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MROH2B Gene

protein-coding   GIFtS: 33
GCID: GC05M041000

Maestro Heat-Like Repeat Family Member 2B

(Previous name: HEAT repeat family member 7B2)
(Previous symbol: HEATR7B2)
  Search for MROH2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Maestro Heat-Like Repeat Family Member 2B1 2
HEATR7B21 2 3
HEAT Repeat Family Member 7B21 2
HEAT Repeat-Containing Protein 7B22 3
HEAT Repeat Family Member B22
Maestro Heat-Like Repeat-Containing Protein Family Member 2B2

External Ids:    HGNC: 268571   Entrez Gene: 1335582   Ensembl: ENSG000001714957   UniProtKB: Q7Z7453   

Export aliases for MROH2B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MROH2B Gene:
MROH2B (maestro heat-like repeat family member 2B) is a protein-coding gene. An important paralog of this gene is MROH2A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MROH2B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MROH2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MROH2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

MROH2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MROH2B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M041000:  view genomic region     (about GC identifiers)

Start:
40,998,119 bp from pter      End:
41,071,444 bp from pter
Size:
73,326 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MRO2B_HUMAN, Q7Z745 (See protein sequence)
Recommended Name: Maestro heat-like repeat-containing protein family member 2B  
Size: 1585 amino acids; 180781 Da
Sequence caution: Sequence=AAP97306.1; Type=Frameshift; Positions=1063, 1080; Sequence=BAC05103.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q68DM1 Q7Z4U4 Q8N7X3
Alternative splicing: 2 isoforms:  Q7Z745-1   Q7Z745-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MROH2B: NX_Q7Z745

Explore proteomics data for MROH2B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MROH2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775760.3  
    ENSEMBL proteins: 
     ENSP00000441504   ENSP00000382476  

    MROH2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MROH2B 

    MROH2B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for MROH2B
    Search for Antibodies for MROH2B at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MROH2B
    Search LSBio for Antibodies for MROH2B

    MROH2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MROH2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MROH2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MROH2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MROH: maestro heat-like repeat containing

    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q7Z745

    ProtoNet protein and cluster: Q7Z745

    1 Blocks protein domain: IPB000357 HEAT repeat

    UniProtKB/Swiss-Prot: MRO2B_HUMAN, Q7Z745
    Similarity: Contains 15 HEAT repeats


    Find genes that share domains with MROH2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    Find genes that share ontologies with MROH2B           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MROH2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MROH2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MROH2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MROH2B

    miRNA
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    Block miRNA regulation of human, mouse, rat MROH2B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MROH2B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MROH2B
    Predesigned siRNA for gene silencing in human, mouse, rat MROH2B

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MROH2B

    Clone
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    OriGene clones in human, mouse for MROH2B (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MROH2B
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MROH2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MROH2B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MROH2B 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MROH2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MROH2B
    Interactions:

        Search GeneGlobe Interaction Network for MROH2B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MROH2B (MRO2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MROH2B gene: 
    NM_173489.4  

    Unigene Cluster for MROH2B:

    Maestro heat-like repeat family member 2B
    Hs.97714  [show with all ESTs]
    Unigene Representative Sequence: NM_173489
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511934 ENST00000503890 ENST00000515297 ENST00000506092(uc003jmi.4)
    ENST00000399564(uc003jmj.4) ENST00000508575(uc021xxt.1)
    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate MROH2B
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MROH2B
    Predesigned siRNA for gene silencing in human, mouse, rat MROH2B
    Clone
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    OriGene clones in human, mouse for MROH2B (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for MROH2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MROH2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MROH2B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MROH2B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MROH2B
      QuantiTect SYBR Green Assays in human, mouse, rat MROH2B
      QuantiFast Probe-based Assays in human, mouse, rat MROH2B

    Additional mRNA sequence: 

    AF432068.1 AK097562.1 AK126005.1 AK128183.1 AL832763.1 BC034600.1 BC044937.1 BC052962.1 
    CR749346.1 

    7 DOTS entries:

    DT.409875  DT.101967018  DT.101981951  DT.95342369  DT.70104792  DT.95147009  DT.97768865 

    Selected AceView cDNA sequences (see all 29):

