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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MROH6 Gene

protein-coding   GIFtS: 29
GCID: GC08M144650

Maestro Heat-Like Repeat Family Member 6

(Previous name: chromosome 8 open reading frame 73)
(Previous symbol: C8orf73)
  Search for MROH6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Maestro Heat-Like Repeat Family Member 61 2
C8orf731 2 3
Chromosome 8 Open Reading Frame 731
Maestro Heat-Like Repeat-Containing Protein Family Member 62

External Ids:    HGNC: 278141   Entrez Gene: 6424752   Ensembl: ENSG000002048397   UniProtKB: A6NGR93   

Export aliases for MROH6 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MROH6 Gene: 
MROH6 (maestro heat-like repeat family member 6) is a protein-coding gene. An important paralog of this gene is MROH9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MROH6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MROH6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MROH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

MROH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MROH6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144650:  view genomic region     (about GC identifiers)

Start:
144,648,357 bp from pter      End:
144,655,141 bp from pter
Size:
6,785 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MROH6_HUMAN, A6NGR9 (See protein sequence)
Recommended Name: Maestro heat-like repeat-containing protein family member 6  
Size: 719 amino acids; 77186 Da
Secondary accessions: A8MWB1

Explore the universe of human proteins at neXtProt for MROH6: NX_A6NGR9

Explore proteomics data for MROH6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NGR9

  • MROH6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MROH6 Protein Expression
    REFSEQ proteins: NP_001094348.1  
    ENSEMBL proteins: 
     ENSP00000381857   ENSP00000434244   ENSP00000435528   ENSP00000431569   ENSP00000436284  
     ENSP00000436959  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MROH: maestro heat-like repeat containing

    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry A6NGR9

    ProtoNet protein and cluster: A6NGR9

    UniProtKB/Swiss-Prot: MROH6_HUMAN, A6NGR9
    Similarity: Contains 7 HEAT repeats


    MROH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    MROH6 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MROH6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MROH6 (ENSP000003818574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MROH6

    Search CenterWatch for drugs/clinical trials and news about MROH6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MROH6 gene: 
    NM_001100878.1  

    Unigene Cluster for MROH6:

    Maestro heat-like repeat family member 6
    Hs.531406  [show with all ESTs]
    Unigene Representative Sequence: NM_001100878
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398882(uc010mff.3 uc010mfg.1) ENST00000533210 ENST00000533679
    ENST00000532704 ENST00000524906 ENST00000533120 ENST00000534459 ENST00000533083
    ENST00000532862 ENST00000533582 ENST00000529971
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    Additional mRNA sequence: 

    AF086255.1 AK292180.1 BC029031.1 BC128444.1 

    7 DOTS entries:

    DT.411435  DT.95150193  DT.100761196  DT.100799860  DT.100696212  DT.121478069  DT.97824106 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See MROH6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MROH6

    SOURCE GeneReport for Unigene cluster: Hs.531406
        SABiosciences Custom PCR Arrays for MROH6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MROH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MROH6 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mroh65
    Gm195701
    predicted gene, 195701, 5 79.56(n)1
    80.73(a)1
      155
    2236451  XM_003688938.11  XP_003688986.11 
     758841375 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 4)
    --

    5(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    1(171267169-171271465)
    1(171273749-171277776)
    lizard
    (Anolis carolinensis)
    Reptilia MROH66
    maestro heat-like repeat family member 6
    29(a)
    1 ↔ 1
    3(99831790-99906023)
    fruit fly
    (Drosophila melanogaster)
    Insecta c11.16
    c11.1
    7(a)
    1 → many
    X(9169681-9177150)
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-276
    Protein HPO-27
    6(a)
    1 → many
    I(5906662-5917782)


    ENSEMBL Gene Tree for MROH6 (if available)
    TreeFam Gene Tree for MROH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MROH6 gene
    MROH92  MROH82  ENSG000002717232  MROH72  

    MROH6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/339 SNPs in MROH6 are shown (see all 339)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737156841,2
    C,F--144647890(+) CGGACG/ATCCAT 1 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs125416471,2
    C,F,A,H--144647928(+) GGGCAT/CCTGGT 1 -- ds500120Minor allele frequency- C:0.18NS EA NA WA 2344
    rs44710561,2
    C,F,A,H--144647964(+) CTCTCG/TATCTG 1 -- ds500125Minor allele frequency- T:0.20NA NS EA WA CSA 2022
    rs1928851551,2
    --144647982(+) TATGTC/TGAATC 1 -- ds50010--------
    rs285079381,2
    C,F--144647991(+) TCCCGT/GTTTGG 1 -- ds50015Minor allele frequency- G:0.13WA NA EA 362
    rs1846186161,2
    C--144648058(+) GACCCA/GGGCCC 1 -- ds50010--------
    rs1174152061,2
    F--144648071(+) CACCTG/CATCCT 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1380760851,2
    --144648095(+) ATGACC/TTGCAA 1 -- ds50010--------
    rs1899414111,2
    --144648116(+) ACCCCA/GGTGCT 1 -- ds50010--------
    rs283722451,2
    C,F--144648129(+) CAGCTC/GTAACC 1 -- ds50012Minor allele frequency- G:0.11WA 120

    HapMap Linkage Disequilibrium report for MROH6 (144648357 - 144655141 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MROH6: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MROH6
    DNA2.0 Custom Variant and Variant Library Synthesis for MROH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MROH6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MROH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    4. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    5. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PubMed id 9776767)1 Bussow K....Walter G. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 642475 HGNC: 27814 Ensembl:ENSG00000204839 euGenes: HUgn642475 ECgene: MROH6
    H-InvDB: MROH6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MROH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MROH6 gene:
    Search GeneIP for patents involving MROH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for MROH6
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     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for MROH6
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for MROH6
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     Search ThermoFisher Antibodies for MROH6
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MROH6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MROH6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MROH6
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     Search LSBio for Antibodies for MROH6
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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