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Aliases for MRGPRX4 Gene

Aliases for MRGPRX4 Gene

  • MAS Related GPR Family Member X4 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 5/6 3 4
  • MAS-Related GPR, Member X4 2 3
  • MRGX4 3 4
  • SNSR6 3 4
  • G Protein-Coupled Receptor MRGX4 3
  • G Protein-Coupled Receptor SNSR5 3
  • G Protein-Coupled Receptor SNSR6 3
  • SNSR5 4
  • GPCR 3

External Ids for MRGPRX4 Gene

Previous GeneCards Identifiers for MRGPRX4 Gene

  • GC11P018152
  • GC11P018194
  • GC11P017877

Summaries for MRGPRX4 Gene

GeneCards Summary for MRGPRX4 Gene

MRGPRX4 (MAS Related GPR Family Member X4) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRF.

UniProtKB/Swiss-Prot for MRGPRX4 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX4 Gene

Genomics for MRGPRX4 Gene

Regulatory Elements for MRGPRX4 Gene

Genomic Location for MRGPRX4 Gene

18,172,837 bp from pter
18,197,348 bp from pter
24,512 bases
Plus strand

Genomic View for MRGPRX4 Gene

Genes around MRGPRX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX4 Gene

Proteins for MRGPRX4 Gene

  • Protein details for MRGPRX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member X4
    Protein Accession:
    Secondary Accessions:
    • Q3KNU3
    • Q3KNU4
    • Q502W0
    • Q8TDD6
    • Q8TDD7

    Protein attributes for MRGPRX4 Gene

    322 amino acids
    Molecular mass:
    36461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX4 Gene

Proteomics data for MRGPRX4 Gene at MOPED

Post-translational modifications for MRGPRX4 Gene

  • Glycosylation at Asn 25 and Asn 89

Other Protein References for MRGPRX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX4 Gene

Domains & Families for MRGPRX4 Gene

Gene Families for MRGPRX4 Gene

Protein Domains for MRGPRX4 Gene

Suggested Antigen Peptide Sequences for MRGPRX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX4: view

Function for MRGPRX4 Gene

Molecular function for MRGPRX4 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Phenotypes for MRGPRX4 Gene

genes like me logo Genes that share phenotypes with MRGPRX4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRX4 Gene

Localization for MRGPRX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MRGPRX4 Gene COMPARTMENTS Subcellular localization image for MRGPRX4 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MRGPRX4 Gene

Pathways & Interactions for MRGPRX4 Gene

SuperPathways for MRGPRX4 Gene

No Data Available

Interacting Proteins for MRGPRX4 Gene

Gene Ontology (GO) - Biological Process for MRGPRX4 Gene


No data available for Pathways by source and SIGNOR curated interactions for MRGPRX4 Gene

Drugs & Compounds for MRGPRX4 Gene

(2) Additional Compounds for MRGPRX4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BAM (8-22)

(2) Tocris Compounds for MRGPRX4 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
BAM 22P Opioid receptor agonist. Also agonist at the sensory neuron specific receptor (SNSR) 76622-26-9
genes like me logo Genes that share compounds with MRGPRX4: view

Transcripts for MRGPRX4 Gene

mRNA/cDNA for MRGPRX4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX4 Gene

MAS-related GPR, member X4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX4 Gene

No ASD Table

Relevant External Links for MRGPRX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRX4 Gene

mRNA expression in normal human tissues for MRGPRX4 Gene

SOURCE GeneReport for Unigene cluster for MRGPRX4 Gene Hs.632138

mRNA Expression by UniProt/SwissProt for MRGPRX4 Gene

Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expression patterns with MRGPRX4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRGPRX4 Gene

Orthologs for MRGPRX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Mrgprx1 35
  • 65.93 (n)
  • 51.9 (a)
Mrgprx1 16
Mrgprb1 36
  • 43 (a)
Mrgprb2 36
  • 46 (a)
Mrgprb3 36
  • 44 (a)
Mrgprb4 36
  • 47 (a)
Mrgprb5 36
  • 45 (a)
Mrgprb8 36
  • 41 (a)
Mrgprx1 36
  • 51 (a)
Mrgprx2 36
  • 45 (a)
(Pan troglodytes)
Mammalia MRGPRX4 35
  • 99.07 (n)
  • 98.14 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Mrgprx1 35
  • 66.25 (n)
  • 51.1 (a)
(Bos Taurus)
Mammalia MRGPRX2 36
  • 52 (a)
(Canis familiaris)
Mammalia -- 36
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
-- 36
  • 37 (a)
-- 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 23 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
-- 36
  • 32 (a)
-- 36
  • 34 (a)
-- 36
  • 31 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 32 (a)
-- 36
  • 28 (a)
-- 36
  • 31 (a)
-- 36
  • 22 (a)
-- 36
  • 27 (a)
-- 36
  • 25 (a)
-- 36
  • 28 (a)
-- 36
  • 27 (a)
-- 36
  • 23 (a)
-- 36
  • 27 (a)
Species with no ortholog for MRGPRX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX4 Gene

Gene Tree for MRGPRX4 (if available)
Gene Tree for MRGPRX4 (if available)

Paralogs for MRGPRX4 Gene

Paralogs for MRGPRX4 Gene

(9) SIMAP similar genes for MRGPRX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRGPRX4: view

Variants for MRGPRX4 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2468774 - 18,173,280(-) GTACC(C/G)AAGAC reference, missense
rs2445180 - 18,173,331(-) GTCTG(A/C)TTGTA reference, missense
rs1869788 - 18,173,417(-) TGCGG(A/C/T)AGCCC reference, missense
rs2445179 - 18,173,504(-) ATGGC(A/G)AACGT reference, missense
rs11024532 - 18,173,801(+) AGTCG(C/T)GTGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX4 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV Gain 19812545
esv2744166 CNV Deletion 23290073
esv2668662 CNV Deletion 23128226
nsv518373 CNV Loss 19592680

Variation tolerance for MRGPRX4 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRGPRX4 Gene

Disorders for MRGPRX4 Gene

Relevant External Links for MRGPRX4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRGPRX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX4 Gene

Publications for MRGPRX4 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MRGPRX4 Gene

Sources for MRGPRX4 Gene