Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRI1 Gene

protein-coding   GIFtS: 54
GCID: GC19P013875

Methylthioribose-1-Phosphate Isomerase 1

(Previous name: methylthioribose-1-phosphate isomerase homolog (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Methylthioribose-1-Phosphate Isomerase 11 2     EC 5.3.1.233 8
Mediator Of RhoA-Dependent Invasion1 2 3     Methylthioribose-1-Phosphate Isomerase Homolog (S. Cerevisiae)1
S-Methyl-5-Thioribose-1-Phosphate Isomerase 11 2     MTNA2
Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein2 3     Ypr118w2
M1Pi2 3     Methylthioribose-1-Phosphate Isomerase2
MRDI2 3     Methylthioribose-1-Phosphate Isomerase Homolog2
MTR-1-P Isomerase2 3     S-Methyl-5-Thioribose-1-Phosphate Isomerase3

External Ids:    HGNC: 284691   Entrez Gene: 842452   Ensembl: ENSG000000377577   OMIM: 6151055   UniProtKB: Q9BV203   

Export aliases for MRI1 gene to outside databases

Previous GC identifers: GC19P013737 GC19P013447


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRI1 Gene: 
MRI1 (methylthioribose-1-phosphate isomerase 1) is a protein-coding gene. Diseases associated with MRI1 include spinal cord melanoma, and visual agnosia, and among its related super-pathways are S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I and Metabolic pathways. GO annotations related to this gene include S-methyl-5-thioribose-1-phosphate isomerase activity and identical protein binding.

UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into
methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in
response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover

Gene Wiki entry for MRI1 (MGC3207) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRI1 gene promoter:
         AhR   RFX1   RP58   AP-4   Arnt   AREB6   E2F   E2F-1   Zic3   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MRI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

MRI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRI1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013875:  view genomic region     (about GC identifiers)

Start:
13,875,337 bp from pter      End:
13,885,096 bp from pter
Size:
9,760 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20 (See protein sequence)
Recommended Name: Methylthioribose-1-phosphate isomerase  
Size: 369 amino acids; 39150 Da
Subcellular location: Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer
cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells
Secondary accessions: Q8NDC9
Alternative splicing: 2 isoforms:  Q9BV20-1   Q9BV20-2   

Explore the universe of human proteins at neXtProt for MRI1: NX_Q9BV20

Explore proteomics data for MRI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BV20

  • 4/14 DME Specific Peptides for MRI1 (Q9BV20) (see all 14)
     NTGALAT  NGDTANK  PFYVAAP  LTHCNTG 

    MRI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRI1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001026897.1  NP_115661.1  

    ENSEMBL proteins: 
     ENSP00000314871   ENSP00000466369   ENSP00000040663  
    Reactome Protein details: Q9BV20
    Human Recombinant Protein Products for MRI1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MRI1
    OriGene Protein Over-expression Lysate for MRI1
    OriGene MassSpec for MRI1 
    OriGene Custom Protein Services for MRI1
    GenScript Custom Purified and Recombinant Proteins Services for MRI1
    Novus Biologicals MRI1 Protein
    Novus Biologicals MRI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRI1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--
    GO:0042995cell projection IEA--

    MRI1 for ontologies           About GeneDecksing



    MRI1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MRI1
    OriGene Custom Antibody Services for MRI1
    GenScript Custom Superior Antibodies Services for MRI1
    Novus Biologicals MRI1 Antibodies
    Abcam antibodies for MRI1
    Cloud-Clone Corp. Antibodies for MRI1 
    Search ThermoFisher Antibodies for MRI1
    LSBio Antibodies in human, mouse, rat for MRI1 

    Assay Products for MRI1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRI1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRI1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRI1 
    Cloud-Clone Corp. CLIAs for MRI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR000649 IF-2B-related
     IPR027363 M1Pi_N
     IPR005251 IF-2BI_MTNA
     IPR011559 Initiation_fac_2B_a/b/d

    Graphical View of Domain Structure for InterPro Entry Q9BV20

    ProtoNet protein and cluster: Q9BV20

    2 Blocks protein domains:
    IPB000649 Initiation factor 2B
    IPB011559 Initiation factor 2B alpha/beta/delta


    UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
    Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily


    MRI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTNA_HUMAN, Q9BV20
    Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into
    methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in
    response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover
    Catalytic activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
    Induction: By RhoA activation in cancer cells (at protein level)

         Enzyme Number (IUBMB): EC 5.3.1.231 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding IPI16189514
    GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity IBA--
         
