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Aliases for MROH2B Gene

Aliases for MROH2B Gene

  • Maestro Heat Like Repeat Family Member 2B 2 3
  • Maestro Heat-Like Repeat Family Member 2B 2 3 5
  • HEAT Repeat-Containing Protein 7B2 3 4
  • HEAT Repeat Family Member 7B2 2 3
  • HEATR7B2 3 4
  • HEAT Repeat Family Member B2 3

External Ids for MROH2B Gene

Previous HGNC Symbols for MROH2B Gene

  • HEATR7B2

Summaries for MROH2B Gene

GeneCards Summary for MROH2B Gene

MROH2B (Maestro Heat Like Repeat Family Member 2B) is a Protein Coding gene. Diseases associated with MROH2B include Interleukin-7 Receptor Alpha Deficiency. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH2B Gene

Genomics for MROH2B Gene

Regulatory Elements for MROH2B Gene

Enhancers for MROH2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MROH2B on UCSC Golden Path with GeneCards custom track

Genomic Location for MROH2B Gene

Chromosome:
5
Start:
40,998,017 bp from pter
End:
41,071,342 bp from pter
Size:
73,326 bases
Orientation:
Minus strand

Genomic View for MROH2B Gene

Genes around MROH2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH2B Gene

Proteins for MROH2B Gene

  • Protein details for MROH2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z745-MRO2B_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 2B
    Protein Accession:
    Q7Z745
    Secondary Accessions:
    • Q68DM1
    • Q7Z4U4
    • Q8N7X3

    Protein attributes for MROH2B Gene

    Size:
    1585 amino acids
    Molecular mass:
    180781 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97306.1; Type=Frameshift; Positions=1063, 1080; Evidence={ECO:0000305}; Sequence=BAC05103.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MROH2B Gene

Proteomics data for MROH2B Gene at MOPED

Post-translational modifications for MROH2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MROH2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MROH2B Gene

Domains & Families for MROH2B Gene

Gene Families for MROH2B Gene

Protein Domains for MROH2B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MROH2B Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z745

UniProtKB/Swiss-Prot:

MRO2B_HUMAN :
  • Contains 15 HEAT repeats.
Similarity:
  • Contains 15 HEAT repeats.
genes like me logo Genes that share domains with MROH2B: view

Function for MROH2B Gene

Phenotypes for MROH2B Gene

genes like me logo Genes that share phenotypes with MROH2B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH2B Gene

Localization for MROH2B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH2B Gene

Pathways & Interactions for MROH2B Gene

SuperPathways for MROH2B Gene

No Data Available

Interacting Proteins for MROH2B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000382476%0d%0a9606.ENSP00000338703%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000382476 for MROH2B Gene via STRING

Gene Ontology (GO) - Biological Process for MROH2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH2B Gene

Drugs & Compounds for MROH2B Gene

No Compound Related Data Available

Transcripts for MROH2B Gene

Unigene Clusters for MROH2B Gene

Maestro heat-like repeat family member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MROH2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: - -
SP2:
SP3:
SP4:

ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42 ^ 43
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for MROH2B Gene

GeneLoc Exon Structure for
MROH2B
ECgene alternative splicing isoforms for
MROH2B

Expression for MROH2B Gene

mRNA expression in normal human tissues for MROH2B Gene

mRNA differential expression in normal tissues according to GTEx for MROH2B Gene

This gene is overexpressed in Testis (x50.0).

Protein differential expression in normal tissues from HIPED for MROH2B Gene

This gene is overexpressed in Nasopharynx (25.1) and Bone marrow stromal cell (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH2B Gene



SOURCE GeneReport for Unigene cluster for MROH2B Gene Hs.97714

genes like me logo Genes that share expression patterns with MROH2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MROH2B Gene

Orthologs for MROH2B Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MROH2B 35
  • 86.52 (n)
  • 85.3 (a)
MROH2B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MROH2B 35
  • 88.39 (n)
  • 87.13 (a)
MROH2B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mroh2b 35
  • 82.57 (n)
  • 81.65 (a)
Mroh2b 16
Mroh2b 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HEATR7B2 35
  • 99.24 (n)
  • 98.61 (a)
MROH2B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mroh2b 35
  • 82.8 (n)
  • 81.63 (a)
oppossum
(Monodelphis domestica)
Mammalia MROH2B 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MROH2B 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101747491 35
  • 50.37 (n)
  • 44.44 (a)
-- 36
  • 20 (a)
OneToMany
-- 36
  • 19 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta c11.1 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-27 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for MROH2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MROH2B Gene

ENSEMBL:
Gene Tree for MROH2B (if available)
TreeFam:
Gene Tree for MROH2B (if available)

Paralogs for MROH2B Gene

Paralogs for MROH2B Gene

(4) SIMAP similar genes for MROH2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MROH2B: view

Variants for MROH2B Gene

Sequence variations from dbSNP and Humsavar for MROH2B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_042983 -
rs865093 - 41,061,614(+) ATACC(A/G)GAACA reference, missense
rs10045243 - 41,057,330(+) ATAAA(G/T)AACTG reference, missense
rs17198125 - 41,049,378(+) GGGGC(A/G/T)CCAGA reference, missense
rs325864 - 41,049,295(-) TTGTC(A/G)TCTCT reference, missense

Variation tolerance for MROH2B Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.69; 98.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MROH2B Gene

Disorders for MROH2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MROH2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
interleukin-7 receptor alpha deficiency
  • il-7r
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MROH2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH2B
genes like me logo Genes that share disorders with MROH2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MROH2B Gene

Publications for MROH2B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. (PMID: 19221116) Kallio S.P. … Saarela J. (Hum. Mol. Genet. 2009) 3

Products for MROH2B Gene

Sources for MROH2B Gene

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