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Aliases for MROH7 Gene

Aliases for MROH7 Gene

  • Maestro Heat Like Repeat Family Member 7 2 3 5
  • HEAT Repeat-Containing Protein 8 3 4
  • C1orf175 3 4
  • HEATR8 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 7 3
  • Maestro Heat-Like Repeat Family Member 7 2
  • Chromosome 1 Open Reading Frame 175 2
  • HEAT Repeat Containing 8 2

External Ids for MROH7 Gene

Previous HGNC Symbols for MROH7 Gene

  • C1orf175
  • HEATR8

Previous GeneCards Identifiers for MROH7 Gene

  • GC01P055110
  • GC01P055111

Summaries for MROH7 Gene

GeneCards Summary for MROH7 Gene

MROH7 (Maestro Heat Like Repeat Family Member 7) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH7 Gene

Genomics for MROH7 Gene

Regulatory Elements for MROH7 Gene

Enhancers for MROH7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G054877 0.8 FANTOM5 ENCODE 38.8 +232.8 232788 0.3 PAF1 TBX3 FOXA2 HLF HHEX MROH7 LEXM PIR36544 GC01P054854
GH01G054563 1.3 Ensembl ENCODE dbSUPER 15.9 -77.0 -76997 2.5 ESRRA TFAP4 KLF1 SAP130 NFIB TAL1 TCF12 GATA2 POLR2A NCOR1 MROH7 TALDO1P1 CDCP2 ACOT11 FAM151A
GH01G054579 1.4 Ensembl ENCODE dbSUPER 14.6 -59.3 -59335 6.7 PKNOX1 ARID4B DMAP1 BMI1 RAD21 YY1 RARA ZNF335 SCRT2 EGR2 MROH7 ACOT11 FAM151A
GH01G054609 0.8 ENCODE 25.4 -32.1 -32148 1.1 ZFP64 BMI1 ZNF354C ZNF680 ZNF654 SP3 ZBTB11 ZNF426 REST ZNF623 MROH7 SSBP3-AS1 CYB5RL ENSG00000237453 TTC22 TTC4 FAM151A ACOT11
GH01G054587 0.8 dbSUPER 24.8 -53.3 -53303 1.5 SOX13 TFAP4 THRB YY1 KAT2B RARA HNF4G NR2F6 CREM GATAD2A MROH7 TTC4 FAM151A ACOT11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MROH7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MROH7 Gene

Chromosome:
1
Start:
54,641,740 bp from pter
End:
54,710,267 bp from pter
Size:
68,528 bases
Orientation:
Plus strand

Genomic View for MROH7 Gene

Genes around MROH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH7 Gene

Proteins for MROH7 Gene

  • Protein details for MROH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CQ1-MROH7_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 7
    Protein Accession:
    Q68CQ1
    Secondary Accessions:
    • A0AUX8
    • Q5TA99
    • Q6ZP40
    • Q6ZRH6
    • Q8N311
    • Q8NA14

    Protein attributes for MROH7 Gene

    Size:
    1323 amino acids
    Molecular mass:
    145647 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87334.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH7 Gene

neXtProt entry for MROH7 Gene

Post-translational modifications for MROH7 Gene

  • Glycosylation at Asn318, posLast=463463, and posLast=611611
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MROH7 Gene

Domains & Families for MROH7 Gene

Gene Families for MROH7 Gene

Protein Domains for MROH7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH7: view

No data available for UniProtKB/Swiss-Prot for MROH7 Gene

Function for MROH7 Gene

Phenotypes for MROH7 Gene

GenomeRNAi human phenotypes for MROH7:
genes like me logo Genes that share phenotypes with MROH7: view

Animal Model Products

miRNA for MROH7 Gene

miRTarBase miRNAs that target MROH7

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH7 Gene

Localization for MROH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MROH7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH7 gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MROH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MROH7: view

Pathways & Interactions for MROH7 Gene

SuperPathways for MROH7 Gene

No Data Available

Interacting Proteins for MROH7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000396622%0d%0a9606.ENSP00000420213%0d%0a
Selected Interacting proteins: ENSP00000396622 for MROH7 Gene via STRING

Symbol External ID(s) Details
FLNB

Gene Ontology (GO) - Biological Process for MROH7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH7 Gene

Drugs & Compounds for MROH7 Gene

No Compound Related Data Available

Transcripts for MROH7 Gene

Unigene Clusters for MROH7 Gene

Maestro heat-like repeat family member 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a ·
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6:
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9:
SP10: -
SP11: - -
SP12:
SP13:
SP14:
SP15:

ExUns: 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7:
SP8:
SP9: - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MROH7 Gene

GeneLoc Exon Structure for
MROH7
ECgene alternative splicing isoforms for
MROH7

Expression for MROH7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MROH7 Gene

mRNA differential expression in normal tissues according to GTEx for MROH7 Gene

This gene is overexpressed in Testis (x13.0).

Protein differential expression in normal tissues from HIPED for MROH7 Gene

This gene is overexpressed in Pancreas (31.2), Platelet (15.9), and Adipocyte (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MROH7 Gene



Protein tissue co-expression partners for MROH7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MROH7 Gene:

MROH7

SOURCE GeneReport for Unigene cluster for MROH7 Gene:

Hs.412482

Evidence on tissue expression from TISSUES for MROH7 Gene

  • Nervous system(4.4)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with MROH7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH7 Gene

Orthologs for MROH7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HEATR8 34
  • 98.87 (n)
-- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HEATR8 34
  • 85.56 (n)
-- 35
  • 76 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HEATR8 34 35
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Mroh7 34 16 35
  • 79.58 (n)
rat
(Rattus norvegicus)
Mammalia Mroh7 34
  • 78.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
Species where no ortholog for MROH7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH7 Gene

ENSEMBL:
Gene Tree for MROH7 (if available)
TreeFam:
Gene Tree for MROH7 (if available)

Paralogs for MROH7 Gene

Paralogs for MROH7 Gene

genes like me logo Genes that share paralogs with MROH7: view

Variants for MROH7 Gene

Sequence variations from dbSNP and Humsavar for MROH7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035495 A breast cancer sample
rs1000000936 -- 54,657,579(+) GCTAT(A/G)TTGCC intron-variant
rs1000011373 -- 54,708,862(+) GGAAT(C/G)TGTCC intron-variant
rs1000074963 -- 54,654,612(+) AGGTT(A/G)CAGTG intron-variant
rs1000110360 -- 54,703,185(+) GACAC(A/C)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MROH7 Gene

Variant ID Type Subtype PubMed ID
dgv38e212 CNV gain 25503493
dgv39e212 CNV loss 25503493
nsv1000673 CNV gain 25217958
nsv1004778 CNV gain 25217958
nsv1145344 CNV deletion 24896259
nsv461561 CNV gain 19166990
nsv461594 CNV gain 19166990
nsv461605 CNV gain 19166990
nsv546266 CNV gain 21841781
nsv546269 CNV gain 21841781
nsv546299 CNV gain 21841781
nsv817614 CNV gain 22305530
nsv829904 CNV loss 17160897
nsv910 CNV deletion 18451855

Variation tolerance for MROH7 Gene

Residual Variation Intolerance Score: 99.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.35; 98.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH7 Gene

Disorders for MROH7 Gene

Relevant External Links for MROH7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH7

No disorders were found for MROH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH7 Gene

Publications for MROH7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 3 64
  4. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64

Products for MROH7 Gene

Sources for MROH7 Gene

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