    MRI1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRI1:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRI1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRI1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MRI1:
    hsa-miR-3616-5p hsa-miR-573 hsa-miR-3647-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRI1
    Sirion Biotech Customized adenovirus for overexpression of MRI1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MRI1 (see all 9)
    OriGene ORF clones in mouse, rat for MRI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRI1 (NM_032285)
    Sino Biological Human cDNA Clone for MRI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1
    Sirion Biotech Customized lentivirus for stable overexpression of MRI1 
                         Customized lentivirus expression plasmids for stable overexpression of MRI1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRI1
    Search LifeMap BioReagents cell lines for MRI1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Methionine salvage pathway
    Methionine salvage pathway0.67
    Metabolism of polyamines0.40
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I0.67
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Cysteine and methionine metabolism
    Cysteine and methionine metabolism0.37
    Sulfur amino acid metabolism0.37
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for MRI1
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I


    5        Reactome Pathways for MRI1
        Metabolism of polyamines
    Metabolism
    Methionine salvage pathway
    Sulfur amino acid metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for MRI1):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6


    MRI1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/21 Interacting proteins for MRI1 (Q9BV201, 2, 3 ENSP000000406634) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61927 I2D: score=3 
    MRI1Q9BV201, 2EBI-747381,EBI-747381 MINT-67041
    RPS13P622773, ENSP000002281404I2D: score=5 STRING: ENSP00000228140
    GCSHP234343, ENSP000003195314I2D: score=1 STRING: ENSP00000319531
    ERHP840903I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0019284L-methionine biosynthetic process from S-adenosylmethionine ----
    GO:0019509L-methionine salvage from methylthioadenosine TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--

    MRI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRI1 (MTNA)

    Search CenterWatch for drugs/clinical trials and news about MRI1 / MTNA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRI1 gene (2 alternative transcripts): 
    NM_001031727.2  NM_032285.2  

    Unigene Cluster for MRI1:

    Methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
    Hs.439370  [show with all ESTs]
    Unigene Representative Sequence: NM_001031727
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588526 ENST00000319545(uc002mxf.3) ENST00000593245 ENST00000591688
    ENST00000040663(uc002mxe.3) ENST00000589290
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRI1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MRI1:
    hsa-miR-3616-5p hsa-miR-573 hsa-miR-3647-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1
    Clone
    Products:
         
    OriGene clones in human, mouse for MRI1 (see all 9)
    OriGene ORF clones in mouse, rat for MRI1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRI1 (NM_032285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1
    Sirion Biotech Customized lentivirus for stable overexpression of MRI1 
                         Customized lentivirus expression plasmids for stable overexpression of MRI1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRI1
    OriGene qSTAR qPCR primer pairs in human, mouse for MRI1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRI1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1

    Additional mRNA sequence: 

    AF318324.1 AK026666.1 AL834276.1 AY358176.1 BC001703.1 

    13 DOTS entries:

    DT.100021762  DT.97841808  DT.100023536  DT.100021763  DT.100779890  DT.97840881  DT.100741593  DT.121447304 
    DT.92009757  DT.95198675  DT.100696001  DT.121447322  DT.95228165 

    24/129 AceView cDNA sequences (see all 129):

    BM464168 C00589 BQ423609 CA443924 BI836320 AI827445 BQ957291 AW628063 
    BQ278850 BQ944049 BF109788 CA390560 BQ641878 BC001703 BG177952 BM560629 
    AI368751 BM311623 BU857713 BU633616 BG679149 BV188669 AI086053 BX372899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MRI1 Expression
    About this image


    See MRI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRI1

    SOURCE GeneReport for Unigene cluster: Hs.439370
        SABiosciences Custom PCR Arrays for MRI1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MRI1
    OriGene qSTAR qPCR primer pairs in human, mouse for MRI1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRI1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRI1 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mri11 , 5 methylthioribose-1-phosphate isomerase homolog (S. more1, 5 83.92(n)1
    86.38(a)1
      8 (40.74 cM)5
    678731  NM_026423.41  NP_080699.31 
     842499065 
    lizard
    (Anolis carolinensis)
    Reptilia MRI16
    methylthioribose-1-phosphate isomerase homolog (S....
    74(a)
    1 ↔ 1
    3(27485312-27496564)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158012 Xenopus laevis transcribed sequence with weak similarity more 76.79(n)    BX854398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mri11 methylthioribose-1-phosphate isomerase homolog (S. more 67.99(n)
    68.75(a)
      100002302  NM_001111238.1  NP_001104708.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113341 CG11334 61.62(n)
    60.78(a)
      43713  NM_143611.3  NP_651868.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C01G10.91 Protein C01G10.9 49.25(n)
    45.37(a)
      180016  NM_074313.5  NP_506714.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRI1(YPR118W)4
    MRI11
    5'-methylthioribose-1-phosphate isomerase; catalyzes more4
    Mri1p1
    50.39(n)1
    49.41(a)1
      16(767752-768987)4
    8562341, 4  NP_015443.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G058301 NagB/RpiA/CoA transferase-like protein 55.62(n)
    60.06(a)
      815134  NM_126596.3  NP_027726.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02169001 hypothetical protein 54.94(n)
    57.18(a)
      4350083  NM_001074043.1  NP_001067511.1 


