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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MRO Gene

protein-coding GIFtS: 45
GCID: GC18M048321

maestro

(Previous name: chromosome 18 open reading frame 3 )
(Previous symbol: C18orf3)

Explore 2 diseases affiliated with
MRO via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Maestro¹		Chromosome 18 Open Reading Frame 3¹
B29¹ ² ³ ⁵		Beside The Ma29 Deletion²
C18orf3¹ ² ³		Protein Maestro²
Male-Specific Transcription In The Developing Reproductive Organs² ³		Protein B29³
FLJ30140¹

External Ids:	HGNC: 24121¹	Entrez Gene: 83876²	Ensembl: ENSG00000134042⁷	OMIM: 608080⁵	UniProtKB: Q9BYG7³

Export aliases for MRO gene to outside databases

Previous GC identifers: GC18M046577 GC18M046578 GC18M045176

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRO:

This gene is specifically transcribed in males before and after differentiation of testis, and the encoded protein may

play an important role in a mammalian sex determination. Multiple transcript variants encoding different isoforms have

been found for this gene. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010966.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MRO gene promoter:
Oct-B1 TBP oct-B2 oct-B3 POU2F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRO promoter sequence

Search SABiosciences Chromatin IP Primers for MRO

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRO

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21

MRO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRO gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M048321: view genomic region (about GC identifiers)

Start:	48,321,490 bp from pter	End:	48,351,772 bp from pter
Size:	30,283 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MSTRO_HUMAN, Q9BYG7 (See protein sequence)

Recommended Name: Protein maestro

Size: 248 amino acids; 29054 Da

Subcellular location: Nucleus, nucleolus (By similarity)

Secondary accessions: B7Z3B2 E9PBI3 Q8N6K5

Alternative splicing: 4 isoforms: Q9BYG7-1 Q9BYG7-2 Q9BYG7-3 Q9BYG7-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRO: NX_Q9BYG7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BYG7

MRO Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001120646.1 NP_001120647.1 NP_001120648.1 NP_114145.2

ENSEMBL proteins:

ENSP00000465783 ENSP00000409509 ENSP00000392614 ENSP00000256425 ENSP00000465653

ENSP00000467427 ENSP00000466218 ENSP00000397900 ENSP00000381465

Human Recombinant Protein Products for MRO:

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	Novus Biologicals MRO Protein Novus Biologicals MRO Lysate
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	Uscn Proteins for MRO

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005730	nucleolus	IEA	--

MRO for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRO for domains About GeneDecksing

2 InterPro domains/families:

IPR011989 ARM-like

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q9BYG7

ProtoNet protein and cluster: Q9BYG7

1 Blocks protein family: IPB000357 HEAT repeat

UniProtKB/Swiss-Prot: MSTRO_HUMAN, Q9BYG7

Similarity: Contains 1 HEAT repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mro):

behavior/neurological

growth/size

no phenotypic analysis

reproductive system

MRO for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRO

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MRO Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRO
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MRO (see all 16):
		hsa-miR-539 hsa-miR-548s hsa-miR-3150a-3p hsa-miR-4314 hsa-miR-1290 hsa-miR-3671 hsa-miR-595 hsa-miR-4268

		SwitchGear 3'UTR luciferase reporter plasmid: MRO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRO

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MRO

1 Interacting protein for MRO (Q9BYG7³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OS9	Q13438³	I2D: score=1

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRO
Search CenterWatch for drugs/clinical trials and news about MRO / MSTRO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRO gene (4 alternative transcripts):

NM_001127174.1 NM_001127175.1 NM_001127176.1 NM_031939.3

Unigene Cluster for MRO:

Maestro

Hs.30495 [show with all ESTs]

Unigene Representative Sequence: NM_031939

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000585524 ENST00000428869(uc010dpc.3) ENST00000431965(uc010dpb.3)

ENST00000256425 ENST00000588444 ENST00000592966 ENST00000587291 ENST00000590988

ENST00000436348(uc010dpa.3) ENST00000398439(uc010xdn.2 uc002lew.4 uc002lex.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MRO Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRO
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate MRO (see all 16):
		hsa-miR-539 hsa-miR-548s hsa-miR-3150a-3p hsa-miR-4314 hsa-miR-1290 hsa-miR-3671 hsa-miR-595 hsa-miR-4268

		SwitchGear 3'UTR luciferase reporter plasmid: MRO 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRO (see all 4) OriGene shRNA RFP: MRO OriGene siRNA: MRO
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MRO

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRO (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRO (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for MRO
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRO

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRO Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRO
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRO

Additional cDNA sequence:

AB042647.1 AK054702.1 AK294757.1 AK295666.1 BC029860.1

6 DOTS entries:

DT.95222495 DT.100018021 DT.75100889 DT.100018022 DT.99997959 DT.121097458

24/25 AceView cDNA sequences (see all 25):

