Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPL11 Gene

protein-coding   GIFtS: 51
GCID: GC11M066202

mitochondrial ribosomal protein L11
 Explore 6 diseases affiliated with
MRPL11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MRPL11    

Aliases
for MRPL11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitochondrial Ribosomal Protein L111 2
MRP-L112 3
39S Ribosomal Protein L11, Mitochondrial2
L11MT2
L11mt3

External Ids:    HGNC: 140421   Entrez Gene: 650032   Ensembl: ENSG000001745477   OMIM: 6118265   UniProtKB: Q9Y3B73   
ORGUL members:         
NONCODE:n342769    

Export aliases for MRPL11 gene to outside databases

Previous GC identifers: GC11M068737 GC11M067883 GC11M066452 GC11M065978 GC11M065959 GC11M062530


Summaries
for MRPL11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MRPL11:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to
this gene are found on chromosomes 5q and 12q. (provided by RefSeq, Jul 2008)

Gene Wiki entry for MRPL11


Genomic Views
for MRPL11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPL11 gene promoter:
         TBP   STAT5B   C/EBPbeta   NRSF form 1   SREBP-1c   NRSF form 2   E47   RORalpha2   SREBP-1b   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRPL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.3   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

MRPL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066202:  view genomic region     (about GC identifiers)

Start:
 66,202,546 bp from pter      End:
 66,234,209 bp from pter
Size:
 31,664 bases      Orientation:
 minus strand

Proteins
for MRPL11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RM11_HUMAN, Q9Y3B7 (See protein sequence)
Recommended Name: 39S ribosomal protein L11, mitochondrial precursor  
Size: 192 amino acids; 20683 Da
Subcellular location: Mitochondrion
Secondary accessions: A6NLT0 A8K219 Q32P46 Q96Q73
Alternative splicing: 3 isoforms:  Q9Y3B7-1   Q9Y3B7-2   Q9Y3B7-3   (No experimental confirmation available. Ref.6 (BM554886) sequence is in conflict in position: 181:V->L)

Explore the universe of human proteins at neXtProt for MRPL11: NX_Q9Y3B7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3B7

    • MRPL11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_057134.1  NP_733934.1  NP_733935.1  

    ENSEMBL proteins: 
     ENSP00000308897   ENSP00000415356   ENSP00000431405   ENSP00000436904   ENSP00000329630  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MRPL11
    OriGene Protein Over-expression Lysate (see all 3): MRPL11
    OriGene Custom Protein Services for MRPL11 
    GenScript Custom Purified and Recombinant Proteins Services for MRPL11
    Novus Biologicals MRPL11 Protein
    Novus Biologicals MRPL11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MRPL11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005761mitochondrial ribosome NAS11543634
    GO:0005840ribosome ----


    MRPL11 for ontologies           About GeneDecksing



    MRPL11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MRPL11 
    OriGene Antibodies (see all 3): MRPL11
    OriGene Custom Antibody Services for MRPL11 
    GenScript Custom Superior Antibodies Services for MRPL11
    Novus Biologicals MRPL11 Antibodies
    Abcam antibodies for MRPL11 
    Uscn Antibodies for MRPL11
    Search ThermoFisher Antibodies for MRPL11

    Assay Products for MRPL11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRPL11
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MRPL11

    Protein Domains /
    Families
    for MRPL11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MRPL11 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR006519 Ribosomal_L11_bac-typ
     IPR020784 Ribosomal_L11_N
     IPR000911 Ribosomal_L11
     IPR020783 Ribosomal_L11_C

    Graphical View of Domain Structure for InterPro Entry Q9Y3B7

    ProtoNet protein and cluster: Q9Y3B7

    1 Blocks protein family: IPB000911 Ribosomal protein L11

    UniProtKB/Swiss-Prot: RM11_HUMAN, Q9Y3B7
    Similarity: Belongs to the ribosomal protein L11P family


    Function
    for MRPL11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): MRPL11
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPL11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MRPL11:
    hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmid: MRPL11 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL11 (see all 4)
    OriGene shRNA RFP: MRPL11
    OriGene siRNA: MRPL11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MRPL11

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MRPL11 (NM_016050)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL11 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MRPL11
    Search LifeMap BioReagents cell lines for MRPL11

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL11

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11543634
    GO:0005515protein binding IPI--


