Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL10 Gene

Aliases for MRPL10 Gene

  • Mitochondrial Ribosomal Protein L10 2 3
  • MRPL8 3 4 6
  • 39S Ribosomal Protein L8, Mitochondrial 3 4
  • MRP-L10 3 4
  • MRP-L8 3 4
  • L10MT 3 4
  • RPML8 3 4
  • L8mt 3 4
  • 39S Ribosomal Protein L10, Mitochondrial 3
  • 39S Ribosomal Protein L10 2
  • Mitochondrial 2

External Ids for MRPL10 Gene

Previous GeneCards Identifiers for MRPL10 Gene

  • GC17M045606
  • GC17M048381
  • GC17M046242
  • GC17M046375
  • GC17M043255
  • GC17M045900
  • GC17M041269

Summaries for MRPL10 Gene

Entrez Gene Summary for MRPL10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

GeneCards Summary for MRPL10 Gene

MRPL10 (Mitochondrial Ribosomal Protein L10) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL10 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL10 Gene

Genomics for MRPL10 Gene

Regulatory Elements for MRPL10 Gene

Genomic Location for MRPL10 Gene

Start:
47,823,272 bp from pter
End:
47,831,541 bp from pter
Size:
8,270 bases
Orientation:
Minus strand

Genomic View for MRPL10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL10 Gene

Proteins for MRPL10 Gene

  • Protein details for MRPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H8-RM10_HUMAN
    Recommended name:
    39S ribosomal protein L10, mitochondrial
    Protein Accession:
    Q7Z7H8
    Secondary Accessions:
    • A6NGJ4
    • Q96B80
    • Q96Q55

    Protein attributes for MRPL10 Gene

    Size:
    261 amino acids
    Molecular mass:
    29283 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL10 Gene

    Alternative splice isoforms for MRPL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL10 Gene

Proteomics data for MRPL10 Gene at MOPED

Post-translational modifications for MRPL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL10 Gene

No data available for DME Specific Peptides for MRPL10 Gene

Domains for MRPL10 Gene

Gene Families for MRPL10 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H8

UniProtKB/Swiss-Prot:

RM10_HUMAN :
  • Q7Z7H8
Family:
  • Belongs to the ribosomal protein L10P family.
genes like me logo Genes that share domains with MRPL10: view

Function for MRPL10 Gene

Gene Ontology (GO) - Molecular Function for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL10: view

Phenotypes for MRPL10 Gene

genes like me logo Genes that share phenotypes with MRPL10: view

Animal Model Products

CRISPR Products

miRNA for MRPL10 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL10 Gene

Localization for MRPL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL10 Gene COMPARTMENTS Subcellular localization image for MRPL10 gene
Compartment Confidence
mitochondrion 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit ISS --
genes like me logo Genes that share ontologies with MRPL10: view

Pathways for MRPL10 Gene

SuperPathways for MRPL10 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPL10: view

Pathways by source for MRPL10 Gene

1 KEGG pathway for MRPL10 Gene

Gene Ontology (GO) - Biological Process for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL10: view

Transcripts for MRPL10 Gene

Unigene Clusters for MRPL10 Gene

Mitochondrial ribosomal protein L10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: - - -

Relevant External Links for MRPL10 Gene

GeneLoc Exon Structure for
MRPL10
ECgene alternative splicing isoforms for
MRPL10

Expression for MRPL10 Gene

mRNA expression in normal human tissues for MRPL10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL10 Gene

SOURCE GeneReport for Unigene cluster for MRPL10 Gene Hs.347535

genes like me logo Genes that share expressions with MRPL10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL10 Gene

Orthologs for MRPL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL10 35
  • 99.62 (n)
  • 99.62 (a)
MRPL10 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL10 35
  • 87.74 (n)
  • 86.21 (a)
MRPL10 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL10 35
  • 86.46 (n)
  • 85.82 (a)
MRPL10 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl10 35
  • 81.99 (n)
  • 78.16 (a)
Mrpl10 16
Mrpl10 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL10 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL10 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl10 35
  • 81.99 (n)
  • 81.61 (a)
chicken
(Gallus gallus)
Aves MRPL10 35
  • 60.51 (n)
  • 54.95 (a)
MRPL10 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL10 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl10 35
  • 60.12 (n)
  • 49.55 (a)
Str.1890 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.434 35
zebrafish
(Danio rerio)
Actinopterygii mrpl10 35
  • 55.19 (n)
  • 49.79 (a)
mrpl10 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009988 35
  • 42.15 (n)
  • 26.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL10 35
  • 45.09 (n)
  • 24.9 (a)
mRpL10 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for MRPL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL10 Gene

ENSEMBL:
Gene Tree for MRPL10 (if available)
TreeFam:
Gene Tree for MRPL10 (if available)

Paralogs for MRPL10 Gene

Pseudogenes.org Pseudogenes for MRPL10 Gene

genes like me logo Genes that share paralogs with MRPL10: view

No data available for Paralogs for MRPL10 Gene

Variants for MRPL10 Gene

Sequence variations from dbSNP and Humsavar for MRPL10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs701984 -- 47,824,114(-) GGTCG(A/G)GGAGT utr-variant-3-prime, nc-transcript-variant
rs2051760 -- 47,824,954(-) ttact(A/G)taacc intron-variant
rs2051761 -- 47,824,929(-) TCAAA(C/T)GATTC intron-variant
rs3809869 -- 47,826,797(+) CAGGG(A/G)AAAAT intron-variant
rs4793671 -- 47,828,484(+) ATGTA(C/T)CCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL10 Gene

Variant ID Type Subtype PubMed ID
nsv908572 CNV Loss 21882294
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680

Relevant External Links for MRPL10 Gene

HapMap Linkage Disequilibrium report
MRPL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL10 Gene

Disorders for MRPL10 Gene

Relevant External Links for MRPL10

Genetic Association Database (GAD)
MRPL10
Human Genome Epidemiology (HuGE) Navigator
MRPL10
genes like me logo Genes that share disorders with MRPL10: view

No data available for UniProtKB/Swiss-Prot for MRPL10 Gene

Publications for MRPL10 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL10 Gene

Sources for MRPL10 Gene

Back to Top

Content