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Aliases for MROH1 Gene

Aliases for MROH1 Gene

  • Maestro Heat Like Repeat Family Member 1 2 3 5
  • HEAT Repeat-Containing Protein 7A 3 4
  • HEAT Repeat Containing 7A 2 3
  • HEATR7A 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 1 3
  • Maestro Heat-Like Repeat Family Member 1 2
  • KIAA1833 4

External Ids for MROH1 Gene

Previous HGNC Symbols for MROH1 Gene

  • HEATR7A

Previous GeneCards Identifiers for MROH1 Gene

  • GC08P145203

Summaries for MROH1 Gene

GeneCards Summary for MROH1 Gene

MROH1 (Maestro Heat Like Repeat Family Member 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH2A.

Additional gene information for MROH1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH1 Gene

Genomics for MROH1 Gene

Regulatory Elements for MROH1 Gene

Enhancers for MROH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144796 1.6 Ensembl ENCODE dbSUPER 10.1 +651.0 650968 4 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143 SP3 SP5 MXD4 ZNF7 CPSF1 RPL8 VPS28 ZNF250 LRRC14 ZNF34 ZNF517 ZNF16 ZNF251
GH08H143453 1.5 Ensembl ENCODE dbSUPER 10.1 -693.5 -693493 1 PKNOX1 FOXA2 ATF1 ARNT ARID4B SIN3A DMAP1 GTF3C2 ATF7 FOS ZNF623 JRK TIGD5 CPSF1 VPS28 GPAA1 ENSG00000255050 SLC52A2 ZNF707 ZNF696
GH08H144766 1.3 Ensembl ENCODE 10.1 +619.9 619879 2 ATF1 FOXA2 ARNT ARID4B SIN3A GLI4 GTF3C2 ZNF121 ATF7 FOS RPL8 ZNF251 ZNF7 ZNF16 SLC52A2 LRRC14 ZNF250 ZNF34 CPSF1 GPAA1
GH08H144147 0.4 ENCODE 0.7 -0.3 -272 0 PKNOX1 MROH1 PIR46799
GH08H144160 0.6 ENCODE 0.4 +12.3 12257 0 FOXA2 SAP130 FOXA3 NR3C1 RFX5 FOXA1 CREB1 FOS FOSL2 MAFK MROH1 PIR33704
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MROH1 on UCSC Golden Path with GeneCards custom track

Promoters for MROH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232212 -116 1801 PKNOX1

Genomic Location for MROH1 Gene

Chromosome:
8
Start:
144,148,016 bp from pter
End:
144,261,940 bp from pter
Size:
113,925 bases
Orientation:
Plus strand

Genomic View for MROH1 Gene

Genes around MROH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH1 Gene

Proteins for MROH1 Gene

  • Protein details for MROH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDA8-MROH1_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 1
    Protein Accession:
    Q8NDA8
    Secondary Accessions:
    • C9JWM5
    • D3DWL5
    • Q0P612
    • Q569G6
    • Q6NVW4
    • Q8N230
    • Q8NAD1
    • Q8ND95
    • Q96JJ4

    Protein attributes for MROH1 Gene

    Size:
    1641 amino acids
    Molecular mass:
    181249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57824.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH67855.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92486.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38979.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH1 Gene

neXtProt entry for MROH1 Gene

Post-translational modifications for MROH1 Gene

  • Ubiquitination at posLast=717717
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MROH1 Gene

Domains & Families for MROH1 Gene

Gene Families for MROH1 Gene

Protein Domains for MROH1 Gene

Suggested Antigen Peptide Sequences for MROH1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MROH1: view

No data available for UniProtKB/Swiss-Prot for MROH1 Gene

Function for MROH1 Gene

genes like me logo Genes that share phenotypes with MROH1: view

Animal Model Products

CRISPR Products

miRNA for MROH1 Gene

miRTarBase miRNAs that target MROH1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MROH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH1 Gene

Localization for MROH1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MROH1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MROH1 Gene

Pathways & Interactions for MROH1 Gene

SuperPathways for MROH1 Gene

No Data Available

Interacting Proteins for MROH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321737%0d%0a9606.ENSP00000326579%0d%0a
Selected Interacting proteins: Q8NDA8-MROH1_HUMAN ENSP00000321737 for MROH1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MROH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH1 Gene

Drugs & Compounds for MROH1 Gene

No Compound Related Data Available

Transcripts for MROH1 Gene

mRNA/cDNA for MROH1 Gene

(25) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH1 Gene

Maestro heat-like repeat family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MROH1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MROH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^
SP1: -
SP2: - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - -
SP3:
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MROH1 Gene

GeneLoc Exon Structure for
MROH1
ECgene alternative splicing isoforms for
MROH1

Expression for MROH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MROH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MROH1 Gene

This gene is overexpressed in Thyroid (x4.1).

