Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRI1 Gene

protein-coding   GIFtS: 52
GCID: GC19P013875

methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)

 Explore 8 diseases affiliated with
MRI1 via our new
 Human Malady Compendium 
Biological research products
for MRI1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Methylthioribose-1-Phosphate Isomerase Homolog (S. Cerevisiae)1 2     MTR-1-P Isomerase2 3
MTNA1 2     S-Methyl-5-Thioribose-1-Phosphate Isomerase2 3
Ypr118w1 2     EC 5.3.1.233 8
Mediator Of RhoA-Dependent Invasion2 3     MGC32071
Translation Initiation Factor EIF-2B Subunit Alpha/Beta/Delta-Like Protein2 3     Methylthioribose-1-Phosphate Isomerase2
M1Pi2 3     MRDI3

External Ids:    HGNC: 284691   Entrez Gene: 842452   Ensembl: ENSG000000377577   UniProtKB: Q9BV203   

Export aliases for MRI1 gene to outside databases

Previous GC identifers: GC19P013737 GC19P013447


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate
(MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation
by promoting FAK tyrosine phosphorylation and stress fiber turnover

Gene Wiki entry for MRI1 (MGC3207)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRI1 gene promoter:
         AhR   RFX1   RP58   AP-4   Arnt   AREB6   E2F   E2F-1   Zic3   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MRI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.13

MRI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRI1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013875:  view genomic region     (about GC identifiers)

Start:
13,875,337 bp from pter      End:
13,885,096 bp from pter
Size:
9,760 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20 (See protein sequence)
Recommended Name: Methylthioribose-1-phosphate isomerase  
Size: 369 amino acids; 39150 Da
Subcellular location: Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells,
with enrichment at leading edge of the plasma membrane in late stage tumor cells
Secondary accessions: Q8NDC9
Alternative splicing: 2 isoforms:  Q9BV20-1   Q9BV20-2   

Explore the universe of human proteins at neXtProt for MRI1: NX_Q9BV20

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BV20

  • 4/14 DME Specific Peptides for MRI1 (Q9BV20) (see all 14)
     NTGALAT  NGDTANK  PFYVAAP  LTHCNTG 

    MRI1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001026897.1  NP_115661.1  

    ENSEMBL proteins: 
     ENSP00000314871   ENSP00000466369   ENSP00000040663  
    Reactome Protein details: Q9BV20
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MRI1
    OriGene Protein Over-expression Lysate: MRI1
    OriGene Custom Protein Services for MRI1 
    GenScript Custom Purified and Recombinant Proteins Services for MRI1
    Novus Biologicals MRI1 Protein
    Novus Biologicals MRI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MRI1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--
    GO:0042995cell projection IEA--


    MRI1 for ontologies           About GeneDecksing



    MRI1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 3): MRI1
    OriGene Custom Antibody Services for MRI1 
    GenScript Custom Superior Antibodies Services for MRI1
    Novus Biologicals MRI1 Antibodies
    Search for Antibodies for MRI1 at Abcam  
    Uscn Antibodies for MRI1
    Search ThermoFisher Antibodies for MRI1

    Assay Products for MRI1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRI1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MRI1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MRI1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000649 IF-2B-related
     IPR005251 IF-2BI_MTNA
     IPR011559 Initiation_fac_2B_a/b/d

    Graphical View of Domain Structure for InterPro Entry Q9BV20

    ProtoNet protein and cluster: Q9BV20

    2 Blocks protein families:
    IPB000649 Initiation factor 2B
    IPB011559 Initiation factor 2B alpha/beta/delta


    UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
    Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
    Function: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate
    (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation
    by promoting FAK tyrosine phosphorylation and stress fiber turnover
    Catalytic activity: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
    Induction: By RhoA activation in cancer cells (at protein level)

    Enzyme Number (IUBMB): EC 5.3.1.231 2

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRI1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MRI1:
    hsa-miR-3616-5p hsa-miR-573 hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRI1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRI1 (see all 3)
    OriGene siRNA: MRI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRI1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MRI1 (NM_032285)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRI1
    Search LifeMap BioReagents cell lines for MRI1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042802identical protein binding IPI19447967
    GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity IBA--


