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Aliases for MROH6 Gene

Aliases for MROH6 Gene

  • Maestro Heat Like Repeat Family Member 6 2 3 5
  • C8orf73 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 6 3
  • Maestro Heat-Like Repeat Family Member 6 2
  • Chromosome 8 Open Reading Frame 73 2

External Ids for MROH6 Gene

Previous HGNC Symbols for MROH6 Gene

  • C8orf73

Previous GeneCards Identifiers for MROH6 Gene

  • GC08M144650

Summaries for MROH6 Gene

GeneCards Summary for MROH6 Gene

MROH6 (Maestro Heat Like Repeat Family Member 6) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH6 Gene

Genomics for MROH6 Gene

Regulatory Elements for MROH6 Gene

Enhancers for MROH6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143570 1 ENCODE 8.3 -0.3 -324 4.6 ATF1 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 NAPRT GSDMD ZNF623 VPS28 AK3P2 MROH6 ENSG00000255050
GH08F143382 1.4 Ensembl ENCODE 5 +187.9 187917 4.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF207 ENSG00000253931 MAFA-AS1 MINCR TOP1MT RHPN1 MROH6 MAFA OPLAH GC08M143377
GH08F143615 1.1 ENCODE 6.1 -44.0 -43995 3.8 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ETS1 ZNF766 LOC105375798 C8orf82 NAPRT TSSK5P GSDMD MROH6 TSTA3 PYCRL
GH08F143557 1 ENCODE 6 +14.5 14467 2.3 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 GSDMD NAPRT ENSG00000254859 MROH6 TOP1MT GC08M143556
GH08F143428 0.9 ENCODE 6.2 +144.1 144078 1.9 HDGF TBL1XR1 ZFP64 BMI1 ZNF2 ZNF48 ZEB1 ZNF263 SP3 ZBTB11 JRK ZNF696 ZNF623 VPS28 TOP1MT MAFA MROH6 ENSG00000254859 MAFA-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MROH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MROH6 Gene

143,566,187 bp from pter
143,572,971 bp from pter
6,785 bases
Minus strand

Genomic View for MROH6 Gene

Genes around MROH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH6 Gene

Proteins for MROH6 Gene

  • Protein details for MROH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Maestro heat-like repeat-containing protein family member 6
    Protein Accession:
    Secondary Accessions:
    • A8MWB1

    Protein attributes for MROH6 Gene

    719 amino acids
    Molecular mass:
    77186 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH6 Gene

Post-translational modifications for MROH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MROH6 Gene

Domains & Families for MROH6 Gene

Gene Families for MROH6 Gene

Protein Domains for MROH6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 7 HEAT repeats.
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with MROH6: view

No data available for Suggested Antigen Peptide Sequences for MROH6 Gene

Function for MROH6 Gene

Phenotypes for MROH6 Gene

GenomeRNAi human phenotypes for MROH6:
genes like me logo Genes that share phenotypes with MROH6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH6 Gene

Localization for MROH6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH6 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MROH6 Gene

Pathways & Interactions for MROH6 Gene

SuperPathways for MROH6 Gene

No Data Available

Interacting Proteins for MROH6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000381857 A6NGR9-MROH6_HUMAN for MROH6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MROH6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MROH6 Gene

Transcripts for MROH6 Gene

mRNA/cDNA for MROH6 Gene

(12) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH6 Gene

Maestro heat-like repeat family member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH6 Gene

No ASD Table

Relevant External Links for MROH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MROH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MROH6 Gene

mRNA differential expression in normal tissues according to GTEx for MROH6 Gene

This gene is overexpressed in Whole Blood (x6.4) and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for MROH6 Gene

This gene is overexpressed in Spleen (31.8), Plasma (20.3), and Heart (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH6 Gene

Protein tissue co-expression partners for MROH6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MROH6 Gene:


SOURCE GeneReport for Unigene cluster for MROH6 Gene:

genes like me logo Genes that share expression patterns with MROH6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH6 Gene

Orthologs for MROH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia MROH6 35
  • 86 (a)
(Bos Taurus)
Mammalia MROH6 34 35
  • 82.45 (n)
(Canis familiaris)
Mammalia C13H8orf73 34
  • 82.13 (n)
-- 35
  • 27 (a)
-- 35
  • 9 (a)
(Mus musculus)
Mammalia Mroh6 34 16 35
  • 79.33 (n)
(Rattus norvegicus)
Mammalia Mroh6 34
  • 79.07 (n)
(Monodelphis domestica)
Mammalia MROH6 35
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
-- 35
  • 10 (a)
Species where no ortholog for MROH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH6 Gene

Gene Tree for MROH6 (if available)
Gene Tree for MROH6 (if available)

Paralogs for MROH6 Gene

Paralogs for MROH6 Gene

genes like me logo Genes that share paralogs with MROH6: view

Variants for MROH6 Gene

Sequence variations from dbSNP and Humsavar for MROH6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10097065 -- 143,566,987(+) CAAGG(A/T)TGGGG intron-variant, utr-variant-3-prime
rs10097556 -- 143,567,455(+) TGCAG(C/T)CGCCC intron-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs10101426 -- 143,568,380(+) GAGAC(C/T)GGATT intron-variant, reference, missense
rs10101505 -- 143,573,643(+) cctta(C/G)aaatt upstream-variant-2KB
rs10102146 -- 143,566,986(+) CCAAG(A/G)TTGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MROH6 Gene

Variant ID Type Subtype PubMed ID
dgv12410n54 CNV loss 21841781
dgv7336n100 CNV gain 25217958
nsv1161809 CNV deletion 26073780
nsv1161810 CNV deletion 26073780
nsv466000 CNV loss 19166990
nsv470247 CNV loss 18288195
nsv470248 CNV gain 18288195
nsv516210 CNV loss 19592680
nsv612774 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612793 CNV loss 21841781
nsv612801 CNV loss 21841781
nsv612812 CNV loss 21841781
nsv612813 CNV loss 21841781
nsv824770 CNV gain 20364138
nsv950013 CNV deletion 24416366

Variation tolerance for MROH6 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.18; 96.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH6 Gene

Disorders for MROH6 Gene

Relevant External Links for MROH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MROH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH6 Gene

Publications for MROH6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64

Products for MROH6 Gene

Sources for MROH6 Gene

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