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MRGPRX3 Gene

protein-coding   GIFtS: 47
GCID: GC11P018142

MAS-Related GPR, Member X3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
MAS-Related GPR, Member X31 2     G Protein-Coupled Receptor MRGX32
MRGX32 3 5     G Protein-Coupled Receptor SNSR12
Sensory Neuron-Specific G-Protein Coupled Receptor 1/22 3     G Protein-Coupled Receptor SNSR22
SNSR12 3     Mas-Related G-Protein Coupled Receptor Member X32
SNSR22 3     Mas-Related GPCR Member X32
GPCR2     

External Ids:    HGNC: 179801   Entrez Gene: 1171952   Ensembl: ENSG000001798267   OMIM: 6072295   UniProtKB: Q96LB03   

Export aliases for MRGPRX3 gene to outside databases

Previous GC identifers: GC11P018100 GC11P017825


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRGPRX3 Gene:
This gene encodes a member of the mas-related/sensory neuron specific subfamily of G protein coupled receptors.
The encoded protein may be involved in sensory neuron regulation and in the modulation of pain. (provided by
RefSeq, Oct 2009)

GeneCards Summary for MRGPRX3 Gene:
MRGPRX3 (MAS-related GPR, member X3) is a protein-coding gene. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is MRGPRD.

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

Gene Wiki entry for MRGPRX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRGPRX3 gene promoter:
         Max1   TBP   FOXD3   POU2F1   FOXJ2 (long isoform)   HOXA5   POU2F1a   POU2F1c   FOXJ2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRGPRX3 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRGPRX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

MRGPRX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRGPRX3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P018142:  view genomic region     (about GC identifiers)

Start:
18,142,502 bp from pter      End:
18,160,027 bp from pter
Size:
17,526 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0 (See protein sequence)
Recommended Name: Mas-related G-protein coupled receptor member X3  
Size: 322 amino acids; 36483 Da
Secondary accessions: B0M0L1 Q8TDE0 Q8TDE1

Explore the universe of human proteins at neXtProt for MRGPRX3: NX_Q96LB0

Explore proteomics data for MRGPRX3 at MOPED


See MRGPRX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_473372.3  
ENSEMBL proteins: 
 ENSP00000379571   ENSP00000436242  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
GPCRAO: GPCR / Class A : Orphans

IUPHAR Guide to PHARMACOLOGY protein family classification: MRGPRX3
Class A Orphans

4 InterPro protein domains:
 IPR017452 GPCR_Rhodpsn_7TM
 IPR027338 MRGPCRX1/X3
 IPR026234 MRGPCRFAMILY
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96LB0

ProtoNet protein and cluster: Q96LB0

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily


Find genes that share domains with MRGPRX3           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: MRGX3_HUMAN, Q96LB0
Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor
function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By
similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity IEA--
     
Find genes that share ontologies with MRGPRX3           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
MRGX3_HUMAN, Q96LB0: Cell membrane; Multi-pass membrane protein
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane IEA--
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MRGPRX3           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX3: 
          G Protein Coupled Receptors 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for MRGPRX3

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----

Find genes that share ontologies with MRGPRX3           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for MRGPRX3 (MRGX3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MRGPRX3 gene: 
NM_054031.3  

Unigene Cluster for MRGPRX3:

MAS-related GPR, member X3
Hs.380177  [show with all ESTs]
Unigene Representative Sequence: BC067292
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000396275(uc001mnu.3) ENST00000531264
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Additional mRNA sequence: 

BC067292.1 EU432126.1 

1 DOTS entry:

DT.91883477 

7 AceView cDNA sequences:

NM_054031 CA455045 BC067292 BE439409 BV173107 CD243595 BU178344 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRGPRX3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAAAGCATTA
MRGPRX3 Expression
About this image

MRGPRX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRGPRX3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.380177

UniProtKB/Swiss-Prot: MRGX3_HUMAN, Q96LB0
Tissue specificity: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons

