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Aliases for MRPL1 Gene

Aliases for MRPL1 Gene

  • Mitochondrial Ribosomal Protein L1 2 3 5
  • MRP-L1 3 4
  • L1MT 3 4
  • BM022 3

External Ids for MRPL1 Gene

Previous GeneCards Identifiers for MRPL1 Gene

  • GC04P078694
  • GC04P078974
  • GC04P079176
  • GC04P079242
  • GC04P079141
  • GC04P079002
  • GC04P074535

Summaries for MRPL1 Gene

Entrez Gene Summary for MRPL1 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL1 Gene

MRPL1 (Mitochondrial Ribosomal Protein L1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL1 Gene

Genomics for MRPL1 Gene

Regulatory Elements for MRPL1 Gene

Promoters for MRPL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL1 Gene

Chromosome:
4
Start:
77,861,955 bp from pter
End:
77,952,790 bp from pter
Size:
90,836 bases
Orientation:
Plus strand

Genomic View for MRPL1 Gene

Genes around MRPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL1 Gene

Proteins for MRPL1 Gene

  • Protein details for MRPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYD6-RM01_HUMAN
    Recommended name:
    39S ribosomal protein L1, mitochondrial
    Protein Accession:
    Q9BYD6
    Secondary Accessions:
    • A6NG03
    • Q4W5B8
    • Q6IAG4
    • Q96BW3
    • Q9H793
    • Q9NRL5

    Protein attributes for MRPL1 Gene

    Size:
    325 amino acids
    Molecular mass:
    36909 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF87327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF87327.1; Type=Frameshift; Positions=4, 6, 19, 123, 139, 147; Evidence={ECO:0000305}; Sequence=AAH14356.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH15109.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH32595.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAY41057.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB15005.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB40180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB40180.1; Type=Frameshift; Positions=20; Evidence={ECO:0000305};

neXtProt entry for MRPL1 Gene

Proteomics data for MRPL1 Gene at MOPED

Post-translational modifications for MRPL1 Gene

  • Ubiquitination at Lys 108
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL1 Gene

Domains & Families for MRPL1 Gene

Gene Families for MRPL1 Gene

Suggested Antigen Peptide Sequences for MRPL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYD6

UniProtKB/Swiss-Prot:

RM01_HUMAN :
  • Belongs to the ribosomal protein L1P family.
Family:
  • Belongs to the ribosomal protein L1P family.
genes like me logo Genes that share domains with MRPL1: view

Function for MRPL1 Gene

Animal Model Products

miRNA for MRPL1 Gene

miRTarBase miRNAs that target MRPL1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL1 Gene

Localization for MRPL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL1 Gene COMPARTMENTS Subcellular localization image for MRPL1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MRPL1: view

Pathways & Interactions for MRPL1 Gene

genes like me logo Genes that share pathways with MRPL1: view

Gene Ontology (GO) - Biological Process for MRPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPL1: view

No data available for SIGNOR curated interactions for MRPL1 Gene

Drugs & Compounds for MRPL1 Gene

No Compound Related Data Available

Transcripts for MRPL1 Gene

Unigene Clusters for MRPL1 Gene

Mitochondrial ribosomal protein L1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: -
SP3:
SP4: -
SP5:
SP6: -

Relevant External Links for MRPL1 Gene

GeneLoc Exon Structure for
MRPL1
ECgene alternative splicing isoforms for
MRPL1

Expression for MRPL1 Gene

mRNA expression in normal human tissues for MRPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPL1 Gene

This gene is overexpressed in Breast (28.4) and Peripheral blood mononuclear cells (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL1 Gene



SOURCE GeneReport for Unigene cluster for MRPL1 Gene Hs.532019

genes like me logo Genes that share expression patterns with MRPL1: view

Protein tissue co-expression partners for MRPL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL1 Gene

Orthologs for MRPL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL1 36
  • 100 (a)
OneToOne
MRPL1 35
  • 99.69 (n)
  • 99.69 (a)
cow
(Bos Taurus)
Mammalia MRPL1 36
  • 81 (a)
OneToOne
MRPL1 35
  • 87.51 (n)
  • 81.11 (a)
dog
(Canis familiaris)
Mammalia MRPL1 35
  • 88.62 (n)
  • 82.46 (a)
MRPL1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl1 16
Mrpl1 35
  • 82.72 (n)
  • 78.7 (a)
Mrpl1 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl1 35
  • 80.31 (n)
  • 75.31 (a)
chicken
(Gallus gallus)
Aves MRPL1 35
  • 64.06 (n)
  • 56.38 (a)
MRPL1 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL1 36
  • 39 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25888 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl1 35
  • 59 (n)
  • 48.24 (a)
Str.16756 35
zebrafish
(Danio rerio)
Actinopterygii mrpl1 36
  • 41 (a)
OneToOne
mrpl1 35
  • 58.84 (n)
  • 47.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL1 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F33D4.5 36
  • 19 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for MRPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL1 Gene

ENSEMBL:
Gene Tree for MRPL1 (if available)
TreeFam:
Gene Tree for MRPL1 (if available)

Paralogs for MRPL1 Gene

No data available for Paralogs for MRPL1 Gene

Variants for MRPL1 Gene

Sequence variations from dbSNP and Humsavar for MRPL1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17851275 - 77,871,852(+) TGCTA(A/C)AAAGT nc-transcript-variant, reference, missense
rs17855456 - 77,887,263(+) TGCAT(C/T)TGCAG nc-transcript-variant, reference, missense
rs1801350 -- 77,909,280(-) GATGT(C/G/T)ACGGC nc-transcript-variant, reference, missense
rs4417999 -- 77,908,795(+) agaga(A/G)gtggt intron-variant
rs4328941 -- 77,872,720(+) tggcc(A/G)ggtgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL1 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
nsv879501 CNV Loss 21882294
esv2752050 CNV Gain 17911159
nsv516836 CNV Gain 19592680
esv273696 CNV Insertion 20981092
esv273689 CNV Insertion 20981092

Variation tolerance for MRPL1 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL1 Gene

HapMap Linkage Disequilibrium report
MRPL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL1 Gene

Disorders for MRPL1 Gene

Relevant External Links for MRPL1

Genetic Association Database (GAD)
MRPL1
Human Genome Epidemiology (HuGE) Navigator
MRPL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL1

No disorders were found for MRPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL1 Gene

Publications for MRPL1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for MRPL1 Gene

Sources for MRPL1 Gene

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