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Aliases for MRPL10 Gene

Aliases for MRPL10 Gene

  • Mitochondrial Ribosomal Protein L10 2 3 5
  • 39S Ribosomal Protein L8, Mitochondrial 3 4
  • MRP-L10 3 4
  • MRP-L8 3 4
  • L10MT 3 4
  • MRPL8 3 4
  • RPML8 3 4
  • L8mt 3 4
  • 39S Ribosomal Protein L10 2
  • Mitochondrial 2

External Ids for MRPL10 Gene

Previous GeneCards Identifiers for MRPL10 Gene

  • GC17M045606
  • GC17M048381
  • GC17M046242
  • GC17M046375
  • GC17M043255
  • GC17M045900
  • GC17M041269

Summaries for MRPL10 Gene

Entrez Gene Summary for MRPL10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

GeneCards Summary for MRPL10 Gene

MRPL10 (Mitochondrial Ribosomal Protein L10) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL10 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL10 Gene

Genomics for MRPL10 Gene

Regulatory Elements for MRPL10 Gene

Enhancers for MRPL10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL10 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL10 Gene

Chromosome:
17
Start:
47,823,272 bp from pter
End:
47,831,541 bp from pter
Size:
8,270 bases
Orientation:
Minus strand

Genomic View for MRPL10 Gene

Genes around MRPL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL10 Gene

Proteins for MRPL10 Gene

  • Protein details for MRPL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7H8-RM10_HUMAN
    Recommended name:
    39S ribosomal protein L10, mitochondrial
    Protein Accession:
    Q7Z7H8
    Secondary Accessions:
    • A6NGJ4
    • Q96B80
    • Q96Q55

    Protein attributes for MRPL10 Gene

    Size:
    261 amino acids
    Molecular mass:
    29283 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL10 Gene

    Alternative splice isoforms for MRPL10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL10 Gene

Proteomics data for MRPL10 Gene at MOPED

Post-translational modifications for MRPL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL10 Gene

No data available for DME Specific Peptides for MRPL10 Gene

Domains & Families for MRPL10 Gene

Gene Families for MRPL10 Gene

Protein Domains for MRPL10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z7H8

UniProtKB/Swiss-Prot:

RM10_HUMAN :
  • Belongs to the ribosomal protein L10P family.
Family:
  • Belongs to the ribosomal protein L10P family.
genes like me logo Genes that share domains with MRPL10: view

Function for MRPL10 Gene

Phenotypes for MRPL10 Gene

MGI mutant phenotypes for MRPL10:
inferred from 1 alleles
GenomeRNAi human phenotypes for MRPL10:
genes like me logo Genes that share phenotypes with MRPL10: view

Animal Models for MRPL10 Gene

MGI Knock Outs for MRPL10:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL10 Gene

Localization for MRPL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL10 Gene COMPARTMENTS Subcellular localization image for MRPL10 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with MRPL10: view

Pathways & Interactions for MRPL10 Gene

genes like me logo Genes that share pathways with MRPL10: view

Gene Ontology (GO) - Biological Process for MRPL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0032543 mitochondrial translation TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with MRPL10: view

No data available for SIGNOR curated interactions for MRPL10 Gene

Drugs & Compounds for MRPL10 Gene

No Compound Related Data Available

Transcripts for MRPL10 Gene

Unigene Clusters for MRPL10 Gene

Mitochondrial ribosomal protein L10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6: - - -

Relevant External Links for MRPL10 Gene

GeneLoc Exon Structure for
MRPL10
ECgene alternative splicing isoforms for
MRPL10

Expression for MRPL10 Gene

mRNA expression in normal human tissues for MRPL10 Gene

Protein differential expression in normal tissues from HIPED for MRPL10 Gene

This gene is overexpressed in Pancreas (28.0) and Bone (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL10 Gene



SOURCE GeneReport for Unigene cluster for MRPL10 Gene Hs.347535

genes like me logo Genes that share expression patterns with MRPL10: view

Protein tissue co-expression partners for MRPL10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL10 Gene

Orthologs for MRPL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL10 35
  • 87.74 (n)
  • 86.21 (a)
MRPL10 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL10 35
  • 86.46 (n)
  • 85.82 (a)
MRPL10 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl10 35
  • 81.99 (n)
  • 78.16 (a)
Mrpl10 16
Mrpl10 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL10 35
  • 99.62 (n)
  • 99.62 (a)
MRPL10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl10 35
  • 81.99 (n)
  • 81.61 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL10 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL10 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL10 35
  • 60.51 (n)
  • 54.95 (a)
MRPL10 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL10 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl10 35
  • 60.12 (n)
  • 49.55 (a)
Str.1890 35
zebrafish
(Danio rerio)
Actinopterygii mrpl10 35
  • 55.19 (n)
  • 49.79 (a)
mrpl10 36
  • 45 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.434 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009988 35
  • 42.15 (n)
  • 26.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL10 35
  • 45.09 (n)
  • 24.9 (a)
mRpL10 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for MRPL10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL10 Gene

ENSEMBL:
Gene Tree for MRPL10 (if available)
TreeFam:
Gene Tree for MRPL10 (if available)

Paralogs for MRPL10 Gene

Pseudogenes.org Pseudogenes for MRPL10 Gene

genes like me logo Genes that share paralogs with MRPL10: view

No data available for Paralogs for MRPL10 Gene

Variants for MRPL10 Gene

Sequence variations from dbSNP and Humsavar for MRPL10 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_030078 -
rs701984 -- 47,824,114(-) GGTCG(A/G)GGAGT nc-transcript-variant, utr-variant-3-prime
rs2051760 -- 47,824,954(-) ttact(A/G)taacc intron-variant
rs2051761 -- 47,824,929(-) TCAAA(C/T)GATTC intron-variant
rs3809869 -- 47,826,797(+) CAGGG(A/C/G)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL10 Gene

Variant ID Type Subtype PubMed ID
nsv908572 CNV Loss 21882294
nsv908573 CNV Loss 21882294
nsv908574 CNV Loss 21882294
nsv517880 CNV Loss 19592680
nsv518892 CNV Loss 19592680

Variation tolerance for MRPL10 Gene

Residual Variation Intolerance Score: 46.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL10 Gene

HapMap Linkage Disequilibrium report
MRPL10
Human Gene Mutation Database (HGMD)
MRPL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL10 Gene

Disorders for MRPL10 Gene

Relevant External Links for MRPL10

Genetic Association Database (GAD)
MRPL10
Human Genome Epidemiology (HuGE) Navigator
MRPL10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL10

No disorders were found for MRPL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL10 Gene

Publications for MRPL10 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genome-wide association study of the rate of cognitive decline in Alzheimer's disease. (PMID: 23535033) Sherva R. … Green R.C. (Alzheimers Dement 2014) 3

Products for MRPL10 Gene

Sources for MRPL10 Gene

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