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Aliases for MRM1 Gene

Aliases for MRM1 Gene

  • Mitochondrial RRNA Methyltransferase 1 Homolog (S. Cerevisiae) 2 3
  • 16S RRNA (Guanosine(1145)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Gm1145] 2-O-Methyltransferase 3 4
  • Mitochondrial Large Ribosomal RNA Ribose Methylase 3
  • RRNA Methyltransferase 1, Mitochondrial 3
  • CTB-75G16.3 3
  • EC 2.1.1.- 4

External Ids for MRM1 Gene

Previous GeneCards Identifiers for MRM1 Gene

  • GC17P032033
  • GC17P034958
  • GC17P030895

Summaries for MRM1 Gene

GeneCards Summary for MRM1 Gene

MRM1 (Mitochondrial RRNA Methyltransferase 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and RNA methyltransferase activity.

UniProtKB/Swiss-Prot for MRM1 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRM1 Gene

Genomics for MRM1 Gene

Genomic Location for MRM1 Gene

Start:
36,601,572 bp from pter
End:
36,608,971 bp from pter
Size:
7,400 bases
Orientation:
Plus strand

Genomic View for MRM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRM1 Gene

Proteins for MRM1 Gene

  • Protein details for MRM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IN84-MRM1_HUMAN
    Recommended name:
    rRNA methyltransferase 1, mitochondrial
    Protein Accession:
    Q6IN84
    Secondary Accessions:
    • A8K8E2
    • Q96GK2
    • Q9H664

    Protein attributes for MRM1 Gene

    Size:
    353 amino acids
    Molecular mass:
    38638 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRM1 Gene

Proteomics data for MRM1 Gene at MOPED

Post-translational modifications for MRM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRM1 Gene

Domains for MRM1 Gene

Suggested Antigen Peptide Sequences for MRM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IN84

UniProtKB/Swiss-Prot:

MRM1_HUMAN :
  • Q6IN84
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
genes like me logo Genes that share domains with MRM1: view

No data available for Gene Families for MRM1 Gene

Function for MRM1 Gene

Molecular function for MRM1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methylguanosine(1145) in 16S rRNA.
UniProtKB/Swiss-Prot Function: S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for MRM1 Gene

Gene Ontology (GO) - Molecular Function for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 25416956
GO:0008168 methyltransferase activity --
GO:0008173 RNA methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRM1: view
genes like me logo Genes that share phenotypes with MRM1: view

miRNA for MRM1 Gene

miRTarBase miRNAs that target MRM1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MRM1 Gene

Localization for MRM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRM1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRM1 Gene COMPARTMENTS Subcellular localization image for MRM1 gene
Compartment Confidence
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MRM1: view

Pathways for MRM1 Gene

SuperPathways for MRM1 Gene

No Data Available

Interacting Proteins for MRM1 Gene

Gene Ontology (GO) - Biological Process for MRM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IEA --
GO:0006364 rRNA processing IEA --
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with MRM1: view

No data available for Pathways by source for MRM1 Gene

Transcripts for MRM1 Gene

Unigene Clusters for MRM1 Gene

Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRM1 Gene

No ASD Table

Relevant External Links for MRM1 Gene

GeneLoc Exon Structure for
MRM1
ECgene alternative splicing isoforms for
MRM1

Expression for MRM1 Gene

mRNA expression in normal human tissues for MRM1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MRM1 Gene

SOURCE GeneReport for Unigene cluster for MRM1 Gene Hs.194864

genes like me logo Genes that share expressions with MRM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRM1 Gene

Orthologs for MRM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRM1 35
  • 99.53 (n)
  • 99.15 (a)
cow
(Bos Taurus)
Mammalia MRM1 35
  • 83.29 (n)
  • 77.62 (a)
dog
(Canis familiaris)
Mammalia MRM1 35
  • 85.76 (n)
  • 82.56 (a)
mouse
(Mus musculus)
Mammalia Mrm1 35
  • 83.01 (n)
  • 81.94 (a)
Mrm1 16
rat
(Rattus norvegicus)
Mammalia Mrm1 35
  • 82.24 (n)
  • 79.62 (a)
chicken
(Gallus gallus)
Aves MRM1 35
  • 57.92 (n)
  • 54.26 (a)
zebrafish
(Danio rerio)
Actinopterygii mrm1 35
  • 51.82 (n)
  • 49.64 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y45F3A.9 35
  • 43.41 (n)
  • 34.27 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL269W 35
  • 45.79 (n)
  • 36.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRM1 35
  • 42.77 (n)
  • 32.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F00946g 35
  • 39.28 (n)
  • 32.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01404 35
  • 45.71 (n)
  • 35.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1347.13c 35
  • 41.6 (n)
  • 36.36 (a)
Species with no ortholog for MRM1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRM1 Gene

ENSEMBL:
Gene Tree for MRM1 (if available)
TreeFam:
Gene Tree for MRM1 (if available)

Paralogs for MRM1 Gene

No data available for Paralogs for MRM1 Gene

Variants for MRM1 Gene

Sequence variations from dbSNP and Humsavar for MRM1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1061121 -- 36,608,913(+) GACTC(C/T)GCACC utr-variant-3-prime
rs1075218 -- 36,603,674(+) GATTA(G/T)AGGCA intron-variant, downstream-variant-500B
rs2078447 -- 36,603,432(+) GTTTC(A/G)TTCTT intron-variant, downstream-variant-500B
rs2301676 -- 36,608,743(-) GGGTC(A/C)CCTGG utr-variant-3-prime
rs4262995 -- 36,604,061(+) AGCTG(A/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRM1 Gene

Variant ID Type Subtype PubMed ID
esv2751645 CNV Gain 17911159
nsv469760 CNV Loss 16826518
essv9000 CNV CNV 17122850
dgv953e1 CNV Complex 17122850
nsv833429 CNV Gain 17160897

Relevant External Links for MRM1 Gene

HapMap Linkage Disequilibrium report
MRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRM1 Gene

Disorders for MRM1 Gene

Relevant External Links for MRM1

Genetic Association Database (GAD)
MRM1
Human Genome Epidemiology (HuGE) Navigator
MRM1
genes like me logo Genes that share disorders with MRM1: view

No data available for UniProtKB/Swiss-Prot for MRM1 Gene

Publications for MRM1 Gene

  1. Mitochondrial ribosomal RNA (rRNA) methyltransferase family members are positioned to modify nascent rRNA in foci near the mitochondrial DNA nucleoid. (PMID: 24036117) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2013) 2 3 4
  2. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA. (PMID: 25074936) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2014) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRM1 Gene

Sources for MRM1 Gene

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