    AA412657 BC044937 BX643012 BC052962 AI026627 CR749346 AK128183 AA383405 
    AK126005 AA412489 AL042749 BC026008 AL042750 BI830953 AA431834 NM_173489 
    AW589908 BC034600 AI696044 AL832763 AK097562 AF432068 BF979306 BG772973 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MROH2B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                                  -                       -                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b ^ 42 ^ 43
    SP1:                                                              -                             -                     
    SP2:                                                                                            -                     
    SP3:                                                                                                                  
    SP4:                                                                                                                  


    ECgene alternative splicing isoforms for MROH2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MROH2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MROH2B Expression
    About this image

    MROH2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MROH2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.97714
        Custom PCR Arrays for MROH2B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MROH2B
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MROH2B
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    QuantiFast Probe-based Assays in human, mouse, rat MROH2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MROH2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MROH2B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mroh2b1 , 5 XVHEAT repeat family member 7B25
    maestro heat-like repeat family member 2B1
    82.57(n)1
    81.65(a)1
      15 (1.98 cM)5
    2238251  NM_001166066.11  NP_001159538.11 
     48987375 
    chicken
    (Gallus gallus)
    Aves LOC1017474911 maestro heat-like repeat-containing protein family more 50.37(n)
    44.44(a)
      101747491  XM_004950735.1  XP_004950792.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    30(a)
    many ↔ many
    GL343744.1(736-72722)
    fruit fly
    (Drosophila melanogaster)
    Insecta c11.16
    c11.1
    16(a)
    1 → many
    X(9169681-9177150)
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-276
    Protein HPO-27 (hpo-27) mRNA, complete cds
    16(a)
    1 → many
    I(5906662-5918229) WBGene00016418


    ENSEMBL Gene Tree for MROH2B (if available)
    TreeFam Gene Tree for MROH2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MROH2B gene
    MROH2A2  MRO2  MROH82  MROH7-TTC42  MROH62  MROH72  MROH12  
    4 SIMAP similar genes for MROH2B using alignment to 2 protein entries:     MRO2B_HUMAN (see all proteins):
    MRO    HEATR7B1    MROH2A    MROH1

    Find genes that share paralogs with MROH2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MROH2B (see all 1880)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464730611,2
    C--40997622(+) ATGATG/TATATT 1 -- int10--------
    rs1158401611,2
    F--40997945(+) CAAATC/GACAGG 1 -- int11Minor allele frequency- G:0.03NA 120
    rs22717071,2
    C,F,O,H--40997996(-) GGTGGC/TTTCCA 1 -- int125Minor allele frequency- N:0.00EA NA NS WA 4460
    rs1410214961,2
    C--40998001(+) GCCACC/TAAGGA 1 -- int10--------
    rs770232191,2
    C,F--40998041(+) CTTCTA/TTATCC 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1909247851,2
    --40998048(+) ATCCCC/TATCGT 1 -- int10--------
    rs1831381821,2
    --40998089(+) AGTTTA/GTGAGG 1 -- int10--------
    rs2009322691,2
    --40998158(+) CTTACA/GGAGGA 2 P L mis10--------
    rs7040401,2
    C,F,A,H--40998196(+) AGGGTC/TTGCAA 2 Q syn129Minor allele frequency- T:0.35NA EA MN NS WA CSA EU 3599
    rs1434248331,2
    C--40998208(+) GCAGCC/TTCAGC 2 E syn10--------

    HapMap Linkage Disequilibrium report for MROH2B (40998119 - 41071444 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MROH2B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MROH2B
    DNA2.0 Custom Variant and Variant Library Synthesis for MROH2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MROH2B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MROH2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Use of a genetic isolate to identify rare disease variants: C7 on 5p associated with MS. (PubMed id 19221116)1 Kallio S.P....Saarela J. (Hum. Mol. Genet. 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 133558 HGNC: 26857 AceView: FLJ40243 Ensembl:ENSG00000171495 euGenes: HUgn133558
    ECgene: MROH2B H-InvDB: MROH2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MROH2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MROH2B gene:
    Search GeneIP for patents involving MROH2B

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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