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Aliases for MRI1 Gene

Aliases for MRI1 Gene

  • Methylthioribose-1-Phosphate Isomerase 1 2 3 5
  • Mediator Of RhoA-Dependent Invasion 2 3 4
  • Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein 3 4
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 1 2 3
  • MTR-1-P Isomerase 3 4
  • EC 5.3.1.23 4 61
  • M1Pi 3 4
  • MRDI 3 4
  • Methylthioribose-1-Phosphate Isomerase Homolog (S. Cerevisiae) 2
  • Methylthioribose-1-Phosphate Isomerase Homolog 3
  • S-Methyl-5-Thioribose-1-Phosphate Isomerase 4
  • Methylthioribose-1-Phosphate Isomerase 3
  • Ypr118w 3
  • MTNA 3

External Ids for MRI1 Gene

Previous GeneCards Identifiers for MRI1 Gene

  • GC19P013875
  • GC19P013447

Summaries for MRI1 Gene

Entrez Gene Summary for MRI1 Gene

  • This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]

GeneCards Summary for MRI1 Gene

MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. Diseases associated with MRI1 include Spinal Cord Melanoma and Visual Agnosia. Among its related pathways are Viral mRNA Translation and S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation. GO annotations related to this gene include identical protein binding and S-methyl-5-thioribose-1-phosphate isomerase activity.

UniProtKB/Swiss-Prot for MRI1 Gene

  • Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.

Gene Wiki entry for MRI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRI1 Gene

Genomics for MRI1 Gene

Regulatory Elements for MRI1 Gene

Enhancers for MRI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G012781 1.9 FANTOM5 ENCODE dbSUPER 51.6 -975.2 -975195 16.0 MLX CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ZNF136 ZNF844 CCDC130 ZNF564 ZNF442 ZNF625 MRI1 ZNF44 C19orf43 WDR83OS
GH19G014111 1.8 FANTOM5 ENCODE dbSUPER 42.3 +351.6 351643 9.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 CCDC130 MRI1 ZNF333 TRMT1 PRKACA LOC284454 RFX1 SNRPGP15 TECR ADGRE5
GH19G012983 2 FANTOM5 Ensembl ENCODE dbSUPER 37 -779.7 -779690 3.2 HDGF FOXA2 PKNOX1 MLX CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF625 ZNF136 ZNF844 ZNF442 ZNF788 ENSG00000242615 ZNF709 ZNF799 ZNF564 CCDC130
GH19G014378 1.7 FANTOM5 ENCODE dbSUPER 37 +618.1 618085 7.7 CREB3L1 MLX DMAP1 FEZF1 YBX1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 AKAP8 CCDC130 ZNF333 MRI1 DDX39A LOC284454 ADGRE5 DCAF15 RFX1 PKN1
GH19G013763 1 ENCODE 57.6 +0.5 485 2.4 HDGF FOXA2 CREB3L1 AGO1 ARID4B SIN3A GATA2 SP3 SP5 REST MRI1 ENSG00000267633
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRI1 on UCSC Golden Path with GeneCards custom track

Promoters for MRI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107432 208 1401 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A GATA2 SP3 SP5 REST

Genomic Location for MRI1 Gene

Chromosome:
19
Start:
13,764,492 bp from pter
End:
13,774,282 bp from pter
Size:
9,791 bases
Orientation:
Plus strand

Genomic View for MRI1 Gene

Genes around MRI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRI1 Gene

Proteins for MRI1 Gene

  • Protein details for MRI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV20-MTNA_HUMAN
    Recommended name:
    Methylthioribose-1-phosphate isomerase
    Protein Accession:
    Q9BV20
    Secondary Accessions:
    • Q8NDC9

    Protein attributes for MRI1 Gene

    Size:
    369 amino acids
    Molecular mass:
    39150 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRI1 Gene

    Alternative splice isoforms for MRI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRI1 Gene

Selected DME Specific Peptides for MRI1 Gene

Q9BV20:
  • NTGALAT
  • PAFDVTP
  • LATAGYGTAL
  • GTALGVI
  • YGTALGV
  • NPAFDVT
  • ETRPYNQG
  • LTHCNTG
  • PFYVAAP
  • GYGTALG
  • AVVVGADR
  • NGDTANK
  • GIITELGVFAP
  • VRGAPAI

Post-translational modifications for MRI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRI1 Gene

Domains & Families for MRI1 Gene

Suggested Antigen Peptide Sequences for MRI1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BV20

UniProtKB/Swiss-Prot:

MTNA_HUMAN :
  • Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Family:
  • Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
genes like me logo Genes that share domains with MRI1: view

No data available for Gene Families for MRI1 Gene

Function for MRI1 Gene

Molecular function for MRI1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.
UniProtKB/Swiss-Prot Induction:
By RhoA activation in cancer cells (at protein level).

Enzyme Numbers (IUBMB) for MRI1 Gene

Gene Ontology (GO) - Molecular Function for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity TAS --
genes like me logo Genes that share ontologies with MRI1: view
genes like me logo Genes that share phenotypes with MRI1: view

Animal Model Products

CRISPR Products

miRNA for MRI1 Gene

miRTarBase miRNAs that target MRI1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRI1 Gene

Localization for MRI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRI1 Gene

Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRI1 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 1

Gene Ontology (GO) - Cellular Components for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MRI1: view

Pathways & Interactions for MRI1 Gene

genes like me logo Genes that share pathways with MRI1: view

UniProtKB/Swiss-Prot Q9BV20-MTNA_HUMAN

  • Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.