    ENSEMBL Gene Tree for MRI1 (if available)
    TreeFam Gene Tree for MRI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/284 SNPs in MRI1 are shown (see all 284)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81036731,2
    C,F--13874633(+) gctggG/Cactac 2 -- us2k13Minor allele frequency- C:0.50WA CSA 6
    rs1905743821,2
    C--13874688(+) GAGACG/TGGGTT 2 -- us2k10--------
    rs1499345111,2
    --13874701(+) ACCATC/GTTGGC 2 -- us2k10--------
    rs1835774161,2
    --13874790(+) CACAGC/TGCCTG 2 -- us2k10--------
    rs1129082201,2
    C--13874898(+) ACCTT-/GGAGAA
            
    GGAAG
    2 -- cds11Minor allele frequency- GGAGAA:0.50CSA 2
    rs578131901,2
    C--13874901(+) TTGGA-/GAAGGA
            
    AGATC
    2 -- cds10--------
    rs1464733381,2
    C--13874982(+) AGCAGA/GTTGTT 2 -- us2k10--------
    rs1889105901,2
    --13875004(+) CTGGTA/GTCCAC 2 -- us2k10--------
    rs1932430501,2
    --13875046(+) GTTCCA/GAGGAG 2 -- us2k10--------
    rs1137171921,2
    F--13875138(+) TCCGCC/GTCCTG 2 -- us2k11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for MRI1 (13875337 - 13885096 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRI1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833757CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRI1
    DNA2.0 Custom Variant and Variant Library Synthesis for MRI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615105    OMIM disorders: --

    9 diseases for MRI1:    About MalaCards
    spinal cord melanoma    visual agnosia    gemistocytic astrocytoma    wernicke encephalopathy
    cavernous hemangioma    agnosia    hemangioma    astrocytoma
    melanoma

    2 diseases from the University of Copenhagen DISEASES database for MRI1:
    Cavernous hemangioma     Visual agnosia

    MRI1 for disorders           About GeneDecksing


    Export disorders for MRI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRI1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with MRI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. (PubMed id 19620624)1, 2, 3 Kabuyama Y....Ahn N.G. (2009)
    2. Identification of MRI1, encoding translation initiatio n factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. (PubMed id 23124037)1, 3 Sunker A. and Alkuraya F.S. (2013)
    3. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. (PubMed id 15215245)1, 3 Bumann M....Baumann U. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84245 HGNC: 28469 AceView: MGC3207 Ensembl:ENSG00000037757 euGenes: HUgn84245
    ECgene: MRI1 Kegg: 84245 H-InvDB: MRI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRI1 gene:
    Search GeneIP for patents involving MRI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRI1   OriGene RNAi products in human, mouse, rat for MRI1  
     OriGene qPCR primer pairs and template standards for MRI1   OriGene Protein Over-expression Lysate for MRI1  
     OriGene MassSpec something-or-other for MRI1   OriGene clones in human, mouse for MRI1  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRI1   OriGene Purified Protein for MRI1  
     OriGene ORF clones in mouse, rat for MRI1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRI1   OriGene Custom Protein Services for MRI1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRI1
     QIAGEN SeqTarget long-range PCR primers for resequencing MRI1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRI1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
     GenScript Custom Purified and Recombinant Proteins Services for MRI1 GenScript cDNA clones with any tag delivered in your preferred vector for MRI1
     GenScript Custom Assay Services for MRI1 GenScript Custom Superior Antibodies Services for MRI1
     GenScript Custom overexpressing Cell Line Services for MRI1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MRI1 promoter
     Search Chromatin IP Primers for MRI1
     RT2 qPCR Primer Assay in human, mouse, rat MRI1
     Search GNC Networks for MRI1
     SABiosciences Custom PCR Arrays for MRI1
     Search Tocris compounds for MRI1 (MTNA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for MRI1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MRI1 antibodies
     MRI1 proteins
     MRI1 lysates
     Antibodies for MRI1
     See all of Abcam's Antibodies, Kits and Proteins for MRI1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for MRI1
     Antibodies for MRI1
     ELISAs for MRI1
     CLIAs for MRI1
     Search LifeMap BioReagents cell lines for MRI1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for MRI1
     Browse SwitchGear Promoter luciferase reporter plasmids for MRI1
     Search ThermoFisher Antibodies for MRI1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for MRI1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRI1
    Customized:
     lentivirus for stable overexpression of MRI1
     lentivirus expression plasmids for stable overexpression of MRI1
     adenovirus for overexpression of MRI1
     LSBio Antibodies in human, mouse, rat for MRI1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRI1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4