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Aliases for MRGPRX3 Gene

Aliases for MRGPRX3 Gene

  • MAS Related GPR Family Member X3 2 3 5
  • Sensory Neuron-Specific G-Protein Coupled Receptor 1/2 3 4
  • MAS-Related GPR, Member X3 2 3
  • MRGX3 3 4
  • SNSR1 3 4
  • SNSR2 3 4
  • G Protein-Coupled Receptor MRGX3 3
  • G Protein-Coupled Receptor SNSR1 3
  • G Protein-Coupled Receptor SNSR2 3
  • Mas-Related GPCR Member X3 3
  • GPCR 3

External Ids for MRGPRX3 Gene

Previous GeneCards Identifiers for MRGPRX3 Gene

  • GC11P018100
  • GC11P018142
  • GC11P017825
  • GC11P018121

Summaries for MRGPRX3 Gene

Entrez Gene Summary for MRGPRX3 Gene

  • This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. [provided by RefSeq, Oct 2009]

GeneCards Summary for MRGPRX3 Gene

MRGPRX3 (MAS Related GPR Family Member X3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRX4.

UniProtKB/Swiss-Prot for MRGPRX3 Gene

  • Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

Gene Wiki entry for MRGPRX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRGPRX3 Gene

Genomics for MRGPRX3 Gene

Regulatory Elements for MRGPRX3 Gene

Enhancers for MRGPRX3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRGPRX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRGPRX3 Gene

18,103,652 bp from pter
18,138,491 bp from pter
34,840 bases
Plus strand

Genomic View for MRGPRX3 Gene

Genes around MRGPRX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRGPRX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRGPRX3 Gene

Proteins for MRGPRX3 Gene

  • Protein details for MRGPRX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mas-related G-protein coupled receptor member X3
    Protein Accession:
    Secondary Accessions:
    • B0M0L1
    • Q8TDE0
    • Q8TDE1

    Protein attributes for MRGPRX3 Gene

    322 amino acids
    Molecular mass:
    36483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRGPRX3 Gene

Proteomics data for MRGPRX3 Gene at MOPED

Post-translational modifications for MRGPRX3 Gene

No Post-translational modifications

Other Protein References for MRGPRX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRGPRX3 Gene

Domains & Families for MRGPRX3 Gene

Gene Families for MRGPRX3 Gene

Protein Domains for MRGPRX3 Gene

Suggested Antigen Peptide Sequences for MRGPRX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
genes like me logo Genes that share domains with MRGPRX3: view

Function for MRGPRX3 Gene

Molecular function for MRGPRX3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
genes like me logo Genes that share phenotypes with MRGPRX3: view

Animal Model Products

CRISPR Products

miRNA for MRGPRX3 Gene

miRTarBase miRNAs that target MRGPRX3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRGPRX3 Gene

Localization for MRGPRX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRGPRX3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MRGPRX3 Gene COMPARTMENTS Subcellular localization image for MRGPRX3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MRGPRX3 Gene

Pathways & Interactions for MRGPRX3 Gene

SuperPathways for MRGPRX3 Gene

No Data Available

Interacting Proteins for MRGPRX3 Gene

Gene Ontology (GO) - Biological Process for MRGPRX3 Gene


No data available for Pathways by source and SIGNOR curated interactions for MRGPRX3 Gene

Drugs & Compounds for MRGPRX3 Gene

(2) Additional Compounds for MRGPRX3 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BAM (8-22)

(2) Tocris Compounds for MRGPRX3 Gene

Compound Action Cas Number
BAM (8-22) Selective agonist for the sensory neuron specific receptor (SNSR) 412961-36-5
BAM 22P Opioid receptor agonist. Also agonist at the sensory neuron specific receptor (SNSR) 76622-26-9
genes like me logo Genes that share compounds with MRGPRX3: view

Transcripts for MRGPRX3 Gene

mRNA/cDNA for MRGPRX3 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRGPRX3 Gene

MAS-related GPR, member X3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRGPRX3 Gene

No ASD Table

Relevant External Links for MRGPRX3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRGPRX3 Gene

mRNA expression in normal human tissues for MRGPRX3 Gene

mRNA differential expression in normal tissues according to GTEx for MRGPRX3 Gene

This gene is overexpressed in Minor Salivary Gland (x26.2), Esophagus - Mucosa (x14.0), and Breast - Mammary Tissue (x5.0).

