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Aliases for MROH1 Gene

Aliases for MROH1 Gene

  • Maestro Heat Like Repeat Family Member 1 2 3
  • Maestro Heat-Like Repeat Family Member 1 2 3 5
  • HEAT Repeat-Containing Protein 7A 3 4
  • HEAT Repeat Containing 7A 2 3
  • HEATR7A 3 4
  • KIAA1833 4

External Ids for MROH1 Gene

Previous HGNC Symbols for MROH1 Gene

  • HEATR7A

Previous GeneCards Identifiers for MROH1 Gene

  • GC08P145203

Summaries for MROH1 Gene

GeneCards Summary for MROH1 Gene

MROH1 (Maestro Heat Like Repeat Family Member 1) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH1 Gene

Genomics for MROH1 Gene

Regulatory Elements for MROH1 Gene

Enhancers for MROH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MROH1 on UCSC Golden Path with GeneCards custom track

Promoters for MROH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MROH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MROH1 Gene

Chromosome:
8
Start:
144,148,016 bp from pter
End:
144,261,940 bp from pter
Size:
113,925 bases
Orientation:
Plus strand

Genomic View for MROH1 Gene

Genes around MROH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MROH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MROH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH1 Gene

Proteins for MROH1 Gene

  • Protein details for MROH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDA8-MROH1_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 1
    Protein Accession:
    Q8NDA8
    Secondary Accessions:
    • C9JWM5
    • D3DWL5
    • Q0P612
    • Q569G6
    • Q6NVW4
    • Q8N230
    • Q8NAD1
    • Q8ND95
    • Q96JJ4

    Protein attributes for MROH1 Gene

    Size:
    1641 amino acids
    Molecular mass:
    181249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57824.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH67855.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92486.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38979.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH1 Gene

neXtProt entry for MROH1 Gene

Proteomics data for MROH1 Gene at MOPED

Post-translational modifications for MROH1 Gene

  • Ubiquitination at Lys 717
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MROH1 Gene

Domains & Families for MROH1 Gene

Gene Families for MROH1 Gene

Protein Domains for MROH1 Gene

Suggested Antigen Peptide Sequences for MROH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDA8

UniProtKB/Swiss-Prot:

MROH1_HUMAN :
  • Contains 7 HEAT repeats.
Similarity:
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with MROH1: view

Function for MROH1 Gene

genes like me logo Genes that share phenotypes with MROH1: view

Animal Model Products

miRNA for MROH1 Gene

miRTarBase miRNAs that target MROH1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MROH1 Gene

Localization for MROH1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MROH1 Gene

Pathways & Interactions for MROH1 Gene

SuperPathways for MROH1 Gene

No Data Available

Interacting Proteins for MROH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321737%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000321737 for MROH1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MROH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MROH1 Gene

Drugs & Compounds for MROH1 Gene

No Compound Related Data Available

Transcripts for MROH1 Gene

mRNA/cDNA for MROH1 Gene

(21) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH1 Gene

Maestro heat-like repeat family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MROH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^
SP1: -
SP2: - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - -
SP3:
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MROH1 Gene

GeneLoc Exon Structure for
MROH1
ECgene alternative splicing isoforms for
MROH1

Expression for MROH1 Gene

mRNA expression in normal human tissues for MROH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MROH1 Gene

This gene is overexpressed in Thyroid (x4.1).

Protein differential expression in normal tissues from HIPED for MROH1 Gene

This gene is overexpressed in Bone (32.5), Tlymphocyte (7.5), and Neutrophil (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MROH1 Gene



SOURCE GeneReport for Unigene cluster for MROH1 Gene Hs.443139

genes like me logo Genes that share expression patterns with MROH1: view

Protein tissue co-expression partners for MROH1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MROH1 Gene

Orthologs for MROH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MROH1 35
  • 81.18 (n)
  • 76.77 (a)
MROH1 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEATR7A 35
  • 83.41 (n)
  • 80.6 (a)
MROH1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mroh1 35
  • 80.79 (n)
  • 79.09 (a)
Mroh1 16
Mroh1 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100609789 35
  • 98.71 (n)
  • 98.89 (a)
-- 36
  • 99 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MROH1 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MROH1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MROH1 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MROH1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489995 35
  • 61.24 (n)
  • 51.97 (a)
zebrafish
(Danio rerio)
Actinopterygii mroh1 35
  • 55.91 (n)
  • 46.44 (a)
mroh1 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000273 35
  • 46.53 (n)
  • 26.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta c11.1 35
  • 44.17 (n)
  • 27.27 (a)
c11.1 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-27 36
  • 25 (a)
OneToMany
Species with no ortholog for MROH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MROH1 Gene

ENSEMBL:
Gene Tree for MROH1 (if available)
TreeFam:
Gene Tree for MROH1 (if available)

Paralogs for MROH1 Gene

Paralogs for MROH1 Gene

(3) SIMAP similar genes for MROH1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MROH1 Gene

genes like me logo Genes that share paralogs with MROH1: view

Variants for MROH1 Gene

Sequence variations from dbSNP and Humsavar for MROH1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs34819224 - 144,168,385(+) GGAGG(C/G/T)GCGGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs7832801 -- 144,217,581(+) CAAAC(C/T)TTATT intron-variant
rs7833720 -- 144,161,320(+) gtggg(A/C)agctt intron-variant
rs7834431 -- 144,259,597(+) AGTCC(A/T)GCTGG intron-variant
rs7835870 -- 144,173,434(+) ttttt(A/T)ttttt intron-variant

Variation tolerance for MROH1 Gene

Gene Damage Index Score: 1.85; 34.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MROH1 Gene

Disorders for MROH1 Gene

Relevant External Links for MROH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MROH1

No disorders were found for MROH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MROH1 Gene

Publications for MROH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for MROH1 Gene

Sources for MROH1 Gene

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