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Aliases for MRNIP Gene

Aliases for MRNIP Gene

  • MRN Complex Interacting Protein 2 3 5
  • MRN-Interacting Protein 2 3 4
  • C5orf45 3 4
  • Chromosome 5 Open Reading Frame 45 2
  • Truncated Calcium Binding Protein 2
  • MRN Complex-Interacting Protein 3
  • UPF0544 Protein C5orf45 3

External Ids for MRNIP Gene

Previous HGNC Symbols for MRNIP Gene

  • C5orf45

Previous GeneCards Identifiers for MRNIP Gene

  • GC05M179840

Summaries for MRNIP Gene

GeneCards Summary for MRNIP Gene

MRNIP (MRN Complex Interacting Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRNIP Gene

  • Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRNIP Gene

Genomics for MRNIP Gene

Regulatory Elements for MRNIP Gene

Enhancers for MRNIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G179836 1.2 ENCODE dbSUPER 29.4 +25.0 24976 2.0 HDGF PKNOX1 MLX ARID4B DMAP1 RAD21 ZNF48 RARA SCRT2 FOS MRNIP LOC100996419 TBC1D9B MGAT4B SQSTM1 MIR1229 LTC4S MAML1 CBY3 RNF130
GH05G179817 1.4 ENCODE dbSUPER 25.2 +41.6 41614 6.5 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MRNIP TBC1D9B RNF130 MAML1 CANX GC05P179824 PIR43055 MGAT4B
GH05G179826 1 ENCODE dbSUPER 27.8 +34.7 34672 1.5 CTCF MAX YBX1 ZIC2 ZNF366 POLR2A ZBTB48 ZNF207 ZNF600 FOS MRNIP SQSTM1 TBC1D9B MGAT4B MIR1229 LTC4S MAML1 GC05P179824 PIR43055 PIR32850
GH05G179839 1 ENCODE dbSUPER 25.4 +22.4 22413 0.9 CTCF KLF1 MAX RAD21 ZFHX2 EGR1 POLR2A SCRT2 ZNF600 EGR2 MRNIP TBC1D9B MGAT4B SQSTM1 MIR1229 LTC4S MAML1 PIR46844 PIR36293
GH05G179825 1.1 ENCODE dbSUPER 20.4 +36.3 36304 1.4 SOX13 TBP CTCF MXI1 FOXA2 SAP130 ARID4B SIN3A CEBPG ZNF384 MRNIP MIR1229 LTC4S MAML1 TBC1D9B GC05P179824 PIR43055 PIR32850
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRNIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MRNIP Gene

Chromosome:
5
Start:
179,835,133 bp from pter
End:
179,862,173 bp from pter
Size:
27,041 bases
Orientation:
Minus strand

Genomic View for MRNIP Gene

Genes around MRNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRNIP Gene

Proteins for MRNIP Gene

  • Protein details for MRNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTE8-MRNIP_HUMAN
    Recommended name:
    MRN complex-interacting protein
    Protein Accession:
    Q6NTE8
    Secondary Accessions:
    • B5MD09
    • E9PAK6
    • Q7Z3D8
    • Q9BUC1
    • Q9UN54

    Protein attributes for MRNIP Gene

    Size:
    343 amino acids
    Molecular mass:
    37743 Da
    Quaternary structure:
    • Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive (PubMed:27568553). Interacts with MRE11 (PubMed:27568553). Interacts with NBN (PubMed:27568553). Interacts with RAD50 (PubMed:27568553).
    SequenceCaution:
    • Sequence=AAD51611.1; Type=Frameshift; Positions=191; Evidence={ECO:0000305}; Sequence=CAD97932.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRNIP Gene

Post-translational modifications for MRNIP Gene

  • Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRNIP Gene

Domains & Families for MRNIP Gene

Protein Domains for MRNIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRNIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NTE8

UniProtKB/Swiss-Prot:

MRNIP_HUMAN :
  • Belongs to the MRNIP family.
Family:
  • Belongs to the MRNIP family.
genes like me logo Genes that share domains with MRNIP: view

No data available for Gene Families for MRNIP Gene

Function for MRNIP Gene

Molecular function for MRNIP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).

