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MROH2A Gene

protein-coding   GIFtS: 29
GCID: GC02P234702          (predicted)

Maestro Heat-Like Repeat Family Member 2A

(Previous name: HEAT repeat containing 7B1)
(Previous symbol: HEATR7B1)
  Search for MROH2A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Maestro Heat-Like Repeat Family Member 2A1 2
HEATR7B11 2 3
HEAT Repeat Containing 7B11 2
HEAT Repeat-Containing Protein 7B12 3
Maestro Heat-Like Repeat-Containing Protein Family Member 2A2

External Ids:    HGNC: 279361   Entrez Gene: 3397662   Ensembl: ENSG000001850387   UniProtKB: A6NES43   

Export aliases for MROH2A gene to outside databases

Previous GC identifers: GC02P234689 GC02P234698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MROH2A Gene:
MROH2A (maestro heat-like repeat family member 2A) is a protein-coding gene. An important paralog of this gene is MROH2B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MROH2A
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MROH2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MROH2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

MROH2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MROH2A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234702:  view genomic region     (about GC identifiers)

Start:
234,684,370 bp from pter      End:
234,742,069 bp from pter
Size:
57,700 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MRO2A_HUMAN, A6NES4 (See protein sequence)
Recommended Name: Maestro heat-like repeat-containing protein family member 2A  
Size: 1706 amino acids; 193176 Da

Explore the universe of human proteins at neXtProt for MROH2A: NX_A6NES4

Explore proteomics data for MROH2A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MROH2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001274324.1  
    ENSEMBL proteins: 
     ENSP00000392128   ENSP00000404614   ENSP00000409355   ENSP00000374408  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MROH: maestro heat-like repeat containing

    1 InterPro protein domain:
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry A6NES4

    ProtoNet protein and cluster: A6NES4

    UniProtKB/Swiss-Prot: MRO2A_HUMAN, A6NES4
    Similarity: Contains 14 HEAT repeats


    MROH2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
         
    MROH2A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MROH2A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MROH2A
    Interactions:

        Search GeneGlobe Interaction Network for MROH2A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MROH2A (MRO2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MROH2A gene: 
    NM_001287395.1  

    Unigene Cluster for MROH2A:

    Maestro heat-like repeat family member 2A
    Hs.361778  [show with all ESTs]
    Unigene Representative Sequence: BC042133
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430892(uc002vvc.1) ENST00000428446(uc002vvd.1) ENST00000454283(uc002vve.1)
    ENST00000389758 ENST00000480634 ENST00000477506 ENST00000487979(uc002vvf.3)

    miRNA
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    Additional mRNA sequence: BC042133.1 

    2 DOTS entries:

    DT.91809574  DT.40192045 

    9 AceView cDNA sequences:

    BC042133 BM562822 BG189469 AW268499 BE168256 AI215430 AW189787 BE168190 
    T64682 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MROH2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MROH2A Expression
    About this image

    MROH2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MROH2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.361778
        Custom PCR Arrays for MROH2A
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MROH2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MROH2A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mroh2a1 , 5 HEAT repeat containing 7B15
    maestro heat-like repeat family member 2A1
    82.34(n)1
    80.08(a)1
      1 (44.55 cM)5
    1000407661  NM_001281466.11  NP_001268395.11 
     882269865 
    chicken
    (Gallus gallus)
    Aves --
    --
    (see all 14)
    Uncharacterized protein
    (see all 14)
    30(a)
    29(a)
    (see all 14)
    many ↔ many
    many ↔ many
    (see all 14)
    Z(67920336-67926684) ENSGALG00000028488
    1(112670966-112673532)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    26(a)
    1 → many
    GL343501.1(41664-122234)
    fruit fly
    (Drosophila melanogaster)
    Insecta c11.16
    c11.1
    17(a)
    1 → many
    X(9169681-9177150)
    worm
    (Caenorhabditis elegans)
    Secernentea hpo-276
    Protein HPO-27 (hpo-27) mRNA, complete cds
    15(a)
    1 → many
    I(5906662-5918229) WBGene00016418


    ENSEMBL Gene Tree for MROH2A (if available)
    TreeFam Gene Tree for MROH2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MROH2A gene
    MROH2B2  MRO2  MROH82  MROH7-TTC42  MROH62  MROH72  MROH12  
    5 SIMAP similar genes for MROH2A using alignment to 3 protein entries:     MRO2A_HUMAN (see all proteins):
    HEATR7B1    HEATR7B2    MRO    MROH2B    MROH1

    MROH2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MROH2A (see all 1538)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7591731,2
    C,F,A,H--226504334(-) TCACCG/AAGGGC 2 /L syn126Minor allele frequency- A:0.13NS EA NA WA CSA EU 2992
    rs115632461,2,,4
    C,F,H--226508512(+) GAGAAG/CTTTTA 2 /N /K mis133Minor allele frequency- C:0.27NA EA NS WA CSA EU 4080
    rs350328151,2
    C--226509140(+) ATAAG-/ATAGGAA 1 -- int10--------
    rs612970021,2
    C--226509141(+) TAAGA-/AT/TA 
            
    GGAAA
    1 -- int10--------
    rs109293061,2
    C,F,A,H--226510473(+) AGGCTG/CCTGTG 2 /L syn119Minor allele frequency- C:0.37NA EA NS WA CSA EU 1667
    rs44309491,2
    C,F,A,H--226513348(+) TTGAGT/CAAAGA 2 /S syn131Minor allele frequency- C:0.37NA EA NS WA CSA EU 3530
    rs718567981,2
    C--226515437(+) CCATT-/TAATATA 1 -- int10--------
    rs115632411,2
    C,F,H--226516068(+) AAAACG/AGTGCT 2 /T syn116Minor allele frequency- A:0.36NA EA NS WA EU 1683
    rs1408036971,2
    C--226524080(+) TACTG-/TTATA 
            
    TTATA
    1 -- int10--------
    rs1417475161,2
    C--226524137(+) TTTGC-/TTTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MROH2A (234684370 - 234742069 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MROH2A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MROH2A
    DNA2.0 Custom Variant and Variant Library Synthesis for MROH2A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MROH2A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MROH2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PubMed id 21646302)1 Bielinski S.J....Chute C.G. (Mayo Clin. Proc. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (Genome Res. 2007)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339766 HGNC: 27936 AceView: LOC339766 Ensembl:ENSG00000185038 euGenes: HUgn339766
    ECgene: MROH2A H-InvDB: MROH2A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MROH2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MROH2A gene:
    Search GeneIP for patents involving MROH2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MROH2A
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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