MRGPRX3 Gene
protein-coding GIFtS: 43
GCID: GC11P018142
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MAS-related GPR, member X3
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Aliases
for MRGPRX3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| MAS-Related GPR, Member X31 2 | | G Protein-Coupled Receptor MRGX32 | | MRGX31 2 3 5 | | G Protein-Coupled Receptor SNSR12 | | Sensory Neuron-Specific G-Protein Coupled Receptor 1/22 3 | | G Protein-Coupled Receptor SNSR22 | | SNSR12 3 | | Mas-Related G-Protein Coupled Receptor Member X32 | | SNSR22 3 | | Mas-Related GPCR Member X32 | | GPCR2 | | |
Export aliases for MRGPRX3 gene to outside databasesPrevious GC identifers: GC11P018100 GC11P017825 |
Summaries
for MRGPRX3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRGPRX3:
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors. Theencoded protein may be involved in sensory neuron regulation and in the modulation of pain. (provided by RefSeq, Oct2009)
UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor functionand/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity)
Gene Wiki entry for MRGPRX3
|
Genomic Views
for MRGPRX3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRGPRX3 gene promoter:
Max1 TBP FOXD3 POU2F1 FOXJ2 (long isoform) HOXA5 POU2F1a POU2F1c FOXJ2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRGPRX3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRGPRX3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P018142: view genomic region
(about GC identifiers)
Start:
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18,142,502 bp from pter |
End:
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18,160,027 bp from pter |
Size:
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17,526 bases |
Orientation:
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plus strand |
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Proteins
for MRGPRX3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0 (See
protein sequence)Recommended Name: Mas-related G-protein coupled receptor member X3 Size: 322 amino acids; 36483 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B0M0L1 Q8TDE0 Q8TDE1Explore the universe of human proteins at neXtProt for MRGPRX3: NX_Q96LB0
MRGPRX3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_473372.3
ENSEMBL proteins: ENSP00000379571 ENSP00000436242
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
MRGPRX3 for ontologies About GeneDecksing
MRGPRX3 Antibody Products:
Assay Products for MRGPRX3: |
Protein
Domains /
Families
for MRGPRX3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRGPRX3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LB0ProtoNet protein and cluster: Q96LB0 UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily |
Function
for MRGPRX3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor functionand/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
IEA | -- |
MRGPRX3 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRGPRX3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRGPRX3
|
Drugs & Compounds
for MRGPRX3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRGPRX3
Search CenterWatch for drugs/clinical trials and news about MRGPRX3 / MRGX3
|
Transcripts
for MRGPRX3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRGPRX3 gene: NM_054031.3 Unigene Cluster for MRGPRX3: MAS-related GPR, member X3 Hs.380177 [show with all ESTs]Unigene Representative Sequence: BC0672922 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396275(uc001mnu.3) ENST00000531264
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRGPRX3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRGPRX3 (NM_054031) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRGPRX3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX3 |
Additional cDNA sequence: BC067292.1 EU432126.1 1 DOTS entry: DT.91883477 7 AceView cDNA sequences: BE439409 BC067292 CA455045 NM_054031 CD243595 BV173107 BU178344
GeneLoc Exon Structure
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Expression
for MRGPRX3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRGPRX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAGCATTA
About this image
Genevestigator expression for MRGPRX3
SOURCE GeneReport for Unigene cluster: Hs.380177
UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons
SABiosciences Expression via Pathway-Focused PCR Array including MRGPRX3: | G Protein Coupled Receptors 384HT in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRGPRX3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat MRGPRX3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRGPRX3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRGPRX3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX3 |
Orthologs
for MRGPRX3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRGPRX3 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for MRGPRX3 (if available)
TreeFam Gene Tree for MRGPRX3 (if available) |
Paralogs
for MRGPRX3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRGPRX3 gene
- MRGPRX12 MRGPRD2 MRGPRE2 MRGPRG2 MRGPRX22 MAS12 MAS1L2 MRGPRF2
- MRGPRX42
9 SIMAP similar genes for MRGPRX3 using alignment to 2 protein entries: MRGX3_HUMAN (see all proteins):MRGPRX1 MRGPRX4 MRGPRX2 MAS1 MAS1L MRGPRD
MRGPRE MRGPRF MRGPRG
MRGPRX3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for MRGPRX3
PGOHUM00000257806 PGOHUM00000242192 PGOHUM00000242608
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Genomic Variants
for MRGPRX3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRGPRX3 (18142502 - 18160027 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRGPRX3
1 CNV: 71290 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRGPRX3 |
|
Disorders
/ Diseases
for MRGPRX3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRGPRX3 for disorders About GeneDecksing
OMIM gene information: 607229
OMIM disorders: --
2  diseases for MRGPRX3: About MalaCardsneuronitis cataract
Export disorders for MRGPRX3 gene to outside databases
|
Publications
for MRGPRX3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRGPRX3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRGPRX3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)1, 2 Lembo P.M.C.... Ahmad S. (2002)
- Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PubMed id 16284629)1 Burstein E.S....Nash N.R. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. (PubMed id 15809047)1 Kaisho Y....Taketomi S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways. (PubMed id 12751793)9 Edalat M....Mannervik B. (2003)
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External Searches for MRGPRX3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRGPRX3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRGPRX3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRGPRX3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRGPRX3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRGPRX3 gene:
Search GeneIP for patents involving MRGPRX3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRGPRX3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | MRGPRX3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRGPRX3 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRGPRX3 |
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