SOURCE GeneReport for Unigene cluster for MRGPRX3 Gene Hs.380177

mRNA Expression by UniProt/SwissProt for MRGPRX3 Gene

Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
genes like me logo Genes that share expression patterns with MRGPRX3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRGPRX3 Gene

Orthologs for MRGPRX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Mrgpra1 35
  • 66.79 (n)
  • 58.21 (a)
Mrgpra9 16
Mrgprb1 36
  • 43 (a)
Mrgprb2 36
  • 46 (a)
Mrgprb3 36
  • 44 (a)
Mrgprb4 36
  • 46 (a)
Mrgprb5 36
  • 45 (a)
Mrgprb8 36
  • 39 (a)
Mrgprx1 36
  • 51 (a)
Mrgprx2 36
  • 46 (a)
(Pan troglodytes)
Mammalia MRGPRX3 35
  • 97.52 (n)
  • 95.34 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Mrgprx3 35
  • 67.89 (n)
  • 58.19 (a)
(Bos Taurus)
Mammalia MRGPRX2 36
  • 51 (a)
(Canis familiaris)
Mammalia -- 36
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
-- 36
  • 35 (a)
-- 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 22 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 28 (a)
-- 36
  • 31 (a)
-- 36
  • 33 (a)
-- 36
  • 30 (a)
-- 36
  • 29 (a)
-- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 20 (a)
-- 36
  • 27 (a)
-- 36
  • 24 (a)
-- 36
  • 26 (a)
-- 36
  • 24 (a)
-- 36
  • 23 (a)
-- 36
  • 26 (a)
Species with no ortholog for MRGPRX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRGPRX3 Gene

Gene Tree for MRGPRX3 (if available)
Gene Tree for MRGPRX3 (if available)

Paralogs for MRGPRX3 Gene

Paralogs for MRGPRX3 Gene

(9) SIMAP similar genes for MRGPRX3 Gene using alignment to 2 proteins: Pseudogenes for MRGPRX3 Gene

genes like me logo Genes that share paralogs with MRGPRX3: view

Variants for MRGPRX3 Gene

Sequence variations from dbSNP and Humsavar for MRGPRX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs4274188 - 18,137,707(+) GTGCT(A/C/G)ATTCT reference, missense
rs12291017 - 18,137,446(+) TTATA(C/T)GTTCG reference, missense
rs867504 -- 18,109,589(+) GCACA(G/T)AATTG intron-variant
rs907922 -- 18,111,495(-) TCAGA(C/T)ACTCC intron-variant
rs907923 -- 18,110,454(-) AACAC(A/C)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRGPRX3 Gene

Variant ID Type Subtype PubMed ID
esv23532 CNV Gain 19812545
esv2744166 CNV Deletion 23290073

Variation tolerance for MRGPRX3 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRGPRX3 Gene

Disorders for MRGPRX3 Gene

Relevant External Links for MRGPRX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRGPRX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRGPRX3 Gene

Publications for MRGPRX3 Gene

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PMID: 11551509) Dong X. … Anderson D.J. (Cell 2001) 2 3 4 67
  2. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PMID: 16284629) Burstein E.S. … Nash N.R. (Br. J. Pharmacol. 2006) 3
  3. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. (PMID: 15809047) Kaisho Y. … Taketomi S. (Biochem. Biophys. Res. Commun. 2005) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways. (PMID: 12751793) Edalat M. … Mannervik B. (Biol. Chem. 2003) 23

Products for MRGPRX3 Gene

Sources for MRGPRX3 Gene