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Aliases for MROH2A Gene

Aliases for MROH2A Gene

  • Maestro Heat-Like Repeat Family Member 2A 2 3
  • HEAT Repeat-Containing Protein 7B1 3 4
  • HEAT Repeat Containing 7B1 2 3
  • HEATR7B1 3 4

External Ids for MROH2A Gene

Previous HGNC Symbols for MROH2A Gene

  • HEATR7B1

Previous GeneCards Identifiers for MROH2A Gene

  • GC02P234689
  • GC02P234698
  • GC02P234702

Summaries for MROH2A Gene

GeneCards Summary for MROH2A Gene

MROH2A (Maestro Heat-Like Repeat Family Member 2A) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH2A Gene

Genomics for MROH2A Gene

Genomic Location for MROH2A Gene

233,775,662 bp from pter
233,833,423 bp from pter
57,762 bases
Plus strand

Genomic View for MROH2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH2A Gene

No data available for Regulatory Elements for MROH2A Gene

Proteins for MROH2A Gene

  • Protein details for MROH2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Maestro heat-like repeat-containing protein family member 2A
    Protein Accession:
    Secondary Accessions:
    • F8VUA0

    Protein attributes for MROH2A Gene

    1674 amino acids
    Molecular mass:
    189561 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MROH2A Gene

Proteomics data for MROH2A Gene at MOPED

Post-translational modifications for MROH2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MROH2A Gene

No data available for DME Specific Peptides for MROH2A Gene

Domains & Families for MROH2A Gene

Gene Families for MROH2A Gene

Protein Domains for MROH2A Gene


Suggested Antigen Peptide Sequences for MROH2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 14 HEAT repeats.
  • Contains 14 HEAT repeats.
genes like me logo Genes that share domains with MROH2A: view

Function for MROH2A Gene

Gene Ontology (GO) - Molecular Function for MROH2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MROH2A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MROH2A Gene

Localization for MROH2A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH2A Gene

Pathways & Interactions for MROH2A Gene

SuperPathways for MROH2A Gene

No Data Available

Interacting Proteins for MROH2A Gene

Gene Ontology (GO) - Biological Process for MROH2A Gene


No data available for Pathways by source and SIGNOR curated interactions for MROH2A Gene

Drugs & Compounds for MROH2A Gene

No Compound Related Data Available

Transcripts for MROH2A Gene

mRNA/cDNA for MROH2A Gene

(13) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH2A Gene

Maestro heat-like repeat family member 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MROH2A Gene

No ASD Table

Relevant External Links for MROH2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MROH2A Gene

mRNA expression in normal human tissues for MROH2A Gene

mRNA differential expression in normal tissues according to GTEx for MROH2A Gene

This gene is overexpressed in Testis (x14.8), Liver (x10.7), Thyroid (x8.1), Kidney - Cortex (x4.8), and Stomach (x4.7).

Protein differential expression in normal tissues from HIPED for MROH2A Gene

This gene is overexpressed in Plasma (56.0) and Brain (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MROH2A Gene

SOURCE GeneReport for Unigene cluster for MROH2A Gene Hs.361778

genes like me logo Genes that share expression patterns with MROH2A: view

Protein tissue co-expression partners for MROH2A Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MROH2A Gene

Orthologs for MROH2A Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH2A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HEATR7B1 35
  • 85.07 (n)
  • 81.72 (a)
  • 79 (a)
(Canis familiaris)
Mammalia MROH2A 35
  • 85.47 (n)
  • 83.1 (a)
  • 84 (a)
(Mus musculus)
Mammalia Mroh2a 35
  • 82.34 (n)
  • 80.08 (a)
Mroh2a 16
Mroh2a 36
  • 80 (a)
(Pan troglodytes)
Mammalia HEATR7B1 35
  • 98.04 (n)
  • 96.54 (a)
(Monodelphis domestica)
Mammalia MROH2A 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
-- 36
  • 61 (a)
-- 36
  • 62 (a)
(Gallus gallus)
Aves -- 36
  • 25 (a)
-- 36
  • 29 (a)
-- 36
  • 23 (a)
-- 36
  • 24 (a)
-- 36
  • 27 (a)
-- 36
  • 24 (a)
-- 36
  • 29 (a)
-- 36
  • 25 (a)
-- 36
  • 26 (a)
-- 36
  • 21 (a)
-- 36
  • 25 (a)
-- 36
  • 23 (a)
-- 36
  • 25 (a)
-- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
fruit fly
(Drosophila melanogaster)
Insecta c11.1 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea hpo-27 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for MROH2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MROH2A Gene

Gene Tree for MROH2A (if available)
Gene Tree for MROH2A (if available)

Paralogs for MROH2A Gene

Paralogs for MROH2A Gene

(5) SIMAP similar genes for MROH2A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MROH2A: view

Variants for MROH2A Gene

Sequence variations from dbSNP and Humsavar for MROH2A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs122856 -- 233,832,376(-) GCCAC(A/G)TGCCT intron-variant
rs213546 -- 233,831,224(+) TGTAC(A/C)TGCAG intron-variant
rs213547 -- 233,832,112(-) ATTCA(C/T)CAAGC intron-variant
rs213548 -- 233,832,797(-) GCCTC(C/T)CCAGG intron-variant, downstream-variant-500B
rs474242 -- 233,832,339(-) AGTGC(C/T)GGGGT intron-variant

Variation tolerance for MROH2A Gene

Gene Damage Index Score: 15.34; 97.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MROH2A Gene

Disorders for MROH2A Gene

Relevant External Links for MROH2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MROH2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH2A Gene

Publications for MROH2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels. (PMID: 21646302) Bielinski S.J. … Chute C.G. (Mayo Clin. Proc. 2011) 67
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  4. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PMID: 17567994) Denoeud F. … Reymond A. (Genome Res. 2007) 67
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67

Products for MROH2A Gene

Sources for MROH2A Gene

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