    MRPL11 for ontologies           About GeneDecksing



    Pathways & Interactions
    for MRPL11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for MRPL11
        Translational Control



    MRPL11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/299 Interacting proteins for MRPL11 (Q9Y3B71, 2, 3 ENSP000003088974) via UniProtKB, MINT, STRING, and/or I2D (see all 299)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL2Q5T6532, 3, ENSP000003734044MINT-8079030 I2D: score=1 STRING: ENSP00000373404
    MRPL3P090012, 3, ENSP000002649954MINT-8079030 I2D: score=2 STRING: ENSP00000264995
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    RPL26P612543, ENSP000002938424I2D: score=2 STRING: ENSP00000293842
    RPL26L1Q9UNX33, ENSP000002651004I2D: score=2 STRING: ENSP00000265100
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11543634


    MRPL11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MRPL11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPL11
    Search CenterWatch for drugs/clinical trials and news about MRPL11 / RM11 

    Transcripts
    for MRPL11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MRPL11 gene (3 alternative transcripts): 
    NM_016050.3  NM_170738.2  NM_170739.2  

    Unigene Cluster for MRPL11:

    Mitochondrial ribosomal protein L11
    Hs.418450  [show with all ESTs]
    Unigene Representative Sequence: AK127603
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310999(uc001ohy.4 uc001ohz.4) ENST00000430466(uc001oia.4)
    ENST00000524576 ENST00000528272 ENST00000534488 ENST00000329819

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): MRPL11
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPL11
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MRPL11:
    hsa-miR-185*
    SwitchGear 3'UTR luciferase reporter plasmid: MRPL11 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL11 (see all 4)
    OriGene shRNA RFP: MRPL11
    OriGene siRNA: MRPL11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL11
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): MRPL11 (NM_016050)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL11 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL11

    Additional cDNA sequence: 

    AB049638.1 AF151871.1 AK127603.1 AK223112.1 AK290084.1 BC005002.1 BC108277.1 

    13 DOTS entries:

    DT.117938  DT.99968216  DT.95239625  DT.92437618  DT.100784905  DT.120710666  DT.95239626  DT.120710665 
    DT.92324178  DT.120710701  DT.102825150  DT.120710728  DT.92437621 

    24/300 AceView cDNA sequences (see all 300):

    BI793287 BE378249 AA765429 CN482715 AA505571 BM674659 BG109783 AW675097 
    AI161081 NM_170738 BM142653 BE786146 AA846602 BQ011327 BI913228 CR600024 
    BG113959 AI310326 BM556747 AL519940 AI096748 BM821866 AI278848 BQ653216 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL11    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
    SP1:                                                                                    
    SP2:                                                        -                           
    SP3:                          -                             -                           
    SP4:                                      -                 -                           
    SP5:                    -     -                             -                           


    ECgene alternative splicing isoforms for MRPL11

    Expression
    for MRPL11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTTGAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MRPL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPL11

    SOURCE GeneReport for Unigene cluster: Hs.418450
        SABiosciences Custom PCR Arrays for MRPL11
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL11
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL11
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL11

    Orthologs
    for MRPL11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MRPL11 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mrpl111 , 5 mitochondrial ribosomal protein L111, 5 85.24(n)1
    87.5(a)1    		   19 (4.19 cM)5
    664191  NM_025553.41  NP_079829.11 
     49623065 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.64532 Xenopus laevis transcribed sequence with weak similarity more 72.22(n)    BG553959.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.272152 Transcribed sequence with weak similarity to protein more 73.96(n)    CK352800.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mRpL111 mitochondrial ribosomal protein L11 53.89(n)
    43.71(a)    		   41757  NM_079627.2  NP_524351.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea B0303.153
    mrpl-111    		 Ribosomal protein L113
    Protein MRPL-111    		 46(a)3
    50.47(n)1
    49.15(a)1    		   III(8789315-8790480)3
    1819171  NM_066522.31  NP_498923.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes MRPL19(YNL185C)4
    MRPL191    		 Mitochondrial ribosomal protein of the large subunit4
    Mrpl19p1    		 47.55(n)1
    44.85(a)1    		   14(292669-292193)4
    8555361, 4  NP_014214.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MRPL111 mitochondrial ribosomal protein L11 50.22(n)
    41.56(a)    		   829701  NM_119714.3  NP_195274.1 
    rice
    (Oryza sativa)    		 Liliopsida Os10g04662001 hypothetical protein 51.49(n)
    45.52(a)    		   4348843  NM_001071338.1  NP_001064803.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria rplK6
    		 50S ribosomal subunit protein L11
    		 38(a)
    		 1 ↔ 1
    		 Chromosome(4176470-4176898) b3983


