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Aliases for MROH1 Gene

Aliases for MROH1 Gene

  • Maestro Heat-Like Repeat Family Member 1 2 3
  • HEAT Repeat-Containing Protein 7A 3 4
  • HEAT Repeat Containing 7A 2 3
  • HEATR7A 3 4
  • Maestro Heat-Like Repeat-Containing Protein Family Member 1 3
  • KIAA1833 4

External Ids for MROH1 Gene

Previous Symbols for MROH1 Gene

  • HEATR7A

Summaries for MROH1 Gene

GeneCards Summary for MROH1 Gene

MROH1 (Maestro Heat-Like Repeat Family Member 1) is a Protein Coding gene. An important paralog of this gene is MROH7-TTC4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MROH1 Gene

Genomics for MROH1 Gene

Genomic Location for MROH1 Gene

Start:
144,148,016 bp from pter
End:
144,261,940 bp from pter
Size:
113,925 bases
Orientation:
Plus strand

Genomic View for MROH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MROH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MROH1 Gene

No data available for Regulatory Elements for MROH1 Gene

Proteins for MROH1 Gene

  • Protein details for MROH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDA8-MROH1_HUMAN
    Recommended name:
    Maestro heat-like repeat-containing protein family member 1
    Protein Accession:
    Q8NDA8
    Secondary Accessions:
    • C9JWM5
    • D3DWL5
    • Q0P612
    • Q569G6
    • Q6NVW4
    • Q8N230
    • Q8NAD1
    • Q8ND95
    • Q96JJ4

    Protein attributes for MROH1 Gene

    Size:
    1641 amino acids
    Molecular mass:
    181249 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH57824.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH67855.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92486.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB47462.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD38979.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MROH1 Gene

neXtProt entry for MROH1 Gene

Proteomics data for MROH1 Gene at MOPED

Post-translational modifications for MROH1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys717

No data available for DME Specific Peptides for MROH1 Gene

Domains for MROH1 Gene

Gene Families for MROH1 Gene

HGNC:
  • MROH :maestro heat-like repeat containing

Protein Domains for MROH1 Gene

UniProtKB/Swiss-Prot:

MROH1_HUMAN
Similarity:
  • Contains 7 HEAT repeats.:
    • Q8NDA8
genes like me logo Genes that share domains with MROH1: view

Function for MROH1 Gene

Gene Ontology (GO) - Molecular Function for MROH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with MROH1: view

Phenotypes for MROH1 Gene

GenomeRNAi human phenotypes for MROH1:
genes like me logo Genes that share phenotypes with MROH1: view

miRNA for MROH1 Gene

miRTarBase miRNAs that target MROH1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MROH1 Gene

Localization for MROH1 Gene

No data available for Gene Ontology (GO) - Cellular Components for MROH1 Gene

Pathways for MROH1 Gene

SuperPathways for MROH1 Gene

No Data Available

Interacting Proteins for MROH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000321737%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000321737 for MROH1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for MROH1 Gene

None

No data available for Pathways by source for MROH1 Gene

Transcripts for MROH1 Gene

mRNA/cDNA for MROH1 Gene

(21) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MROH1 Gene

Maestro heat-like repeat family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MROH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b · 22c ^
SP1: -
SP2: - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b · 40c ^ 41 ^ 42 ^
SP1:
SP2: - -
SP3:
SP4:
SP5: - - - - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - - - - - - - - -
SP7: -
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MROH1 Gene

GeneLoc Exon Structure for
MROH1
ECgene alternative splicing isoforms for
MROH1

Expression for MROH1 Gene

mRNA expression in normal human tissues for MROH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MROH1 Gene

This gene is overexpressed in Thyroid (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MROH1 Gene

SOURCE GeneReport for Unigene cluster for MROH1 Gene Hs.443139

genes like me logo Genes that share expressions with MROH1: view

Orthologs for MROH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MROH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 99 (a)
OneToMany
-- 37
  • 87 (a)
OneToMany
LOC100609789 36
  • 98.71 (n)
  • 98.89 (a)
cow
(Bos Taurus)
Mammalia MROH1 36
  • 81.18 (n)
  • 76.77 (a)
MROH1 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HEATR7A 36
  • 83.41 (n)
  • 80.6 (a)
MROH1 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mroh1 36
  • 80.79 (n)
  • 79.09 (a)
Mroh1 16
Mroh1 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MROH1 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MROH1 37
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MROH1 37
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MROH1 37
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489995 36
  • 61.24 (n)
  • 51.97 (a)
zebrafish
(Danio rerio)
Actinopterygii mroh1 36
  • 55.91 (n)
  • 46.44 (a)
mroh1 37
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000273 36
  • 46.53 (n)
  • 26.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta c11.1 36
  • 44.17 (n)
  • 27.27 (a)
c11.1 37
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-27 37
  • 25 (a)
OneToMany
Species with no ortholog for MROH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MROH1 Gene

ENSEMBL:
Gene Tree for MROH1 (if available)
TreeFam:
Gene Tree for MROH1 (if available)

Paralogs for MROH1 Gene

Paralogs for MROH1 Gene

Selected SIMAP similar genes for MROH1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MROH1 Gene

genes like me logo Genes that share paralogs with MROH1: view

Variants for MROH1 Gene

Sequence variations from dbSNP and Humsavar for MROH1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1134638 -- 144,213,269(+) AGGTT(A/C)CATGG utr-variant-3-prime, intron-variant
rs3905292 -- 144,228,892(-) atgac(A/G)cccat intron-variant
rs4910258 -- 144,231,163(-) GAAAA(A/C/G)TTCTT intron-variant
rs4977179 -- 144,173,713(-) gggcg(C/G)agtgg intron-variant
rs4977190 -- 144,168,872(-) GGTGC(A/G)GGAAG intron-variant

Relevant External Links for MROH1 Gene

HapMap Linkage Disequilibrium report
MROH1

No data available for Structural Variations from Database of Genomic Variants (DGV) for MROH1 Gene

Disorders for MROH1 Gene

No disorders were found for MROH1 Gene.

No data available for UniProtKB/Swiss-Prot for MROH1 Gene

Publications for MROH1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for MROH1 Gene

Sources for MROH1 Gene

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