    MRI1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MRI1:
     Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Methionine salvage pathway
    Methionine salvage pathway1.00
    Metabolism of polyamines0.40
    S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation0.67
    2Sulfur amino acid metabolism
    Sulfur amino acid metabolism1.00
    Cysteine and methionine metabolism0.36
    3Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    4Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for MRI1 
        S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation

    5        Reactome Pathways for MRI1
        Metabolism of polyamines
    Metabolism
    Methionine salvage pathway
    Sulfur amino acid metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for MRI1):
        Cysteine and methionine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: MTNA_HUMAN, Q9BV20
    Pathway: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from
    S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6


    MRI1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/21 Interacting proteins for MRI1 (Q9BV201, 2, 3 ENSP000000406634) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATF7IPQ6VMQ62, 3MINT-61927 I2D: score=3 
    MRI1Q9BV201, 2EBI-747381,EBI-747381 MINT-67041
    RPS13P622773, ENSP000002281404I2D: score=5 STRING: ENSP00000228140
    GCSHP234343, ENSP000003195314I2D: score=1 STRING: ENSP00000319531
    ERHP840903I2D: score=5 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000096sulfur amino acid metabolic process TAS--
    GO:0006595polyamine metabolic process TAS--
    GO:0019284L-methionine biosynthetic process from S-adenosylmethionine IEA--
    GO:0019509L-methionine salvage from methylthioadenosine TAS--
    GO:0034641cellular nitrogen compound metabolic process TAS--


    MRI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRI1
    Search CenterWatch for drugs/clinical trials and news about MRI1 / MTNA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRI1 gene (2 alternative transcripts): 
    NM_001031727.2  NM_032285.2  

    Unigene Cluster for MRI1:

    Methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
    Hs.439370  [show with all ESTs]
    Unigene Representative Sequence: NM_001031727
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588526 ENST00000319545(uc002mxf.3) ENST00000593245 ENST00000591688
    ENST00000040663(uc002mxe.3) ENST00000589290

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRI1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MRI1:
    hsa-miR-3616-5p hsa-miR-573 hsa-miR-3647-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRI1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRI1 (see all 3)
    OriGene siRNA: MRI1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MRI1 (NM_032285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRI1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRI1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1

    Additional cDNA sequence: 

    AF318324.1 AK026666.1 AL834276.1 AY358176.1 BC001703.1 

    13 DOTS entries:

    DT.100021762  DT.97841808  DT.100023536  DT.100021763  DT.100779890  DT.97840881  DT.100741593  DT.121447304 
    DT.92009757  DT.95198675  DT.100696001  DT.121447322  DT.95228165 

    24/129 AceView cDNA sequences (see all 129):

    CA443924 BQ423609 BM464168 BQ957291 C00589 BQ944049 AW628063 BI836320 
    AI827445 BQ278850 AY358176 BV188669 AW191869 BU619575 AI659046 CK821590 
    BX369663 BM693580 AA768616 BU857713 BI823048 CA390560 BX383983 AI199259 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MRI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRI1

    SOURCE GeneReport for Unigene cluster: Hs.439370
        SABiosciences Custom PCR Arrays for MRI1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRI1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRI1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRI1 gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mri11 , 5 methylthioribose-1-phosphate isomerase homolog (S. more1, 5 83.92(n)1
    86.38(a)1
      8 (40.74 cM)5
    678731  NM_026423.41  NP_080699.31 
     842499065 
    lizard
    (Anolis carolinensis)
    Reptilia MRI16
    --
    72(a)
    1 ↔ 1
    3(27489232-27496336)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.158012 Xenopus laevis transcribed sequence with weak similarity more 76.79(n)    BX854398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mri11 methylthioribose-1-phosphate isomerase homolog (S. more 67.99(n)
    68.75(a)
      100002302  NM_001111238.1  NP_001104708.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113341 CG11334 61.62(n)
    60.78(a)
      43713  NM_143611.3  NP_651868.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C01G10.91 Protein C01G10.9 49.25(n)
    45.37(a)
      180016  NM_074313.5  NP_506714.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRI1(YPR118W)4
    MRI11
    5'-methylthioribose-1-phosphate isomerase; catalyzes more4
    Mri1p1
    50.39(n)1
    49.41(a)1
      16(767752-768987)4
    8562341, 4  NP_015443.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G058301 NagB/RpiA/CoA transferase-like protein 55.62(n)
    60.06(a)
      815134  NM_126596.3  NP_027726.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g02169001 hypothetical protein 54.94(n)
    57.18(a)
      4350083  NM_001074043.1  NP_001067511.1 


