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Aliases for MRGPRX4 Gene

Aliases for MRGPRX4 Gene

  • MAS Related GPR Family Member X4 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 5/6 3 4
  • MAS-Related GPR, Member X4 2 3
  • MRGX4 3 4
  • SNSR6 3 4
  • Mas-Related G-Protein Coupled Receptor Member X4 3
  • G Protein-Coupled Receptor MRGX4 3
  • G Protein-Coupled Receptor SNSR5 3
  • G Protein-Coupled Receptor SNSR6 3
  • SNSR5 4
  • GPCR 3

External Ids for MRGPRX4 Gene

Previous GeneCards Identifiers for MRGPRX4 Gene

  • GC11P018152
  • GC11P018194
  • GC11P017877

Summaries for MRGPRX4 Gene

GeneCards Summary for MRGPRX4 Gene

MRGPRX4 (MAS Related GPR Family Member X4) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot for MRGPRX4 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX4 Gene

Genomics for MRGPRX4 Gene

Regulatory Elements for MRGPRX4 Gene


Genomic Location for MRGPRX4 Gene

Chromosome:
11
Start:
18,172,837 bp from pter
End:
18,174,280 bp from pter
Size:
1,444 bases
Orientation:
Plus strand

Genomic View for MRGPRX4 Gene

Genes around MRGPRX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX4 Gene

Proteins for MRGPRX4 Gene

  • Protein details for MRGPRX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LA9-MRGX4_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X4
    Protein Accession:
    Q96LA9
    Secondary Accessions:
    • Q3KNU3
    • Q3KNU4
    • Q502W0
    • Q8TDD6
    • Q8TDD7

    Protein attributes for MRGPRX4 Gene

    Size:
    322 amino acids
    Molecular mass:
    36461 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX4 Gene

Post-translational modifications for MRGPRX4 Gene

  • Glycosylation at posLast=2525 and Asn89

Other Protein References for MRGPRX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX4 Gene

Domains & Families for MRGPRX4 Gene

Gene Families for MRGPRX4 Gene

Protein Domains for MRGPRX4 Gene

Suggested Antigen Peptide Sequences for MRGPRX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LA9

UniProtKB/Swiss-Prot:

MRGX4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX4: view

Function for MRGPRX4 Gene

Molecular function for MRGPRX4 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view
genes like me logo Genes that share phenotypes with MRGPRX4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRGPRX4 Gene

Localization for MRGPRX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRX4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view

Pathways & Interactions for MRGPRX4 Gene

SuperPathways for MRGPRX4 Gene

No Data Available

Interacting Proteins for MRGPRX4 Gene

Gene Ontology (GO) - Biological Process for MRGPRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX4: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRX4 Gene

Drugs & Compounds for MRGPRX4 Gene

(2) Drugs for MRGPRX4 Gene - From: ApexBio and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAM 22P Pharma Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 0
BAM (8-22) Pharma Selective agonist for the sensory neuron specific receptor (SNSR) 0

(1) Additional Compounds for MRGPRX4 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ML 382
1646499-97-9

(2) Tocris Compounds for MRGPRX4 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
ML 382 MrgX1 (SNSR4) positive allosteric modulator 1646499-97-9

(1) ApexBio Compounds for MRGPRX4 Gene

Compound Action Cas Number
BAM 22P Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 76622-26-9
genes like me logo Genes that share compounds with MRGPRX4: view

Drug Products

Transcripts for MRGPRX4 Gene

mRNA/cDNA for MRGPRX4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX4 Gene

MAS-related GPR, member X4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX4 Gene

No ASD Table

Relevant External Links for MRGPRX4 Gene

GeneLoc Exon Structure for
MRGPRX4
ECgene alternative splicing isoforms for
MRGPRX4

Expression for MRGPRX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRGPRX4 Gene:

MRGPRX4

SOURCE GeneReport for Unigene cluster for MRGPRX4 Gene:

Hs.632138

mRNA Expression by UniProt/SwissProt for MRGPRX4 Gene:

Q96LA9-MRGX4_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expression patterns with MRGPRX4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRX4 Gene

Orthologs for MRGPRX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX4 34 35
  • 99.07 (n)
rat
(Rattus norvegicus)
Mammalia Mrgprx1 34
  • 66.25 (n)
mouse
(Mus musculus)
Mammalia Mrgprx1 34 16 35
  • 65.93 (n)
Mrgprb4 35
  • 47 (a)
ManyToMany
Mrgprb2 35
  • 46 (a)
ManyToMany
Mrgprb5 35
  • 45 (a)
ManyToMany
Mrgprx2 35
  • 45 (a)
ManyToMany
Mrgprb3 35
  • 44 (a)
ManyToMany
Mrgprb1 35
  • 43 (a)
ManyToMany
Mrgprb8 35
  • 41 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 53 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRGPRX2 35
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 37 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 34 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 31 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
Species where no ortholog for MRGPRX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX4 Gene

ENSEMBL:
Gene Tree for MRGPRX4 (if available)
TreeFam:
Gene Tree for MRGPRX4 (if available)

Paralogs for MRGPRX4 Gene

Paralogs for MRGPRX4 Gene

(9) SIMAP similar genes for MRGPRX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRGPRX4: view

Variants for MRGPRX4 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000939021 -- 18,174,447(+) TTACC(A/T)ATACA downstream-variant-500B
rs1001267766 -- 18,170,870(+) TGAGC(A/T)AGGAA upstream-variant-2KB
rs1001579204 -- 18,171,077(+) CATCA(A/G)GATTT upstream-variant-2KB
rs1002843211 -- 18,172,355(+) CAGCT(C/T)AGACC upstream-variant-2KB
rs1004067898 -- 18,172,494(+) ACACA(A/G)ATACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX4 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV gain 19812545
esv2668662 CNV deletion 23128226
esv2744166 CNV deletion 23290073
esv2762898 CNV gain 21179565
nsv1038257 CNV loss 25217958
nsv518373 CNV loss 19592680
nsv971991 CNV duplication 23825009

Variation tolerance for MRGPRX4 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX4 Gene

Disorders for MRGPRX4 Gene

Relevant External Links for MRGPRX4

Genetic Association Database (GAD)
MRGPRX4
Human Genome Epidemiology (HuGE) Navigator
MRGPRX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRX4

No disorders were found for MRGPRX4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX4 Gene

Publications for MRGPRX4 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3 4 64
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for MRGPRX4 Gene

Sources for MRGPRX4 Gene

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