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Aliases for MRPL11 Gene

Aliases for MRPL11 Gene

  • Mitochondrial Ribosomal Protein L11 2 3
  • MRP-L11 3 4
  • L11MT 3 4
  • 39S Ribosomal Protein L11, Mitochondrial 3
  • CGI-113 3

External Ids for MRPL11 Gene

Previous GeneCards Identifiers for MRPL11 Gene

  • GC11M068737
  • GC11M067883
  • GC11M065978
  • GC11M065959
  • GC11M066202
  • GC11M062530

Summaries for MRPL11 Gene

Entrez Gene Summary for MRPL11 Gene

  • This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]

GeneCards Summary for MRPL11 Gene

MRPL11 (Mitochondrial Ribosomal Protein L11) is a Protein Coding gene. Among its related pathways are Translational Control and CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL11 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL11 Gene

Genomics for MRPL11 Gene

Regulatory Elements for MRPL11 Gene

Genomic Location for MRPL11 Gene

66,435,075 bp from pter
66,466,738 bp from pter
31,664 bases
Minus strand

Genomic View for MRPL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL11 Gene

Proteins for MRPL11 Gene

  • Protein details for MRPL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L11, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NLT0
    • A8K219
    • Q32P46
    • Q96Q73

    Protein attributes for MRPL11 Gene

    192 amino acids
    Molecular mass:
    20683 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL11 Gene

    Alternative splice isoforms for MRPL11 Gene


neXtProt entry for MRPL11 Gene

Proteomics data for MRPL11 Gene at MOPED

Post-translational modifications for MRPL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MRPL11 (MRPL11)

No data available for DME Specific Peptides for MRPL11 Gene

Domains for MRPL11 Gene

Gene Families for MRPL11 Gene

Protein Domains for MRPL11 Gene

Suggested Antigen Peptide Sequences for MRPL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L11P family.
  • Belongs to the ribosomal protein L11P family.
genes like me logo Genes that share domains with MRPL11: view

Function for MRPL11 Gene

Gene Ontology (GO) - Molecular Function for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11543634
GO:0005515 protein binding IPI 22190034
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPL11: view

miRNA for MRPL11 Gene

miRTarBase miRNAs that target MRPL11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL11

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL11 Gene

Localization for MRPL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL11 Gene


Subcellular locations from

Jensen Localization Image for MRPL11 Gene COMPARTMENTS Subcellular localization image for MRPL11 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL11: view

Pathways for MRPL11 Gene

genes like me logo Genes that share pathways with MRPL11: view

Pathways by source for MRPL11 Gene

1 Cell Signaling Technology pathway for MRPL11 Gene
1 KEGG pathway for MRPL11 Gene

Gene Ontology (GO) - Biological Process for MRPL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11543634
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL11: view

Transcripts for MRPL11 Gene

Unigene Clusters for MRPL11 Gene

Mitochondrial ribosomal protein L11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for MRPL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL11 Gene

mRNA expression in normal human tissues for MRPL11 Gene

Protein differential expression in normal tissues for MRPL11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.4), Lung (7.4), and Breast (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL11 Gene

SOURCE GeneReport for Unigene cluster for MRPL11 Gene Hs.418450

genes like me logo Genes that share expressions with MRPL11: view

Expression partners for MRPL11 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL11 Gene

Orthologs for MRPL11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL11 35
  • 89.07 (n)
  • 91.67 (a)
MRPL11 36
  • 92 (a)
(Canis familiaris)
Mammalia MRPL11 35
  • 89.07 (n)
  • 93.33 (a)
MRPL11 36
  • 93 (a)
(Mus musculus)
Mammalia Mrpl11 35
  • 85.24 (n)
  • 87.5 (a)
Mrpl11 16
Mrpl11 36
  • 88 (a)
(Pan troglodytes)
Mammalia MRPL11 35
  • 99.48 (n)
  • 100 (a)
MRPL11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia mrpl11 35
  • 83.99 (n)
  • 87.15 (a)
(Monodelphis domestica)
Mammalia MRPL11 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL11 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl11 35
  • 63 (n)
  • 66.49 (a)
Str.19345 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6453 35
(Danio rerio)
Actinopterygii Dr.27215 35
mrpl11 35
  • 65.07 (n)
  • 67.02 (a)
mrpl11 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8314 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002332 35
  • 55.69 (n)
  • 47.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL11 35
  • 54.22 (n)
  • 44.3 (a)
mRpL11 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea B0303.15 37
  • 46 (a)
mrpl-11 35
  • 50.94 (n)
  • 48.88 (a)
mrpl-11 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL144C 35
  • 46.81 (n)
  • 42.65 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08437g 35
  • 49.75 (n)
  • 47.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL19 35
  • 48.04 (n)
  • 44.85 (a)
MRPL19 36
  • 41 (a)
MRPL19 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MRPL11 35
  • 52.51 (n)
  • 45.21 (a)
(Oryza sativa)
Liliopsida Os10g0466200 35
  • 51.49 (n)
  • 45.52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04336 35
  • 51.96 (n)
  • 49.26 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrpl19 35
  • 48.04 (n)
  • 44.12 (a)
Species with no ortholog for MRPL11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL11 Gene

Gene Tree for MRPL11 (if available)
Gene Tree for MRPL11 (if available)

Paralogs for MRPL11 Gene Pseudogenes for MRPL11 Gene

genes like me logo Genes that share paralogs with MRPL11: view

No data available for Paralogs for MRPL11 Gene

Variants for MRPL11 Gene

Sequence variations from dbSNP and Humsavar for MRPL11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11110 -- 66,438,698(-) GGTGT(A/G)ATCCG synonymous-codon, reference, intron-variant, nc-transcript-variant
rs1056655 -- 66,435,214(-) GAGAG(C/T)AGGAG utr-variant-3-prime, nc-transcript-variant
rs2279865 -- 66,435,554(+) TAGCA(A/C)CCATA utr-variant-3-prime, nc-transcript-variant
rs2511221 -- 66,440,049(+) GGCGC(A/G)TCTGG upstream-variant-2KB
rs3107024 -- 66,434,744(+) ttagc(C/T)ggtgt downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL11 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
nsv832193 CNV Loss 17160897
nsv897786 CNV Loss 21882294

Relevant External Links for MRPL11 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL11 Gene

Disorders for MRPL11 Gene

Relevant External Links for MRPL11

Genetic Association Database (GAD)

No disorders were found for MRPL11 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPL11 Gene

Publications for MRPL11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PMID: 11279069) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4

Products for MRPL11 Gene

Sources for MRPL11 Gene

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