Gene Ontology (GO) - Biological Process for MRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008652 cellular amino acid biosynthetic process IEA --
GO:0009086 methionine biosynthetic process IEA --
GO:0019509 L-methionine biosynthetic process from methylthioadenosine TAS --
GO:0044237 cellular metabolic process IEA --
GO:0044249 cellular biosynthetic process IEA --
genes like me logo Genes that share ontologies with MRI1: view

No data available for SIGNOR curated interactions for MRI1 Gene

Drugs & Compounds for MRI1 Gene

(2) Additional Compounds for MRI1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Methylthioribose 1-phosphate
  • 1-Phospho-5-S-methylthioribose
  • 1-Phosphomethylthioribose
  • 5-Methylthio-5-deoxy-D-ribose 1-phosphate
  • 5-Methylthio-5-deoxy-D-ribose-1-phosphate
  • 5-Methylthio-D-ribose-1-phosphate
72843-83-5
5-Methylthioribulose 1-phosphate
  • 1-Phospho-5-S-methylthioribulose
  • 1-Phosphomethylthioribulose
  • 1PMT-ribulose
  • 5-Methylthio-2-ribulose-1-phosphate
  • 5-Methylthio-5-deoxy-D-ribulose 1-phosphate
86316-83-8
genes like me logo Genes that share compounds with MRI1: view

Transcripts for MRI1 Gene

Unigene Clusters for MRI1 Gene

Methylthioribose-1-phosphate isomerase homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRI1 Gene

No ASD Table

Relevant External Links for MRI1 Gene

GeneLoc Exon Structure for
MRI1
ECgene alternative splicing isoforms for
MRI1

Expression for MRI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRI1 Gene

Protein differential expression in normal tissues from HIPED for MRI1 Gene

This gene is overexpressed in Salivary gland (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRI1 Gene



Protein tissue co-expression partners for MRI1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRI1 Gene:

MRI1

SOURCE GeneReport for Unigene cluster for MRI1 Gene:

Hs.439370

Evidence on tissue expression from TISSUES for MRI1 Gene

  • Nervous system(4.5)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with MRI1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRI1 Gene

Orthologs for MRI1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRI1 34 35
  • 98.64 (n)
dog
(Canis familiaris)
Mammalia MRI1 34 35
  • 89.22 (n)
cow
(Bos Taurus)
Mammalia MRI1 34 35
  • 88.55 (n)
mouse
(Mus musculus)
Mammalia Mri1 34 16 35
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Mri1 34
  • 83.74 (n)
oppossum
(Monodelphis domestica)
Mammalia MRI1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRI1 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRI1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mri1 34
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15801 34
zebrafish
(Danio rerio)
Actinopterygii mri1 35 34
  • 68.59 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11334 34 35
  • 61.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001589 34
  • 58.82 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C01G10.9 34
  • 48.63 (n)
C01G10.9 35
  • 41 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR098W 34
  • 55.2 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D15455g 34
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRI1 34 35 37
  • 49.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G05830 34
  • 55.36 (n)
rice
(Oryza sativa)
Liliopsida Os11g0216900 34
  • 54.13 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.181 34
wheat
(Triticum aestivum)
Liliopsida Ta.14479 34
corn
(Zea mays)
Liliopsida Zm.9981 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02226 34
  • 60.66 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC23E6.10c 34
  • 53.55 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2138 34
Species where no ortholog for MRI1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MRI1 Gene

ENSEMBL:
Gene Tree for MRI1 (if available)
TreeFam:
Gene Tree for MRI1 (if available)

Paralogs for MRI1 Gene

No data available for Paralogs for MRI1 Gene

Variants for MRI1 Gene

Sequence variations from dbSNP and Humsavar for MRI1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs141094096 Likely pathogenic 13,768,642(+) AGCCC(A/G)GCTGA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1000063474 -- 13,764,464(+) GGAAT(C/T)GGGTT upstream-variant-2KB
rs1000111408 -- 13,769,648(+) CAGGC(A/G)AGGTG intron-variant, utr-variant-3-prime
rs1000226332 -- 13,769,453(+) GCCAC(A/G)GCACG intron-variant
rs1000447039 -- 13,767,224(+) ATATT(C/T)TTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRI1 Gene

Variant ID Type Subtype PubMed ID
esv3893166 CNV gain 25118596
nsv833757 CNV loss 17160897

Variation tolerance for MRI1 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRI1 Gene

Human Gene Mutation Database (HGMD)
MRI1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRI1 Gene

Disorders for MRI1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MRI1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinal cord melanoma
  • melanoma of the spinal cord
visual agnosia
  • primary visual agnosia
arachnoiditis
  • spinal arachnoiditis
epidural abscess
  • abscess epidural
discitis
- elite association - COSMIC cancer census association via MalaCards
Search MRI1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRI1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRI1
genes like me logo Genes that share disorders with MRI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRI1 Gene

Publications for MRI1 Gene

  1. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. (PMID: 19620624) Kabuyama Y. … Ahn N.G. (Mol. Cell. Proteomics 2009) 2 3 4 64
  2. Identification of MRI1, encoding translation initiation factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. (PMID: 23124037) Sunker A. … Alkuraya F.S. (Gene 2013) 2 3 64
  3. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. (PMID: 15215245) Bumann M. … Baumann U. (J. Biol. Chem. 2004) 2 3 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for MRI1 Gene

Sources for MRI1 Gene

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