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Aliases for MROH6 Gene

Aliases for MROH6 Gene

  • Maestro Heat Like Repeat Family Member 6 2 3
  • Maestro Heat-Like Repeat Family Member 6 2 3 5
  • C8orf73 3 4
  • Chromosome 8 Open Reading Frame 73 2

External Ids for MROH6 Gene

Previous HGNC Symbols for MROH6 Gene

  • C8orf73

Previous GeneCards Identifiers for MROH6 Gene

  • GC08M144650

Summaries for MROH6 Gene

GeneCards Summary for MROH6 Gene

MROH6 (Maestro Heat Like Repeat Family Member 6) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH6 Gene

Genomics for MROH6 Gene

Regulatory Elements for MROH6 Gene

Enhancers for MROH6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MROH6 on UCSC Golden Path with GeneCards custom track

Promoters for MROH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MROH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for MROH6 Gene

143,566,187 bp from pter
143,572,971 bp from pter
6,785 bases
Minus strand

Genomic View for MROH6 Gene

Genes around MROH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH6 Gene

Proteins for MROH6 Gene

  • Protein details for MROH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Maestro heat-like repeat-containing protein family member 6
    Protein Accession:
    Secondary Accessions:
    • A8MWB1

    Protein attributes for MROH6 Gene

    719 amino acids
    Molecular mass:
    77186 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH6 Gene

Proteomics data for MROH6 Gene at MOPED

Post-translational modifications for MROH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MROH6 Gene

No data available for DME Specific Peptides for MROH6 Gene

Domains & Families for MROH6 Gene

Gene Families for MROH6 Gene

Protein Domains for MROH6 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 7 HEAT repeats.
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with MROH6: view

No data available for Suggested Antigen Peptide Sequences for MROH6 Gene

Function for MROH6 Gene

Phenotypes for MROH6 Gene

GenomeRNAi human phenotypes for MROH6:
genes like me logo Genes that share phenotypes with MROH6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH6 Gene

Localization for MROH6 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH6 Gene

Pathways & Interactions for MROH6 Gene

SuperPathways for MROH6 Gene

No Data Available

Interacting Proteins for MROH6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000381857 for MROH6 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MROH6 Gene


No data available for Pathways by source and SIGNOR curated interactions for MROH6 Gene

Drugs & Compounds for MROH6 Gene

No Compound Related Data Available

Transcripts for MROH6 Gene

mRNA/cDNA for MROH6 Gene

(25) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH6 Gene

Maestro heat-like repeat family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MROH6 Gene

No ASD Table

Relevant External Links for MROH6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MROH6 Gene

mRNA expression in normal human tissues for MROH6 Gene

mRNA differential expression in normal tissues according to GTEx for MROH6 Gene

This gene is overexpressed in Whole Blood (x6.4) and Esophagus - Mucosa (x6.2).

Protein differential expression in normal tissues from HIPED for MROH6 Gene

This gene is overexpressed in Spleen (31.8), Plasma (20.3), and Heart (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH6 Gene

SOURCE GeneReport for Unigene cluster for MROH6 Gene Hs.531406

genes like me logo Genes that share expression patterns with MROH6: view

Protein tissue co-expression partners for MROH6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH6 Gene

Orthologs for MROH6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MROH6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MROH6 35
  • 82.45 (n)
  • 83.17 (a)
MROH6 36
  • 82 (a)
(Canis familiaris)
Mammalia C13H8orf73 35
  • 82.13 (n)
  • 80.87 (a)
-- 36
  • 9 (a)
-- 36
  • 27 (a)
(Mus musculus)
Mammalia Mroh6 35
  • 79.33 (n)
  • 80.31 (a)
Mroh6 16
Mroh6 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Mroh6 35
  • 79.07 (n)
  • 80.7 (a)
(Monodelphis domestica)
Mammalia MROH6 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia MROH6 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
-- 36
  • 10 (a)
Species with no ortholog for MROH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MROH6 Gene

Gene Tree for MROH6 (if available)
Gene Tree for MROH6 (if available)

Paralogs for MROH6 Gene

Paralogs for MROH6 Gene

genes like me logo Genes that share paralogs with MROH6: view

Variants for MROH6 Gene

Sequence variations from dbSNP and Humsavar for MROH6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4873803 - 143,572,424(+) ACCTG(G/T)TGGGG nc-transcript-variant, reference, missense
rs4874153 - 143,572,085(+) TGAGC(A/G)CTGTC nc-transcript-variant, reference, missense
rs10866911 - 143,572,079(+) ACAGG(A/G)TGAGC nc-transcript-variant, reference, missense
rs13255489 - 143,567,798(+) CACGG(C/G/T)GGCTG nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs10097065 -- 143,566,987(+) CAAGG(A/T)TGGGG intron-variant, nc-transcript-variant, utr-variant-3-prime

Variation tolerance for MROH6 Gene

Residual Variation Intolerance Score: 83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.18; 96.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MROH6 Gene

Disorders for MROH6 Gene

Relevant External Links for MROH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MROH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH6 Gene

Publications for MROH6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PMID: 9776767) BA1ssow K. … Walter G. (Nucleic Acids Res. 1998) 3

Products for MROH6 Gene

Sources for MROH6 Gene