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Aliases for MRM1 Gene

Aliases for MRM1 Gene

  • Mitochondrial RRNA Methyltransferase 1 2 3
  • 16S RRNA (Guanosine(1145)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Gm1145] 2-O-Methyltransferase 3 4
  • Mitochondrial RRNA Methyltransferase 1 Homolog (S. Cerevisiae) 2
  • Mitochondrial Large Ribosomal RNA Ribose Methylase 3
  • Mitochondrial RRNA Methyltransferase 1 Homolog 3
  • CTB-75G16.3 3
  • EC 2.1.1.- 4

External Ids for MRM1 Gene

Previous GeneCards Identifiers for MRM1 Gene

  • GC17P032033
  • GC17P034958
  • GC17P030895
  • GC17P036609

Summaries for MRM1 Gene

GeneCards Summary for MRM1 Gene

MRM1 (Mitochondrial RRNA Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and methyltransferase activity.

UniProtKB/Swiss-Prot for MRM1 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRM1 Gene

Genomics for MRM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRM1 Gene

Chromosome:
17
Start:
36,601,572 bp from pter
End:
36,634,698 bp from pter
Size:
33,127 bases
Orientation:
Plus strand

Genomic View for MRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRM1 Gene

Proteins for MRM1 Gene

  • Protein details for MRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IN84-MRM1_HUMAN
    Recommended name:
    rRNA methyltransferase 1, mitochondrial
    Protein Accession:
    Q6IN84
    Secondary Accessions:
    • A8K8E2
    • Q96GK2
    • Q9H664

    Protein attributes for MRM1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38638 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRM1 Gene

Proteomics data for MRM1 Gene at MOPED

Post-translational modifications for MRM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRM1 Gene

Domains & Families for MRM1 Gene

Suggested Antigen Peptide Sequences for MRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IN84

UniProtKB/Swiss-Prot:

MRM1_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with MRM1: view

No data available for Gene Families for MRM1 Gene

Function for MRM1 Gene

Molecular function for MRM1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methylguanosine(1145) in 16S rRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for MRM1 Gene

Gene Ontology (GO) - Molecular Function for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0008173 RNA methyltransferase activity --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRM1: view
genes like me logo Genes that share phenotypes with MRM1: view

Animal Model Products

miRNA for MRM1 Gene

miRTarBase miRNAs that target MRM1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRM1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MRM1 Gene

Localization for MRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRM1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRM1 Gene COMPARTMENTS Subcellular localization image for MRM1 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with MRM1: view

Pathways & Interactions for MRM1 Gene

SuperPathways for MRM1 Gene

No Data Available

Interacting Proteins for MRM1 Gene

Gene Ontology (GO) - Biological Process for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2-O-methylation IBA --
GO:0001510 RNA methylation --
GO:0006364 rRNA processing --
GO:0006396 RNA processing --
genes like me logo Genes that share ontologies with MRM1: view

No data available for Pathways by source and SIGNOR curated interactions for MRM1 Gene

Drugs & Compounds for MRM1 Gene

No Compound Related Data Available

Transcripts for MRM1 Gene

Unigene Clusters for MRM1 Gene

Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRM1 Gene

No ASD Table

Relevant External Links for MRM1 Gene

GeneLoc Exon Structure for
MRM1
ECgene alternative splicing isoforms for
MRM1

Expression for MRM1 Gene

mRNA expression in normal human tissues for MRM1 Gene

Protein differential expression in normal tissues from HIPED for MRM1 Gene

This gene is overexpressed in Frontal cortex (32.1), Spinal cord (21.0), and Lung (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MRM1 Gene



SOURCE GeneReport for Unigene cluster for MRM1 Gene Hs.194864

genes like me logo Genes that share expression patterns with MRM1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MRM1 Gene

Orthologs for MRM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRM1 35
  • 83.29 (n)
  • 77.62 (a)
dog
(Canis familiaris)
Mammalia MRM1 35
  • 85.76 (n)
  • 82.56 (a)
mouse
(Mus musculus)
Mammalia Mrm1 35
  • 83.01 (n)
  • 81.94 (a)
Mrm1 16
chimpanzee
(Pan troglodytes)
Mammalia MRM1 35
  • 99.53 (n)
  • 99.15 (a)
rat
(Rattus norvegicus)
Mammalia Mrm1 35
  • 82.24 (n)
  • 79.62 (a)
chicken
(Gallus gallus)
Aves MRM1 35
  • 57.92 (n)
  • 54.26 (a)
zebrafish
(Danio rerio)
Actinopterygii mrm1 35
  • 51.82 (n)
  • 49.64 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y45F3A.9 35
  • 43.41 (n)
  • 34.27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL269W 35
  • 45.79 (n)
  • 36.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00946g 35
  • 39.28 (n)
  • 32.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRM1 35
  • 42.77 (n)
  • 32.35 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01404 35
  • 45.71 (n)
  • 35.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1347.13c 35
  • 41.6 (n)
  • 36.36 (a)
Species with no ortholog for MRM1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRM1 Gene

ENSEMBL:
Gene Tree for MRM1 (if available)
TreeFam:
Gene Tree for MRM1 (if available)

Paralogs for MRM1 Gene

No data available for Paralogs for MRM1 Gene

Variants for MRM1 Gene

Sequence variations from dbSNP and Humsavar for MRM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2028068 -- 36,610,527(-) Aggcc(A/G)ggcgc intron-variant
rs2028069 -- 36,610,478(-) gaggc(A/G)ggtga intron-variant
rs4262995 -- 36,604,061(+) AGCTG(A/G)AGGTG intron-variant
rs6607328 -- 36,620,275(+) CTCCT(C/T)TATGC intron-variant
rs6607329 -- 36,620,351(+) AATGA(C/T)GACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRM1 Gene

Variant ID Type Subtype PubMed ID
esv2751645 CNV Gain 17911159
nsv469760 CNV Loss 16826518
essv9000 CNV CNV 17122850
dgv953e1 CNV Complex 17122850
nsv833429 CNV Gain 17160897

Variation tolerance for MRM1 Gene

Residual Variation Intolerance Score: 52.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRM1 Gene

HapMap Linkage Disequilibrium report
MRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRM1 Gene

Disorders for MRM1 Gene

Relevant External Links for MRM1

Genetic Association Database (GAD)
MRM1
Human Genome Epidemiology (HuGE) Navigator
MRM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRM1
genes like me logo Genes that share disorders with MRM1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRM1 Gene

Publications for MRM1 Gene

  1. Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid. (PMID: 24036117) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2013) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA. (PMID: 25074936) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2014) 67
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 67

Products for MRM1 Gene

Sources for MRM1 Gene

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