MRP63 Gene
protein-coding GIFtS: 43
GCID: GC13P021750
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mitochondrial ribosomal protein 63
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Aliases
for MRP63 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein 631 2 | | HMRP631 | | BMRP631 | | Mitochondrial Ribosomal Protein BMRP632 | | Ribosomal Protein 63, Mitochondrial2 |
Export aliases for MRP63 gene to outside databasesPrevious GC identifers: GC13P019730 GC13P015730 GC13P020680 GC13P019548 GC13P020648 GC13P002551 |
Summaries
for MRP63 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRP63:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein whichbelongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenescorresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. (provided by RefSeq, Jul 2008)
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Genomic Views
for MRP63 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRP63 gene promoter:
STAT1 Pax-5 NRSF form 1 POU3F1 STAT1beta NRSF form 2 LCR-F1 STAT1alpha GATA-1 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRP63
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRP63 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12.11 Ensembl cytogenetic band: 13q12.11 HGNC cytogenetic band: 13q12.11MRP63 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P021750: view genomic region
(about GC identifiers)
Start:
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21,750,372 bp from pter |
End:
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21,753,223 bp from pter |
Size:
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2,852 bases |
Orientation:
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plus strand |
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Proteins
for MRP63 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT63_HUMAN, Q9BQC6 (See
protein sequence)Recommended Name: Ribosomal protein 63, mitochondrial Size: 102 amino acids; 12266 Da
Subcellular location: Mitochondrion (By similarity)
Miscellaneous: Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39Ssubunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation
Secondary accessions: A2A332Explore the universe of human proteins at neXtProt for MRP63: NX_Q9BQC6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BQC6
MRP63 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076931.1
ENSEMBL proteins: ENSP00000310726
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005761 | mitochondrial ribosome |
IEA | -- |
MRP63 for ontologies About GeneDecksing
MRP63 Antibody Products:
Assay Products for MRP63: |
Protein
Domains /
Families
for MRP63 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRP63 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BQC6ProtoNet protein and cluster: Q9BQC6 |
Function
for MRP63 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRP63 (NM_024026) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRP63 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRP63 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRP63 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRP63 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRP63 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRP63
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for MRP63 (Q9BQC63 ENSP000003107264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRP63 for ontologies About GeneDecksing
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Drugs & Compounds
for MRP63 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRP63
Search CenterWatch for drugs/clinical trials and news about MRP63 / RT63
|
Transcripts
for MRP63 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRP63 gene: NM_024026.4 Unigene Cluster for MRP63: Mitochondrial ribosomal protein 63 Hs.458367 [show with all ESTs]Unigene Representative Sequence: NM_0240261 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000309594(uc001unw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRP63 (NM_024026) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRP63 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRP63 |
Additional cDNA sequence: AB049957.1 BC023616.2 BC068492.1 7 DOTS entries: DT.435699 DT.92427399 DT.116749 DT.455709 DT.99943061 DT.441004 DT.95163667 24/87 AceView cDNA sequences (see all 87): BQ082763 BC023616 AA316019 AW592151 NM_024026 BI761165 AB049957 CF890784 C02370 CF887066 AW445203 F25277 BE407715 BX473801 BC068492 BM017642 AA976679 BU148955 BE251789 AA847592 BE299970 BQ436814 BF792501 BU681712
GeneLoc Exon Structure
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Expression
for MRP63 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRP63 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGCTGCACT
About this image
See MRP63 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRP63
SOURCE GeneReport for Unigene cluster: Hs.458367
SABiosciences Custom PCR Arrays for MRP63
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRP63
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRP63 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRP63 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRP63 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRP63 |
Orthologs
for MRP63 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRP63 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for MRP63 (if available)
TreeFam Gene Tree for MRP63 (if available) |
Paralogs
for MRP63 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRP63 gene
MRP63 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for MRP63
PGOHUM00000244152 PGOHUM00000238021 PGOHUM00000235826 PGOHUM00000249448
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Genomic Variants
for MRP63 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRP63 (21750372 - 21753223 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRP63
1 CNV: 39128 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRP63 |
|
Disorders
/ Diseases
for MRP63 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRP63 for disorders About MalaCards
MRP63 for disorders About GeneDecksing
OMIM gene information: 611997
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRP63 (1 document)
Export disorders for MRP63 gene to outside databases
|
Publications
for MRP63 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRP63 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MRP63) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
- A common set of gene regulatory networks links metabolism and growth inhibition. (PubMed id 15525513)1 Cam H....Dynlacht B.D. (2004)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for MRP63 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRP63 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRP63 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRP63 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRP63 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRP63 gene:
Search GeneIP for patents involving MRP63
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRP63 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRP63 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRP63 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRP63 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRP63 | | OriGene 3'-UTR Clone for MRP63 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRP63 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MRP63 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRP63 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRP63 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRP63 |
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