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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRGPRX4 Gene

protein-coding   GIFtS: 46
GCID: GC11P018194

MAS-Related GPR, Member X4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAS-Related GPR, Member X41 2     G Protein-Coupled Receptor MRGX42
MRGX42 3 5     G Protein-Coupled Receptor SNSR52
Sensory Neuron-Specific G-Protein Coupled Receptor 5/62 3     G Protein-Coupled Receptor SNSR62
SNSR62 3     Mas-Related G-Protein Coupled Receptor Member X42
GPCR2     SNSR53

External Ids:    HGNC: 176171   Entrez Gene: 1171962   Ensembl: ENSG000001798177   OMIM: 6072305   UniProtKB: Q96LA93   

Export aliases for MRGPRX4 gene to outside databases

Previous GC identifers: GC11P018152 GC11P017877


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRGPRX4 Gene: 
MRGPRX4 (MAS-related GPR, member X4) is a protein-coding gene. Diseases associated with MRGPRX4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

Gene Wiki entry for MRGPRX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRGPRX4 gene promoter:
         FOXD1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LUN-1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRGPRX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018194:  view genomic region     (about GC identifiers)

Start:
18,194,384 bp from pter      End:
18,195,827 bp from pter
Size:
1,444 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X4  
Size: 322 amino acids; 36461 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q3KNU3 Q3KNU4 Q502W0 Q8TDD6 Q8TDD7

Explore the universe of human proteins at neXtProt for MRGPRX4: NX_Q96LA9

Explore proteomics data for MRGPRX4 at MOPED 

MRGPRX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

MRGPRX4 Protein Expression

REFSEQ proteins: NP_473373.2  
ENSEMBL proteins: 
 ENSP00000314042  

Human Recombinant Protein Products for MRGPRX4: 
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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

MRGPRX4 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX4 
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR026234 MRGPCRFAMILY
 IPR027344 MRGPCRX4
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96LA9

ProtoNet protein and cluster: Q96LA9

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


MRGPRX4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGX4_HUMAN, Q96LA9
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
MRGPRX4 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRX4

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

MRGPRX4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for MRGPRX4 (MRGX4)

Search CenterWatch for drugs/clinical trials and news about MRGPRX4 / MRGX4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRGPRX4 gene: 
NM_054032.3  

Unigene Cluster for MRGPRX4:

MAS-related GPR, member X4
Hs.632138  [show with all ESTs]
Unigene Representative Sequence: BC095509
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000314254(uc001mnv.1)
miRNA
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Additional mRNA sequence: 

BC095509.1 BC107099.1 BC107100.1 

2 DOTS entries:

DT.97767716  DT.99943097 

10 AceView cDNA sequences:

CN839634 CN835944 CN839711 NM_054032 CN839827 CN835770 CN839765 CN834097 
CN839609 CN840024 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRGPRX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGGGAGAGCC
MRGPRX4 Expression
About this image


See MRGPRX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRGPRX4

SOURCE GeneReport for Unigene cluster: Hs.632138

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons

    SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX4: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX4 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgprx11 , 5 MAS-related GPR, member X11, 5 66.67(n)1
53.65(a)1
  7 (31.09 cM)5
4042421  NM_207540.31  NP_997423.11 
 480209715 
chicken
(Gallus gallus)
Aves LOC4304331 proto-oncogene Mas-like 56.61(n)
43.25(a)
  430433  XM_427992.3  XP_427992.3 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 19)
Uncharacterized protein
(see all 19)
33(a)
31(a)
(see all 19)
many ↔ many
many ↔ many
(see all 19)
4(16394563-16395360)
4(16466473-16468643)


ENSEMBL Gene Tree for MRGPRX4 (if available)
TreeFam Gene Tree for MRGPRX4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MRGPRX4 gene
MRGPRX32  MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX12  MRGPRE2  
MRGPRX22  
9 SIMAP similar genes for MRGPRX4 using alignment to 1 protein entry:     MRGX4_HUMAN:
MRGPRX3    MRGPRX1    MRGPRX2    MAS1    MAS1L    MRGPRD
MRGPRF    MRGPRE    MRGPRG

MRGPRX4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/147 SNPs in MRGPRX4 are shown (see all 147)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1483090601,2
C--18192429(+) TGCTTA/GCATCA 1 -- us2k10--------
rs24032481,2
C,F,H--18192524(-) GAGTAT/AAAAAG 1 -- us2k1 tfbs310Minor allele frequency- A:0.35NS EA WA NA CSA 778
rs18405961,2
C,F,A,H--18192694(-) CTGGAA/GCCCTG 1 -- us2k18Minor allele frequency- G:0.34NA WA EA 370
rs1812506431,2
--18192721(+) TTAGAA/CTTGCT 1 -- us2k10--------
rs20780661,2
C,F,A,H--18192836(-) CACCAA/TCATTT 1 -- us2k122Minor allele frequency- T:0.33NS EA NA WA CSA 2354
rs1158140231,2
C,F--18192932(+) ATAGAT/CAGAGA 1 -- us2k11Minor allele frequency- C:0.02WA 118
rs20146941,2
C,F,O,A,H--18193020(-) GCAAGG/CTGCCA 1 -- us2k114Minor allele frequency- C:0.35NS EA NA WA 924
rs110245281,2
C,H--18193077(+) CTGTAC/ATCCCA 1 -- us2k14Minor allele frequency- A:0.00NS EA 414
rs169351171,2
C,F,H--18193092(+) AGGGTG/ACATCT 1 -- us2k18Minor allele frequency- A:0.06NA NS EA WA 680
rs71079571,2
C,F,A,H--18193107(+) TCCACC/TAGGAG 1 -- us2k110Minor allele frequency- T:0.14NS EA NA WA 782

HapMap Linkage Disequilibrium report for MRGPRX4 (18194384 - 18195827 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for MRGPRX4:    About this table     
Variant IDTypeSubtypePubMed ID
esv2744166CNV Deletion23290073
esv2668662CNV Deletion23128226
nsv518373CNV Loss19592680
esv23532CNV Gain19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607230    OMIM disorders: --

2 diseases for MRGPRX4:    About MalaCards
neuronitis    


MRGPRX4 for disorders           About GeneDecksing

Genetic Association Database (GAD): MRGPRX4
Human Genome Epidemiology (HuGE) Navigator: MRGPRX4 (1 document)

Export disorders for MRGPRX4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MRGPRX4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRX4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (2001)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)1, 2 Lembo P.M.C.... Ahmad S. (2002)
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 117196 HGNC: 17617 AceView: MRGX4 Ensembl:ENSG00000179817 euGenes: HUgn117196
ECgene: MRGPRX4 H-InvDB: MRGPRX4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MRGPRX4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MRGPRX4 gene:
Search GeneIP for patents involving MRGPRX4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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