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Aliases for MRGPRX4 Gene

Aliases for MRGPRX4 Gene

  • MAS-Related GPR, Member X4 2 3
  • MRGX4 3 4 6
  • Sensory Neuron-Specific G-Protein Coupled Receptor 5/6 3 4
  • SNSR6 3 4
  • Mas-Related G-Protein Coupled Receptor Member X4 3
  • G Protein-Coupled Receptor MRGX4 3
  • G Protein-Coupled Receptor SNSR5 3
  • G Protein-Coupled Receptor SNSR6 3
  • SNSR5 4
  • GPCR 3

External Ids for MRGPRX4 Gene

Summaries for MRGPRX4 Gene

GeneCards Summary for MRGPRX4 Gene

MRGPRX4 (MAS-Related GPR, Member X4) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRF.

UniProtKB/Swiss-Prot for MRGPRX4 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX4 Gene

Genomics for MRGPRX4 Gene

Genomic Location for MRGPRX4 Gene

Start:
18,172,837 bp from pter
End:
18,197,348 bp from pter
Size:
24,512 bases
Orientation:
Plus strand

Genomic View for MRGPRX4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX4 Gene

Regulatory Elements for MRGPRX4 Gene

Proteins for MRGPRX4 Gene

  • Protein details for MRGPRX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA9-MRGX4_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X4
    Protein Accession:
    Q96LA9
    Secondary Accessions:
    • Q3KNU3
    • Q3KNU4
    • Q502W0
    • Q8TDD6
    • Q8TDD7

    Protein attributes for MRGPRX4 Gene

    Size:
    322 amino acids
    Molecular mass:
    36461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX4 Gene

Proteomics data for MRGPRX4 Gene at MOPED

Post-translational modifications for MRGPRX4 Gene

Other Protein References for MRGPRX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX4 Gene

Domains for MRGPRX4 Gene

Gene Families for MRGPRX4 Gene

HGNC:
  • GPCRAO :GPCR / Class A : Orphans
IUPHAR :

Protein Domains for MRGPRX4 Gene

UniProtKB/Swiss-Prot:

MRGX4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.:
    • Q96LA9
genes like me logo Genes that share domains with MRGPRX4: view

Function for MRGPRX4 Gene

Molecular function for MRGPRX4 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRGPRX4 Gene

Localization for MRGPRX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRGPRX4 Gene COMPARTMENTS Subcellular localization image for MRGPRX4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view

Pathways for MRGPRX4 Gene

SuperPathways for MRGPRX4 Gene

No Data Available

Interacting Proteins for MRGPRX4 Gene

Gene Ontology (GO) - Biological Process for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view

No data available for Pathways by source for MRGPRX4 Gene

Transcripts for MRGPRX4 Gene

mRNA/cDNA for MRGPRX4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX4 Gene

MAS-related GPR, member X4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX4 Gene

No ASD Table

Relevant External Links for MRGPRX4 Gene

GeneLoc Exon Structure for
MRGPRX4
ECgene alternative splicing isoforms for
MRGPRX4

Expression for MRGPRX4 Gene

mRNA expression in normal human tissues for MRGPRX4 Gene

SOURCE GeneReport for Unigene cluster for MRGPRX4 Gene Hs.632138

mRNA Expression by UniProt/SwissProt for MRGPRX4 Gene

Q96LA9-MRGX4_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expressions with MRGPRX4: view

Orthologs for MRGPRX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX4 36
  • 99.07 (n)
  • 98.14 (a)
MRGPRX4 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRGPRX2 37
  • 52 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrgprb1 37
  • 43 (a)
ManyToMany
Mrgprb2 37
  • 46 (a)
ManyToMany
Mrgprb3 37
  • 44 (a)
ManyToMany
Mrgprb4 37
  • 47 (a)
ManyToMany
Mrgprb5 37
  • 45 (a)
ManyToMany
Mrgprb8 37
  • 41 (a)
ManyToMany
Mrgprx1 36
  • 65.93 (n)
  • 51.9 (a)
Mrgprx1 16
Mrgprx1 37
  • 51 (a)
ManyToMany
Mrgprx2 37
  • 45 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 34 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mrgprx1 36
  • 66.25 (n)
  • 51.1 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 30 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 29 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 31 (a)
ManyToMany
-- 37
  • 22 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 25 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
-- 37
  • 23 (a)
ManyToMany
-- 37
  • 27 (a)
ManyToMany
Species with no ortholog for MRGPRX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX4 Gene

ENSEMBL:
Gene Tree for MRGPRX4 (if available)
TreeFam:
Gene Tree for MRGPRX4 (if available)

Paralogs for MRGPRX4 Gene

Paralogs for MRGPRX4 Gene

Selected SIMAP similar genes for MRGPRX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRGPRX4: view

Variants for MRGPRX4 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1378610 -- 18,172,561(-) TATTA(A/G)AACAC upstream-variant-2KB
rs1531104 -- 18,172,536(-) ATGAA(G/T)AAAAT upstream-variant-2KB
rs1531105 -- 18,171,758(-) TCCAA(A/G)TTGGC upstream-variant-2KB
rs1840596 -- 18,171,147(-) CTGGA(A/G)CCCTG upstream-variant-2KB
rs1869788 - 18,173,417(-) TGCGG(A/C/T)AGCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX4 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV Gain 19812545
esv2744166 CNV Deletion 23290073
esv2668662 CNV Deletion 23128226
nsv518373 CNV Loss 19592680

Relevant External Links for MRGPRX4 Gene

HapMap Linkage Disequilibrium report
MRGPRX4

Disorders for MRGPRX4 Gene

Relevant External Links for MRGPRX4

Genetic Association Database (GAD)
MRGPRX4
Human Genome Epidemiology (HuGE) Navigator
MRGPRX4
genes like me logo Genes that share disorders with MRGPRX4: view

No data available for UniProtKB/Swiss-Prot for MRGPRX4 Gene

Publications for MRGPRX4 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4
  2. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for MRGPRX4 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MRGPRX4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRX4
    • Block miRNA regulation of MRGPRX4 using miScript Target Protectors
    • antibodies-online peptides for MRGPRX4
    • antibodies-online antibodies for MRGPRX4
    • antibodies-online kits for MRGPRX4

    Sources for MRGPRX4 Gene

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