    ENSEMBL Gene Tree for MRPL11 (if available)
    TreeFam Gene Tree for MRPL11 (if available) 

    Paralogs
    for MRPL11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPL11 gene

    MRPL11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPL11
    PGOHUM00000235411


    Genomic Variants
    for MRPL11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/105 NCBI SNPs in MRPL11 are shown (see all 105)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1870195911,2
    		--66202129(+) GAGGCA/GGGCAG 3 -- ds50010--------
    rs31070241,2
    		C,A,--66202215(+) TTAGCT/CGGTGT 3 -- ds50015Minor allele frequency- C:0.10NA 10
    rs1895491941,2
    		--66202257(+) GGAGGC/GTGAGG 3 -- ds50010--------
    rs1399670771,2
    		C,--66202361(+) CAAAA-/GAAAAA 3 -- ds50010--------
    rs1826226081,2
    		--66202388(+) TTAAAC/TGTTCT 3 -- ds50010--------
    rs1162762921,2
    		C,F,--66202503(+) AAAAAG/AGAGCA 3 -- ds50011Minor allele frequency- A:0.06WA 118
    rs1152886581,2
    		F,--66202631(+) AGTGTC/GTAGCA 3 -- ut311Minor allele frequency- G:0.02WA 118
    rs1158180451,2
    		--66202660(+) AATGCG/AAATCT 3 -- ut311Minor allele frequency- A:0.01WA 118
    rs10566551,2
    		C--66202685(-) GAGAGC/TAGGAG 3 -- ut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1172186161,2
    		F,--66202755(+) AGGCAG/CGAACC 3 -- ut311Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for MRPL11 (66202546 - 66234209 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MRPL11: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL11
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL11

    Disorders / Diseases
    for MRPL11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MRPL11 for disorders           About GeneDecksing

    OMIM gene information: 611826    OMIM disorders: --

    6 diseases for MRPL11:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis


    Export disorders for MRPL11 gene to outside databases

    Publications
    for MRPL11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPL11 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MRPL11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. (PubMed id 11279069)1, 2 Suzuki T....Watanabe K. (2001)
    4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for MRPL11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MRPL11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65003 HGNC: 14042 AceView: MRPL11 Ensembl:ENSG00000174547 euGenes: HUgn65003
    ECgene: MRPL11 H-InvDB: MRPL11

    Other Databases showing MRPL11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MRPL11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPL11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MRPL11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MRPL11 gene:
    Search GeneIP for patents involving MRPL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MRPL11 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MRPL11   OriGene shRNA RFP for MRPL11  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL11   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL11  
     OriGene Protein Over-expression Lysate for MRPL11   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MRPL11   OriGene 3'-UTR Clone for MRPL11  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL11  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MRPL11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRPL11   OriGene Custom Protein Services for MRPL11  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL11
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL11
     GenScript Custom Purified and Recombinant Proteins Services for MRPL11 GenScript cDNA clones with any tag delivered in your preferred vector for MRPL11
     GenScript Custom Assay Services for MRPL11 GenScript Custom Superior Antibodies Services for MRPL11
     GenScript Custom overexpressing Cell Line Services for MRPL11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MRPL11 

     Regulatory tfbs in MRPL11 promoter
     Search Chromatin IP Primers for MRPL11
     RT2 qPCR Primer Assay in human, mouse, rat MRPL11
     Search GNC Networks for MRPL11
     SABiosciences Custom PCR Arrays for MRPL11
     Search Tocris compounds for MRPL11
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MRPL11 antibodies
     MRPL11 proteins
     MRPL11 lysates
     Antibodies for MRPL11
     See all of Abcam's Antibodies, Kits and Proteins for MRPL11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MRPL11 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MRPL11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL11
     SwitchGear 3'UTR luciferase reporter plasmids for MRPL11
     SwitchGear Promoter luciferase reporter plasmids for MRPL11
     Search ThermoFisher Antibodies for MRPL11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL11
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MRPL11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4