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Aliases for MROH7 Gene

Aliases for MROH7 Gene

  • Maestro Heat-Like Repeat Family Member 7 2 3
  • HEAT Repeat-Containing Protein 8 3 4
  • C1orf175 3 4
  • HEATR8 3 4
  • Chromosome 1 Open Reading Frame 175 2
  • HEAT Repeat Containing 8 2

External Ids for MROH7 Gene

Previous HGNC Symbols for MROH7 Gene

  • C1orf175
  • HEATR8

Previous GeneCards Identifiers for MROH7 Gene

  • GC01P055110
  • GC01P055111

Summaries for MROH7 Gene

GeneCards Summary for MROH7 Gene

MROH7 (Maestro Heat-Like Repeat Family Member 7) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH7 Gene

Genomics for MROH7 Gene

Genomic Location for MROH7 Gene

Chromosome:
1
Start:
54,641,740 bp from pter
End:
54,710,267 bp from pter
Size:
68,528 bases
Orientation:
Plus strand

Genomic View for MROH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH7 Gene

No data available for Regulatory Elements for MROH7 Gene

Proteins for MROH7 Gene

  • Protein details for MROH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ1-MROH7_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 7
    Protein Accession:
    Q68CQ1
    Secondary Accessions:
    • A0AUX8
    • Q5TA99
    • Q6ZP40
    • Q6ZRH6
    • Q8N311
    • Q8NA14

    Protein attributes for MROH7 Gene

    Size:
    1323 amino acids
    Molecular mass:
    145647 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87334.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH7 Gene

neXtProt entry for MROH7 Gene

Proteomics data for MROH7 Gene at MOPED

Post-translational modifications for MROH7 Gene

  • Glycosylation at Asn 318, Asn 463, and Asn 611
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MROH7 Gene

Domains & Families for MROH7 Gene

Gene Families for MROH7 Gene

Protein Domains for MROH7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH7 Gene

Graphical View of Domain Structure for InterPro Entry

Q68CQ1

UniProtKB/Swiss-Prot:

MROH7_HUMAN :
  • Contains 4 HEAT repeats.
Similarity:
  • Contains 4 HEAT repeats.
genes like me logo Genes that share domains with MROH7: view

Function for MROH7 Gene

Gene Ontology (GO) - Molecular Function for MROH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MROH7: view

Animal Model Products

miRNA for MROH7 Gene

miRTarBase miRNAs that target MROH7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MROH7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH7 Gene

Localization for MROH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MROH7 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MROH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MROH7: view

No data available for Subcellular locations from COMPARTMENTS for MROH7 Gene

Pathways & Interactions for MROH7 Gene

SuperPathways for MROH7 Gene

No Data Available

Interacting Proteins for MROH7 Gene

Gene Ontology (GO) - Biological Process for MROH7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH7 Gene

Drugs & Compounds for MROH7 Gene

No Compound Related Data Available

Transcripts for MROH7 Gene

Unigene Clusters for MROH7 Gene

Maestro heat-like repeat family member 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MROH7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6:
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:
SP15:

ExUns: 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MROH7 Gene

GeneLoc Exon Structure for
MROH7
ECgene alternative splicing isoforms for
MROH7

Expression for MROH7 Gene

mRNA expression in normal human tissues for MROH7 Gene

mRNA differential expression in normal tissues according to GTEx for MROH7 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for MROH7 Gene

This gene is overexpressed in Pancreas (31.2), Platelet (15.9), and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH7 Gene



SOURCE GeneReport for Unigene cluster for MROH7 Gene Hs.412482

genes like me logo Genes that share expression patterns with MROH7: view

Protein tissue co-expression partners for MROH7 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH7 Gene

Orthologs for MROH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HEATR8 35
  • 84.66 (n)
  • 77.55 (a)
HEATR8 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HEATR8 35
  • 85.56 (n)
  • 80.73 (a)
-- 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mroh7 35
  • 79.58 (n)
  • 71.99 (a)
Mroh7 16
Mroh7 36
  • 72 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HEATR8 35
  • 98.87 (n)
  • 98.26 (a)
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mroh7 35
  • 78.44 (n)
  • 71.39 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
OneToMany
Species with no ortholog for MROH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH7 Gene

ENSEMBL:
Gene Tree for MROH7 (if available)
TreeFam:
Gene Tree for MROH7 (if available)

Paralogs for MROH7 Gene

Paralogs for MROH7 Gene

genes like me logo Genes that share paralogs with MROH7: view

Variants for MROH7 Gene

Sequence variations from dbSNP and Humsavar for MROH7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_032218 -
VAR_032219 -
VAR_032220 -
VAR_032221 -
VAR_032222 -

Variation tolerance for MROH7 Gene

Residual Variation Intolerance Score: 99.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.35; 98.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH7 Gene

HapMap Linkage Disequilibrium report
MROH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MROH7 Gene

Disorders for MROH7 Gene

Relevant External Links for MROH7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH7
genes like me logo Genes that share disorders with MROH7: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH7 Gene

Publications for MROH7 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 67
  3. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67

Products for MROH7 Gene

Sources for MROH7 Gene

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