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MROH6 Gene

protein-coding   GIFtS: 28
GCID: GC08M144650

Maestro Heat-Like Repeat Family Member 6

(Previous name: chromosome 8 open reading frame 73)
(Previous symbol: C8orf73)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Maestro Heat-Like Repeat Family Member 61 2
C8orf731 2 3
Chromosome 8 Open Reading Frame 731
Maestro Heat-Like Repeat-Containing Protein Family Member 62

External Ids:    HGNC: 278141   Entrez Gene: 6424752   Ensembl: ENSG000002048397   UniProtKB: A6NGR93   

Export aliases for MROH6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MROH6 Gene:
MROH6 (maestro heat-like repeat family member 6) is a protein-coding gene. An important paralog of this gene is MROH2A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NT_187571.1  NC_018919.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MROH6
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MROH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MROH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

MROH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MROH6 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M144650:  view genomic region     (about GC identifiers)

Start:
144,648,357 bp from pter      End:
144,655,141 bp from pter
Size:
6,785 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MROH6_HUMAN, A6NGR9 (See protein sequence)
Recommended Name: Maestro heat-like repeat-containing protein family member 6  
Size: 719 amino acids; 77186 Da
Secondary accessions: A8MWB1

Explore the universe of human proteins at neXtProt for MROH6: NX_A6NGR9

Explore proteomics data for MROH6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MROH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094348.1  
    ENSEMBL proteins: 
     ENSP00000381857   ENSP00000434244   ENSP00000435528   ENSP00000431569   ENSP00000436284  
     ENSP00000436959  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MROH: maestro heat-like repeat containing

    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry A6NGR9

    ProtoNet protein and cluster: A6NGR9

    UniProtKB/Swiss-Prot: MROH6_HUMAN, A6NGR9
    Similarity: Contains 7 HEAT repeats


    Find genes that share domains with MROH6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with MROH6           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MROH6
    Interactions:

        Search GeneGlobe Interaction Network for MROH6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MROH6 (ENSP000003818574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MROH6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MROH6 gene: 
    NM_001100878.1  

    Unigene Cluster for MROH6:

    Maestro heat-like repeat family member 6
    Hs.531406  [show with all ESTs]
    Unigene Representative Sequence: NM_001100878
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398882(uc010mff.3 uc010mfg.1) ENST00000533210 ENST00000533679
    ENST00000532704 ENST00000524906 ENST00000533120 ENST00000534459 ENST00000533083
    ENST00000532862 ENST00000533582 ENST00000529971
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      QuantiFast Probe-based Assays in human, mouse, rat MROH6

    Additional mRNA sequence: 

    AF086255.1 AK292180.1 BC029031.1 BC128444.1 

    7 DOTS entries:

    DT.411435  DT.95150193  DT.100761196  DT.100799860  DT.100696212  DT.121478069  DT.97824106 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MROH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MROH6 Expression
    About this image

    MROH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MROH6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531406
        Custom PCR Arrays for MROH6
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MROH6 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mroh61 , 5 predicted gene, 195705
    maestro heat-like repeat family member 61
    79.33(n)1
    80.31(a)1
      155
    2236451  NM_001282443.11  NP_001269372.11 
     758841375 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    30(a)
    10(a)
    1 ↔ many
    1 ↔ many
    3(99831790-99906023)
    GL343372.1(474960-486438)


    ENSEMBL Gene Tree for MROH6 (if available)
    TreeFam Gene Tree for MROH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MROH6 gene
    MROH2A2  MROH2B2  MRO2  MROH82  MROH7-TTC42  MROH72  MROH12  

    Find genes that share paralogs with MROH6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MROH6 (see all 339)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737156841,2
    C,F--144647890(+) CGGACG/ATCCAT 1 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs125416471,2
    C,F,A,H--144647928(+) GGGCAT/CCTGGT 1 -- ds500120Minor allele frequency- C:0.18NS EA NA WA 2344
    rs44710561,2
    C,F,A,H--144647964(+) CTCTCG/TATCTG 1 -- ds500125Minor allele frequency- T:0.20NA NS EA WA CSA 2022
    rs1928851551,2
    --144647982(+) TATGTC/TGAATC 1 -- ds50010--------
    rs285079381,2
    C,F--144647991(+) TCCCGT/GTTTGG 1 -- ds50015Minor allele frequency- G:0.13WA NA EA 362
    rs1846186161,2
    C--144648058(+) GACCCA/GGGCCC 1 -- ds50010--------
    rs1174152061,2
    F--144648071(+) CACCTG/CATCCT 1 -- ds50011Minor allele frequency- C:0.03NA 120
    rs1380760851,2
    --144648095(+) ATGACC/TTGCAA 1 -- ds50010--------
    rs1899414111,2
    --144648116(+) ACCCCA/GGTGCT 1 -- ds50010--------
    rs283722451,2
    C,F--144648129(+) CAGCTC/GTAACC 1 -- ds50012Minor allele frequency- G:0.11WA 120

    HapMap Linkage Disequilibrium report for MROH6 (144648357 - 144655141 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MROH6: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MROH6
    DNA2.0 Custom Variant and Variant Library Synthesis for MROH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MROH6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MROH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
    6. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. (PubMed id 9776767)1 BA1ssow K....Walter G. (Nucleic Acids Res. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 642475 HGNC: 27814 Ensembl:ENSG00000204839 euGenes: HUgn642475 ECgene: MROH6
    H-InvDB: MROH6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MROH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MROH6 gene:
    Search GeneIP for patents involving MROH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for MROH6
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for MROH6
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     Search ThermoFisher Antibodies for MROH6
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MROH6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MROH6
     Search LSBio for Antibodies for MROH6
     Browse compounds at ApexBio
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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