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Aliases for MRM3 Gene

Aliases for MRM3 Gene

  • Mitochondrial RRNA Methyltransferase 3 2 3
  • RNA Methyltransferase Like 1 2 3 5
  • RNMTL1 3 4 5
  • 16S RRNA (Guanosine(1370)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Gm1370] 2-O-Methyltransferase 3 4
  • RNA Methyltransferase-Like Protein 1 3 4
  • Putative RNA Methyltransferase 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • RMTL1 3

External Ids for MRM3 Gene

Previous HGNC Symbols for MRM3 Gene

  • RNMTL1

Summaries for MRM3 Gene

Entrez Gene Summary for MRM3 Gene

  • Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for MRM3 Gene

MRM3 (Mitochondrial RRNA Methyltransferase 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRM3 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Gene Wiki entry for MRM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRM3 Gene

Genomics for MRM3 Gene

Regulatory Elements for MRM3 Gene

Enhancers for MRM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRM3 on UCSC Golden Path with GeneCards custom track

Promoters for MRM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRM3 Gene

Chromosome:
17
Start:
782,273 bp from pter
End:
792,509 bp from pter
Size:
10,237 bases
Orientation:
Plus strand

Genomic View for MRM3 Gene

Genes around MRM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRM3 Gene

Proteins for MRM3 Gene

  • Protein details for MRM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC36-MRM3_HUMAN
    Recommended name:
    rRNA methyltransferase 3, mitochondrial
    Protein Accession:
    Q9HC36
    Secondary Accessions:
    • Q53GN1
    • Q86VC3
    • Q96F76
    • Q9NVQ5

    Protein attributes for MRM3 Gene

    Size:
    420 amino acids
    Molecular mass:
    47020 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRM3 Gene

Proteomics data for MRM3 Gene at MOPED

Selected DME Specific Peptides for MRM3 Gene

Post-translational modifications for MRM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRM3 Gene

Domains & Families for MRM3 Gene

Suggested Antigen Peptide Sequences for MRM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HC36

UniProtKB/Swiss-Prot:

MRM3_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with MRM3: view

No data available for Gene Families for MRM3 Gene

Function for MRM3 Gene

Molecular function for MRM3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + guanosine(1370) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methylguanosine(1370) in 16S rRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for MRM3 Gene

Gene Ontology (GO) - Molecular Function for MRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IBA --
GO:0008168 methyltransferase activity IEA,IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRM3: view
genes like me logo Genes that share phenotypes with MRM3: view

Animal Models for MRM3 Gene

MGI Knock Outs for MRM3:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRM3 Gene

Localization for MRM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRM3 Gene

Mitochondrion.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MRM3 Gene

Pathways & Interactions for MRM3 Gene

SuperPathways for MRM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
genes like me logo Genes that share ontologies with MRM3: view

No data available for Pathways by source and SIGNOR curated interactions for MRM3 Gene

Drugs & Compounds for MRM3 Gene

No Compound Related Data Available

Transcripts for MRM3 Gene

Unigene Clusters for MRM3 Gene

RNA methyltransferase like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRM3 Gene

No ASD Table

Relevant External Links for MRM3 Gene

GeneLoc Exon Structure for
MRM3
ECgene alternative splicing isoforms for
MRM3

Expression for MRM3 Gene

SOURCE GeneReport for Unigene cluster for MRM3 Gene Hs.182729

mRNA Expression by UniProt/SwissProt for MRM3 Gene

Q9HC36-MRM3_HUMAN
Tissue specificity: Expressed at same level in normal liver and hepatocarcinoma.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRM3 Gene

Orthologs for MRM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNMTL1 35
  • 85.21 (n)
  • 85.54 (a)
RNMTL1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNMTL1 35
  • 86.43 (n)
  • 84.52 (a)
RNMTL1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnmtl1 35
  • 85.31 (n)
  • 83.66 (a)
Rnmtl1 16
Rnmtl1 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNMTL1 35
  • 99.29 (n)
  • 99.29 (a)
RNMTL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnmtl1 35
  • 84.61 (n)
  • 83.01 (a)
oppossum
(Monodelphis domestica)
Mammalia RNMTL1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNMTL1 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNMTL1 35
  • 62.65 (n)
  • 57.44 (a)
RNMTL1 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNMTL1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmtl1 35
  • 60.19 (n)
  • 57.32 (a)
Str.10696 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14923 35
rnmtl1a 35
  • 58.99 (n)
  • 52.62 (a)
rnmtl1a 36
  • 46 (a)
OneToMany
rnmtl1b 36
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003655 35
  • 48.76 (n)
  • 39.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14100 35
  • 46 (n)
  • 35.75 (a)
CG14100 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToOne
Species with no ortholog for MRM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRM3 Gene

ENSEMBL:
Gene Tree for MRM3 (if available)
TreeFam:
Gene Tree for MRM3 (if available)

Paralogs for MRM3 Gene

Pseudogenes.org Pseudogenes for MRM3 Gene

genes like me logo Genes that share paralogs with MRM3: view

No data available for Paralogs for MRM3 Gene

Variants for MRM3 Gene

Sequence variations from dbSNP and Humsavar for MRM3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1570000 -- 788,283(+) attag(C/T)tgggt intron-variant
rs3744743 -- 792,776(+) AGAGA(C/T)GGAAG downstream-variant-500B
rs3786062 -- 790,114(+) AATAA(C/T)TCGTC intron-variant
rs3786063 -- 790,176(+) AGTCA(C/T)TGCGA intron-variant
rs3833168 -- 791,520(+) TTCCT(-/GTCT/GTTT)TTTTA intron-variant

Variation tolerance for MRM3 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.06; 87.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRM3 Gene

Disorders for MRM3 Gene

Relevant External Links for MRM3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRM3

No disorders were found for MRM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRM3 Gene

Publications for MRM3 Gene

  1. The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene. (PMID: 12296377) Xu J. … Gu J.R. (Cell Res. 2002) 2 3 4 23 67
  2. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. (PMID: 25009282) Rorbach J. … Minczuk M. (Mol. Biol. Cell 2014) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for MRM3 Gene

Sources for MRM3 Gene

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