Gene Ontology (GO) - Molecular Function for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003682 chromatin binding IDA 27568553
GO:0005515 protein binding IPI 27568553
genes like me logo Genes that share ontologies with MRNIP: view
genes like me logo Genes that share phenotypes with MRNIP: view

Animal Models for MRNIP Gene

MGI Knock Outs for MRNIP:

Animal Model Products

CRISPR Products

miRNA for MRNIP Gene

miRTarBase miRNAs that target MRNIP

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRNIP Gene

Localization for MRNIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRNIP Gene

Nucleus. Nucleus, nucleoplasm. Note=Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553). {ECO:0000269 PubMed:27568553}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRNIP gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA,IEA 27568553
GO:0005654 nucleoplasm IDA,IEA 27568553
GO:0030870 colocalizes_with Mre11 complex IDA 27568553
genes like me logo Genes that share ontologies with MRNIP: view

Pathways & Interactions for MRNIP Gene

SuperPathways for MRNIP Gene

No Data Available

Interacting Proteins for MRNIP Gene

Selected Interacting proteins: Q6NTE8-MRNIP_HUMAN for MRNIP Gene via IID

Symbol External ID(s) Details
LRRK2

Gene Ontology (GO) - Biological Process for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 27568553
GO:0007095 mitotic G2 DNA damage checkpoint IMP 27568553
GO:0008150 biological_process ND --
GO:0010212 response to ionizing radiation IMP 27568553
genes like me logo Genes that share ontologies with MRNIP: view

No data available for Pathways by source and SIGNOR curated interactions for MRNIP Gene

Drugs & Compounds for MRNIP Gene

No Compound Related Data Available

Transcripts for MRNIP Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRNIP Gene

No ASD Table

Relevant External Links for MRNIP Gene

GeneLoc Exon Structure for
MRNIP
ECgene alternative splicing isoforms for
MRNIP

Expression for MRNIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MRNIP Gene:

MRNIP

Evidence on tissue expression from TISSUES for MRNIP Gene

  • Lung(4.2)
  • Nervous system(3.3)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRNIP Gene

Orthologs for MRNIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf45 34
  • 99.13 (n)
C5orf45 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5orf45 35
  • 83 (a)
OneToOne
C11H5orf45 34
  • 71.26 (n)
cow
(Bos Taurus)
Mammalia C7H5orf45 35 34
  • 72.07 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564036 34
  • 67.94 (n)
mouse
(Mus musculus)
Mammalia 3010026O09Rik 35 34
  • 67.57 (n)
OneToOne
Mrnip 16
lizard
(Anolis carolinensis)
Reptilia C5orf45 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C14H5orf45 35
  • 21 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43295 35
  • 27 (a)
OneToOne
Species where no ortholog for MRNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRNIP Gene

ENSEMBL:
Gene Tree for MRNIP (if available)
TreeFam:
Gene Tree for MRNIP (if available)

Paralogs for MRNIP Gene

No data available for Paralogs for MRNIP Gene

Variants for MRNIP Gene

Sequence variations from dbSNP and Humsavar for MRNIP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10277 Likely benign 179,837,731(+) CAAAT(C/T)GCGCC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1060271 Likely benign 179,837,132(-) AAGAG(A/C)CCAGG intron-variant, utr-variant-3-prime
rs1065154 Likely benign 179,837,915(-) TTACA(A/C)ATGGA intron-variant, utr-variant-3-prime
rs10688915 Likely benign 179,836,781(+) GTGTG(-/TG)CTGAT intron-variant, utr-variant-3-prime
rs11548631 Likely benign 179,836,872(-) CCCCT(C/G)CAGGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRNIP Gene

Variant ID Type Subtype PubMed ID
esv2667626 CNV deletion 23128226
esv2731309 CNV deletion 23290073
esv2731310 CNV deletion 23290073
esv2731311 CNV deletion 23290073
esv3567108 CNV deletion 23714750
esv3607755 CNV loss 21293372
nsv1109752 CNV deletion 24896259
nsv469579 CNV loss 16826518

Variation tolerance for MRNIP Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRNIP Gene

Disorders for MRNIP Gene

Relevant External Links for MRNIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRNIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRNIP

No disorders were found for MRNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRNIP Gene

Publications for MRNIP Gene

  1. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. (PMID: 27568553) Staples C.J. … Collis S.J. (Cell Rep 2016) 2 3 4 64
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3 64

Products for MRNIP Gene

Sources for MRNIP Gene

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