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Aliases for MRGPRX3 Gene

Aliases for MRGPRX3 Gene

  • MAS Related GPR Family Member X3 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 1/2 3 4
  • MAS-Related GPR, Member X3 2 3
  • MRGX3 3 4
  • SNSR1 3 4
  • SNSR2 3 4
  • Mas-Related G-Protein Coupled Receptor Member X3 3
  • G Protein-Coupled Receptor MRGX3 3
  • G Protein-Coupled Receptor SNSR1 3
  • G Protein-Coupled Receptor SNSR2 3
  • Mas-Related GPCR Member X3 3
  • GPCR 3

External Ids for MRGPRX3 Gene

Previous GeneCards Identifiers for MRGPRX3 Gene

  • GC11P018100
  • GC11P018142
  • GC11P017825
  • GC11P018121

Summaries for MRGPRX3 Gene

Entrez Gene Summary for MRGPRX3 Gene

  • This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

GeneCards Summary for MRGPRX3 Gene

MRGPRX3 (MAS Related GPR Family Member X3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX1.

UniProtKB/Swiss-Prot for MRGPRX3 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX3 Gene

Additional gene information for MRGPRX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX3 Gene

Genomics for MRGPRX3 Gene

Regulatory Elements for MRGPRX3 Gene

Enhancers for MRGPRX3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H018105 1.1 ENCODE 13.2 +2.3 2328 1 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 SAAL1 GTF2H1 SPTY2D1 MRGPRX3 LOC100129966 TSG101 ENSG00000256361 TPH1
GH11H018101 0.4 FANTOM5 27 -2.3 -2277 0 ZNF184 MRGPRX3 SAAL1 HPS5 TSG101 GTF2H1 UEVLD GC11P018102
GH11H018143 0.4 ENCODE 11.1 +40.6 40639 1 CTCF JUND MRGPRX3 TPH1 LOC645297 GC11P018120
GH11H017821 0.6 Ensembl ENCODE 4.9 -281.4 -281374 1 NFE2 MRGPRX3 SPTY2D1-AS1 GC11P017794 GC11M017875
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRGPRX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRGPRX3 Gene

Chromosome:
11
Start:
18,103,652 bp from pter
End:
18,138,491 bp from pter
Size:
34,840 bases
Orientation:
Plus strand

Genomic View for MRGPRX3 Gene

Genes around MRGPRX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX3 Gene

Proteins for MRGPRX3 Gene

  • Protein details for MRGPRX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LB0-MRGX3_HUMAN
    Recommended name:
    Mas-related G-protein coupled receptor member X3
    Protein Accession:
    Q96LB0
    Secondary Accessions:
    • B0M0L1
    • Q8TDE0
    • Q8TDE1

    Protein attributes for MRGPRX3 Gene

    Size:
    322 amino acids
    Molecular mass:
    36483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX3 Gene

Post-translational modifications for MRGPRX3 Gene

No Post-translational modifications

Other Protein References for MRGPRX3 Gene

No data available for DME Specific Peptides for MRGPRX3 Gene

Domains & Families for MRGPRX3 Gene

Gene Families for MRGPRX3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for MRGPRX3 Gene

Suggested Antigen Peptide Sequences for MRGPRX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LB0

UniProtKB/Swiss-Prot:

MRGX3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX3: view

Function for MRGPRX3 Gene

Molecular function for MRGPRX3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Ontology (GO) - Molecular Function for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
genes like me logo Genes that share ontologies with MRGPRX3: view
genes like me logo Genes that share phenotypes with MRGPRX3: view

Animal Model Products

CRISPR Products

miRNA for MRGPRX3 Gene

miRTarBase miRNAs that target MRGPRX3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRGPRX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX3 Gene

Localization for MRGPRX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRGPRX3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MRGPRX3 Gene

Pathways & Interactions for MRGPRX3 Gene

SuperPathways for MRGPRX3 Gene

No Data Available

Interacting Proteins for MRGPRX3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000379571%0d%0a9606.ENSP00000363998%0d%0a
Selected Interacting proteins: ENSP00000379571 for MRGPRX3 Gene via STRING

Symbol External ID(s) Details
ITCH

Gene Ontology (GO) - Biological Process for MRGPRX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with MRGPRX3: view

No data available for Pathways by source and SIGNOR curated interactions for MRGPRX3 Gene

Drugs & Compounds for MRGPRX3 Gene

(2) Drugs for MRGPRX3 Gene - From: ApexBio and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BAM 22P Pharma Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 0
BAM (8-22) Pharma Selective agonist for the sensory neuron specific receptor (SNSR) 0

