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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MRGPRX4 Gene

protein-coding GIFtS: 44
GCID: GC11P018194

MAS-related GPR, member X4

Explore 1 disease affiliated with
MRGPRX4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MAS-Related GPR, Member X4¹ ²		G Protein-Coupled Receptor MRGX4²
MRGX4¹ ² ³ ⁵		G Protein-Coupled Receptor SNSR5²
Sensory Neuron-Specific G-Protein Coupled Receptor 5/6² ³		G Protein-Coupled Receptor SNSR6²
SNSR6² ³		Mas-Related G-Protein Coupled Receptor Member X4²
GPCR²		SNSR5³

External Ids:	HGNC: 17617¹	Entrez Gene: 117196²	Ensembl: ENSG00000179817⁷	OMIM: 607230⁵	UniProtKB: Q96LA9³

Export aliases for MRGPRX4 gene to outside databases

Previous GC identifers: GC11P018152 GC11P017877

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9

Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function

and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity)

Gene Wiki entry for MRGPRX4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MRGPRX4 gene promoter:
FOXD1 POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) LUN-1 POU3F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRGPRX4 promoter sequence

Search SABiosciences Chromatin IP Primers for MRGPRX4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

MRGPRX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX4 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P018194: view genomic region (about GC identifiers)

Start:	18,194,384 bp from pter	End:	18,195,827 bp from pter
Size:	1,444 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9 (See protein sequence)

Recommended Name: Mas-related G-protein coupled receptor member X4

Size: 322 amino acids; 36461 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q3KNU3 Q3KNU4 Q502W0 Q8TDD6 Q8TDD7

Explore the universe of human proteins at neXtProt for MRGPRX4: NX_Q96LA9

MRGPRX4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_473373.2

ENSEMBL proteins:

ENSP00000314042

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

MRGPRX4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRGPRX4 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR026234 MRGPCRFAMILY

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96LA9

ProtoNet protein and cluster: Q96LA9

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9

Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MRGX4_HUMAN, Q96LA9

Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function

and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--

MRGPRX4 for ontologies About GeneDecksing

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MRGPRX4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for MRGPRX4 gene:

NM_054032.3

Unigene Cluster for MRGPRX4:

MAS-related GPR, member X4

Hs.632138 [show with all ESTs]

Unigene Representative Sequence: BC095509

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000314254(uc001mnv.1)

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Additional cDNA sequence:

BC095509.1 BC107099.1 BC107100.1

2 DOTS entries:

DT.97767716 DT.99943097

10 AceView cDNA sequences:

CN839634 CN835944 CN839765 CN835770 CN839827 NM_054032 CN839711 CN834097

CN839609 CN840024

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRGPRX4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGAGAGCC

About this image

MRGPRX4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Yolk Sac

Definitive Yolk Sac

Erythroid Progenitor Cells

Blood

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MRGPRX4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRGPRX4

SOURCE GeneReport for Unigene cluster: Hs.632138

UniProtKB/Swiss-Prot: MRGX4_HUMAN, Q96LA9

Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons

SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX4:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX4 gene from 2/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC430433¹	proto-oncogene Mas-like	56.61(n) 43.25(a)		430433 XM_427992.3 XP_427992.3
zebrafish (Danio rerio)	Actinopterygii	CU571081.1⁶	--	18(a)	1 → many	1(426972-432957)

ENSEMBL Gene Tree for MRGPRX4 (if available)
TreeFam Gene Tree for MRGPRX4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MRGPRX4 gene

MRGPRX3² MRGPRX1² MRGPRD² MRGPRE² MRGPRG² MRGPRX2² MAS1² MAS1L²

MRGPRF²

9 SIMAP similar genes for MRGPRX4 using alignment to 1 protein entry: MRGX4_HUMAN:

MRGPRX3 MRGPRX1 MRGPRX2 MAS1 MAS1L MRGPRD

MRGPRF MRGPRE MRGPRG

MRGPRX4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148309060^1,2		--	18192429(+)	`TGCTTA/GCATCA`	1	--	us2k¹		0	--	--	--	--
rs2403248^1,2	C,F,H	--	18192524(-)	`GAGTAT/AAAAAG`	1	--	us2k¹ tfbs³		10		NS EA WA NA CSA	778
rs1840596^1,2	C,F,A,H	--	18192694(-)	`CTGGAA/GCCCTG`	1	--	us2k¹		8		NA WA EA	370
rs181250643^1,2		--	18192721(+)	`TTAGAA/CTTGCT`	1	--	us2k¹		0	--	--	--	--
rs2078066^1,2	C,F,A,H	--	18192836(-)	`CACCAA/TCATTT`	1	--	us2k¹		22		NS EA NA WA CSA	2354
rs115814023^1,2	F	--	18192932(+)	`ATAGAT/CAGAGA`	1	--	us2k¹		1		WA	118
rs2014694^1,2	C,F,O,A,H	--	18193020(-)	`GCAAGG/CTGCCA`	1	--	us2k¹		14		NS EA NA WA	924
rs11024528^1,2	C,H	--	18193077(+)	`CTGTAC/ATCCCA`	1	--	us2k¹		4		NS EA	414
rs16935117^1,2	C,F,H	--	18193092(+)	`AGGGTG/ACATCT`	1	--	us2k¹		8		NA NS EA WA	680
rs7107957^1,2	C,F,A,H	--	18193107(+)	`TCCACC/TAGGAG`	1	--	us2k¹		10		NS EA NA WA	782

HapMap Linkage Disequilibrium report for MRGPRX4 (18194384 - 18195827 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MRGPRX4
2 CNVs: 71289 71290

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MRGPRX4 for disorders           About GeneDecksing

OMIM gene information: 607230    OMIM disorders: --

1 disease for MRGPRX4:    About MalaCards

neuronitis

Human Genome Epidemiology (HuGE) Navigator: MRGPRX4 (1 document)

Export disorders for MRGPRX4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MRGPRX4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRX4)

Utopia: connect your pdf to the dynamic
world of online information

A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)^{1, 2, 3} Dong X.... Anderson D.J. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)^{1, 2} Lembo P.M.C.... Ahmad S. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 117196	HGNC: 17617	AceView: MRGX4	Ensembl:ENSG00000179817	euGenes: HUgn117196
ECgene: MRGPRX4	H-InvDB: MRGPRX4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MRGPRX4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MRGPRX4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MRGPRX4 gene:
Search GeneIP for patents involving MRGPRX4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene Custom Antibody Services for MRGPRX4		OriGene Custom Protein Services for MRGPRX4
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	GenScript Custom Purified and Recombinant Proteins Services for MRGPRX4		GenScript cDNA clones with any tag delivered in your preferred vector for MRGPRX4
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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ThermoFisher Antibodies for MRGPRX4

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inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRGPRX4

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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MRGPRX4 Gene

MAS-related GPR, member X4

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MRGPRX4 Gene

MAS-related GPR, member X4

Aliasesfor MRGPRX4 gene

Summariesfor MRGPRX4 gene

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Proteinsfor MRGPRX4 gene

Protein Domains /Familiesfor MRGPRX4 gene

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Expression for MRGPRX4 gene

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Disorders / Diseasesfor MRGPRX4 gene

Publicationsfor MRGPRX4 gene

External Searches for MRGPRX4 gene

Genome Databases showing MRGPRX4 gene

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Specialized Databases showing MRGPRX4 gene

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for MRGPRX4 gene

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for MRGPRX4 gene

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for MRGPRX4 gene

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for MRGPRX4 gene

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Expression
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for MRGPRX4 gene

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