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Aliases for MRNIP Gene

Aliases for MRNIP Gene

  • MRN Complex Interacting Protein 2 3 5
  • MRN-Interacting Protein 2 3
  • C5orf45 3 4
  • Chromosome 5 Open Reading Frame 45 2
  • Truncated Calcium Binding Protein 2
  • UPF0544 Protein C5orf45 3

External Ids for MRNIP Gene

Previous HGNC Symbols for MRNIP Gene

  • C5orf45

Summaries for MRNIP Gene

GeneCards Summary for MRNIP Gene

MRNIP (MRN Complex Interacting Protein) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRNIP Gene

Genomics for MRNIP Gene

Regulatory Elements for MRNIP Gene

Enhancers for MRNIP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F179836 0.6 ENCODE 29.3 +25.0 24976 2.0 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 RAD21 RARA SCRT2 CREM MRNIP MAML1 LOC101928445 LOC100996419 TBC1D9B MGAT4B SQSTM1 MIR1229 LTC4S CBY3
GH05F179826 0.2 ENCODE 27.8 +34.7 34672 1.5 CTCF SMAD5 MAX YBX1 ZIC2 ZNF366 HDAC2 ZBTB48 POLR2A ZNF207 MRNIP SQSTM1 TBC1D9B MGAT4B MIR1229 LTC4S MAML1 GC05P179824 PIR43055 PIR32850
GH05F179839 0.2 ENCODE 25.4 +22.4 22413 0.9 SCRT1 CTCF KLF1 USF2 NR3C1 RAD21 JUND SSRP1 RAD51 ZFHX2 MRNIP TBC1D9B MGAT4B SQSTM1 MIR1229 LTC4S MAML1 PIR36293 PIR46844
GH05F179817 0.2 ENCODE 25.2 +41.6 41614 6.5 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MRNIP MAML1 TBC1D9B LOC100502572 LOC100289470 ENSG00000253652 ENSG00000250674 LOC100420514 OR2AI1P LOC100129457
GH05F179825 0.6 ENCODE 20.4 +36.3 36304 1.4 SOX13 CTCF TBP MXI1 SAP130 ARID4B SIN3A ZNF384 CEBPG ZNF48 MRNIP MIR1229 LTC4S MAML1 TBC1D9B GC05P179824 PIR43055 PIR32850
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRNIP on UCSC Golden Path with GeneCards custom track

Genomic Location for MRNIP Gene

Chromosome:
5
Start:
179,835,133 bp from pter
End:
179,862,173 bp from pter
Size:
27,041 bases
Orientation:
Minus strand

Genomic View for MRNIP Gene

Genes around MRNIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRNIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRNIP Gene

Proteins for MRNIP Gene

  • Protein details for MRNIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NTE8-CE045_HUMAN
    Recommended name:
    UPF0544 protein C5orf45
    Protein Accession:
    Q6NTE8
    Secondary Accessions:
    • B5MD09
    • E9PAK6
    • Q7Z3D8
    • Q9BUC1
    • Q9UN54

    Protein attributes for MRNIP Gene

    Size:
    343 amino acids
    Molecular mass:
    37743 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD51611.1; Type=Frameshift; Positions=191; Evidence={ECO:0000305}; Sequence=CAD97932.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRNIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRNIP Gene

Post-translational modifications for MRNIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRNIP Gene

Domains & Families for MRNIP Gene

Protein Domains for MRNIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRNIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NTE8

UniProtKB/Swiss-Prot:

CE045_HUMAN :
  • Belongs to the UPF0544 family.
Family:
  • Belongs to the UPF0544 family.
genes like me logo Genes that share domains with MRNIP: view

No data available for Gene Families for MRNIP Gene

Function for MRNIP Gene

Gene Ontology (GO) - Molecular Function for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003682 chromatin binding IDA 27568553
GO:0005515 protein binding IPI 27568553
genes like me logo Genes that share ontologies with MRNIP: view
genes like me logo Genes that share phenotypes with MRNIP: view

Animal Models for MRNIP Gene

MGI Knock Outs for MRNIP:

Animal Model Products

miRNA for MRNIP Gene

miRTarBase miRNAs that target MRNIP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRNIP Gene

