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Aliases for MROH8 Gene

Aliases for MROH8 Gene

  • Maestro Heat-Like Repeat Family Member 8 2 3
  • Maestro Heat-Like Repeat-Containing Protein Family Member 8 3 4
  • C20orf131 3 4
  • C20orf132 3 4
  • Chromosome 20 Open Reading Frame 131 2
  • Chromosome 20 Open Reading Frame 132 2
  • Hypothetical Protein LOC140699 2
  • Protein MROH8 3
  • DJ621N11.3 3
  • DJ621N11.4 3

External Ids for MROH8 Gene

Previous HGNC Symbols for MROH8 Gene

  • C20orf131
  • C20orf132

Previous GeneCards Identifiers for MROH8 Gene

  • GC20M035730

Summaries for MROH8 Gene

Entrez Gene Summary for MROH8 Gene

  • The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for MROH8 Gene

MROH8 (Maestro Heat-Like Repeat Family Member 8) is a Protein Coding gene. An important paralog of this gene is MROH7-TTC4.

Gene Wiki entry for MROH8 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH8 Gene

Genomics for MROH8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MROH8 Gene

37,101,226 bp from pter
37,179,588 bp from pter
78,363 bases
Minus strand

Genomic View for MROH8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH8 Gene

No data available for Regulatory Elements for MROH8 Gene

Proteins for MROH8 Gene

  • Protein details for MROH8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein MROH8
    Protein Accession:
    Secondary Accessions:
    • Q5JYQ6

    Protein attributes for MROH8 Gene

    483 amino acids
    Molecular mass:
    54816 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04162.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI42666.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95719.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH8 Gene


neXtProt entry for MROH8 Gene

Proteomics data for MROH8 Gene at MOPED

Post-translational modifications for MROH8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MROH8 Gene

Domains for MROH8 Gene

Gene Families for MROH8 Gene

Protein Domains for MROH8 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH8: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MROH8 Gene

Function for MROH8 Gene

Gene Ontology (GO) - Molecular Function for MROH8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MROH8: view

Phenotypes for MROH8 Gene

GenomeRNAi human phenotypes for MROH8:
genes like me logo Genes that share phenotypes with MROH8: view

miRNA for MROH8 Gene

miRTarBase miRNAs that target MROH8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MROH8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH8 Gene

Localization for MROH8 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH8 Gene

Pathways for MROH8 Gene

SuperPathways for MROH8 Gene

No Data Available

Interacting Proteins for MROH8 Gene

Gene Ontology (GO) - Biological Process for MROH8 Gene


No data available for Pathways by source for MROH8 Gene

Transcripts for MROH8 Gene

Unigene Clusters for MROH8 Gene

Maestro heat-like repeat family member 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MROH8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH8 Gene

No ASD Table

Relevant External Links for MROH8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MROH8 Gene

mRNA expression in normal human tissues for MROH8 Gene

mRNA differential expression in normal tissues according to GTEx for MROH8 Gene

This gene is overexpressed in Testis (8.0).

Protein differential expression in normal tissues for MROH8 Gene

This gene is overexpressed in Breast (67.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MROH8 Gene

SOURCE GeneReport for Unigene cluster for MROH8 Gene Hs.349125

genes like me logo Genes that share expressions with MROH8: view

Expression partners for MROH8 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH8 Gene

Orthologs for MROH8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MROH8 35
  • 83.37 (n)
  • 73.14 (a)
MROH8 36
  • 74 (a)
(Canis familiaris)
Mammalia MROH8 35
  • 85.77 (n)
  • 77.93 (a)
MROH8 36
  • 77 (a)
(Mus musculus)
Mammalia Mroh8 35
  • 78.2 (n)
  • 69.7 (a)
Mroh8 16
Mroh8 36
  • 68 (a)
(Pan troglodytes)
Mammalia MROH8 35
  • 99.27 (n)
  • 98.57 (a)
MROH8 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mroh8 35
  • 79.12 (n)
  • 70.21 (a)
(Monodelphis domestica)
Mammalia MROH8 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia MROH8 36
  • 51 (a)
(Gallus gallus)
Aves LOC770556 35
  • 44.44 (n)
  • 31 (a)
(Anolis carolinensis)
Reptilia MROH8 36
  • 34 (a)
Species with no ortholog for MROH8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH8 Gene

Gene Tree for MROH8 (if available)
Gene Tree for MROH8 (if available)

Paralogs for MROH8 Gene

Paralogs for MROH8 Gene

genes like me logo Genes that share paralogs with MROH8: view

Variants for MROH8 Gene

Sequence variations from dbSNP and Humsavar for MROH8 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs56044988 -- 37,156,019(+) GCTGC(A/T)CGGGA intron-variant
rs56153743 -- 37,105,050(+) CAGGA(C/G/T)TTTGG intron-variant
rs56172367 -- 37,176,073(+) TTTTT(A/T)GTAGA intron-variant
rs56180011 -- 37,164,409(+) TCTCT(-/CTCT)ATTTC intron-variant
rs57942742 -- 37,167,340(+) CATCA(A/G)CTCCT intron-variant

Relevant External Links for MROH8 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MROH8 Gene

Disorders for MROH8 Gene

No disorders were found for MROH8 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MROH8 Gene

Publications for MROH8 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Nucleolar proteome dynamics. (PMID: 15635413) Andersen J.S. … Mann M. (Nature 2005) 2 3
  4. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3
  5. Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. (PMID: 19668339) Potkin S.G. … Macciardi F. (PLoS ONE 2009) 3

Products for MROH8 Gene

Sources for MROH8 Gene

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