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Aliases for MRI1 Gene

Aliases for MRI1 Gene

  • Methylthioribose-1-Phosphate Isomerase 1 2 3
  • Mediator Of RhoA-Dependent Invasion 2 3 4
  • MRDI 3 4 6
  • Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein 3 4
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 1 2 3
  • MTR-1-P Isomerase 3 4
  • EC 4 63
  • M1Pi 3 4
  • Methylthioribose-1-Phosphate Isomerase Homolog (S. Cerevisiae) 2
  • Methylthioribose-1-Phosphate Isomerase Homolog 3
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 4
  • Methylthioribose-1-Phosphate Isomerase 3
  • Ypr118w 3
  • MTNA 3

External Ids for MRI1 Gene

Previous GeneCards Identifiers for MRI1 Gene

  • GC19P013875
  • GC19P013447

Summaries for MRI1 Gene

GeneCards Summary for MRI1 Gene

MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. Diseases associated with MRI1 include visual agnosia and cavernous hemangioma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding and S-methyl-5-thioribose-1-phosphate isomerase activity.

UniProtKB/Swiss-Prot for MRI1 Gene

  • Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

Gene Wiki entry for MRI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRI1 Gene

Genomics for MRI1 Gene

Regulatory Elements for MRI1 Gene

Genomic Location for MRI1 Gene

13,764,514 bp from pter
13,774,282 bp from pter
9,769 bases
Plus strand

Genomic View for MRI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRI1 Gene

Proteins for MRI1 Gene

  • Protein details for MRI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methylthioribose-1-phosphate isomerase
    Protein Accession:
    Secondary Accessions:
    • Q8NDC9

    Protein attributes for MRI1 Gene

    369 amino acids
    Molecular mass:
    39150 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRI1 Gene

    Alternative splice isoforms for MRI1 Gene


neXtProt entry for MRI1 Gene

Proteomics data for MRI1 Gene at MOPED

Post-translational modifications for MRI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRI1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MRI1 Gene

Suggested Antigen Peptide Sequences for MRI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BV20
  • Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
genes like me logo Genes that share domains with MRI1: view

No data available for Gene Families for MRI1 Gene

Function for MRI1 Gene

Molecular function for MRI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.
UniProtKB/Swiss-Prot Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
UniProtKB/Swiss-Prot Induction: By RhoA activation in cancer cells (at protein level).

Enzyme Numbers (IUBMB) for MRI1 Gene

Gene Ontology (GO) - Molecular Function for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 16189514
GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity IBA --
genes like me logo Genes that share ontologies with MRI1: view

Phenotypes for MRI1 Gene

GenomeRNAi human phenotypes for MRI1:
genes like me logo Genes that share phenotypes with MRI1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRI1 Gene

Localization for MRI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRI1 Gene

Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

Subcellular locations from

Jensen Localization Image for MRI1 Gene COMPARTMENTS Subcellular localization image for MRI1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with MRI1: view

Pathways for MRI1 Gene

genes like me logo Genes that share pathways with MRI1: view

UniProtKB/Swiss-Prot Q9BV20-MTNA_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.

Gene Ontology (GO) - Biological Process for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000096 sulfur amino acid metabolic process TAS --
GO:0006595 polyamine metabolic process TAS --
GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine IEA --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with MRI1: view

Transcripts for MRI1 Gene

Unigene Clusters for MRI1 Gene

Methylthioribose-1-phosphate isomerase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRI1 Gene

No ASD Table

Relevant External Links for MRI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRI1 Gene

mRNA expression in normal human tissues for MRI1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRI1 Gene

SOURCE GeneReport for Unigene cluster for MRI1 Gene Hs.439370

genes like me logo Genes that share expressions with MRI1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRI1 Gene

Orthologs for MRI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRI1 35
  • 98.64 (n)
  • 97.56 (a)
MRI1 36
  • 98 (a)
(Bos Taurus)
Mammalia MRI1 35
  • 88.55 (n)
  • 93.02 (a)
MRI1 36
  • 93 (a)
(Canis familiaris)
Mammalia MRI1 35
  • 89.22 (n)
  • 91.83 (a)
MRI1 36
  • 92 (a)
(Mus musculus)
Mammalia Mri1 35
  • 83.92 (n)
  • 86.38 (a)
Mri1 16
Mri1 36
  • 86 (a)
(Monodelphis domestica)
Mammalia MRI1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia MRI1 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Mri1 35
  • 83.74 (n)
  • 86.45 (a)
(Anolis carolinensis)
Reptilia MRI1 36
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15801 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mri1 35
  • 66.67 (n)
  • 69.52 (a)
(Danio rerio)
Actinopterygii mri1 35
  • 68.59 (n)
  • 69.74 (a)
mri1 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001589 35
  • 58.82 (n)
  • 60.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11334 35
  • 61.72 (n)
  • 60.5 (a)
CG11334 36
  • 59 (a)
(Caenorhabditis elegans)
Secernentea C01G10.9 36
  • 41 (a)
CELE_C01G10.9 35
  • 48.63 (n)
  • 45.29 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR098W 35
  • 55.2 (n)
  • 51.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRI1 35
  • 49.61 (n)
  • 49.11 (a)
MRI1 36
  • 40 (a)
MRI1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15455g 35
  • 50.29 (n)
  • 49.12 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G05830 35
  • 55.36 (n)
  • 59 (a)
(Hordeum vulgare)
Liliopsida Hv.181 35
(Zea mays)
Liliopsida Zm.9981 35
(Oryza sativa)
Liliopsida Os11g0216900 35
  • 54.13 (n)
  • 56.27 (a)
(Triticum aestivum)
Liliopsida Ta.14479 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02226 35
  • 60.66 (n)
  • 54.65 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC23E6.10c 35
  • 53.55 (n)
  • 55.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2138 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for MRI1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MRI1 Gene

Gene Tree for MRI1 (if available)
Gene Tree for MRI1 (if available)

Paralogs for MRI1 Gene

No data available for Paralogs for MRI1 Gene

Variants for MRI1 Gene

Sequence variations from dbSNP and Humsavar for MRI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs171118 -- 13,769,368(-) tggtc(A/C)acatg intron-variant
rs346150 -- 13,767,249(-) gccaa(C/T)gtcgt intron-variant
rs346151 -- 13,767,666(-) cacta(C/T)accca intron-variant
rs346152 -- 13,768,808(-) GGCGT(A/G)TGAGA intron-variant
rs346153 -- 13,771,387(-) tgtct(A/G)gctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRI1 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897

Relevant External Links for MRI1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRI1 Gene

Disorders for MRI1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MRI1 Gene including...

Search for MRI1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MRI1 Gene

genes like me logo Genes that share disorders with MRI1: view

No data available for UniProtKB/Swiss-Prot for MRI1 Gene

Publications for MRI1 Gene

  1. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. (PMID: 19620624) Kabuyama Y. … Ahn N.G. (Mol. Cell. Proteomics 2009) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. (PMID: 15215245) Bumann M. … Baumann U. (J. Biol. Chem. 2004) 2 3
  4. Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. (PMID: 23124037) Sunker A. … Alkuraya F.S. (Gene 2013) 2 3
  5. Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion. (PMID: 23859498) Templeton P.D. … Sousa M.C. (Biochemistry 2013) 3

Products for MRI1 Gene

Sources for MRI1 Gene

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