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Aliases for MRM2 Gene

Aliases for MRM2 Gene

  • Mitochondrial RRNA Methyltransferase 2 2 3
  • FTSJ2 3 4 5
  • FtsJ RNA Methyltransferase Homolog 2 (E. Coli) 2 5
  • 16S RRNA (Uridine(1369)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Um1369] 2-O-Methyltransferase 3 4
  • RRNA (Uridine-2-O-)-Methyltransferase 2 3
  • Protein FtsJ Homolog 2 3 4
  • FJH1 3 4
  • MRM2 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • Putative Ribosomal RNA Methyltransferase 2 3
  • FtsJ RNA Methyltransferase Homolog 2 3
  • MRM2 RNA Methyltransferase Homolog 3
  • Epididymis Luminal Protein 97 3
  • Cell Division Protein FtsJ 3
  • FtsJ Homolog 2 3
  • EC 2.1.1.- 4
  • HEL97 3
  • RRMJ2 3

External Ids for MRM2 Gene

Previous HGNC Symbols for MRM2 Gene

  • FTSJ2

Summaries for MRM2 Gene

Entrez Gene Summary for MRM2 Gene

  • The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRM2 Gene

MRM2 (Mitochondrial RRNA Methyltransferase 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRM2 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRM2 Gene

Genomics for MRM2 Gene

Regulatory Elements for MRM2 Gene

Promoters for MRM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRM2 Gene

Chromosome:
7
Start:
2,234,231 bp from pter
End:
2,242,198 bp from pter
Size:
7,968 bases
Orientation:
Minus strand

Genomic View for MRM2 Gene

Genes around MRM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRM2 Gene

Proteins for MRM2 Gene

  • Protein details for MRM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI43-MRM2_HUMAN
    Recommended name:
    rRNA methyltransferase 2, mitochondrial
    Protein Accession:
    Q9UI43
    Secondary Accessions:
    • Q24JR8

    Protein attributes for MRM2 Gene

    Size:
    246 amino acids
    Molecular mass:
    27424 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRM2 Gene

neXtProt entry for MRM2 Gene

Proteomics data for MRM2 Gene at MOPED

Post-translational modifications for MRM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRM2 Gene

Domains & Families for MRM2 Gene

Protein Domains for MRM2 Gene

Suggested Antigen Peptide Sequences for MRM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UI43

UniProtKB/Swiss-Prot:

MRM2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
genes like me logo Genes that share domains with MRM2: view

No data available for Gene Families for MRM2 Gene

Function for MRM2 Gene

Molecular function for MRM2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methyluridine(1369) in 16S rRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for MRM2 Gene

genes like me logo Genes that share phenotypes with MRM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRM2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRM2 Gene

Localization for MRM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRM2 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for MRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 11827451
genes like me logo Genes that share ontologies with MRM2: view

No data available for Subcellular locations from COMPARTMENTS for MRM2 Gene

Pathways & Interactions for MRM2 Gene

SuperPathways for MRM2 Gene

No Data Available

Interacting Proteins for MRM2 Gene

Gene Ontology (GO) - Biological Process for MRM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2-O-methylation IBA --
GO:0008283 cell proliferation NAS 11827451
GO:0031167 rRNA methylation NAS 11827451
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with MRM2: view

No data available for Pathways by source and SIGNOR curated interactions for MRM2 Gene

Drugs & Compounds for MRM2 Gene

(2) Drugs for MRM2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with MRM2: view

Transcripts for MRM2 Gene

Unigene Clusters for MRM2 Gene

FtsJ RNA methyltransferase homolog 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRM2 Gene

No ASD Table

Relevant External Links for MRM2 Gene

GeneLoc Exon Structure for
MRM2
ECgene alternative splicing isoforms for
MRM2

Expression for MRM2 Gene

SOURCE GeneReport for Unigene cluster for MRM2 Gene Hs.279877

mRNA Expression by UniProt/SwissProt for MRM2 Gene

Q9UI43-MRM2_HUMAN
Tissue specificity: Widely expressed, with highest expression in muscle, placenta, and heart.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRM2 Gene

Orthologs for MRM2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FTSJ2 35
  • 84.99 (n)
  • 84.71 (a)
FTSJ2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FTSJ2 35
  • 81.51 (n)
  • 80.67 (a)
FTSJ2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ftsj2 35
  • 80.11 (n)
  • 79.84 (a)
Ftsj2 16
Ftsj2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FTSJ2 35
  • 99.05 (n)
  • 98.37 (a)
FTSJ2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ftsj2 35
  • 79.81 (n)
  • 77.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FTSJ2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ2 35
  • 63.68 (n)
  • 61.54 (a)
FTSJ2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FTSJ2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj2 35
  • 61.99 (n)
  • 56.14 (a)
Str.10962 35
zebrafish
(Danio rerio)
Actinopterygii LOC555586 35
  • 60.49 (n)
  • 55.09 (a)
FTSJ2 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9100 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004177 35
  • 49.4 (n)
  • 41.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11447 35
  • 50.39 (n)
  • 41.86 (a)
CG11447 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F45G2.9 35
  • 49.35 (n)
  • 44.61 (a)
F45G2.9 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL117C 35
  • 49.48 (n)
  • 46.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01980g 35
  • 50.51 (n)
  • 42.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRM2 35
  • 46.73 (n)
  • 40.2 (a)
MRM2 36
  • 25 (a)
OneToOne
Species with no ortholog for MRM2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRM2 Gene

ENSEMBL:
Gene Tree for MRM2 (if available)
TreeFam:
Gene Tree for MRM2 (if available)

Paralogs for MRM2 Gene

No data available for Paralogs for MRM2 Gene

Variants for MRM2 Gene

Sequence variations from dbSNP and Humsavar for MRM2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4721496 -- 2,239,028(+) ATATA(A/T)AATAC intron-variant
rs6951825 -- 2,238,764(+) accct(A/G)tctct intron-variant
rs6962067 -- 2,240,216(+) GACTC(C/T)GTCTC intron-variant
rs6963660 -- 2,237,691(+) ACCTC(A/G)AGGAT intron-variant
rs7787274 -- 2,236,358(+) GTCAA(A/G)AGATG intron-variant

Variation tolerance for MRM2 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRM2 Gene

HapMap Linkage Disequilibrium report
MRM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRM2 Gene

Disorders for MRM2 Gene

Relevant External Links for MRM2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRM2

No disorders were found for MRM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRM2 Gene

Publications for MRM2 Gene

  1. Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. (PMID: 11827451) Ching Y.-P. … Jin D.-Y. (Genomics 2002) 2 3 4 23 67
  2. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. (PMID: 25009282) Rorbach J. … Minczuk M. (Mol. Biol. Cell 2014) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration. (PMID: 24595062) Lai C.W. … Chen C.M. (PLoS ONE 2014) 3
  5. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA. (PMID: 25074936) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2014) 3

Products for MRM2 Gene

Sources for MRM2 Gene

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