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL19 34
  • 48.04 (n)
  • 44.85 (a)
MRPL19 35
  • 41 (a)
OneToOne
MRPL19 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MRPL11 34
  • 52.51 (n)
  • 45.21 (a)
rice
(Oryza sativa)
Liliopsida Os10g0466200 34
  • 51.49 (n)
  • 45.52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04336 34
  • 51.96 (n)
  • 49.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl19 34
  • 48.04 (n)
  • 44.12 (a)
Species where no ortholog for MRPL11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL11 Gene

ENSEMBL:
Gene Tree for MRPL11 (if available)
TreeFam:
Gene Tree for MRPL11 (if available)

Paralogs for MRPL11 Gene

Pseudogenes.org Pseudogenes for MRPL11 Gene

genes like me logo Genes that share paralogs with MRPL11: view

No data available for Paralogs for MRPL11 Gene

Variants for MRPL11 Gene

Sequence variations from dbSNP and Humsavar for MRPL11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1056655 -- 66,435,214(-) GAGAG(C/T)AGGAG nc-transcript-variant, utr-variant-3-prime
rs34413882 -- 66,434,972(+) GAGTA(-/T)TGACC downstream-variant-500B
rs34452272 -- 66,437,913(+) AACAT(-/C)CCCTG intron-variant
rs11110 -- 66,438,698(-) GGTGT(A/G)ATCCG intron-variant, nc-transcript-variant, reference, synonymous-codon
rs2279865 -- 66,435,554(+) TAGCA(A/C)CCATA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL11 Gene

Variant ID Type Subtype PubMed ID
nsv832193 CNV loss 17160897

Variation tolerance for MRPL11 Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL11 Gene

Disorders for MRPL11 Gene

Relevant External Links for MRPL11

Genetic Association Database (GAD)
MRPL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL11

No disorders were found for MRPL11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL11 Gene

Publications for MRPL11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 65
  4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4 65
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4 65

Products for MRPL11 Gene

Sources for MRPL11 Gene

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