    Pathway & Disease-focused RT2 Profiler PCR Array including MRGPRX3: 
          G Protein Coupled Receptors 384HT in human mouse rat

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MRGPRX3 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrgpra11 , 5 MAS-related GPR, member A11, 5 66.79(n)1
58.21(a)1
  7 (30.80 cM)5
2332211  NM_153095.21  NP_694735.21 
 473348755 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
22(a)
1 → many
JH376180.1(56001-57008)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 16)
Uncharacterized protein
(see all 16)
33(a)
31(a)
(see all 16)
many ↔ many
many ↔ many
(see all 16)
4(16394563-16395360)
4(16384879-16387025)


ENSEMBL Gene Tree for MRGPRX3 (if available)
TreeFam Gene Tree for MRGPRX3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for MRGPRX3 gene
MRGPRD2  MRGPRG2  MAS12  MAS1L2  MRGPRF2  MRGPRX42  MRGPRX12  MRGPRE2  
MRGPRX22  
9 SIMAP similar genes for MRGPRX3 using alignment to 2 protein entries:     MRGX3_HUMAN (see all proteins):
MRGPRX1    MRGPRX4    MRGPRX2    MAS1    MAS1L    MRGPRD
MRGPRE    MRGPRF    MRGPRG

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3 Pseudogenes.org Pseudogenes for MRGPRX3
PGOHUM00000257806 PGOHUM00000242192 PGOHUM00000242608


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MRGPRX3 (see all 462)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs79380821,2
C,F--18140545(+) tggcaC/Tgcgct 1 -- us2k11Minor allele frequency- T:0.14WA 118
rs1132368751,2
C,F--18140546(+) GGCACG/ACGCTT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1852417111,2
--18140558(+) TAGTCC/TGAGCT 1 -- us2k10--------
rs1132027451,2
C,F--18140598(+) TGAATC/ACAGGA 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs3749066181,2
C--18140674(+) CATCTA/CAAAAA 1 -- us2k10--------
rs1131193101,2
C,F--18140715(+) CAAAAC/TATAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1924034861,2
--18140831(+) CCCAAC/TATGGC 1 -- us2k10--------
rs1838503651,2
--18140873(+) TAGCTC/GTGCGT 1 -- us2k10--------
rs1871329931,2
--18140912(+) TTGGGA/TGGCTG 1 -- us2k10--------
rs1414067751,2
--18140930(+) AGAATC/TGCTTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MRGPRX3 (18142502 - 18160027 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MRGPRX3:    About this table    
Variant IDTypeSubtypePubMed ID
esv2744166CNV Deletion23290073
esv23532CNV Gain19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607229    OMIM disorders: --


Find genes that share disorders with MRGPRX3           About GenesLikeMe


Export disorders for MRGPRX3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRGPRX3 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MRGPRX3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. (PubMed id 11551509)1, 2, 3 Dong X.... Anderson D.J. (Cell 2001)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. (PubMed id 11850634)1, 2 Lembo P.M.C.... Ahmad S. (Nat. Neurosci. 2002)
  4. Characterization of the Mas-related gene family: structural and functional conservation of human and rhesus MrgX receptors. (PubMed id 16284629)1 Burstein E.S....Nash N.R. (Br. J. Pharmacol. 2006)
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  6. Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. (PubMed id 15809047)1 Kaisho Y....Taketomi S. (Biochem. Biophys. Res. Commun. 2005)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Selective recognition of peptide sequences by glutathione transferases: a possible mechanism for modulation of cellular stress-induced signaling pathways. (PubMed id 12751793)9 Edalat M....Mannervik B. (Biol. Chem. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 117195 HGNC: 17980 AceView: MRGX3 Ensembl:ENSG00000179826 euGenes: HUgn117195
ECgene: MRGPRX3 H-InvDB: MRGPRX3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRGPRX3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRGPRX3 gene:
Search GeneIP for patents involving MRGPRX3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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