Localization for MRNIP Gene

Gene Ontology (GO) - Cellular Components for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA 27568553
GO:0005654 nucleoplasm IDA 27568553
GO:0030870 colocalizes_with Mre11 complex IDA 27568553
genes like me logo Genes that share ontologies with MRNIP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MRNIP Gene

Pathways & Interactions for MRNIP Gene

SuperPathways for MRNIP Gene

No Data Available

Interacting Proteins for MRNIP Gene

Selected Interacting proteins: Q6NTE8-CE045_HUMAN for MRNIP Gene via IID

Symbol External ID(s) Details
LRRK2

Gene Ontology (GO) - Biological Process for MRNIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 27568553
GO:0007095 mitotic G2 DNA damage checkpoint IMP 27568553
GO:0008150 biological_process ND --
GO:0010212 response to ionizing radiation IMP 27568553
GO:0045860 positive regulation of protein kinase activity IMP 27568553
genes like me logo Genes that share ontologies with MRNIP: view

No data available for Pathways by source and SIGNOR curated interactions for MRNIP Gene

Transcripts for MRNIP Gene

Unigene Clusters for MRNIP Gene

Chromosome 5 open reading frame 45:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRNIP Gene

No ASD Table

Relevant External Links for MRNIP Gene

GeneLoc Exon Structure for
MRNIP
ECgene alternative splicing isoforms for
MRNIP

Expression for MRNIP Gene

NURSA nuclear receptor signaling pathways regulating expression of MRNIP Gene:

MRNIP

SOURCE GeneReport for Unigene cluster for MRNIP Gene:

Hs.741169
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MRNIP Gene

Orthologs for MRNIP Gene

This gene was present in the common ancestor of animals.

Orthologs for MRNIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf45 34
  • 99.13 (n)
C5orf45 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5orf45 35
  • 83 (a)
OneToOne
C11H5orf45 34
  • 71.26 (n)
cow
(Bos Taurus)
Mammalia C7H5orf45 34 35
  • 72.07 (n)
rat
(Rattus norvegicus)
Mammalia RGD1564036 34
  • 67.94 (n)
mouse
(Mus musculus)
Mammalia 3010026O09Rik 34 16 35
  • 67.57 (n)
lizard
(Anolis carolinensis)
Reptilia C5orf45 35
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C14H5orf45 35
  • 21 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43295 35
  • 27 (a)
OneToOne
Species where no ortholog for MRNIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRNIP Gene

ENSEMBL:
Gene Tree for MRNIP (if available)
TreeFam:
Gene Tree for MRNIP (if available)

Paralogs for MRNIP Gene

No data available for Paralogs for MRNIP Gene

Variants for MRNIP Gene

Sequence variations from dbSNP and Humsavar for MRNIP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10060182 -- 179,858,752(+) AGGCG(A/G)CAGCT upstream-variant-2KB, reference, synonymous-codon
rs10069530 -- 179,855,990(+) tgcaa(A/C)ctctg intron-variant
rs10173 -- 179,837,226(+) CAATC(C/T)AATTA intron-variant, utr-variant-3-prime
rs10277 -- 179,837,731(+) CAAAT(C/T)GCGCC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs10434803 -- 179,857,205(+) gcact(A/G)taatc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRNIP Gene

Variant ID Type Subtype PubMed ID
esv2667626 CNV deletion 23128226
esv2731309 CNV deletion 23290073
esv2731310 CNV deletion 23290073
esv2731311 CNV deletion 23290073
esv3567108 CNV deletion 23714750
esv3607755 CNV loss 21293372
nsv1109752 CNV deletion 24896259
nsv469579 CNV loss 16826518

Variation tolerance for MRNIP Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRNIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRNIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRNIP Gene

Disorders for MRNIP Gene

Relevant External Links for MRNIP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRNIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRNIP

No disorders were found for MRNIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRNIP Gene

Publications for MRNIP Gene

  1. MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response. (PMID: 27568553) Staples C.J. … Collis S.J. (Cell Rep 2016) 2 3 64
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3 64

Products for MRNIP Gene

Sources for MRNIP Gene

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