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Aliases for MRI1 Gene

Aliases for MRI1 Gene

  • Methylthioribose-1-Phosphate Isomerase 1 2 3 5
  • Mediator Of RhoA-Dependent Invasion 2 3 4
  • Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein 3 4
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 1 2 3
  • MTR-1-P Isomerase 3 4
  • EC 5.3.1.23 4 63
  • M1Pi 3 4
  • MRDI 3 4
  • Methylthioribose-1-Phosphate Isomerase Homolog (S. Cerevisiae) 2
  • Methylthioribose-1-Phosphate Isomerase Homolog 3
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 4
  • Ypr118w 3
  • MTNA 3

External Ids for MRI1 Gene

Previous GeneCards Identifiers for MRI1 Gene

  • GC19P013875
  • GC19P013447

Summaries for MRI1 Gene

GeneCards Summary for MRI1 Gene

MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. Diseases associated with MRI1 include spinal cord melanoma and visual agnosia. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include identical protein binding and S-methyl-5-thioribose-1-phosphate isomerase activity.

UniProtKB/Swiss-Prot for MRI1 Gene

  • Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

Gene Wiki entry for MRI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRI1 Gene

Genomics for MRI1 Gene

Regulatory Elements for MRI1 Gene

Promoters for MRI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRI1 Gene

Chromosome:
19
Start:
13,764,492 bp from pter
End:
13,774,282 bp from pter
Size:
9,791 bases
Orientation:
Plus strand

Genomic View for MRI1 Gene

Genes around MRI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRI1 Gene

Proteins for MRI1 Gene

  • Protein details for MRI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV20-MTNA_HUMAN
    Recommended name:
    Methylthioribose-1-phosphate isomerase
    Protein Accession:
    Q9BV20
    Secondary Accessions:
    • Q8NDC9

    Protein attributes for MRI1 Gene

    Size:
    369 amino acids
    Molecular mass:
    39150 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRI1 Gene

    Alternative splice isoforms for MRI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRI1 Gene

Proteomics data for MRI1 Gene at MOPED

Post-translational modifications for MRI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MRI1

Domains & Families for MRI1 Gene

Suggested Antigen Peptide Sequences for MRI1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BV20

UniProtKB/Swiss-Prot:

MTNA_HUMAN :
  • Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Family:
  • Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
genes like me logo Genes that share domains with MRI1: view

No data available for Gene Families for MRI1 Gene

Function for MRI1 Gene

Molecular function for MRI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
UniProtKB/Swiss-Prot Induction:
By RhoA activation in cancer cells (at protein level).

Enzyme Numbers (IUBMB) for MRI1 Gene

genes like me logo Genes that share phenotypes with MRI1: view

Animal Model Products

CRISPR Products

miRNA for MRI1 Gene

miRTarBase miRNAs that target MRI1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRI1 Gene

Localization for MRI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRI1 Gene

Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRI1 Gene COMPARTMENTS Subcellular localization image for MRI1 gene
Compartment Confidence
cytosol 5
nucleus 5
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for MRI1 Gene

Pathways & Interactions for MRI1 Gene

genes like me logo Genes that share pathways with MRI1: view

UniProtKB/Swiss-Prot Q9BV20-MTNA_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.

Gene Ontology (GO) - Biological Process for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006595 polyamine metabolic process TAS --
GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
genes like me logo Genes that share ontologies with MRI1: view

No data available for SIGNOR curated interactions for MRI1 Gene

Drugs & Compounds for MRI1 Gene

(2) Additional Compounds for MRI1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Methylthioribose 1-phosphate
  • 1-Phospho-5-S-methylthioribose
  • 1-Phosphomethylthioribose
  • 5-Methylthio-5-deoxy-D-ribose 1-phosphate
  • 5-Methylthio-5-deoxy-D-ribose-1-phosphate
  • 5-Methylthio-D-ribose-1-phosphate
72843-83-5
5-Methylthioribulose 1-phosphate
  • 1-Phospho-5-S-methylthioribulose
  • 1-Phosphomethylthioribulose
  • 1PMT-ribulose
  • 5-Methylthio-2-ribulose-1-phosphate
  • 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
86316-83-8
genes like me logo Genes that share compounds with MRI1: view

