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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRGPRX3 Gene

protein-coding   GIFtS: 45
GCID: GC11P018142

MAS-Related GPR, Member X3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MAS-Related GPR, Member X31 2     G Protein-Coupled Receptor MRGX32
MRGX32 3 5     G Protein-Coupled Receptor SNSR12
Sensory Neuron-Specific G-Protein Coupled Receptor 1/22 3     G Protein-Coupled Receptor SNSR22
SNSR12 3     Mas-Related G-Protein Coupled Receptor Member X32
SNSR22 3     Mas-Related GPCR Member X32
GPCR2     

External Ids:    HGNC: 179801   Entrez Gene: 1171952   Ensembl: ENSG000001798267   OMIM: 6072295   UniProtKB: Q96LB03   

Export aliases for MRGPRX3 gene to outside databases

Previous GC identifers: GC11P018100 GC11P017825


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRGPRX3 Gene:
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors.
The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. (provided by
RefSeq, Oct 2009)

GeneCards Summary for MRGPRX3 Gene: 
MRGPRX3 (MAS-related GPR, member X3) is a protein-coding gene. Diseases associated with MRGPRX3 include neuronitis, and cataract. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRD.

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

Gene Wiki entry for MRGPRX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRGPRX3 gene promoter:
         Max1   TBP   FOXD3   POU2F1   FOXJ2 (long isoform)   HOXA5   POU2F1a   POU2F1c   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX3 promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018142:  view genomic region     (about GC identifiers)

Start:
18,142,502 bp from pter      End:
18,160,027 bp from pter
Size:
17,526 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X3  
Size: 322 amino acids; 36483 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0M0L1 Q8TDE0 Q8TDE1

Explore the universe of human proteins at neXtProt for MRGPRX3: NX_Q96LB0

MRGPRX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_473372.3  
ENSEMBL proteins: 
 ENSP00000379571   ENSP00000436242  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral to membrane IEA--

MRGPRX3 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX3 
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR026234 MRGPCRFAMILY
 IPR000276 GPCR_Rhodpsn
 IPR027343 MRGPCRX3

Graphical View of Domain Structure for InterPro Entry Q96LB0

ProtoNet protein and cluster: Q96LB0

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


MRGPRX3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGX3_HUMAN, Q96LB0
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
MRGPRX3 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRX3

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

MRGPRX3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Search CenterWatch for drugs/clinical trials and news about MRGPRX3 / MRGX3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRGPRX3 gene: 
NM_054031.3  

Unigene Cluster for MRGPRX3:

MAS-related GPR, member X3
Hs.380177  [show with all ESTs]
Unigene Representative Sequence: BC067292
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000396275(uc001mnu.3) ENST00000531264
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Additional mRNA sequence: 

BC067292.1 EU432126.1 

1 DOTS entry:

DT.91883477 

7 AceView cDNA sequences:

BC067292 BE439409 CA455045 NM_054031 BV173107 CD243595 BU178344 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRGPRX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAAGCATTA
MRGPRX3 Expression
About this image


Genevestigator expression for MRGPRX3

SOURCE GeneReport for Unigene cluster: Hs.380177

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons

    SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX3: 
          G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgpra11 , 5 MAS-related GPR, member A11, 5 67.17(n)1
58.87(a)1
  7 (30.80 cM)5
2332211  NM_153095.21  NP_694735.21 
 473348755 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
22(a)
1 → many
JH376180.1(56001-57008)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 19)
Uncharacterized protein
(see all 19)
32(a)
29(a)
(see all 19)
many ↔ many
many ↔ many
(see all 19)
4(16394563-16395360)
4(16384879-16387025)


ENSEMBL Gene Tree for MRGPRX3 (if available)
TreeFam Gene Tree for MRGPRX3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MRGPRX3 gene
MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
MRGPRX22  
9 SIMAP similar genes for MRGPRX3 using alignment to 2 protein entries:     MRGX3_HUMAN (see all proteins):
MRGPRX1    MRGPRX4    MRGPRX2    MAS1    MAS1L    MRGPRD
MRGPRE    MRGPRF    MRGPRG

MRGPRX3 for paralogs           About GeneDecksing


3 Pseudogenes.org Pseudogenes for MRGPRX3
PGOHUM00000257806 PGOHUM00000242192 PGOHUM00000242608


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/462 SNPs in MRGPRX3 are shown (see all 462)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs79380821,2
C,F--18140545(+) tggcaC/Tgcgct 1 -- us2k11Minor allele frequency- T:0.14WA 118
rs1132368751,2
C,F--18140546(+) GGCACG/ACGCTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1852417111,2
--18140558(+) TAGTCC/TGAGCT 1 -- us2k10--------
rs1132027451,2
C,F--18140598(+) TGAATC/ACAGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs3749066181,2
C--18140674(+) CATCTA/CAAAAA 1 -- us2k10--------
rs1131193101,2
C,F--18140715(+) CAAAAC/TATAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1924034861,2
--18140831(+) CCCAAC/TATGGC 1 -- us2k10--------
rs1838503651,2
--18140873(+) TAGCTC/GTGCGT 1 -- us2k10--------
rs1871329931,2
--18140912(+) TTGGGA/TGGCTG 1 -- us2k10--------
rs1414067751,2
--18140930(+) AGAATC/TGCTTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MRGPRX3 (18142502 - 18160027 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MRGPRX3:    About this table     
Variant IDTypeSubtypePubMed ID
esv2744166CNV Deletion23290073
esv23532CNV Gain19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607229    OMIM disorders: --

2 diseases for MRGPRX3:    About MalaCards
neuronitis    cataract


MRGPRX3 for disorders           About GeneDecksing


Export disorders for MRGPRX3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MRGPRX3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRX3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)1, 2 Lembo P.M.C.... Ahmad S. (2002)
  4. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PubMed id 16284629)1 Burstein E.S....Nash N.R. (2006)
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  6. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. (PubMed id 15809047)1 Kaisho Y....Taketomi S. (2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways. (PubMed id 12751793)9 Edalat M....Mannervik B. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 117195 HGNC: 17980 AceView: MRGX3 Ensembl:ENSG00000179826 euGenes: HUgn117195
ECgene: MRGPRX3 H-InvDB: MRGPRX3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MRGPRX3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MRGPRX3 gene:
Search GeneIP for patents involving MRGPRX3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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