AI538185 AI016513 BI829978 AI431829 BP348764 CD673156 BF512298 AL705398

AI538175 AK054702 AA884302 BX114686 AI829586 AI568156 BC029860 AB042647

NM_031939 AW070224 CD243973 BE466301 AW271651 AI827773 BF511412 BU854524

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for MRO About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b
SP1:									-
SP2:					-		-		-		-														-
SP3:					-		-		-
SP4:									-		-				-										-
SP5:

ECgene alternative splicing isoforms for MRO

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTGTAAGTG

About this image

MRO expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MRO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRO

SOURCE GeneReport for Unigene cluster: Hs.30495

UniProtKB/Swiss-Prot: MSTRO_HUMAN, Q9BYG7

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for MRO

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRO

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRO

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRO gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	HEATR7A⁶ HEATR7B2⁶	--	5(a)	possible ortholog 1 ↔ many	GL343744.1(3750-50493) GL343501.1(44245-118165)
fruit fly (Drosophila melanogaster)	Insecta	c11.1⁶	c11.1	3(a)	1 → many	X(9169681-9177150)
worm (Caenorhabditis elegans)	Secernentea	hpo-27⁶	Protein HPO-27	2(a)	1 → many	I(5906665-5917784)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G36810⁶	uncharacterized protein	2(a)	1 → many	2(15425479-15439462)
rice (Oryza sativa)	Liliopsida	--	HEAT repeat family protein, putative, expressed	5(a)	1 → many	3(2592125-2604498)

ENSEMBL Gene Tree for MRO (if available)
TreeFam Gene Tree for MRO (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2847541^1,2	C,F,H	--	48321014(-)	`AATTGC/TTGGGC`	4	--	ds500¹		22		NS EA NA	2646
rs7232670^1,2	C,F,H	--	48321026(+)	`tatacA/Cttggg`	4	--	ds500¹		5		NS EA WA	538
rs186802035^1,2		--	48321100(+)	`CTAAAC/TGGCAG`	4	--	ds500¹		0	--	--	--	--
rs142945031^1,2		--	48321158(+)	`GGGCAC/TTTGGA`	4	--	ds500¹		0	--	--	--	--
rs191274496^1,2		--	48321176(+)	`CAGGGA/CATGGC`	4	--	ds500¹		0	--	--	--	--
rs151115704^1,2		--	48321225(+)	`GGAATC/TGAGGA`	4	--	ds500¹		0	--	--	--	--
rs184097975^1,2		--	48321245(+)	`GGAAAC/TTCTAG`	4	--	ds500¹		0	--	--	--	--
rs141052162^1,2		--	48321410(+)	`TGAAAC/TCATTT`	4	--	ds500¹		0	--	--	--	--
rs145014641^1,2		--	48321415(+)	`CCATTC/TAACAT`	4	--	ds500¹		0	--	--	--	--
rs189785528^1,2		--	48321419(+)	`TTAACA/GTGTAA`	4	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MRO (48321490 - 48351772 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRO: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRO

DNA2.0 Custom Variant and Variant Library Synthesis for MRO

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MRO for disorders           About GeneDecksing

OMIM gene information: 608080    OMIM disorders: --

2 diseases for MRO:    About MalaCards

melorheostosis osteopoikilosis

2 diseases from the University of Copenhagen DISEASES database for MRO:

Melorheostosis Osteopoikilosis

Export disorders for MRO gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MRO gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRO)

Utopia: connect your pdf to the dynamic
world of online information

Physical and transcriptional map of a 311-kb segment of chromosome 18q21, a candidate lung tumor suppressor locus. (PubMed id 11401430)^{1, 2, 3} Yanaihara N.... Yokota J. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
DNA sequence and analysis of human chromosome 18. (PubMed id 16177791)² Nusbaum C.... Lander E.S. (2005)
Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein. (PubMed id 12889070)¹ Smith L....Greenfield A. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83876	HGNC: 24121	AceView: MRO	Ensembl:ENSG00000134042	euGenes: HUgn83876
ECgene: MRO	H-InvDB: MRO

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MRO	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MRO gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MRO gene:
Search GeneIP for patents involving MRO

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for MRO
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRO		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRO
	OriGene Protein Over-expression Lysate for MRO		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MRO		OriGene 3'-UTR Clone for MRO
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRO		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRO
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MRO		OriGene Custom Protein Services for MRO
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRO
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRO
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRO
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRO
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRO
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRO

	GenScript Custom Purified and Recombinant Proteins Services for MRO		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MRO
	GenScript Custom Assay Services for MRO		GenScript Custom Superior Antibodies Services for MRO
	GenScript Custom overexpressing Cell Line Services for MRO		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRO

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRO

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRO

Sirion Biotech Customized:

	stable knockdown cell line services for MRO
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	design and validation of potent shRNA sequences against MRO
	adenovirus for potent knockdown of MRO
	adenovirus for overexpression of MRO
	stable overexpressing cell line services for MRO
	inducible overexpressing cell line services for MRO

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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