Protein differential expression in normal tissues from HIPED for MROH1 Gene

This gene is overexpressed in Bone (32.5), Tlymphocyte (7.5), and Neutrophil (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MROH1 Gene



Protein tissue co-expression partners for MROH1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MROH1 Gene:

MROH1

SOURCE GeneReport for Unigene cluster for MROH1 Gene:

Hs.443139
genes like me logo Genes that share expression patterns with MROH1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MROH1 Gene

Orthologs for MROH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 99 (a)
OneToMany
LOC100609789 33
  • 98.71 (n)
-- 34
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HEATR7A 33
  • 83.41 (n)
MROH1 34
  • 81 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MROH1 34 33
  • 81.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mroh1 33 16 34
  • 80.79 (n)
oppossum
(Monodelphis domestica)
Mammalia MROH1 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MROH1 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MROH1 34
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MROH1 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489995 33
  • 61.24 (n)
zebrafish
(Danio rerio)
Actinopterygii mroh1 33 34
  • 55.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000273 33
  • 46.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta c11.1 33 34
  • 44.17 (n)
worm
(Caenorhabditis elegans)
Secernentea hpo-27 34
  • 25 (a)
OneToMany
Species where no ortholog for MROH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MROH1 Gene

ENSEMBL:
Gene Tree for MROH1 (if available)
TreeFam:
Gene Tree for MROH1 (if available)

Paralogs for MROH1 Gene

Paralogs for MROH1 Gene

(3) SIMAP similar genes for MROH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MROH1: view

Variants for MROH1 Gene

Sequence variations from dbSNP and Humsavar for MROH1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000054419 -- 144,176,213(+) AATAC(A/G)AAAAA intron-variant
rs1000058845 -- 144,255,558(+) GCCCG(C/T)GGTGC nc-transcript-variant, reference, missense
rs1000087238 -- 144,250,910(+) CCACC(C/T)ACCAG intron-variant, utr-variant-3-prime
rs1000118506 -- 144,251,049(+) ACTCC(A/C)TGCTG intron-variant, utr-variant-3-prime
rs1000137051 -- 144,187,536(+) AAATT(A/T)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MROH1 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv3932n106 CNV deletion 24896259
dgv906n27 CNV loss 19166990
esv1268119 CNV deletion 17803354
esv1342065 CNV insertion 17803354
esv1534291 CNV insertion 17803354
esv2068640 CNV deletion 18987734
esv2502973 CNV insertion 19546169
esv2738052 CNV deletion 23290073
esv2738053 CNV deletion 23290073
esv2738054 CNV deletion 23290073
esv2759651 CNV gain 17122850
esv2761475 CNV loss 21179565
esv29971 CNV loss 17803354
esv3336198 CNV duplication 20981092
esv3445951 CNV insertion 20981092
esv3619125 CNV loss 21293372
esv995753 CNV deletion 20482838
nsv1025071 CNV gain 25217958
nsv1030888 CNV gain 25217958
nsv1075180 CNV deletion 25765185
nsv1075598 CNV deletion 25765185
nsv1075599 CNV deletion 25765185
nsv1122205 CNV deletion 24896259
nsv1126867 CNV deletion 24896259
nsv1145205 CNV deletion 24896259
nsv397598 CNV deletion 16902084
nsv398283 CNV deletion 16902084
nsv428208 CNV gain 18775914
nsv466014 CNV loss 19166990
nsv470249 CNV loss 18288195
nsv512980 CNV insertion 21212237
nsv515809 CNV gain+loss 19592680
nsv612915 CNV loss 21841781
nsv824802 CNV gain 20364138
nsv824803 CNV gain 20364138
nsv8395 CNV gain+loss 18304495
nsv950016 CNV deletion 24416366
nsv950822 CNV deletion 24416366

Variation tolerance for MROH1 Gene

Gene Damage Index Score: 1.85; 34.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MROH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MROH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MROH1 Gene

Disorders for MROH1 Gene

Relevant External Links for MROH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH1

No disorders were found for MROH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH1 Gene

Publications for MROH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for MROH1 Gene

Sources for MROH1 Gene

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