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Aliases for MROH6 Gene

Aliases for MROH6 Gene

  • Maestro Heat-Like Repeat Family Member 6 2 3
  • C8orf73 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 6 3
  • Chromosome 8 Open Reading Frame 73 2

External Ids for MROH6 Gene

Previous HGNC Symbols for MROH6 Gene

  • C8orf73

Previous GeneCards Identifiers for MROH6 Gene

  • GC08M144650

Summaries for MROH6 Gene

GeneCards Summary for MROH6 Gene

MROH6 (Maestro Heat-Like Repeat Family Member 6) is a Protein Coding gene. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH6 Gene

Genomics for MROH6 Gene

Genomic Location for MROH6 Gene

Start:
143,566,187 bp from pter
End:
143,573,053 bp from pter
Size:
6,867 bases
Orientation:
Minus strand

Genomic View for MROH6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH6 Gene

No data available for Regulatory Elements for MROH6 Gene

Proteins for MROH6 Gene

  • Protein details for MROH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGR9-MROH6_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 6
    Protein Accession:
    A6NGR9
    Secondary Accessions:
    • A8MWB1

    Protein attributes for MROH6 Gene

    Size:
    719 amino acids
    Molecular mass:
    77186 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH6 Gene

Proteomics data for MROH6 Gene at MOPED

Post-translational modifications for MROH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MROH6 Gene

No data available for DME Specific Peptides for MROH6 Gene

Domains for MROH6 Gene

Gene Families for MROH6 Gene

HGNC:
  • MROH :maestro heat-like repeat containing

Protein Domains for MROH6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A6NGR9

UniProtKB/Swiss-Prot:

MROH6_HUMAN :
  • A6NGR9
Similarity:
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with MROH6: view

No data available for Suggested Antigen Peptide Sequences for MROH6 Gene

Function for MROH6 Gene

Gene Ontology (GO) - Molecular Function for MROH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MROH6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MROH6 Gene

Localization for MROH6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH6 Gene

Pathways for MROH6 Gene

SuperPathways for MROH6 Gene

No Data Available

Interacting Proteins for MROH6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381857%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381857 for MROH6 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MROH6 Gene

None

No data available for Pathways by source for MROH6 Gene

Transcripts for MROH6 Gene

mRNA/cDNA for MROH6 Gene

(25) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH6 Gene

Maestro heat-like repeat family member 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MROH6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MROH6 Gene

No ASD Table

Relevant External Links for MROH6 Gene

GeneLoc Exon Structure for
MROH6
ECgene alternative splicing isoforms for
MROH6

Expression for MROH6 Gene

mRNA expression in normal human tissues for MROH6 Gene

mRNA differential expression in normal tissues according to GTEx for MROH6 Gene

This gene is overexpressed in Whole Blood (6.4) and Esophagus - Mucosa (6.2).

Protein differential expression in normal tissues for MROH6 Gene

This gene is overexpressed in Spleen (31.8), Plasma (20.3), and Heart (13.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MROH6 Gene

SOURCE GeneReport for Unigene cluster for MROH6 Gene Hs.531406

genes like me logo Genes that share expressions with MROH6: view

Expression partners for MROH6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH6 Gene

Orthologs for MROH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MROH6 35
  • 82.45 (n)
  • 83.17 (a)
MROH6 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C13H8orf73 35
  • 82.13 (n)
  • 80.87 (a)
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mroh6 35
  • 79.33 (n)
  • 80.31 (a)
Mroh6 16
Mroh6 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mroh6 35
  • 79.07 (n)
  • 80.7 (a)
oppossum
(Monodelphis domestica)
Mammalia MROH6 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MROH6 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
-- 36
  • 10 (a)
OneToMany
Species with no ortholog for MROH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH6 Gene

ENSEMBL:
Gene Tree for MROH6 (if available)
TreeFam:
Gene Tree for MROH6 (if available)

Paralogs for MROH6 Gene

Paralogs for MROH6 Gene

genes like me logo Genes that share paralogs with MROH6: view

Variants for MROH6 Gene

Sequence variations from dbSNP and Humsavar for MROH6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs12168 -- 143,566,339(-) TCTGC(A/G)AGTGC utr-variant-3-prime
rs896946 -- 143,566,472(+) CCCAG(A/G)GCAGC utr-variant-3-prime
rs896947 -- 143,566,574(+) CACAC(A/G)GGACC utr-variant-3-prime
rs4471056 -- 143,565,794(+) CTCTC(G/T)ATCTG downstream-variant-500B
rs4873803 - 143,572,424(+) ACCTG(G/T)TGGGG missense, reference

Relevant External Links for MROH6 Gene

HapMap Linkage Disequilibrium report
MROH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MROH6 Gene

Disorders for MROH6 Gene

No disorders were found for MROH6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MROH6 Gene

Publications for MROH6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  4. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4
  5. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PMID: 9776767) BA1ssow K. … Walter G. (Nucleic Acids Res. 1998) 3

Products for MROH6 Gene

Sources for MROH6 Gene

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