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Aliases for MRO Gene

Aliases for MRO Gene

  • Maestro 2 3
  • B29 3 4 6
  • Male-Specific Transcription In The Developing Reproductive Organs 3 4
  • Beside The Ma29 Deletion 2 3
  • C18orf3 3 4
  • Chromosome 18 Open Reading Frame 3 2
  • Protein Maestro 3
  • B29 Protein 2
  • Protein B29 4

External Ids for MRO Gene

Previous HGNC Symbols for MRO Gene

  • C18orf3

Previous GeneCards Identifiers for MRO Gene

  • GC18M046577
  • GC18M046578
  • GC18M048321
  • GC18M045176

Summaries for MRO Gene

Entrez Gene Summary for MRO Gene

  • This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRO Gene

MRO (Maestro) is a Protein Coding gene. Diseases associated with MRO include melorheostosis. An important paralog of this gene is MROH7-TTC4.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRO Gene

Genomics for MRO Gene

Regulatory Elements for MRO Gene

Genomic Location for MRO Gene

Start:
50,795,120 bp from pter
End:
50,825,438 bp from pter
Size:
30,319 bases
Orientation:
Minus strand

Genomic View for MRO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRO Gene

Proteins for MRO Gene

  • Protein details for MRO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYG7-MSTRO_HUMAN
    Recommended name:
    Protein maestro
    Protein Accession:
    Q9BYG7
    Secondary Accessions:
    • B7Z2I5
    • B7Z3B2
    • E9PAT5
    • E9PBI3
    • K7EKJ8
    • Q8N6K5

    Protein attributes for MRO Gene

    Size:
    248 amino acids
    Molecular mass:
    29054 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRO Gene

neXtProt entry for MRO Gene

Proteomics data for MRO Gene at MOPED

Post-translational modifications for MRO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRO Gene

Domains for MRO Gene

Gene Families for MRO Gene

HGNC:
  • MROH :maestro heat-like repeat containing

Protein Domains for MRO Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYG7

UniProtKB/Swiss-Prot:

MSTRO_HUMAN :
  • Q9BYG7
Similarity:
  • Contains 1 HEAT repeat.
genes like me logo Genes that share domains with MRO: view

Function for MRO Gene

Gene Ontology (GO) - Molecular Function for MRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
genes like me logo Genes that share ontologies with MRO: view
genes like me logo Genes that share phenotypes with MRO: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRO Gene

Localization for MRO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRO Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRO Gene COMPARTMENTS Subcellular localization image for MRO gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with MRO: view

Pathways for MRO Gene

SuperPathways for MRO Gene

No Data Available

Interacting Proteins for MRO Gene

Selected Interacting proteins: Q9BYG7-MSTRO_HUMAN for MRO Gene via I2D

Symbol External ID(s) Details
OS9

Gene Ontology (GO) - Biological Process for MRO Gene

None

No data available for Pathways by source for MRO Gene

Transcripts for MRO Gene

Unigene Clusters for MRO Gene

Maestro:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRO

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for MRO Gene

GeneLoc Exon Structure for
MRO
ECgene alternative splicing isoforms for
MRO

Expression for MRO Gene

mRNA expression in normal human tissues for MRO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRO Gene

This gene is overexpressed in Brain - Amygdala (5.5), Brain - Caudate (basal ganglia) (5.2), and Brain - Nucleus accumbens (basal ganglia) (5.0).

SOURCE GeneReport for Unigene cluster for MRO Gene Hs.30495

mRNA Expression by UniProt/SwissProt for MRO Gene

Q9BYG7-MSTRO_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MRO: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for MRO Gene

Orthologs for MRO Gene

This gene was present in the common ancestor of animals.

Orthologs for MRO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRO 35
  • 85.28 (n)
  • 80.95 (a)
MRO 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483979 35
  • 85.75 (n)
  • 80.24 (a)
MRO 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mro 35
  • 79.23 (n)
  • 74.18 (a)
Mro 16
Mro 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRO 35
  • 99.19 (n)
  • 98.39 (a)
MRO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mro 35
  • 73.6 (n)
  • 65.93 (a)
oppossum
(Monodelphis domestica)
Mammalia MRO 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRO 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
  • 1 (a)
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
ManyToMany
-- 36
  • 1 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 5 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta c11.1 36
  • 3 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpo-27 36
  • 2 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
OneToMany
Species with no ortholog for MRO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MRO Gene

ENSEMBL:
Gene Tree for MRO (if available)
TreeFam:
Gene Tree for MRO (if available)

Paralogs for MRO Gene

Paralogs for MRO Gene

Selected SIMAP similar genes for MRO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MRO: view

Variants for MRO Gene

Sequence variations from dbSNP and Humsavar for MRO Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1115081 -- 50,811,993(-) aggct(A/G)aggta intron-variant
rs1822462 -- 50,809,957(+) GGGCA(A/G)GGGAA intron-variant
rs2218369 -- 50,813,747(-) CATGC(A/G)GTACT intron-variant
rs2255059 -- 50,801,633(+) ATCGA(C/T)CTTGA intron-variant
rs2255672 -- 50,806,997(+) TTTGT(C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRO Gene

Variant ID Type Subtype PubMed ID
nsv9630 CNV Loss 18304495
nsv527714 CNV Gain 19592680

Relevant External Links for MRO Gene

HapMap Linkage Disequilibrium report
MRO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRO Gene

Disorders for MRO Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MRO Gene in MalaCards »

(1) Diseases for MRO Gene including...

(2) University of Copenhagen DISEASES for MRO Gene

genes like me logo Genes that share disorders with MRO: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for MRO Gene

Publications for MRO Gene

  1. Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PMID: 11401430) Yanaihara N. … Yokota J. (Genomics 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MRO Gene

Sources for MRO Gene

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