    ENSEMBL Gene Tree for MRI1 (if available)
    TreeFam Gene Tree for MRI1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in MRI1 are shown (see all 215    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81036731,2
    C,F,--13874633(+) gctggG/Cactac 2 -- us2k13Minor allele frequency- C:0.50WA CSA 6
    rs1905743821,2
    --13874688(+) GAGACG/TGGGTT 2 -- us2k10--------
    rs1499345111,2
    --13874701(+) ACCATC/GTTGGC 2 -- us2k10--------
    rs1835774161,2
    --13874790(+) CACAGC/TGCCTG 2 -- us2k10--------
    rs1129082201,2
    C,--13874898(+) ACCTT-/GGAGAA
            
    GGAAG
    2 -- us2k11Minor allele frequency- GGAGAA:0.50CSA 2
    rs578131901,2
    C--13874901(+) TTGGA-/GAAGGA
            
    AGATC
    2 -- us2k10--------
    rs1464733381,2
    --13874982(+) AGCAGA/GTTGTT 2 -- us2k10--------
    rs1889105901,2
    --13875004(+) CTGGTA/GTCCAC 2 -- us2k10--------
    rs1932430501,2
    --13875046(+) GTTCCA/GAGGAG 2 -- us2k10--------
    rs1137171921,2
    --13875138(+) TCCGCC/GTCCTG 2 -- us2k11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for MRI1 (13875337 - 13885096 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MRI1
         1 CNV: 5088

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRI1
    DNA2.0 Custom Variant and Variant Library Synthesis for MRI1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRI1 for disorders           About GeneDecksing

    8 diseases for MRI1:    About MalaCards
    epilepsia partialis continua    spinal cord melanoma    wernicke encephalopathy    gemistocytic astrocytoma
    cavernous hemangioma    hemangioma    melanoma    astrocytoma

    3 diseases from the University of Copenhagen DISEASES database for MRI1:
    Visual agnosia     Cavernous hemangioma     Wernicke encephalopathy

    Export disorders for MRI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRI1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MRI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits. (PubMed id 15215245)1, 3 Bumann M....Baumann U. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Identification of MRI1, encoding translation initiatio n factor eIF-2B subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. (PubMed id 23124037)1 Sunker A. and Alkuraya F.S. (2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. (PubMed id 19620624)2 Kabuyama Y....Ahn N.G. (2009)
    9. Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84245 HGNC: 28469 AceView: MGC3207 Ensembl:ENSG00000037757 euGenes: HUgn84245
    ECgene: MRI1 Kegg: 84245 H-InvDB: MRI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRI1 gene:
    Search GeneIP for patents involving MRI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MRI1   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRI1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRI1  
     OriGene Protein Over-expression Lysate for MRI1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MRI1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRI1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MRI1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRI1   OriGene Custom Protein Services for MRI1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRI1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRI1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRI1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRI1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRI1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRI1
     GenScript Custom Purified and Recombinant Proteins Services for MRI1 GenScript cDNA clones with any tag delivered in your preferred vector for MRI1
     GenScript Custom Assay Services for MRI1 GenScript Custom Superior Antibodies Services for MRI1
     GenScript Custom overexpressing Cell Line Services for MRI1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in MRI1 promoter
     Search Chromatin IP Primers for MRI1
     RT2 qPCR Primer Assay in human, mouse, rat MRI1
     Search GNC Networks for MRI1
     SABiosciences Custom PCR Arrays for MRI1
     Search Tocris compounds for MRI1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MRI1 antibodies
     MRI1 proteins
     MRI1 lysates
     Search for Antibodies for MRI1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for MRI1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MRI1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MRI1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRI1
     SwitchGear 3'UTR luciferase reporter plasmids for MRI1
     Browse SwitchGear Promoter luciferase reporter plasmids for MRI1
     Search ThermoFisher Antibodies for MRI1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRI1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRI1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4