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MRGPRX4 Gene

protein-coding   GIFtS: 48
GCID: GC11P018194

MAS-Related GPR, Member X4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS-Related GPR, Member X41 2     G Protein-Coupled Receptor MRGX42
MRGX42 3 5     G Protein-Coupled Receptor SNSR52
Sensory Neuron-Specific G-Protein Coupled Receptor 5/62 3     G Protein-Coupled Receptor SNSR62
SNSR62 3     Mas-Related G-Protein Coupled Receptor Member X42
GPCR2     SNSR53

External Ids:    HGNC: 176171   Entrez Gene: 1171962   Ensembl: ENSG000001798177   OMIM: 6072305   UniProtKB: Q96LA93   

Export aliases for MRGPRX4 gene to outside databases

Previous GC identifers: GC11P018152 GC11P017877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRGPRX4 Gene:
MRGPRX4 (MAS-related GPR, member X4) is a protein-coding gene. Diseases associated with MRGPRX4 include neuronitis. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX3.

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

Gene Wiki entry for MRGPRX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRGPRX4 gene promoter:
         FOXD1   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   LUN-1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX4 promoter sequence
   Search Chromatin IP Primers for MRGPRX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGPRX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018194:  view genomic region     (about GC identifiers)

Start:
18,194,384 bp from pter      End:
18,195,827 bp from pter
Size:
1,444 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X4  
Size: 322 amino acids; 36461 Da
Secondary accessions: Q3KNU3 Q3KNU4 Q502W0 Q8TDD6 Q8TDD7

Explore the universe of human proteins at neXtProt for MRGPRX4: NX_Q96LA9

Explore proteomics data for MRGPRX4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn25, Asn89

  • See MRGPRX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_473373.2  
    ENSEMBL proteins: 
     ENSP00000314042  

    MRGPRX4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX4
    Class A Orphans

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR026234 MRGPCRFAMILY
     IPR027344 MRGPCRX4
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96LA9

    ProtoNet protein and cluster: Q96LA9

    UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
    Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


    MRGPRX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRGX4_HUMAN, Q96LA9
    Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
    function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    MRGPRX4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRGPRX4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRGPRX4
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    miRNA
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRGX4_HUMAN, Q96LA9: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    MRGPRX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MRGPRX4

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    MRGPRX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRGPRX4 (MRGX4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRGPRX4 gene: 
    NM_054032.3  

    Unigene Cluster for MRGPRX4:

    MAS-related GPR, member X4
    Hs.632138  [show with all ESTs]
    Unigene Representative Sequence: BC095509
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000314254(uc001mnv.1)
    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRGPRX4
      QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX4
      QuantiFast Probe-based Assays in human, mouse, rat MRGPRX4

    Additional mRNA sequence: 

    BC095509.1 BC107099.1 BC107100.1 

    2 DOTS entries:

    DT.97767716  DT.99943097 

    10 AceView cDNA sequences:

    CN839634 NM_054032 CN839827 CN839765 CN835944 CN839711 CN835770 CN834097 
    CN839609 CN840024 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRGPRX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGAGAGCC
    MRGPRX4 Expression
    About this image

    MRGPRX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRGPRX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632138

    UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9
    Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons

        Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MRGPRX4
    OriGene qSTAR qPCR primer pairs in human, mouse for MRGPRX4
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    QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX4
    QuantiFast Probe-based Assays in human, mouse, rat MRGPRX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MRGPRX4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrgprx11 , 5 MAS-related GPR, member X11, 5 65.93(n)1
    51.9(a)1
      7 (31.09 cM)5
    4042421  NM_207540.31  NP_997423.11 
     480209715 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    23(a)
    1 → many
    JH376180.1(56001-57008)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 16)
    Uncharacterized protein
    (see all 16)
    34(a)
    32(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    4(16394563-16395360)
    4(16466473-16468643)


    ENSEMBL Gene Tree for MRGPRX4 (if available)
    TreeFam Gene Tree for MRGPRX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRGPRX4 gene
    MRGPRX32  MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX12  MRGPRE2  
    MRGPRX22  
    9 SIMAP similar genes for MRGPRX4 using alignment to 1 protein entry:     MRGX4_HUMAN:
    MRGPRX3    MRGPRX1    MRGPRX2    MAS1    MAS1L    MRGPRD
    MRGPRF    MRGPRE    MRGPRG

    MRGPRX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRGPRX4 (see all 147)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483090601,2
    C--18192429(+) TGCTTA/GCATCA 1 -- us2k10--------
    rs24032481,2
    C,F,H--18192524(-) GAGTAT/AAAAAG 1 -- us2k1 tfbs310Minor allele frequency- A:0.35NS EA WA NA CSA 778
    rs18405961,2
    C,F,A,H--18192694(-) CTGGAA/GCCCTG 1 -- us2k18Minor allele frequency- G:0.34NA WA EA 370
    rs1812506431,2
    --18192721(+) TTAGAA/CTTGCT 1 -- us2k10--------
    rs20780661,2
    C,F,A,H--18192836(-) CACCAA/TCATTT 1 -- us2k122Minor allele frequency- T:0.33NS EA NA WA CSA 2354
    rs1158140231,2
    C,F--18192932(+) ATAGAT/CAGAGA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs20146941,2
    C,F,O,A,H--18193020(-) GCAAGG/CTGCCA 1 -- us2k114Minor allele frequency- C:0.35NS EA NA WA 924
    rs110245281,2
    C,H--18193077(+) CTGTAC/ATCCCA 1 -- us2k14Minor allele frequency- A:0.00NS EA 414
    rs169351171,2
    C,F,H--18193092(+) AGGGTG/ACATCT 1 -- us2k18Minor allele frequency- A:0.06NA NS EA WA 680
    rs71079571,2
    C,F,A,H--18193107(+) TCCACC/TAGGAG 1 -- us2k110Minor allele frequency- T:0.14NS EA NA WA 782

    HapMap Linkage Disequilibrium report for MRGPRX4 (18194384 - 18195827 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MRGPRX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744166CNV Deletion23290073
    esv2668662CNV Deletion23128226
    nsv518373CNV Loss19592680
    esv23532CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRGPRX4
    DNA2.0 Custom Variant and Variant Library Synthesis for MRGPRX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607230    OMIM disorders: --

    1 disease for MRGPRX4:    About MalaCards
    neuronitis


    MRGPRX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRGPRX4
    Human Genome Epidemiology (HuGE) Navigator: MRGPRX4 (1 document)

    Export disorders for MRGPRX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRGPRX4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MRGPRX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (Cell 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)1, 2 Lembo P.M.C.... Ahmad S. (Nat. Neurosci. 2002)
    5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 117196 HGNC: 17617 AceView: MRGX4 Ensembl:ENSG00000179817 euGenes: HUgn117196
    ECgene: MRGPRX4 H-InvDB: MRGPRX4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRGPRX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRGPRX4 gene:
    Search GeneIP for patents involving MRGPRX4

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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