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Aliases for MRGPRX3 Gene

Aliases for MRGPRX3 Gene

  • MAS-Related GPR, Member X3 2 3
  • MRGX3 3 4 6
  • Sensory Neuron-Specific G-Protein Coupled Receptor 1/2 3 4
  • SNSR1 3 4
  • SNSR2 3 4
  • Mas-Related G-Protein Coupled Receptor Member X3 3
  • G Protein-Coupled Receptor MRGX3 3
  • G Protein-Coupled Receptor SNSR1 3
  • G Protein-Coupled Receptor SNSR2 3
  • Mas-Related GPCR Member X3 3
  • GPCR 3

External Ids for MRGPRX3 Gene

Summaries for MRGPRX3 Gene

Entrez Gene Summary for MRGPRX3 Gene

  • This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

GeneCards Summary for MRGPRX3 Gene

MRGPRX3 (MAS-Related GPR, Member X3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX3 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX3 Gene

Genomics for MRGPRX3 Gene

Genomic Location for MRGPRX3 Gene

18,120,955 bp from pter
18,138,480 bp from pter
17,526 bases
Plus strand

Genomic View for MRGPRX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRGPRX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX3 Gene

Regulatory Elements for MRGPRX3 Gene

Proteins for MRGPRX3 Gene

  • Protein details for MRGPRX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member X3
    Protein Accession:
    Secondary Accessions:
    • B0M0L1
    • Q8TDE0
    • Q8TDE1

    Protein attributes for MRGPRX3 Gene

    322 amino acids
    Molecular mass:
    36483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX3 Gene

Proteomics data for MRGPRX3 Gene at MOPED

Post-translational modifications for MRGPRX3 Gene

No Post-translational modifications

Other Protein References for MRGPRX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX3 Gene

Domains for MRGPRX3 Gene

Gene Families for MRGPRX3 Gene

  • GPCRAO :GPCR / Class A : Orphans

Protein Domains for MRGPRX3 Gene


  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.:
    • Q96LB0
genes like me logo Genes that share domains with MRGPRX3: view

Function for MRGPRX3 Gene

Molecular function for MRGPRX3 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

miRNA for MRGPRX3 Gene

miRTarBase miRNAs that target MRGPRX3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRGPRX3 Gene

Localization for MRGPRX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MRGPRX3 Gene COMPARTMENTS Subcellular localization image for MRGPRX3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

Pathways for MRGPRX3 Gene

SuperPathways for MRGPRX3 Gene

No Data Available

Interacting Proteins for MRGPRX3 Gene

Gene Ontology (GO) - Biological Process for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

No data available for Pathways by source for MRGPRX3 Gene

Transcripts for MRGPRX3 Gene

mRNA/cDNA for MRGPRX3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX3 Gene

MAS-related GPR, member X3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX3 Gene

No ASD Table

Relevant External Links for MRGPRX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRX3 Gene

mRNA expression in normal human tissues for MRGPRX3 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX3 Gene

This gene is overexpressed in Minor Salivary Gland (26.2), Esophagus - Mucosa (14.0), and Breast - Mammary Tissue (5.0).

SOURCE GeneReport for Unigene cluster for MRGPRX3 Gene Hs.380177

mRNA Expression by UniProt/SwissProt for MRGPRX3 Gene

Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expressions with MRGPRX3: view

Orthologs for MRGPRX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRGPRX3 36
  • 97.52 (n)
  • 95.34 (a)
  • 95 (a)
(Bos Taurus)
Mammalia MRGPRX2 37
  • 51 (a)
(Canis familiaris)
Mammalia -- 37
  • 52 (a)
(Mus musculus)
Mammalia Mrgpra1 36
  • 66.79 (n)
  • 58.21 (a)
Mrgpra1 16
Mrgprb1 37
  • 43 (a)
Mrgprb2 37
  • 46 (a)
Mrgprb3 37
  • 44 (a)
Mrgprb4 37
  • 46 (a)
Mrgprb5 37
  • 45 (a)
Mrgprb8 37
  • 39 (a)
Mrgprx1 37
  • 51 (a)
Mrgprx2 37
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 37
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 31 (a)
-- 37
  • 35 (a)
-- 37
  • 33 (a)
(Rattus norvegicus)
Mammalia Mrgprx3 36
  • 67.89 (n)
  • 58.19 (a)
(Gallus gallus)
Aves -- 37
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 28 (a)
-- 37
  • 31 (a)
-- 37
  • 33 (a)
-- 37
  • 30 (a)
-- 37
  • 29 (a)
-- 37
  • 27 (a)
-- 37
  • 30 (a)
-- 37
  • 27 (a)
-- 37
  • 30 (a)
-- 37
  • 20 (a)
-- 37
  • 27 (a)
-- 37
  • 24 (a)
-- 37
  • 26 (a)
-- 37
  • 24 (a)
-- 37
  • 23 (a)
-- 37
  • 26 (a)
Species with no ortholog for MRGPRX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX3 Gene

Gene Tree for MRGPRX3 (if available)
Gene Tree for MRGPRX3 (if available)

Paralogs for MRGPRX3 Gene

Paralogs for MRGPRX3 Gene

Selected SIMAP similar genes for MRGPRX3 Gene using alignment to 2 proteins: Pseudogenes for MRGPRX3 Gene

genes like me logo Genes that share paralogs with MRGPRX3: view

Variants for MRGPRX3 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1824018 -- 18,131,945(+) ACACA(A/T)TGGGT intron-variant
rs1975777 -- 18,132,676(+) TCCCA(G/T)AAAGG utr-variant-5-prime
rs2004412 -- 18,136,800(-) ACTGG(A/T)CATCT intron-variant
rs2085274 -- 18,130,579(+) tgtga(A/T)aatga intron-variant
rs2085275 -- 18,130,868(+) ATCCA(G/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX3 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV Gain 19812545
esv2744166 CNV Deletion 23290073

Relevant External Links for MRGPRX3 Gene

HapMap Linkage Disequilibrium report

Disorders for MRGPRX3 Gene

No disorders were found for MRGPRX3 Gene.

No data available for UniProtKB/Swiss-Prot for MRGPRX3 Gene

Publications for MRGPRX3 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4
  2. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PMID: 11850634) Lembo P.M.C. … Ahmad S. (Nat. Neurosci. 2002) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. (PMID: 15809047) Kaisho Y. … Taketomi S. (Biochem. Biophys. Res. Commun. 2005) 3
  5. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PMID: 16284629) Burstein E.S. … Nash N.R. (Br. J. Pharmacol. 2006) 3

Products for MRGPRX3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MRGPRX3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MRGPRX3
    • Block miRNA regulation of MRGPRX3 using miScript Target Protectors

    Sources for MRGPRX3 Gene

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