Transcripts for MRI1 Gene

Unigene Clusters for MRI1 Gene

Methylthioribose-1-phosphate isomerase homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRI1 Gene

No ASD Table

Relevant External Links for MRI1 Gene

GeneLoc Exon Structure for
MRI1
ECgene alternative splicing isoforms for
MRI1

Expression for MRI1 Gene

mRNA expression in normal human tissues for MRI1 Gene

Protein differential expression in normal tissues from HIPED for MRI1 Gene

This gene is overexpressed in Salivary gland (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRI1 Gene



SOURCE GeneReport for Unigene cluster for MRI1 Gene Hs.439370

genes like me logo Genes that share expression patterns with MRI1: view

Protein tissue co-expression partners for MRI1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRI1 Gene

Orthologs for MRI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRI1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRI1 35
  • 88.55 (n)
  • 93.02 (a)
MRI1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRI1 35
  • 89.22 (n)
  • 91.83 (a)
MRI1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mri1 35
  • 83.92 (n)
  • 86.38 (a)
Mri1 16
Mri1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRI1 35
  • 98.64 (n)
  • 97.56 (a)
MRI1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mri1 35
  • 83.74 (n)
  • 86.45 (a)
oppossum
(Monodelphis domestica)
Mammalia MRI1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRI1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRI1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mri1 35
  • 66.67 (n)
  • 69.52 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15801 35
zebrafish
(Danio rerio)
Actinopterygii mri1 35
  • 68.59 (n)
  • 69.74 (a)
mri1 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001589 35
  • 58.82 (n)
  • 60.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11334 35
  • 61.72 (n)
  • 60.5 (a)
CG11334 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C01G10.9 35
  • 48.63 (n)
  • 45.29 (a)
C01G10.9 36
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR098W 35
  • 55.2 (n)
  • 51.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15455g 35
  • 50.29 (n)
  • 49.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRI1 35
  • 49.61 (n)
  • 49.11 (a)
MRI1 36
  • 40 (a)
OneToOne
MRI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G05830 35
  • 55.36 (n)
  • 59 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.181 35
rice
(Oryza sativa)
Liliopsida Os11g0216900 35
  • 54.13 (n)
  • 56.27 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14479 35
corn
(Zea mays)
Liliopsida Zm.9981 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2138 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02226 35
  • 60.66 (n)
  • 54.65 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC23E6.10c 35
  • 53.55 (n)
  • 55.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for MRI1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MRI1 Gene

ENSEMBL:
Gene Tree for MRI1 (if available)
TreeFam:
Gene Tree for MRI1 (if available)

Paralogs for MRI1 Gene

No data available for Paralogs for MRI1 Gene

Variants for MRI1 Gene

Sequence variations from dbSNP and Humsavar for MRI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35098252 - 13,768,716(+) CTGCC(A/G)TGGCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs10402855 - 13,772,127(+) GATTG(C/G/T)AGTTT nc-transcript-variant, reference, missense
rs443029 -- 13,764,420(-) CAGGA(C/G)GCGGA upstream-variant-2KB
rs455093 -- 13,764,444(-) CAGGA(C/G)GCGGA upstream-variant-2KB
rs171118 -- 13,769,368(-) tggtc(A/C)acatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRI1 Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897

Variation tolerance for MRI1 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRI1 Gene

HapMap Linkage Disequilibrium report
MRI1
Human Gene Mutation Database (HGMD)
MRI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRI1 Gene

Disorders for MRI1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MRI1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal cord melanoma
  • melanoma of the spinal cord
visual agnosia
  • primary visual agnosia
arachnoiditis
  • other meningitis nos
epidural abscess
  • abscess epidural
vascular hemostatic disease
  • hemostatic disorders
- elite association - COSMIC cancer census association via MalaCards
Search MRI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRI1
genes like me logo Genes that share disorders with MRI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRI1 Gene

Publications for MRI1 Gene

  1. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. (PMID: 19620624) Kabuyama Y. … Ahn N.G. (Mol. Cell. Proteomics 2009) 2 3 4 67
  2. Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. (PMID: 23124037) Sunker A. … Alkuraya F.S. (Gene 2013) 2 3
  3. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. (PMID: 15215245) Bumann M. … Baumann U. (J. Biol. Chem. 2004) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRI1 Gene

Sources for MRI1 Gene

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