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Aliases for MROH7-TTC4 Gene

Subcategory (RNA class) for MROH7-TTC4 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for MROH7-TTC4 Gene

  • MROH7-TTC4 Readthrough (NMD Candidate) 2 3
  • HEATR8-TTC4 Readthrough 3
  • HEATR8-TTC4 3

External Ids for MROH7-TTC4 Gene

Previous GeneCards Identifiers for MROH7-TTC4 Gene

  • GC01P055112

Summaries for MROH7-TTC4 Gene

Entrez Gene Summary for MROH7-TTC4 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring MROH7 (maestro heat-like repeat family member 7) and TTC4 (tetratricopeptide repeat domain 4) genes. Alternative splicing results in multiple transcript variants, which are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to produce protein products. [provided by RefSeq, Aug 2013]

GeneCards Summary for MROH7-TTC4 Gene

MROH7-TTC4 (MROH7-TTC4 Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include binding. An important paralog of this gene is MROH8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH7-TTC4 Gene

Genomics for MROH7-TTC4 Gene

Genomic Location for MROH7-TTC4 Gene

Chromosome:
1
Start:
54,641,740 bp from pter
End:
54,742,657 bp from pter
Size:
100,918 bases
Orientation:
Plus strand

Genomic View for MROH7-TTC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH7-TTC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH7-TTC4 Gene

No data available for Regulatory Elements for MROH7-TTC4 Gene

Proteins for MROH7-TTC4 Gene

  • Protein details for MROH7-TTC4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A0MT08
    Recommended name:
    Protein MROH7-TTC4
    Protein Accession:
    A0A0A0MT08

    Protein attributes for MROH7-TTC4 Gene

    Size:
    1334 amino acids
    Molecular mass:
    147102 Da
    Quaternary structure:
    No Data Available
  • Protein details for MROH7-TTC4 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    F8WC02
    Recommended name:
    Protein MROH7-TTC4
    Protein Accession:
    F8WC02

    Protein attributes for MROH7-TTC4 Gene

    Size:
    652 amino acids
    Molecular mass:
    69240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH7-TTC4 Gene

Proteomics data for MROH7-TTC4 Gene at MOPED

Post-translational modifications for MROH7-TTC4 Gene

No Post-translational modifications

Other Protein References for MROH7-TTC4 Gene

No data available for DME Specific Peptides for MROH7-TTC4 Gene

Domains & Families for MROH7-TTC4 Gene

Protein Domains for MROH7-TTC4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH7-TTC4: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MROH7-TTC4 Gene

Function for MROH7-TTC4 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH7-TTC4 Gene

Localization for MROH7-TTC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH7-TTC4 Gene

Pathways & Interactions for MROH7-TTC4 Gene

SuperPathways for MROH7-TTC4 Gene

No Data Available

Interacting Proteins for MROH7-TTC4 Gene

Gene Ontology (GO) - Biological Process for MROH7-TTC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH7-TTC4 Gene

Drugs & Compounds for MROH7-TTC4 Gene

No Compound Related Data Available

Transcripts for MROH7-TTC4 Gene

mRNA/cDNA for MROH7-TTC4 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MROH7-TTC4 Gene

No ASD Table

Relevant External Links for MROH7-TTC4 Gene

GeneLoc Exon Structure for
MROH7-TTC4
ECgene alternative splicing isoforms for
MROH7-TTC4

Expression for MROH7-TTC4 Gene

mRNA expression in normal human tissues for MROH7-TTC4 Gene

mRNA differential expression in normal tissues according to GTEx for MROH7-TTC4 Gene

This gene is overexpressed in Pituitary (x5.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from for MROH7-TTC4 Gene



genes like me logo Genes that share expression patterns with MROH7-TTC4: view

Protein tissue co-expression partners for MROH7-TTC4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MROH7-TTC4 Gene

Orthologs for MROH7-TTC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH7-TTC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEATR8 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mroh7 36
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
Species with no ortholog for MROH7-TTC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH7-TTC4 Gene

ENSEMBL:
Gene Tree for MROH7-TTC4 (if available)
TreeFam:
Gene Tree for MROH7-TTC4 (if available)

Paralogs for MROH7-TTC4 Gene

Paralogs for MROH7-TTC4 Gene

(4) SIMAP similar genes for MROH7-TTC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MROH7-TTC4: view

Variants for MROH7-TTC4 Gene

Sequence variations from dbSNP and Humsavar for MROH7-TTC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1147991 -- 54,713,464(-) ATCCA(G/T)TCTGC intron-variant
rs1702011 -- 54,713,422(-) ATCCA(G/T)TCTGC intron-variant
rs1749859 -- 54,713,332(-) TGCAA(A/T)TGAAT intron-variant
rs1749860 -- 54,711,637(-) TCCAC(A/G)GCACA intron-variant
rs4927151 -- 54,710,979(+) AAACT(G/T)TGGTC intron-variant

Variation tolerance for MROH7-TTC4 Gene

Gene Damage Index Score: 0.25; 5.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH7-TTC4 Gene

HapMap Linkage Disequilibrium report
MROH7-TTC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MROH7-TTC4 Gene

Disorders for MROH7-TTC4 Gene

Relevant External Links for MROH7-TTC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH7-TTC4
genes like me logo Genes that share disorders with MROH7-TTC4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH7-TTC4 Gene

Publications for MROH7-TTC4 Gene

  1. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for MROH7-TTC4 Gene

Sources for MROH7-TTC4 Gene

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