(1) Additional Compounds for MRGPRX3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ML 382
1646499-97-9

(2) Tocris Compounds for MRGPRX3 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
ML 382 MrgX1 (SNSR4) positive allosteric modulator 1646499-97-9

(1) ApexBio Compounds for MRGPRX3 Gene

Compound Action Cas Number
BAM 22P Potent endogenous agonist peptide for the newly identified sensory neuron specific receptor (SNSR); 76622-26-9
genes like me logo Genes that share compounds with MRGPRX3: view

Drug Products

Transcripts for MRGPRX3 Gene

mRNA/cDNA for MRGPRX3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX3 Gene

MAS-related GPR, member X3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRGPRX3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX3 Gene

No ASD Table

Relevant External Links for MRGPRX3 Gene

GeneLoc Exon Structure for
MRGPRX3
ECgene alternative splicing isoforms for
MRGPRX3

Expression for MRGPRX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRGPRX3 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX3 Gene

This gene is overexpressed in Minor Salivary Gland (x26.2), Esophagus - Mucosa (x14.0), and Breast - Mammary Tissue (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of MRGPRX3 Gene:

MRGPRX3

SOURCE GeneReport for Unigene cluster for MRGPRX3 Gene:

Hs.380177

mRNA Expression by UniProt/SwissProt for MRGPRX3 Gene:

Q96LB0-MRGX3_HUMAN
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Evidence on tissue expression from TISSUES for MRGPRX3 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with MRGPRX3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRGPRX3 Gene

Orthologs for MRGPRX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRGPRX3 33 34
  • 97.52 (n)
rat
(Rattus norvegicus)
Mammalia Mrgprx3 33
  • 67.89 (n)
mouse
(Mus musculus)
Mammalia Mrgpra1 33
  • 66.79 (n)
Mrgprx1 34
  • 51 (a)
ManyToMany
Mrgprb2 34
  • 46 (a)
ManyToMany
Mrgprb4 34
  • 46 (a)
ManyToMany
Mrgprx2 34
  • 46 (a)
ManyToMany
Mrgprb5 34
  • 45 (a)
ManyToMany
Mrgprb3 34
  • 44 (a)
ManyToMany
Mrgprb1 34
  • 43 (a)
ManyToMany
Mrgprb8 34
  • 39 (a)
ManyToMany
Mrgpra9 16
dog
(Canis familiaris)
Mammalia -- 34
  • 52 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRGPRX2 34
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 22 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
ManyToMany
-- 34
  • 31 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
-- 34
  • 29 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 27 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 26 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 24 (a)
ManyToMany
-- 34
  • 23 (a)
ManyToMany
-- 34
  • 20 (a)
ManyToMany
Species where no ortholog for MRGPRX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX3 Gene

ENSEMBL:
Gene Tree for MRGPRX3 (if available)
TreeFam:
Gene Tree for MRGPRX3 (if available)

Paralogs for MRGPRX3 Gene

Paralogs for MRGPRX3 Gene

(9) SIMAP similar genes for MRGPRX3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MRGPRX3 Gene

genes like me logo Genes that share paralogs with MRGPRX3: view

Variants for MRGPRX3 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000034070 -- 18,124,905(+) TCTTC(A/G)TTTAG intron-variant
rs1000076297 -- 18,135,603(+) GGCAC(A/G/T)CACTC intron-variant
rs1000122906 -- 18,124,360(+) TACGT(C/T)CCATC intron-variant
rs1000239421 -- 18,124,172(+) GAATA(C/T)CCTTT intron-variant
rs1000414119 -- 18,122,019(+) AAAAA(A/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX3 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV gain 19812545
esv2744166 CNV deletion 23290073
nsv971990 CNV duplication 23825009

Variation tolerance for MRGPRX3 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRGPRX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRGPRX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Disorders for MRGPRX3 Gene

Relevant External Links for MRGPRX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRGPRX3

No disorders were found for MRGPRX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX3 Gene

Publications for MRGPRX3 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X … Anderson DJ (Cell 2001) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs. (PMID: 11850634) Lembo PM … Ahmad S (Nature neuroscience 2002) 3 4 60
  4. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. (PMID: 28189739) Franco R … Zamarbide M (Progress in neurobiology 2017) 3 60
  5. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PMID: 16284629) Burstein ES … Nash NR (British journal of pharmacology 2006) 3 60

Products for MRGPRX3 Gene

Sources for MRGPRX3 Gene

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