MRM1 Gene
protein-coding GIFtS: 50
GCID: GC17P034958
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|
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
| |
Aliases
for MRM1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial RRNA Methyltransferase 1 Homolog (S. Cerevisiae)1 2 | | Mitochondrial Large Ribosomal RNA Ribose Methylase2 3 | | FLJ225781 | | RRNA Methyltransferase 1, Mitochondrial2 | | EC 2.1.1.-3 |
Export aliases for MRM1 gene to outside databasesPrevious GC identifers: GC17P032033 GC17P030895 |
Summaries
for MRM1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MRM1_HUMAN, Q6IN84Function: Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondriallarge ribosomal RNA (21S) (By similarity)
|
Genomic Views
for MRM1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRM1 gene promoter:
Max1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) CUTL1 Nkx2-5 POU3F2 c-Ets-1 PPAR-gamma1 SEF-1 (1) PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRM1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRM1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12MRM1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P034958: view genomic region
(about GC identifiers)
Start:
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34,958,001 bp from pter |
End:
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34,965,407 bp from pter |
Size:
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7,407 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17+,PATCHES 34,943,789-34,951,171 |
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Proteins
for MRM1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRM1_HUMAN, Q6IN84 (See
protein sequence)Recommended Name: rRNA methyltransferase 1, mitochondrial precursor Size: 353 amino acids; 38638 Da
Subcellular location: Mitochondrion (Potential)
Secondary accessions: A8K8E2 Q96GK2 Q9H664Alternative splicing: 2 isoforms: Q6IN84-1 Q6IN84-2 Explore the universe of human proteins at neXtProt for MRM1: NX_Q6IN84
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IN84
MRM1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079140.2
ENSEMBL proteins: ENSP00000250156 ENSP00000465317
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
MRM1 for ontologies About GeneDecksing
MRM1 Antibody Products:
Assay Products for MRM1: |
Protein
Domains /
Families
for MRM1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRM1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IN84ProtoNet protein and cluster: Q6IN84 2 Blocks protein families: IPB001537 tRNA/rRNA methyltransferase (SpoU) IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: MRM1_HUMAN, Q6IN84Similarity: Belongs to the RNA methyltransferase TrmH family |
Function
for MRM1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRM1_HUMAN, Q6IN84Function: Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondriallarge ribosomal RNA (21S) (By similarity)Enzyme Number (IUBMB): EC 2.1.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRM1 (NM_024864) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRM1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRM1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRM1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- | | GO:0008173 | RNA methyltransferase activity |
IEA | -- |
MRM1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MRM1:
|
Pathways & Interactions
for MRM1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRM1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/232 Interacting proteins for MRM1 (Q6IN842, 3 ENSP000002501564) via UniProtKB, MINT, STRING, and/or I2D (see all 232)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006396 | RNA processing |
IEA | -- |
MRM1 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRM1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRM1
Search CenterWatch for drugs/clinical trials and news about MRM1
|
Transcripts
for MRM1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRM1 gene: NM_024864.3 Unigene Cluster for MRM1: Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) Hs.194864 [show with all ESTs]Unigene Representative Sequence: NM_0248642 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000250156(uc002hne.3 uc002hnf.3) ENST00000585770
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRM1 (NM_024864) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRM1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRM1 |
Additional cDNA sequence: AK026231.1 AK225449.1 AK292307.1 BC009416.1 BC072411.1 CR457357.1 4 DOTS entries: DT.100778309 DT.102822734 DT.99999079 DT.100844427 24/61 AceView cDNA sequences (see all 61): BX458442 AI675805 CR622648 CR607365 CR616141 BU734592 BC009416 BE047635 BX385549 AI611025 CR601982 CB137408 CF129667 BU161348 NM_024864 BM558424 AW663201 CR618401 AW204625 BX401804 BX349372 AA931152 AW651675 AI990504
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for MRM1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for MRM1
|
Expression
for MRM1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGGAATCT
About this image
See MRM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRM1
SOURCE GeneReport for Unigene cluster: Hs.194864
SABiosciences Custom PCR Arrays for MRM1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRM1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRM1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRM1 |
Orthologs
for MRM1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRM1 gene from 9/28 species (see all 28) About this table
ENSEMBL Gene Tree for MRM1 (if available)
TreeFam Gene Tree for MRM1 (if available) |
Paralogs
for MRM1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRM1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRM1 (34958001 - 34965407 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MRM1
4 CNVs: 3143 2223 4032 8843
1 Inversion: 37189 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRM1 |
|
Disorders
/ Diseases
for MRM1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRM1 for disorders About GeneDecksing
6  diseases for MRM1: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma pneumonia tuberculosis
malaria mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRM1 (1 document)
Export disorders for MRM1 gene to outside databases
|
Publications
for MRM1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRM1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRM1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for MRM1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRM1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRM1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRM1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRM1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRM1 gene:
Search GeneIP for patents involving MRM1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRM1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRM1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRM1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRM1 | | | OriGene Protein Over-expression Lysate for MRM1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRM1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRM1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRM1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRM1 | | OriGene Custom Protein Services for MRM1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRM1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRM1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRM1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRM1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRM1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRM1 |
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| | | | Search Tocris compounds for MRM1 |
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 | | | MRM1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRM1 |
|  |  |  | | | | ThermoFisher Antibody for MRM1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRM1 |
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